Gunilla Karlsson Hedestam group
Our research focuses on adaptive immune responses and qualitative properties of B- and T-cell repertoires. A specific interest in the group is to understand individual variation in germline V, D and J genes and how this influences antigen-specific responses in the context of infection, vaccination and autoimmunity.
The computational tool, IgDiscover, allows the production of individualized genetic profiles of adaptive immune receptor V, D and J genes, which is central for many areas of research and personalized medicine applications.
Macaque IG VDJ database
This database incorporates IGHV, IGHJ and IGHD sequences from four subgroups of macaques, namely Indian and Chinese origin Rhesus macaques and Indonesian and Mauritian origin Cynomolgus macaques.
Human TCR VDJ database
Population-based human V, D and J germline gene sequences for TRA, TRD, TRB and TRG.
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