Outi Sareila

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Article: ADVANCED SCIENCE. 2024;11(23):e2401513
Human MHC Class II and Invariant Chain Knock-in Mice Mimic Rheumatoid Arthritis with Allele Restriction in Immune Response and Arthritis Association
Romero-Castillo L; Li T; Do N-N; Sareila O; Xu B; Hennings V; Xu Z; Svensson C; Oliveira-Coelho A; Sener Z; Urbonaviciute V; Ekwall O; Burkhardt H; Holmdahl R
Article: ARTHRITIS & RHEUMATOLOGY. 2023;75(7):1110-1119
Autoantibodies to Disease-Related Proteins in Joints as Novel Biomarkers for the Diagnosis of Rheumatoid Arthritis
Lonnblom E; Leu Agelii M; Sareila O; Cheng L; Xu B; Viljanen J; Hafstrom I; Andersson MLE; Bergstrom G; Ekwall A-KH; Rudin A; Kastbom A; Sjowall C; Jacobsson LTH; Kihlberg J; Gjertsson I; Holmdahl R
Article: ANNALS OF THE RHEUMATIC DISEASES. 2023;82(6):799-808
Pathogenic antibody response to glucose-6-phosphate isomerase targets a modified epitope uniquely exposed on joint cartilage
Li T; Ge C; Kramer A; Sareila O; Agelii ML; Johansson L; Forslind K; Lonnblom E; Yang M; Xu B; Li Q; Cheng L; Bergstrom G; Fernandez G; Kastbom A; Rantapaa-Dahlqvist S; Gjertsson I; Holmdahl R
Article: ARTHRITIS & RHEUMATOLOGY. 2023;75(5):856-863
Early Increase of Circulating Transitional B Cells and Autoantibodies to Joint-Related Proteins in Patients With Metastatic Melanoma Developing Checkpoint Inhibitor-Induced Inflammatory Arthritis
Gatto M; Bjursten S; Jonsson CA; Agelii ML; Jonell C; McGrath S; Loennblom E; Sareila O; Holmdahl R; Rudin A; Levin M; Gjertsson I
Article: COMMUNICATIONS BIOLOGY. 2022;5(1):449
Variants of beta-glucan polysaccharides downregulate autoimmune inflammation
Fahlquist-Hagert C; Sareila O; Rosendahl S; Holmdahl R
Article: ARTHRITIS & RHEUMATOLOGY. 2018;70(8):1343-1353
Chronic Active Arthritis Driven by Macrophages Without Involvement of T Cells A Novel Experimental Model of Rheumatoid Arthritis
Hagert C; Sareila O; Kelkka T; Nandakumar KS; Collin M; Xu B; Guerard S; Backlund J; Jalkanen S; Holmdahl R
Article: FRONTIERS IN IMMUNOLOGY. 2018;9:114
The Macrophage Mannose Receptor Regulate Mannan-Induced Psoriasis, Psoriatic Arthritis, and Rheumatoid Arthritis-Like Disease Models
Hagert C; Sareila O; Kelkka T; Jalkanen S; Holmdahl R
Article: ANTIOXIDANTS AND REDOX SIGNALING. 2017;27(18):1473-1490
Reactive Oxygen Species Regulate Both Priming and Established Arthritis, but with Different Mechanisms
Sareila O; Hagert C; Kelkka T; Linja M; Xu B; Kihlberg J; Holmdahl R
Article: ACS MEDICINAL CHEMISTRY LETTERS. 2016;7(9):826-830
¹⁸F-Labeling of Mannan for Inflammation Research with Positron Emission Tomography
Li X-G; Hagert C; Siitonen R; Virtanen H; Sareila O; Liljenback H; Tuisku J; Knuuti J; Bergman J; Holmdahl R; Roivainen A
Article: PLOS ONE. 2015;10(11):e0141974
Direct Comparison of a Natural Loss-Of-Function Single Nucleotide Polymorphism with a Targeted Deletion in the Ncf1 Gene Reveals Different Phenotypes
Sareila O; Hagert C; Rantakari P; Poutanen M; Holmdahl R
Article: ANTIOXIDANTS AND REDOX SIGNALING. 2014;21(16):2231-2245
Reactive Oxygen Species Deficiency Induces Autoimmunity with Type 1 Interferon Signature
Kelkka T; Kienhoefer D; Hoffmann M; Linja M; Wing K; Sareila O; Hultqvist M; Laajala E; Chen Z; Vasconcelos J; Neves E; Guedes M; Marques L; Kroenke G; Helminen M; Kainulainen L; Olofsson P; Jalkanen S; Lahesmaa R; Margarida Souto-Carneiro M; Holmdahl R
Article: INFLAMMATORY BOWEL DISEASES. 2014;20(8):1435-1447
In Vivo Imaging of Reactive Oxygen and Nitrogen Species in Murine Colitis
Asghar MN; Emani R; Alam C; Helenius TO; Gronroos TJ; Sareila O; Din MU; Holmdahl R; Hanninen A; Toivola DM
Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2012;93(3):427-435
Identification of a region in p47phox/NCF1 crucial for phagocytic NADPH oxidase (NOX2) activation
Sareila O; Jaakkola N; Olofsson P; Kelkka T; Holmdahl R
Article: MEDIATORS OF INFLAMMATION. 2012;2012:730469-9
Superoxide Dismutase 3 Limits Collagen-Induced Arthritis in the Absence of Phagocyte Oxidative Burst
Kelkka T; Laurila JP; Sareila O; Olofsson P; Laukkanen MO; Holmdahl R
