Catharina Larsson's Group
The research aims to explain tumor initiation and malignification in endocrine organs (the parathyroid glands, thyroid, and neuroendocrine tumors of the abdomen) focusing on genetic predisposing, initiating and acquired events and their cellular effects and influence of the natural course of the disease.
The research aims to understand the role of different types of non-coding RNA e.g. miRNA in cancer development and therapy response and their relation to known alterations such as known driver mutations and viral background utilizing both in vitro and in vivo approaches.
The research aims to understand tumor development to achieve improved patient handling in clinical oncology including: Genetic predisposition in hereditary cancer syndromes with focus on breast cancer; and genetic markers for early detection and tumor spread in breast cancer.
The research aims to identify key molecular and mutational events in thyroid, adrenal and other endocrine tumors, and their clinical applications in endocrine pathology and molecular pathology for improved decisions in diagnosis, prognosis and treatment.