Xaquin Castro Dopico

About me
Publications
Public outreach and news

About me

Immunologist-veterinarian interested in gene-environment interactions and molecular mechanisms in adaptive immunity

Research

Primary samples &
comparative immunology
antigen-specific T and B cell responses
lymphocyte metabolism
antibody therapies and vaccines.

Articles

Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2024;13(5):e1508
Maintenance of caecal homeostasis by diverse adaptive immune cells in the rhesus macaque
Dopico XC; Guryleva M; Mandolesi M; Corcoran M; Coquet JM; Murrell B; Hedestam GBK
Article: JCI INSIGHT. 2023;8(17):e167656
Antigen receptor stimulation induces purifying selection against pathogenic mitochondrial tRNA mutations
Zhang J; Koolmeister C; Han J; Filograna R; Hanke L; Adori M; Sheward DJ; Teifel S; Gopalakrishna S; Shao Q; Liu Y; Zhu K; Harris RA; Mcinerney G; Murrell B; Aoun M; Baeckdahl L; Holmdahl R; Pekalski M; Wedell A; Engvall M; Wredenberg A; Hedestam GBK; Dopico XC; Rorbach J
Article: IMMUNOLOGY LETTERS. 2023;259:24-29
Untangling associations between immunoglobulin genotypes, repertoires and function
Dopico XC; Mandolesi M; Hedestam GBK
Article: OPEN BIOLOGY. 2023;13(5):220369
Caprin-1 binding to the critical stress granule protein G3BP1 is influenced by pH
Schulte T; Panas MD; Han X; Williams L; Kedersha N; Fleck JS; Tan TJC; Dopico XC; Olsson A; Morro AM; Hanke L; Nilvebrant J; Giang KA; Nygren P-A; Anderson P; Achour A; McInerney GM
Article: CELLS. 2023;12(9):1229
Enhanced B Cell Receptor Signaling Partially Compensates for Impaired Toll-like Receptor 4 Responses in LPS-Stimulated IκBNS-Deficient B Cells
Adori M; Khoenkhoen S; Zhang J; Dopico XC; Karlsson Hedestam GB
Article: FRONTIERS IN VIROLOGY. 2023;3:1128253
Frequent use of IGHV3-30-3 in SARS-CoV-2 neutralizing antibody responses
Pushparaj P; Nicoletto A; Castro Dopico X; Sheward DJ; Kim S; Ekstrom S; Murrell B; Corcoran M; Karlsson Hedestam GB
Article: NUCLEIC ACIDS RESEARCH (NAR). 2023;51(2):891-907
Translation initiation of leaderless and polycistronic transcripts in mammalian mitochondria
Remes C; Khawaja A; Pearce SF; Dinan AM; Gopalakrishna S; Cipullo M; Kyriakidis V; Zhang J; Dopico XC; Yukhnovets O; Atanassov I; Firth AE; Cooperman B; Rorbach J
Article: IMMUNITY. 2023;56(1):193-206.e7
Immunoglobulin germline gene polymorphisms influence the function of SARS-CoV-2 neutralizing antibodies
Pushparaj P; Nicoletto A; Sheward DJ; Das H; Dopico XC; Vidakovics LP; Hanke L; Chernyshev M; Narang S; Kim S; Fischbach J; Ekstrom S; McInerney G; Hallberg BM; Murrell B; Corcoran M; Hedestam GBK
Article: THE LANCET INFECTIOUS DISEASES. 2022;22(6):813-820
Neutralisation sensitivity of the SARS-CoV-2 omicron (B.1.1.529) variant: a cross-sectional study
Sheward DJ; Kim C; Ehling RA; Pankow A; Dopico XC; Dyrdak R; Martin DP; Reddy ST; Dillner J; Hedestam GBK; Albert J; Murrell B
Article: CELLULAR IMMUNOLOGY. 2022;375:104516
Impaired plasma cell differentiation associates with increased oxidative metabolism in I?BNS-deficient B cells
Erikson E; Adori M; Khoenkhoen S; Zhang J; Rorbach J; Dopico XC; Hedestam GK
Article: JOURNAL OF INFECTIOUS DISEASES. 2022;225(6):965-970
Antibody Responses to Severe Acute Respiratory Syndrome Coronavirus 2 in the Serum and Cerebrospinal Fluid of Patients With Coronavirus Disease 2019 and Neurological Symptoms
Cunningham JL; Virhammar J; Ronnberg B; Dopico XC; Kolstad L; Albinsson B; Kumlien E; Naas A; Klang A; Westman G; Zetterberg H; Frithiof R; Lundkvist A; Hedestam GBK; Rostami E
Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2022;11(3):e1379
Probabilistic classification of anti-SARS-CoV-2 antibody responses improves seroprevalence estimates
Dopico XC; Muschiol S; Grinberg NF; Aleman S; Sheward DJ; Hanke L; Ahl M; Vikstrom L; Forsell M; Coquet JM; McInerney G; Dillner J; Bogdanovic G; Murrell B; Albert J; Wallace C; Hedestam GBK
Article: CELL REPORTS MEDICINE. 2021;2(11):100450
Beta RBD boost broadens antibody-mediated protection against SARS-CoV-2 variants in animal models
Sheward DJ; Mandolesi M; Urgard E; Kim C; Hanke L; Vidakovics LP; Pankow A; Smith NL; Dopico XC; McInerney GM; Coquet JM; Hedestam GBK; Murrell B
