Svetlana Bajalica Lagercrantz

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About me

Svetlana Bajalica Lagercrantz is an Adjunct Professor of Cancer Genetics,
especially hereditary cancers.
Read more about her research [1]
[1] https://ki.se/en/onkpat/research-team-svetlana-bajalica-lagercrantz

Articles

Article: BIOMEDICINES. 2022;10(5):1004
Whole-Exome Sequencing of Germline Variants in Non-BRCA Families with Hereditary Breast Cancer
Liu Y; Helgadottir HT; Kharaziha P; Choi J; Lopez-Giraldez F; Mane SM; Hoiom V; Juhlin CC; Larsson C; Bajalica-Lagercrantz S
Article: NATURE CANCER. 2022;3(2):251-261
The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology
Tamborero D; Dienstmann R; Rachid MH; Boekel J; Lopez-Fernandez A; Jonsson M; Razzak A; Brana I; De Petris L; Yachnin J; Baird RD; Loriot Y; Massard C; Martin-Romano P; Opdam F; Schlenk RF; Vernieri C; Masucci M; Villalobos X; Chavarria E; Balmana J; Apolone G; Caldas C; Bergh J; Ernberg I; Frohling S; Garralda E; Karlsson C; Tabernero J; Voest E; Rodon J; Lehtio J
Article: CANCERS. 2022;14(2):380
Whole-Body MRI Surveillance-Baseline Findings in the Swedish Multicentre Hereditary TP53-Related Cancer Syndrome Study (SWEP53)
Omran M; Tham E; Brandberg Y; Ahlstrom H; Lundgren C; Paulsson-Karlsson Y; Kuchinskaya E; Silander G; Rosen A; Persson F; Leonhardt H; Stenmark-Askmalm M; Berg J; van Westen D; Bajalica-Lagercrantz S; Blomqvist L
Article: EUROPEAN JOURNAL OF MEDICAL GENETICS. 2021;64(12):104350
Overview of hereditary breast and ovarian cancer (HBOC) guidelines across Europe
Marmolejo DH; Wong MYZ; Bajalica-Lagercrantz S; Tischkowitz M; Balmana J
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(12):6345
Association between Predicted Effects of TP53 Missense Variants on Protein Conformation and Their Phenotypic Presentation as Li-Fraumeni Syndrome or Hereditary Breast Cancer
Liu Y; Axell O; van Leeuwen T; Konrat R; Kharaziha P; Larsson C; Wright APH; Bajalica-Lagercrantz S
Article: EUROPEAN JOURNAL OF HUMAN GENETICS. 2020;28(10):1379-1386
Guidelines for the Li-Fraumeni and heritable TP53-related cancer syndromes.
Frebourg T; Bajalica Lagercrantz S; Oliveira C; Magenheim R; Evans DG; European Reference Network GENTURIS
Article: EUROPEAN JOURNAL OF HUMAN GENETICS. 2020;28(10):1387-1393
Cancer Surveillance Guideline for individuals with PTEN hamartoma tumour syndrome.
Tischkowitz M; Colas C; Pouwels S; Hoogerbrugge N; PHTS Guideline Development Group; European Reference Network GENTURIS
Article: HEREDITARY CANCER IN CLINICAL PRACTICE. 2020;18(1):1
Whole-body MRI within a surveillance program for carriers with clinically actionable germline TP53 variants-the Swedish constitutional TP53 study SWEP53
Omran M; Blomqvist L; Brandberg Y; Pal N; Kogner P; Stahlbom AK; Tham E; Bajalica-Lagercrantz S
Article: CLINICAL GENETICS. 2019;96(3):216-225
Functional characterization of novel germline TP53 variants in Swedish families
Kharaziha P; Ceder S; Axell O; Krall M; Fotouhi O; Bohm S; Lain S; Borg A; Larsson C; Wiman KG; Tham E; Bajalica-Lagercrantz S
Article: FAMILIAL CANCER. 2019;18(2):281-284
Boosting care and knowledge about hereditary cancer: European Reference Network on Genetic Tumour Risk Syndromes
Vos JR; Giepmans L; Roehl C; Geverink N; Hoogerbrugge N; Ligtenberg M; Kets M; Sijmons R; Evans G; Woodward E; Tischkowitz M; Maher E; Steinke-Lange V; Holinski-Feder E; Frebourg T; Houdayer C; Ferner RE; Lubinski J; Ertmanska K; Bajalica Lagercrantz S; Tham E; Guillermo IB; Capella G; Vidal JB; Lazaro C; Balmana J; Bours V; Legius E; Wolkenstein P; Melegh B; Oliveira C; Teixeira M; Poppe B; Claes K; Hernandez HS; Aretz S; Spier I; Oostenbrink R; Krajc M; Blatnik A; Schrock E; Peltonen S; Hietala M
Article: INTERNATIONAL JOURNAL OF CANCER. 2019;144(5):1195-1204
Prevalence of BRCA1 and BRCA2 pathogenic variants in a large, unselected breast cancer cohort
