Bertrand Joseph

Bertrand Joseph

Professor
Telephone: +46852487945
Visiting address: Nobels väg 13, 17177 Stockholm
Postal address: C6 Institutet för miljömedicin, C6 Toxikologi Joseph, 171 77 Stockholm
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About me

  • Bertrand Joseph, Professor of Molecular Cancer Biology specialising in Cell Death at the Institute of Environmental Medicine, researches signals at cellular level that determine if cells are to die or not. His work is relevant for many diseases, such as neurodegenerative diseases and cancer, in which cells take the wrong decision in this choice between life and death.

Articles

All other publications

Grants

  • Swedish Research Council
    1 January 2024 - 31 December 2026
    Microglia, resident immune cells of the brain, fulfil multiple and contrasting functions in the brain from its development throughout the entire lifespan under normal conditions, but also in the context of brain disorders. How can the microglia be multitasking?The prevailing view in the field remains that microglia are highly plastic cells that acquire different reactive states and functions when exposed to extrinsic cues in their environment. However, emerging evidence, including from our team, indicates that the microglial cell population exhibits several cellular subsets with unique intrinsic properties. Hence, we argue that the plasticity of microglia, i.e., microglia reactive states, as well as the inherent diversity of microglia, i.e., the microglia subtypes, must be considered to understand the multitasking microglia.We aim at elucidating the molecular events, which control the acquisition of microglia reactive states exerting unique functions in the healthy or pathologic brain. We also propose to uncover the microglia subtypes that co-exist within the developing brain, characterize the programs that regulate their intrinsic phenotypes and unique functions, and thereafter establish their contribution to brain development and disorders throughout life.We are convinced that increased knowledge of microglia plasticity and diversity will provide a platform for novel innovative therapeutic strategies to combat devastating disorders of the developing and the mature brain.

Employments

  • Professor, Molecular Cancer Biology, Institute of Environmental Medicine, Karolinska Institutet, 2017-
  • Professor, Department of Oncology-Pathology, Karolinska Institutet, 2015-2017

Degrees and Education

  • Docent, Karolinska Institutet, 2004

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