Theoaris Panaretakis

Publications
CV
Public outreach and news

Articles

Article: EUROPEAN JOURNAL OF CANCER. 2018;97:33-40
Weekly versus 3-weekly cabazitaxel for the treatment of castration-resistant prostate cancer: A randomised phase II trial (ConCab)
Yachnin J; Gilje B; Thon K; Johansson H; Brandberg Y; Panaretakis T; Ullen A
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2018;499(4):822-828
Caspase-2 associates with FAN through direct interaction and overlapping functionality
Forsberg J; Li X; Zamaraev AV; Panaretakis T; Zhivotovsky B; Olsson M
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2017;6(1):1321455
A novel community driven software for functional enrichment analysis of extracellular vesicles data
Pathan M; Keerthikumar S; Chisanga D; Alessandro R; Ang C-S; Askenase P; Batagov AO; Benito-Martin A; Camussi G; Clayton A; Collino F; Di Vizio D; Falcon-Perez J; Fonseca P; Fonseka P; Fontana S; Gho YS; Hendrix A; Nolte-'t Hoen E; Iraci N; Kastaniegaard K; Kislinger T; Kowal J; Kurochkin IV; Leonardi T; Liang Y; Llorente A; Lunavat TR; Maji S; Monteleone F; Overbye A; Panaretakis T; Patel T; Peinado H; Pluchino S; Principe S; Ronquist G; Royo F; Sahoo S; Spinelli C; Stensballe A; Thery C; van Herwijnen MJC; Wauben M; Welton JL; Zhao K; Mathivanan S
Article: BLOOD. 2016;128(23):2655-2665
Caspase-3-dependent cleavage of Bcl-xL in the stroma exosomes is required for their uptake by hematological malignant cells
Vardaki I; Sanchez C; Fonseca P; Olsson M; Chioureas D; Rassidakis G; Ullen A; Zhivotovsky B; Bjorkholm M; Panaretakis T
Article: ONCOTARGET. 2016;7(46):74966-74978
Periostin is identified as a putative metastatic marker in breast cancer-derived exosomes
Vardaki I; Ceder S; Rutishauser D; Baltatzis G; Foukakis T; Panaretakis T
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2016;5:29877
Energy-requiring uptake of prostasomes and PC3 cell-derived exosomes into non-malignant and malignant cells
Ronquist KG; Sanchez C; Dubois L; Chioureas D; Fonseca P; Larsson A; Ullen A; Yachnin J; Ronquist G; Panaretakis T
Article: ONCOTARGET. 2015;6(35):37066-37082
Sorafenib-induced defective autophagy promotes cell death by necroptosis
Kharaziha P; Chioureas D; Baltatzis G; Fonseca P; Rodriguez P; Gogvadze V; Lennartsson L; Bjorklund A-C; Zhivotovsky B; Grander D; Egevad L; Nilsson S; Panaretakis T
Article: ONCOTARGET. 2015;6(25):21740-21754
Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel
Kharaziha P; Chioureas D; Rutishauser D; Baltatzis G; Lennartsson L; Fonseca P; Azimi A; Hultenby K; Zubarev R; Ullen A; Yachnin J; Nilsson S; Panaretakis T
Article: PROSTATE. 2015;75(10):1063-1073
Malignant Cell-Derived Extracellular Vesicles Express Different Chromogranin Epitopes Compared to Prostasomes
Dubois L; Stridsberg M; Kharaziha P; Chioureas D; Meersman N; Panaretakis T; Ronquist KG
Article: PLOS ONE. 2013;8(7):e67579
Effect of Acute Exercise on Prostate Cancer Cell Growth
Rundqvist H; Augsten M; Stromberg A; Rullman E; Mijwel S; Kharaziha P; Panaretakis T; Gustafsson T; Ostman A
Article: CANCER RESEARCH. 2012;72(20):5348-5362
Sorafenib Has Potent Antitumor Activity against Multiple Myeloma In Vitro, Ex Vivo, and In Vivo in the 5T33MM Mouse Model
Kharaziha P; De Raeve H; Fristedt C; Li Q; Gruber A; Johnsson P; Kokaraki G; Panzar M; Laane E; Osterborg A; Zhivotovsky B; Jernberg-Wiklund H; Grander D; Celsing F; Bjorkholm M; Vanderkerken K; Panaretakis T
Article: CELL DEATH & DISEASE. 2012;3(1):e262
Targeting of distinct signaling cascades and cancer-associated fibroblasts define the efficacy of Sorafenib against prostate cancer cells
Kharaziha P; Rodriguez P; Li Q; Rundqvist H; Bjoerklund A-C; Augsten M; Ullen A; Egevad L; Wiklund P; Nilsson S; Kroemer G; Grander D; Panaretakis T