Li J; Wen WX; Eklund M; Kvist A; Eriksson M; Christensen HN; Torstensson A; Bajalica-Lagercrantz S; Dunning AM; Decker B; Allen J; Luccarini C; Pooley K; Simard J; Dorling L; Easton DF; Teo S-H; Hall P; Borg A; Gronberg H; Czene K
Article: PATHOBIOLOGY. 2018;85(4):211-219
Proteomic Profiling of Diffuse Large B-Cell Lymphomas
Kwiecinska A; Porwit A; Souchelnytskyi N; Kaufeldt A; Larsson C; Bajalica-Lagercrantz S; Souchelnytskyi S
Article: ONCOTARGET. 2016;7(24):35703-35723
Tumor acidosis enhances cytotoxic effects and autophagy inhibition by salinomycin on cancer cell lines and cancer stem cells
Pellegrini P; Dyczynski M; Sbrana FV; Karlgren M; Buoncervello M; Hagg-Olofsson M; Ma R; Hartman J; Bajalica-Lagercrantz S; Grander D; Kharaziha P; De Milito A
Article: JOURNAL OF OVARIAN RESEARCH. 2016;9(1):27
Strong synergy with APR-246 and DNA-damaging drugs in primary cancer cells from patients with TP53 mutant High-Grade Serous ovarian cancer
Fransson A; Glaessgen D; Alfredsson J; Wiman KG; Bajalica-Lagercrantz S; Mohell N
Article: ONCOTARGET. 2015;6(34):36894-36902
Alterations of biomarker profiles after neoadjuvant chemotherapy in breast cancer: tumor heterogeneity should be taken into consideration
Zhou X; Zhang J; Yun H; Shi R; Wang Y; Wang W; Lagercrantz SB; Mu K
Article: ANNALS OF DIAGNOSTIC PATHOLOGY. 2015;19(4):243-248
A standardized method for quantifying proliferation by Ki-67 and cyclin A immunohistochemistry in breast cancer
Mu K; Li L; Yang Q; Yun H; Kharaziha P; Ye D-W; Auer G; Lagercrantz SB; Zetterberg A
Article: THE LANCET. 2015;386(9992):433-443
Adjuvant denosumab in breast cancer (ABCSG-18): a multicentre, randomised, double-blind, placebo-controlled trial
Gnant M; Pfeiler G; Dubsky PC; Hubalek M; Greil R; Jakesz R; Wette V; Balic M; Haslbauer F; Melbinger E; Bjelic-Radisic V; Artner-Matuschek S; Fitzal F; Marth C; Sevelda P; Mlineritsch B; Steger GG; Manfreda D; Exner R; Egle D; Bergh J; Kainberger F; Talbot S; Warner D; Fesl C; Singer CF
Article: GENES CHROMOSOMES AND CANCER. 2014;53(9):750-768
Amplification of 2p as a Genomic Marker for Transformation in Lymphoma
Kwiecinska A; Ichimura K; Berglund M; Dinets A; Sulaiman L; Collins VP; Larsson C; Porwit A; Lagercrantz SB
Article: PLOS ONE. 2014;9(11):e111125
Expression of the p53 Target Wig-1 Is Associated with HPV Status and Patient Survival in Cervical Carcinoma
Xu L-D; Muller S; Thoppe SR; Hellborg F; Kanter L; Lerner M; Zheng B; Lagercrantz SB; Grander D; Wallin KL; Wiman KG; Larsson C; Andersson S
Article: INTERNATIONAL JOURNAL OF CANCER. 2008;123(5):1190-1195
Ror1, a cell surface receptor tyrosine kinase is expressed in chronic lymphocytic leukemia and may serve as a putative target for therapy
DaneshManesh AH; Mikaelsson E; Jeddi-Tehrani M; Bayat AA; Ghods R; Ostadkarampour M; Akhondi M; Lagercrantz S; Larsson C; Osterborg A; Shokri F; Mellstedt H; Rabbani H
Article: LEUKEMIA AND LYMPHOMA. 2008;49(3):477-487
Characterization of 6q deletions in mature B cell lymphomas and childhood acute lymphoblastic leukemia
Thelander EF; Ichimura K; Corcoran M; Barbany G; Nordgren A; Heyman M; Berglund M; Mungall A; Rosenquist R; Collins VP; Grander D; Larsson C; Lagercrantz S
Article: LEUKEMIA RESEARCH. 2007;31(9):1219-1230
Detailed assessment of copy number alterations revealing homozygous deletions in 1p and 13q in mantle cell lymphoma
Thelander EF; Ichimura K; Collins VP; Walsh SH; Barbany G; Hagberg A; Laurell A; Rosenquist R; Larsson C; Lagercrantz S
Article: MODERN PATHOLOGY. 2007;20(1):63-75
Genomic imbalances during transformation from follicular lymphoma to diffuse large B-cell lymphoma
Berglund M; Enblad G; Thunberg U; Amini R-M; Sundstrom C; Roos G; Erlanson M; Rosenquist R; Larsson C; Lagercrantz S
Article: INTERNATIONAL JOURNAL OF RADIATION BIOLOGY. 2006;82(2):87-96
Evaluation of spectral karyotyping (SKY) in biodosimetry for the triage situation following gamma irradiation
Szeles A; Joussineau S; Lewensohn R; Lagercrantz S; Larsson C
Article: INTERNATIONAL JOURNAL OF CANCER. 2006;118(3):555-563
