Gunilla Karlsson Hedestam group
Our research focuses on the function of B lymphocytes and qualitative properties of antibody repertoires. A specific interest in the group is to understand individual variation in antibody germline (VDJ) genes and how this influences the elicitation of antigen-specific B cell responses.
The computational tool, IgDiscover, allows the production of individualized genetic profiles of adaptive immune receptor V, D and J genes, which is central for many areas of research and personalized medicine applications.
The latest set of VDJ alleles reported in Vázquez Bernat et al., available for download and assignments.