Article: CELL DEATH & DISEASE. 2010;1(12):e104
Calreticulin exposure on malignant blasts predicts a cellular anticancer immune response in patients with acute myeloid leukemia
Wemeau M; Kepp O; Tesniere A; Panaretakis T; Flament C; De Botton S; Zitvogel L; Kroemer G; Chaput N
Article: CELL CYCLE. 2010;9(15):3072-3077
Lysyl tRNA synthetase is required for the translocation of calreticulin to the cell surface in immunogenic death
Kepp O; Gdoura A; Martins I; Panaretakis T; Schlemmer F; Tesniere A; Fimia GM; Ciccosanti F; Burgevin A; Piacentini M; Eggleton P; Young PJ; Zitvogel L; van Endert P; Kroemer G
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2010;37(1):15-20
Sorafenib induces apoptosis and autophagy in prostate cancer cells in vitro
Ullen A; Farnebo M; Thyrell L; Mahmoudi S; Kharaziha P; Lennartsson L; Grander D; Panaretakis T; Nilsson S
Article: AUTOPHAGY. 2009;5(8):1198-1200
Autophagy as the main means of cytotoxicity by glucocorticoids in hematological malignancies
Grander D; Kharaziha P; Laane E; Pokrovskaja K; Panaretakis T
Article: NATURE MEDICINE. 2009;15(10):1170-1178
Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β-dependent adaptive immunity against tumors
Ghiringhelli F; Apetoh L; Tesniere A; Aymeric L; Ma Y; Ortiz C; Vermaelen K; Panaretakis T; Mignot G; Ullrich E; Perfettini J-L; Schlemmer F; Tasdemir E; Uhl M; Genin P; Civas A; Ryffel B; Kanellopoulos J; Tschopp J; Andre F; Lidereau R; McLaughlin NM; Haynes NM; Smyth MJ; Kroemer G; Zitvogel L
Article: CELL DEATH AND DIFFERENTIATION. 2009;16(7):1018-1029
Cell death induced by dexamethasone in lymphoid leukemia is mediated through initiation of autophagy
Laane E; Tamm KP; Buentke E; Ito K; Kharaziha P; Oscarsson J; Corcoran M; Bjorklund A-C; Hultenby K; Lundin J; Heyman M; Soderhall S; Mazur J; Porwit A; Pandolfi PP; Zhivotovsky B; Panaretakis T; Grander D
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2009;46(12):1607-1613
Cisplatin-induced nitrosylation of p53 prevents its mitochondrial translocation
Hernlund E; Kutuk O; Basaga H; Linder S; Panaretakis T; Shoshan M
Article: CELL DEATH AND DIFFERENTIATION. 2009;16(5):749-757
Horizontal transfer of tumor DNA to endothelial cells in vivo
Ehnfors J; Kost-Alimova M; Persson NL; Bergsmedh A; Castro J; Levchenko-Tegnebratt T; Yang L; Panaretakis T; Holmgren L
Article: EMBO JOURNAL. 2009;28(5):578-590
Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death
Panaretakis T; Kepp O; Brockmeier U; Tesniere A; Bjorklund A-C; Chapman DC; Durchschlag M; Joza N; Pierron G; van Endert P; Yuan J; Zitvogel L; Madeo F; Williams DB; Kroemer G
Article: CELL CYCLE. 2009;8(4):639-642
Phylogenetic conservation of the preapoptotic calreticulin exposure pathway from yeast to mammals
Madeo F; Durchschlag M; Kepp O; Panaretakis T; Zitvogel L; Froehlich K-U; Kroemer G
Article: CELL DEATH AND DIFFERENTIATION. 2008;15(9):1499-1509
The co-translocation of ERp57 and calreticulin determines the immunogenicity of cell death
Panaretakis T; Joza N; Modjtahedi N; Tesniere A; Vitale I; Durchschlag M; Durchschlag M; Fimia GM; Kepp O; Piacentini M; Froehlich K-U; van Endert P; Zitvogel L; Madeo F; Kroemer G
Article: INTERNATIONAL JOURNAL OF CANCER. 2008;123(2):476-483
Potentiation of chemotherapeutic drugs by energy metabolism inhibitors 2-deoxyglucose and etomoxir
Hernlund E; Ihrlund LS; Khan O; Ates YO; Linder S; Panaretakis T; Shoshan MC
Article: CANCER RESEARCH. 2008;68(13):5301-5308
Improved cellular pharmacokinetics and pharmacodynamics underlie the wide anticancer activity of sagopilone
Hoffmann J; Vitale I; Buchmann B; Galluzzi L; Schwede W; Senovilla L; Skuballa W; Vivet S; Lichtner RB; Vicencio JM; Panaretakis T; Siemeister G; Lage H; Nanty L; Hammer S; Mittelstaedt K; Winsel S; Eschenbrenner J; Castedo M; Demarche C; Klar U; Kroemer G