U-2940, a human B-cell line derived from a diffuse large cell lymphoma sequential to Hodgkin lymphoma
Sambade C; Berglund M; Lagercrantz S; Sällström JS; Reis RM; Enblad G; Glimelius B; Sundström C
Article: MODERN PATHOLOGY. 2005;18(3):331-339
Mantle cell lymphomas with clonal immunoglobulin V_H3-21 gene rearrangements exhibit fewer genomic imbalances than mantle cell lymphomas utilizing other immunoglobulin V_H genes
Thelander EF; Walsh SH; Thorsélius M; Laurell A; Landgren O; Larsson C; Rosenquist R; Lagercrantz S
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2005;26(1):141-149
Molecular cytogenetic characterization of primary cultures and established cell lines from non-medullary thyroid tumors
Foukakis T; Thoppe SR; Lagercrantz S; Dwight T; Weng WH; Svensson A; Höög A; Zedenius J; Wallin G; Lui WO; Larsson C
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2004;25(4):955-960
Molecular cytogenetic characterization shows higher genetic homogeneity in conventional renal cell carcinoma compared to other kidney cancers
Alimov A; Sundelin B; Bergerheim U; Pavlenko M; Pisa P; Zetterberg A; Larsson C; Lagercrantz S
Article: GENES CHROMOSOMES AND CANCER. 2004;41(2):133-144
Spontaneously immortalized human T lymphocytes develop gain of chromosomal region 2p13-24 as an early and common genetic event
Siwicki JK; Berglund M; Rygier J; Pienkowska-Grela B; Grygalewicz B; Degerman S; Golovleva I; Chrzanowska KH; Lagercrantz S; Blennow E; Roos G; Larsson C
Article: CANCER GENETICS. 2003;141(1):43-48
Molecular cytogenetic characterization of four commonly used cell lines derived from Hodgkin lymphoma
Berglund M; Flordal E; Gullander J; Lui WO; Larsson C; Lagercrantz S; Enblad G
Article: BIOCHEMICAL PHARMACOLOGY. 2003;65(2):237-247
Down-regulation of deoxycytidine kinase in human leukemic cell lines resistant to cladribine and clofarabine and increased ribonucleotide reductase activity contributes to fludarabine resistance
Månsson E; Flordal E; Liliemark J; Spasokoukotskaja T; Elford H; Lagercrantz S; Eriksson S; Albertioni F
Article: CANCER GENETICS. 2002;139(1):38-43
Clonal development of a blastoid mantle cell lymphoma studied with comparative genomic hybridization
Flordal E; Berglund M; Rosenquist R; Erlanson M; Enblad G; Roos G; Larsson C; Lagercrantz S
Article: LEUKEMIA AND LYMPHOMA. 2002;43(11):2179-2189
A novel B-cell line (U-2932) established from a patient with diffuse large B-cell lymphoma following Hodgkin lymphoma
Amini RM; Berglund M; Rosenquist R; Von Heideman A; Lagercrantz S; Thunberg U; Bergh J; Sundström C; Glimelius B; Enblad G
Article: MODERN PATHOLOGY. 2002;15(8):807-816
Chromosomal imbalances in diffuse large B-cell lymphoma detected by comparative genomic hybridization
Berglund M; Enblad G; Flordal E; Lui WO; Backlin C; Thunberg U; Sundström C; Roos G; Allander SV; Erlanson M; Rosenquist R; Larsson C; Lagercrantz S
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2002;20(6):1161-1165
Aberrations of centrosomes in adrenocortical tumors
Roshani L; Fujioka K; Auer G; Kjellman M; Lagercrantz S; Larsson C
Article: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. 2001;8(6):681-689
Differential expression of multiple alternative spliceforms of the Men1 tumor suppressor gene in mouse
Forsberg L; Zablewska B; Piehl F; Weber G; Lagercrantz S; Gaudray P; Höög C; Larsson C
Article: EUROPEAN JOURNAL OF ENDOCRINOLOGY (EJE). 2001;145(4):415-420
Homozygous inactivation of the MEN1 gene as a specific somatic event in a case of secondary hyperparathyroidism
Forsberg L; Villablanca A; Välimäki S; Farnebo F; Farnebo LO; Lagercrantz S; Larsson C
Article: GENES CHROMOSOMES AND CANCER. 2001;32(1):43-49
Gain of 1q and loss of 9q21.3-q32 are associated with a less favorable prognosis in papillary thyroid carcinoma
Kjellman P; Lagercrantz S; Höög A; Wallin G; Larsson C; Zedenius J
Article: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. 2000;5(5):485-492
New chromosomal breakpoints in non-Hodgkin's lymphomas revealed by spectral karyotyping and G-banding