Article: JOURNAL OF INTERNAL MEDICINE. 2021;290(3):666-676
Seropositivity in blood donors and pregnant women during the first year of SARS-CoV-2 transmission in Stockholm, Sweden
Castro Dopico X; Muschiol S; Christian M; Hanke L; Sheward DJ; Grinberg NF; Rorbach J; Bogdanovic G; Mcinerney GM; Allander T; Wallace C; Murrell B; Albert J; Karlsson Hedestam GB
Article: CELL REPORTS MEDICINE. 2021;2(4):100252
SARS-CoV-2 protein subunit vaccination of mice and rhesus macaques elicits potent and durable neutralizing antibody responses
Mandolesi M; Sheward DJ; Hanke L; Ma J; Pushparaj P; Vidakovics LP; Kim C; Adori M; Lenart K; Lore K; Dopico XC; Coquet JM; McInerney GM; Hedestam GBK; Murrell B
Article: IMMUNITY. 2021;54(2):355-366.e4
Rhesus and cynomolgus macaque immunoglobulin heavy-chain genotyping yields comprehensive databases of germline VDJ alleles
Bernat NV; Corcoran M; Nowak I; Kaduk M; Dopico XC; Narang S; Maisonasse P; Dereuddre-Bosquet N; Murrell B; Hedestam GBK
Article: FRONTIERS IN IMMUNOLOGY. 2019;10:2606
Chronic Immune Activation in Systemic Lupus Erythematosus and the Autoimmune PTPN22 Trp⁶²⁰ Risk Allele Drive the Expansion of FOXP3⁺ Regulatory T Cells and PD-1 Expression
Ferreira RC; Dopico XC; Oliveira JJ; Rainbow DB; Yang JH; Trzupek D; Todd SA; McNeill M; Steri M; Orru V; Fiorillo E; Crouch DJM; Pekalski ML; Cucca F; Tree TI; Vyse TJ; Wicker LS; Todd JA
Article: JOURNAL OF AUTOIMMUNITY. 2017;84:75-86
Cells with Treg-specific &ITFOXP3&IT demethylation but low CD25 are prevalent in autoimmunity
Ferreira RC; Simons HZ; Thompson WS; Rainbow DB; Yang X; Cutler AJ; Oliveira J; Dopico XC; Smyth DJ; Savinykh N; Mashar M; Vyse TJ; Dunge DB; Baxendale H; Chandra A; Wallace C; Todd JA; Wicker LS; Pekalski ML
Article: GENOME BIOLOGY. 2017;18(1):165
Chromosome contacts in activated T cells identify autoimmune disease candidate genes
Burren OS; Garcia AR; Javierre B-M; Rainbow DB; Cairns J; Cooper NJ; Lambourne JJ; Schofield E; Dopico XC; Ferreira RC; Coulson R; Burden F; Rowlston SP; Downes K; Wingett SW; Frontini M; Ouwehand WH; Fraser P; Spivakov M; Todd JA; Wicker LS; Cutler AJ; Wallace C
Article: JCI INSIGHT. 2017;2(16):93739
Neonatal and adult recent thymic emigrants produce IL-8 and express complement receptors CR1 and CR2
Pekalski ML; Garcia AR; Ferreira RC; Rainbow DB; Smyth DJ; Mashar M; Brady J; Savinykh N; Dopico XC; Mahmood S; Duley S; Stevens HE; Walker NM; Cutler AJ; Waldron-Lynch F; Dunger DB; Shannon-Lowe C; Coles AJ; Jones JL; Wallace C; Todd JA; Wicker LS
Article: HYPERTENSION. 2017;70(3):HYPERTENSIONAHA.117.09242-633
Complement Factor B Is a Determinant of Both Metabolic and Cardiovascular Features of Metabolic Syndrome
Coan PM; Barrier M; Alfazema N; Carter RN; de Proce SM; Dopico XC; Diaz AG; Thomson A; Jackson-Jones LH; Moyon B; Webster Z; Ross D; Moss J; Arends MJ; Morton NM; Aitman TJ
Article: NATURE COMMUNICATIONS. 2015;6:7000
Widespread seasonal gene expression reveals annual differences in human immunity and physiology
Dopico XC; Evangelou M; Ferreira RC; Guo H; Pekalski ML; Smyth DJ; Cooper N; Burren OS; Fulford AJ; Hennig BJ; Prentice AM; Ziegler A-G; Bonifacio E; Wallace C; Todd JA
Article: DIABETOLOGIA. 2015;58(4):781-790
IL-21 production by CD4⁺ effector T cells and frequency of circulating follicular helper T cells are increased in type 1 diabetes patients
Ferreira RC; Simons HZ; Thompson WS; Cutler AJ; Dopico XC; Smyth DJ; Mashar M; Schuilenburg H; Walker NM; Dunger DB; Wallace C; Todd JA; Wicker LS; Pekalski ML
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2014;177(3):571-585
Multi-parametric flow cytometric and genetic investigation of the peripheral B cell compartment in human type 1 diabetes
Thompson WS; Pekalski ML; Simons HZ; Smyth DJ; Castro-Dopico X; Guo H; Guy C; Dunger DB; Arif S; Peakman M; Wallace C; Wicker LS; Todd JA; Ferreira RC
Article: JOURNAL OF IMMUNOLOGY. 2013;190(6):2554-2566
Postthymic Expansion in Human CD4 Naive T Cells Defined by Expression of Functional High-Affinity IL-2 Receptors
Pekalski ML; Ferreira RC; Coulson RMR; Cutler AJ; Guo H; Smyth DJ; Downes K; Dendrou CA; Dopico XC; Esposito L; Coleman G; Stevens HE; Nutland S; Walker NM; Guy C; Dunger DB; Wallace C; Tree TIM; Todd JA; Wicker LS
Show more

