Jiri Bartek group

Cells employ an extensive network of DNA damage response (DDR) processes to maintain genome integrity and to promote survival after exposure to genotoxic stresses. Distinct DNA repair pathways respond to different types of damage, while cell cycle checkpoints provide the time that is needed to repair DNA lesions. Research in the Bartek lab focuses on various mechanistic aspects of the DDR and DNA repair pathways.

Jiri Bartek group


Research in the Bartek lab focuses on various mechanistic aspects of the DDR and DNA repair pathways. Of particular interest is discovery of targets and markers for personalized cancer treatment and finding novel components or mechanisms of genome integrity maintenance. Another of our long-term goals is to further unravel the principles of ribosome biogenesis surveillance and to understand the dynamics and the finer details of the p53 pathway in sensing ribosome dysfunction, and how ribosomal stress crosstalk with the DNA damage response.

Examples of projects currently running in the lab include: the search for new treatments and markers for malignant brain tumors with a focus on the nucleolus and ribosome biogenesis; characterization of proteins involved in the DNA damage response in particular in R loop formation and resolution; characterization of proteins involved in rRNA processing and mRNA translation; and the exploration of novel links between the nucleolus and the protein degradation machinery.

External funding

Logotypes for Cancerfonden, Vetenskapsrådet and Radiumhemmets Forskningsfonder.


Selected publications

Members and contact

Group leader

All members of the group


  • Asimina Zisi, PhD student, 2017-2022
  • Katja Bekcic, master student, 2022
  • Kacper Szklarczyk, undergraduate student, 2022
  • Andrea Björk, postdoctoral researcher, 2016-2021
  • Terezie Imrachova, visiting researcher, 2021
  • Athina Eleftheraki, master student, 2021
  • Karla Paola Leal Villegas, visiting PhD student, 2021
  • Gábor Merényi, research assistant, 2019-2021
  • Sidorela Selami, research assistant, 2020
  • Kenneth Schou, postdoctoral researcher, 2017-2020
  • Fenne Van Dongen, master student, 2019
  • Anastasios Mastroanastasiou, undergraduate summer intern, 2018
  • Kaveh Moazemi-Goudarzi, PhD student, 2015-2018
  • Annika Ranta, undergraduate summer intern, 2017
  • Alexandros Iskantar, undergraduate student Erasmus+, 2017