Nordgren A; Sorensen AG; Tinggaard-Pedersen N; Blennow E; Larsson C; Lagercrantz S
Article: MAMMALIAN GENOME. 1999;10(4):376-380
Characterization and chromosomal localization of the human insulin-like growth factor binding protein 6 gene
Ehrenborg E; Zazzi H; Lagercrantz S; Granqvist M; Hillerbrand U; Allander SV; Larsson C; Luthman H
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1998;247(2):357-360
Expression of the BCL6 gene in the pre- and postnatal mouse
Bajalica-Lagercrantz S; Piehl F; Farnebo F; Larsson C; Lagercrantz J
Article: GENOMICS. 1998;50(2):275-280
Cloning, expression pattern, and chromosomal assignment to 16q23 of the human gamma-adaptin gene (ADTG).
Peyrard M; Parveneh S; Lagercrantz S; Ekman M; Fransson I; Sahlén S; Dumanski JP
Article: MAMMALIAN GENOME. 1998;9(4):310-311
Mapping of the human Ca²⁺ channel β₄ subunit to 2q22-23 and its expression in developing mouse
Betz R; Leibiger B; Farnebo F; Lagercrantz S; Piehl F; Leibiger I; Larsson C
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 1997;82(12):4258-4265
Human estrogen receptor β-gene structure, chromosomal localization, and expression pattern
Enmark E; Pelto-Huikko M; Grandien K; Lagercrantz S; Lagercrantz J; Fried G; Nordenskjöld M; Gustafsson J
Article: GENOMICS. 1997;46(1):78-85
Cloning and characterization of freac-9 (FKHL17), a novel kidney-expressed human forkhead gene that maps to chromosome 1p32-p34
Ernstsson S; Betz R; Lagercrantz S; Larsson C; Ericksson S; Cederberg A; Carlsson P; Enerback S
Article: GENOMICS. 1997;44(3):344-346
Chromosome localization, sequence analysis, and expression pattern identify FKHL 18 as a novel human forkhead gene
Cederberg A; Betz R; Lagercrantz S; Larsson C; Hulander M; Carlsson P; Enerback S
Article: LEUKEMIA. 1997;11(4):594-598
Expression of LAZ3/BCL6 in follicular center (FC) B cells of reactive lymph nodes and FC-derived non-Hodgkin lymphomas
BajalicaLagercrantz S; Piehl F; Lagercrantz J; Lindahl J; Weber G; Kerckeart JP; PorwitMacDonald A; Nordenskjold M
Article: GENOMICS. 1996;38(3):450-451
Localization of the human deoxyguanosine kinase gene (DGUOK) to chromosome 2p13
Johansson M; BajalicaLagercrantz S; Lagercrantz J; Karlsson A
Article: GENOMICS. 1996;36(3):424-430
Primary structure of human 11-cis retinol dehydrogenase and organization and chromosomal localization of the corresponding gene
Simon A; Lagercrantz J; BajalicaLagercrantz S; Eriksson U
Article: CANCER GENETICS. 1996;90(2):102-105
Duplication of 2q31-qter as a sole aberration in a case of non-Hodgkin's lymphoma
BajalicaLagercrantz S; Pedersen NT; Sorensen AG; Nordenskjold M
Article: CHROMOSOME RESEARCH. 1996;4(4):310-313
Mapping of a new MAP kinase activated protein kinase gene (3PK) to human chromosome band 3p21.2 and ordering of 3PK and two cosmid markers in the 3p22-p21 tumour-suppressor region by two-colour fluorescence in situ hybridization
Szeles A; BajalicaLagercrantz S; Lindblom A; Lushnikova T; Kashuba VI; Imreh S; Nordenskjold M; Klein G; Zabarovsky ER
Article: IUBMB LIFE. 1996;39(2):303-306
Nucleotide sequence of a cDNA clone (SUBT1) partly homologous to a human subtelomeric repeat sequence.
Lagercrantz J; Lagercrantz S
Article: GENOMICS. 1996;32(3):455-457
The gene for human glutaredoxin (GLRX) is localized to human chromosome 5q14
Padilla CA; Bajalica S; Lagercrantz J; Holmgren A
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1996;218(2):514-517
Chromosomal localization and 5' sequence of the human protein serine threonine phosphatase 5' gene
Xu XL; Lagercrantz J; Zickert P; BajalicaLagercrantz S; Zetterberg A
Article: GENES CHROMOSOMES AND CANCER. 1995;13(1):34-39
CHARACTERIZATION OF ADD(I)(P36) IN NON-HODGKIN LYMPHOMAS BY FLUORESCENCE IN-SITU HYBRIDIZATION
BAJALICA S; BRONDUMNIELSEN K; SORENSEN AG; PEDERSEN NT; KRISTOFFERSSON U; AKERMAN M; ANDERSON M; PISA P; NORDENSKJOLD M
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All other publications