All other publications

Preprint: BIORXIV. 2022
A semi-supervised Bayesian mixture modelling approach for joint batch correction and classification
Coleman S; Nicholls K; Nicholls K; Dopico XC; Karlsson Hedestam G; Kirk PDW; Wallace C
Editorial comment: IMMUNITY. 2022;55(1):8-10
A family matter: Anti-viral antibody responses
Dopico XC; Hedestam GBK
Review: JOURNAL OF INTERNAL MEDICINE. 2022;291(1):32-50
Immunity to SARS-CoV-2 induced by infection or vaccination
Castro Dopico X; Ols S; Lore K; Karlsson Hedestam GB
Preprint: BIORXIV. 2021
Variable loss of antibody potency against SARS-CoV-2 B.1.1.529 (Omicron)
Sheward D; Kim C; Ehling R; Pankow A; Dopico XC; Martin D; Reddy S; Dillner J; Karlsson Hedestam G; Albert J; Murrell B
Preprint: MEDRXIV. 2021
Antigen receptor stimulation drives selection against pathogenic mtDNA variants that dysregulate lymphocyte responses
Zhang J; Koolmeister C; Han J; Filograna R; Hanke L; Àdori M; Sheward D; Teifel S; Liu Y; Harris R; Murrell B; Mcinerney G; Aoun M; Bäckdahl L; Holmdahl R; Pekalski M; Wedell A; Engvall M; Wredenberg A; Karlsson Hedestam G; Dopico XC; Rorbach J
Preprint: BIORXIV. 2021
Driving potent neutralization of a SARS-CoV-2 Variant of Concern with a heterotypic boost
Sheward D; Mandolesi M; Urgard E; Kim C; Hanke L; Vidakovics LP; Pankow A; Smith N; Dopico XC; McInerney G; Coquet J; Hedestam GK; Murrell B
Review: JOURNAL OF BIOLOGICAL RHYTHMS. 2021;36(1):35-54
Drivers of Infectious Disease Seasonality: Potential Implications for COVID-19
Kronfeld-Schor N; Stevenson TJ; Nickbakhsh S; Schernhammer ES; Dopico XC; Dayan T; Martinez M; Helm B
Preprint: MEDRXIV. 2020
Seropositivity in blood donors and pregnant women during the first year of SARS-CoV-2 transmission in Stockholm, Sweden
Dopico XC; Muschiol S; Christian M; Hanke L; Sheward D; Grinberg N; Rorbach J; Bogdanovic G; Mcinerney G; Allander T; Wallace C; Murrell B; Albert J; Hedestam GK
Preprint: BIORXIV. 2020
SARS-CoV-2 protein subunit vaccination elicits potent neutralizing antibody responses
Mandolesi M; Sheward D; Hanke L; Ma J; Pushparaj P; Perez Vidakovics L; Kim C; Loré K; Castro Dopico X; Coquet J; McInerney G; Karlsson Hedestam G; Murrell B
Preprint: MEDRXIV. 2020
Probabilistic approaches for classifying highly variable anti-SARS-CoV-2 antibody responses
Dopico X; Hanke L; Sheward D; Muschiol S; Aleman S; Grinberg N; Adori M; Christian M; Vidakovics LP; Kim C; Khoenkhoen S; Pushparaj P; Morro AM; Mandolesi M; Ahl M; Forsell M; Coquet J; Corcoran M; Rorbach J; Dillner J; Bogdanovic G; McInerney G; Allander T; Murrell B; Wallace C; Albert J; Karlsson Hedestam G

About me

Research

Articles

All other publications

News from KI

Events from KI