Research Division of Medical Inflammation Research

Humanity is suffering from many inflammatory diseases affecting specific tissues of the body. In rheumatoid arthritis, the joints of hands and feet are inflamed and destroyed, in multiple sclerosis the spinal chord and brain, in diabetes insulin-producing cells of the pancreas, in lupus the kidneys and in Sjögren's syndrome the salivary glands. In spite of very large research efforts we do not know why these diseases develop and we have no effective curative treatment for them.

At Medical Inflammation Research (MIR) we believe that it is necessary to take one step back to advance two steps forward. We need to analyse the basic mechanisms behind these diseases and for this work we need animal models. With the animal models we try to find out which genes are important for the human diseases and why the immune system suddenly starts to attack our own tissues. With the increased knowledge we hope to find new ways to predict the diseases, to develop new therapies to stop the disease process and optimally to find ways to completely abrogate development of disease in susceptible individuals.

Research interests

Our main goals are:

  1. To identify the genes that control animal models for rheumatoid arthritis and multiple sclerosis.
  2. To use the animal models not only for understanding the basic mechanism of autoimmune disease but also as models for developing new diagnostic, preventive and therapeutic strategies.
  3. To understand the role of MHC class II genes in explaining the immune specificity of autoimmune disease.

Research Groups

Rikard Holmdahl

Kajsa Wing

Contact

Head of Division, Professor

Rikard Holmdahl

Phone: +46-(0)8-524 846 07
Organizational unit: Holmdahl
E-mail: Rikard.Holmdahl@ki.se

Project coordinator

Angel Yao Mattisson

Phone: +46-(0)8-524 866 38
Organizational unit: Holmdahl
E-mail: Angel.Yao-Mattisson@ki.se

Adress

Division of Medical Inflammation Research
Department of Medical Biochemistry and Biophysics (MBB)
Karolinska Institutet
Biomedicum, 9D, floor 9
Solnavägen 9
171 65 Solna
Sweden

Phone Central Lab: +46-8-524 877 15

 

 

Collaborations and Networks

National Networks

JointID clinical treatment research: A new unique diagnostic test for Rheumatoid Arthrit (2017 - 2019)

Coordinator: Prof. Inger Gjertsson, Dept of Rheumatology, Gothenburg University

Partners:

  • Prof. Rikard Holmdahl, Medical Inflammation Research, MBB, Karolinska Institutet
  • Docent Christopher Sjöwall, Linköping University
  • Prof. Ingiäld Hafström,  Karolinska University Hospital Huddinge
  • Prof. Solbritt Rantapää-Dahlqvist, Umeå university
  • Prof. Jan Kihlberg, Uppsala university
  • Prof. Kristian Bolin, Gothenburg University
  • Prof. Lennart Jacobsson, Gothenburg University

Vaccination - to develop vaccin to occur autoimmune diseases

Coordinator:  Prof. Rikard Holmdahl, Medical Inflammation Research, MBB, Karolinska Institutet

Partners:

  • Prof. Jan Kihlberg, Uppsala university
  • Ass. prof. Kajsa Wing, MBB, Karolinska Institutet
  • Prof. Roman Zubarev, Physiological chemistry I, MBB, Karolinska Institutet

Cancer Redox - targeting redox pathways for improved cancer therapy

Coordinator: Prof. Elias Arnér, Biochemistry, MBB, Karolinska Institutet.

Partners:

  • Prof. Rikard Holmdahl, Medical Inflammation Research, MBB, Karolinska Institutet
  • Prof. Roman Zubarev, Physiological chemistry I, MBB, Karolinska Institutet
  • Prof. Rolf Kiessling, Oncology-Pathology, Karolinska University Hospital
  • Prof. Stig Linder, Oncology-Pathology, Karolinska University Hospital

Center for Autoimmune Diseases

CERIC

International Collaborations

Inflammation