Review: CANCERS. 2022;14(19):4665
Pharmacogenomics for Prediction of Cardiovascular Toxicity: Landscape of Emerging Data in Breast Cancer Therapies
Altena R; Bajalica-Lagercrantz S; Papakonstantinou A
Corrigendum: NATURE CANCER. 2022;3(5):649
The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology (vol 3, pg 251, 2022)
Tamborero D; Dienstmann R; Rachid MH; Boekel J; Lopez-Fernandez A; Jonsson M; Razzak A; Brana I; De Petris L; Yachnin J; Baird RD; Loriot Y; Massard C; Martin-Romano P; Opdam F; Schlenk RF; Vernieri C; Masucci M; Villalobos X; Chavarria E; Balmana J; Apolone G; Caldas C; Bergh J; Ernberg I; Frohling S; Garralda E; Karlsson C; Tabernero J; Voest E; Rodon J; Lehtio J
Review: CANCERS. 2020;12(12):E3762-3762
Germline TP53 Testing in Breast Cancers: Why, When and How?
Evans DG; Woodward ER; Bajalica-Lagercrantz S; Oliveira C; Frebourg T
Letter: EUROPEAN JOURNAL OF HUMAN GENETICS. 2020;28(11):1483-1485
Reply to Kratz et al.
Frebourg T; Lagercrantz SB; Oliveira C; Magenheim R; Evans DG; European Reference Network GENTURIS
Letter: NATURE MEDICINE. 2020;26(7):992-994
Support systems to guide clinical decision-making in precision oncology: The Cancer Core Europe Molecular Tumor Board Portal
Tamborero D; Dienstmann R; Rachid MH; Boekel J; Baird R; Brana I; De Petris L; Yachnin J; Massard C; Opdam FL; Schlenk R; Vernieri C; Garralda E; Masucci M; Villalobos X; Chavarria E; Calvo F; Frohling S; Eggermont A; Apolone G; Voest EE; Caldas C; Tabernero J; Ernberg I; Rodon J; Lehtio J
Letter: LEUKEMIA AND LYMPHOMA. 2007;48(5):1038-1041
Establishment of a cell line from a chemotherapy resistant diffuse large B-cell lymphoma
Berglund M; Thunberg U; Fridberg M; Wingren AG; Gullbo J; Leuchowius K-J; Amini R-M; Lagercrantz S; Horvat A; Enblad G; Soderberg O
Thesis / dissertation: 1996
Genetic characterization of non-Hodgkin lymphomas using in situ hybridization
Lagercrantz, Svetlana
Other: JOURNAL OF MEDICAL GENETICS. 1995;32(12):987-990
Partial disomy of Xp and the presence of SRY in a phenotypic female.
Bajalica S; Blennow E; Tşezou A; Galla-Voumvouraki A; Alevizaki M; Sinaniotis C; Kitsiou-Tzeli S

Employments

Adjunct Professor, Department of Oncology-Pathology, Karolinska Institutet, 2023-2027

Degrees and Education

Docent, Karolinska Institutet, 2003
University Medical Degree, Karolinska Institutet, 2001

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