Article: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2011;46(9):3845-3850
Synthesis and anti-inflammatory effects of a series of novel 7-hydroxycoumarin derivatives
Timonen JM; Nieminen RM; Sareila O; Goulas A; Moilanen LJ; Haukka M; Vainiotalo P; Moilanen E; Aulaskari PH
Article: ANTIOXIDANTS AND REDOX SIGNALING. 2011;14(12):2373-2383
Positioning of a Polymorphic Quantitative Trait Nucleotide in the Ncf1 Gene Controlling Oxidative Burst Response and Arthritis Severity in Rats
Hultqvist M; Sareila O; Vilhardt F; Norin U; Olsson LM; Olofsson P; Hellman U; Holmdahl R
Article: MEDIATORS OF INFLAMMATION. 2011;2011:127587-15
Dual Specificity Phosphatase 1 Regulates Human Inducible Nitric Oxide Synthase Expression by p38MAP Kinase
Turpeinen T; Nieminen R; Taimi V; Heittola T; Sareila O; Clark AR; Moilanen E; Korhonen R
Article: PULMONARY PHARMACOLOGY AND THERAPEUTICS. 2009;22(3):167-176
Bacterial DNA delays human eosinophil apoptosis
Ilmarinen P; Hasala H; Sareila O; Moilanen E; Kankaanranta H
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2008;155(6):884-895
Effects of levo- and dextrosimendan on NF-κB-mediated transcription, iNOS expression and NO production in response to inflammatory stimuli
Sareila O; Korhonen R; Auvinen H; Hamalainen M; Kankaanranta H; Nissinen E; Moilanen E
Article: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 2008;324(2):858-866
Orazipone inhibits activation of inflammatory transcription factors nuclear factor-κB and signal transducer and activator of transcription 1 and decreases inducible nitric-oxide synthase expression and nitric oxide production in response to inflammatory stimuli
Sareila O; Hamalainen M; Nissinen E; Kankaanranta H; Moilanen E
Article: INTERNATIONAL IMMUNOPHARMACOLOGY. 2008;8(1):100-108
Janus kinase 3 inhibitor WHI-P154 in macrophages activated by bacterial endotoxin:: Differential effects on the expression of iNOS, COX-2 and TNF-α
Sareila O; Korhonen R; Karpanniemi O; Nieminen R; Kankaanranta H; Moilanen E
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2007;152(7):1081-1091
PPARα agonists inhibit nitric oxide production by enhancing iNOS degradation in LPS-treated macrophages
Paukkeri E-L; Leppaenen T; Sareila O; Vuolteenaho K; Kankaanranta H; Moilanen E
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2006;147(7):790-799
Inhibition of classical PKC isoenzymes downregulates STAT1 activation and iNOS expression in LPS-treated murine J774 macrophages
Salonen T; Sareila O; Jalonen U; Kankaanranta H; Tuominen R; Moilanen E
Article: BMC PHARMACOLOGY. 2006;6:5
Inhibition of p38 mitogen-activated protein kinase enhances c-Jun N-terminal kinase activity: implication in inducible nitric oxide synthase expression.
Lahti A; Sareila O; Kankaanranta H; Moilanen E
Article: MEDIATORS OF INFLAMMATION. 2006;2006(2):16161
JAK inhibitors AG-490 and WHI-P154 decrease IFN-γ-induced iNOS expression and NO production in macrophages
Sareila O; Korhonen R; Karpanniemi O; Nieminen R; Kankaanranta H; Moilanen E
Article: JOURNAL OF PHYTOPATHOLOGY. 2004;152(11-12):622-629
Role of viral movement and coat proteins and RNA in phloem-dependent movement and phloem unloading of tobamoviruses
Sareila O; Hohkuri M; Wahlroos T; Susi P
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Review: IMMUNOLOGICAL REVIEWS. 2016;269(1):228-247
Ncf1 polymorphism reveals oxidative regulation of autoimmune chronic inflammation
Holmdahl R; Sareila O; Olsson LM; Backdahl L; Wing K
Review: ANTIOXIDANTS AND REDOX SIGNALING. 2013;18(12):1463-1474
Hydrogen Peroxide As an Immunological Transmitter Regulating Autoreactive T Cells
Holmdahl R; Sareila O; Pizzolla A; Winter S; Hagert C; Jaakkola N; Kelkka T; Olsson LM; Wing K; Backdahl L
Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2012;71:a83-A84
CONDITIONAL MODEL TO STUDY THE TISSUE- AND TIME SPECIFIC EFFECTS OF NADPH OXIDASE 2-DERIVED REACTIVE OXYGEN SPECIES DURING ARTHRITIS
Sareila O; Rantakari P; Poutanen M; Holmdahl R
Review: ANTIOXIDANTS AND REDOX SIGNALING. 2011;15(8):2197-2208
NOX2 Complex-Derived ROS as Immune Regulators
Sareila O; Kelkka T; Pizzolla A; Hultqvist M; Holmdahl R

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