Article: CELL DEATH AND DIFFERENTIATION. 2008;15(2):274-282
Reduction of endoplasmic reticulum Ca²⁺ levels favors plasma membrane surface exposure of calreticulin
Tufi R; Panaretakis T; Bianchi K; Criollo A; Fazi B; Di Sano F; Tesniere A; Kepp O; Paterlini-Brechot P; Zitvogel L; Piacentini M; Szabadkai G; Kroemer G
Article: MOLECULAR BIOLOGY OF THE CELL. 2008;19(1):41-50
Interferon α induces nucleus-independent apoptosis by activating extracellular signal-regulated kinase 1/2 and c-Jun NH₂-terminal kinase downstream of phosphatidylinositol 3-kinase and mammalian target of rapamycin
Panaretakis T; Hjortsberg L; Tamm KP; Bjorklund A-C; Joseph B; Grander D
Article: NATURE MEDICINE. 2007;13(1):54-61
Calreticulin exposure dictates the immunogenicity of cancer cell death
Obeid M; Tesniere A; Ghiringhelli F; Fimia GM; Apetoh L; Perfettini J-L; Castedo M; Mignot G; Panaretakis T; Casares N; Metivier D; Larochette N; van Endert P; Ciccosanti F; Piacentini M; Zitvogel L; Kroemer G
Article: INTERNATIONAL JOURNAL OF CANCER. 2007;120(1):175-180
Acute apoptosis by cisplatin requires induction of reactive oxygen species but is not associated with damage to nuclear DNA
Berndtsson M; Hagg M; Panaretakis T; Havelka AM; Shoshan MC; Linder S
Article: EXPERIMENTAL CELL RESEARCH. 2006;312(9):1581-1589
Two distinct steps of Bak regulation during apoptotic stress signaling: Different roles of MEKK1 and JNK1
Ihrlund LS; Hernlund E; Viktorsson K; Panaretakis T; Barna G; Sabapathy K; Linder S; Shoshan MC
Article: MOLECULAR BIOLOGY OF THE CELL. 2005;16(8):3821-3831
Doxorubicin requires the sequential activation of caspase-2, protein kinase Cδ, and c-Jun NH₂-terminal kinase to induce apoptosis
Panaretakis T; Laane E; Pokrovskaja K; Björklund AC; Moustakas A; Zhivotovsky B; Heyman M; Shoshan MC; Grandér D
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(23):24152-24162
Interferon α-induced apoptosis in tumor cells is mediated through the phosphoinositide 3-kinase/mammalian target of rapamycin signaling pathway
Thyrell L; Hjortsberg L; Arulampalam V; Panaretakis T; Uhles S; Dagnell M; Zhivotovsky B; Leibiger I; Grandér D; Pokrovskaja K
Article: ONCOGENE. 2003;22(29):4543-4556
Interferon-α-induced apoptosis in U266 cells is associated with activation of the proapoptotic Bcl-2 family members Bak and Bax
Panaretakis T; Pokrovskaja K; Shoshan MC; Grandér D
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(46):44317-44326
Activation of Bak, Bax, and BH3-only proteins in the apoptotic response to doxorubicin
Panaretakis T; Pokrovskaja K; Shoshan MC; Grandér D
Article: JOURNAL OF MEMBRANE BIOLOGY. 2001;183(1):39-50
Proton- and sodium-coupled phosphate transport systems and energy status of Yarrowia lipolytica cells grown in acidic and alkaline conditions
Zvyagilskaya R; Parchomenko O; Abramova N; Allard P; Panaretakis T; Pattison-Granberg J; Persson BL
Article: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2001;173(1):56-64
Reactive oxygen species and mitochondria mediate the induction of apoptosis in human hepatoma HepG2 cells by the rodent peroxisome proliferator and hepatocarcinogen, perfluorooctanoic acid
Panaretakis T; Shabalina IG; Grandér D; Shoshan MC; DePierre JW
Article: CARCINOGENESIS. 1999;20(12):2237-2246
Effects of the rodent peroxisome proliferator and hepatocarcinogen, perfluorooctanoic acid, on apoptosis in human hepatoma HepG2 cells
Shabalina IG; Panaretakis T; Bergstrand A; DePierre JW
Show more

Employments

Affiliated to Research, Institute of Environmental Medicine, Karolinska Institutet, 2023-2026

Degrees and Education

Docent, Karolinska Institutet, 2009
Doctor Of Philosophy, Department of Oncology-Pathology, Karolinska Institutet, 2003

Articles

Employments

Degrees and Education

News from KI

Events from KI