Clinical and translational research within lupus and autoimmunity – Team Ioannis Parodis

We perform clinical and translational research within the field of inflammation and autoimmunity, with a focus on systemic lupus erythematosus. Our research includes biomarker exploration, as well as investigation and prediction of effects of biological and non-biological immunomodulatory therapies on clinical, molecular, and patient-reported outcomes. A separate research trajectory comprises projects within medical pedagogy.

Team Ioannis Parodis is one of the teams within the research group: Translational inflammation research at the Division of Rheumatology.

Clinical and translational research within lupus and autoimmunity

Main focus: Precision medicine in autoimmune disease, with a particular focus on systemic lupus erythematosus (SLE) and its clinical manifestations.

Our goals: The overall goal of our research is to contribute to personalised management of people living with autoimmune disease, particularly SLE. Driven by the hypothesis that molecular patterns better inform treatment selection, we develop prediction models of treatment response and prognosis based on molecular patterns rather than clinical phenotypes.

Our research in brief: We study molecular phenotypes based on gene expression and protein levels in blood, urine, and tissues. We determine drug repurposing potentiality using systems biology and propose markers of disease activity, response to therapies, and prognosis, that are amenable to use in routine clinical practice. One of our objectives focuses on identification of peripheral markers in blood and urine that best mirror cellular and molecular profiling of kidney tissue from patients with lupus nephritis (LN).

Lupus in brief: SLE is a chronic, inflammatory, autoimmune disease that predominantly affects women of childbearing age. LN constitutes a severe, potentially life-threatening disease manifestation with still ill-defined pathogenesis, which affects 35–60% of patients with SLE.

The illustration depicts some of the manifestations of systemic lupus erythematosus.
The illustration depicts some of the manifestations of systemic lupus erythematosus. Photo: Despina Katsouli and Georgia Maltezou.

Societal benefit: Our research is driven by simple but important aims. Findings from our projects are anticipated to have an unprecedented impact on the clinical care of patients with SLE and autoimmune diseases, contributing to improved quality of life and lower healthcare demand, including lower frequencies of hospitalisation. This in turn contributes to reduced healthcare costs, deceleration of organ damage accrual, and an overall decreased morbidity and mortality for patients with SLE.

Medical pedagogy: In a distinct research avenue, we examine the potential of virtual patients to enhance clinical reasoning skills within the realm of medical education using an innovative AI-embedded social robotic platform.

Group photo of team Parodis.
Group picture from the 2023 Rheuma Retreat. From the left: Sahar Sarrafzadeh Zargar, Julius Lindblom, Dionysis Nikolopoulos, Denis Lagutkin, Roberto Depascale, Maria Helena Lourenço, Ioannis Parodis, Alvaro Gomez Gonzalez, Nursen Cetrez, Yvonne Enman, Alexander Borg, Alexander Tsoi. Photo: Erdem Aybay

Publications

Selected publications

Funding

Research support

  • EU - IHI/EFPIA
  • Reumatikerfonden
  • Stiftelsen Konung Gustaf V:s 80-årsfond
  • Svenska Läkaresällskapet
  • Nyckelfonden
  • Stiftelsen Professor Nanna Svartz 
  • Ulla och Roland Gustafssons donationsfond
  • Region Stockholm 
  • Karolinska Institutet

Pharmaceutical companies

  • Aurinia
  • Bristol-Myers Squibb
  • Gilead
  • GlaxoSmithKline
  • Otsuka
  • Roche

Members and contact

Group leader

All members of the group