Tobias Granberg and Maria Kristoffersen´s research group
Imaging of Neurodegenerative and Neuroinflammatory disorders
Neurological disorders often cause changes in the brain and spinal cord that can be visualized and quantified using different imaging modalities. Our translational research group focuses on developing and applying new neuroimaging techniques clinically to benefit the diagnosis and follow-up of neurodegenerative and neuroinflammatory disorders. Our main research areas include dementia disorders, movement disorders, multiple sclerosis (MS) and rare neurological diseases.
The research team consists of a wide range of radiological and psychological expertise in close collaboration with neurologists, physicists and engineers at Karolinska as well as internationally. We create, validate and perform visual radiological ratings for morphometric analysis, complemented by volumetric segmentations. We work mainly with FreeSurfer, FSL, SPM and SyMRI but also create in-house analytic tools. A majority of our research projects is based on MRI (structural, functional, diffusion and synthetic) but we also work with CT and nuclear medicine modalities.
- Karolinska Imaging Dementia Study (KIDS): A large retrospective cohort study evaluating imaging biomarkers in patients with cognitive impairment.
- Karolinska Imaging in Movement Disorders Study (KIMOVE): A combined retro- and prospective longitudinal cohort study of Parkinson’s disease and atypical Parkinsonism with both conventional and advanced MRI techniques.
- Stockholm prospective assessment of MS (STOPMS): A large prospective study of new-onset MS-patients started in 2001 using volumetric MRI to study the value of imaging biomarkers in MS.
- Synthetic MRI: Validation studies and practical neuroapplications of SyMRI including myelin quantification using REMyDI (Rapid Estimation of Myelin for Diagnostic Imaging).
- Other projects include the study of: Gadolinium retention in brain structures, Radiolologically Isolated Syndrome (RIS), spinal atrophy, Quantitative Susceptibility Mapping (QSM).
Validation of Rapid Magnetic Resonance Myelin Imaging in Multiple Sclerosis.
Ouellette R, Mangeat G, Polyak I, Warntjes M, Forslin Y, Bergendal Å, et al
Ann. Neurol. 2020 Feb;():
Gadolinium Retention in the Brain: An MRI Relaxometry Study of Linear and Macrocyclic Gadolinium-Based Contrast Agents in Multiple Sclerosis.
Forslin Y, Martola J, Bergendal Å, Fredrikson S, Wiberg MK, Granberg T
AJNR Am J Neuroradiol 2019 08;40(8):1265-1273
Longitudinal Characterization of Cortical Lesion Development and Evolution in Multiple Sclerosis with 7.0-T MRI.
Treaba CA, Granberg TE, Sormani MP, Herranz E, Ouellette RA, Louapre C, et al
Radiology 2019 06;291(3):740-749
The contribution of small vessel disease to subtypes of Alzheimer's disease: a study on cerebrospinal fluid and imaging biomarkers.
Ferreira D, Shams S, Cavallin L, Viitanen M, Martola J, Granberg T, et al
Neurobiol. Aging 2018 10;70():18-29
Cerebral microbleeds topography and cerebrospinal fluid biomarkers in cognitive impairment.
Shams S, Granberg T, Martola J, Charidimou A, Li X, Shams M, et al
J. Cereb. Blood Flow Metab. 2017 Mar;37(3):1006-1013
In vivo characterization of cortical and white matter neuroaxonal pathology in early multiple sclerosis.
Granberg T, Fan Q, Treaba CA, Ouellette R, Herranz E, Mangeat G, et al
Brain 2017 Nov;140(11):2912-2926
Quantitative susceptibility mapping differentiates between parkinsonian disorders.
Sjöström H, Granberg T, Westman E, Svenningsson P
Parkinsonism Relat. Disord. 2017 Nov;44():51-57
Clinical Feasibility of Synthetic MRI in Multiple Sclerosis: A Diagnostic and Volumetric Validation Study.
Granberg T, Uppman M, Hashim F, Cananau C, Nordin LE, Shams S, et al
AJNR Am J Neuroradiol 2016 Jun;37(6):1023-9