Carmine Belin Laboratory
The purpose of our research is to increase the understanding of the pathophysiology of neurological disorders with a focus on primary headache disorders such as cluster headache by identifying, characterizing and modelling genetic markers within the human genome.
Cluster headache (CH) strikes as a unilateral pain of extreme intensity and a majority of patients report a circadian and circannual pattern in their attacks.
The cause of this potentially life-threatening disorder (referred to as suicide headache due to suicide attempts when treatment is insufficient), is currently unknown and there is no cure.
Cluster headache affects 0.1% of the population world-wide and genetic factors in addition to circadian rhythm has been proposed to be involved in the pathophysiology.
The objectives of our research is to investigate the potential molecular mechanisms behind cluster headache and the link to circadian rhythm and genetic factors. This will allow insight into pathogenic mechanisms of cluster headache and lead to the identification of targets in the development of novel and more efficient treatment strategies.
This project is performed by using and further extending a unique biobank of biological tissue and clinical data from patients with cluster headache and controls in Sweden.
Anoctamin 3: A Possible Link between Cluster Headache and Ca2+ Signaling.
Ran C, Fourier C, Arafa D, Liesecke F, Sjöstrand C, Waldenlind E, et al
Brain Sci 2019 Jul;9(8):
Analysis of HCRTR2 Gene Variants and Cluster Headache in Sweden.
Fourier C, Ran C, Steinberg A, Sjöstrand C, Waldenlind E, Belin AC
Headache 2019 Mar;59(3):410-417
Implications for the migraine SNP rs1835740 in a Swedish cluster headache population.
Ran C, Fourier C, Zinnegger M, Steinberg A, Sjöstrand C, Waldenlind E, et al
J Headache Pain 2018 Nov;19(1):100
Cluster headache - clinical pattern and a new severity scale in a Swedish cohort.
Steinberg A, Fourier C, Ran C, Waldenlind E, Sjöstrand C, Belin AC
Cephalalgia 2018 06;38(7):1286-1295
A genetic CLOCK variant associated with cluster headache causing increased mRNA levels.
Fourier C, Ran C, Zinnegger M, Johansson AS, Sjöstrand C, Waldenlind E, et al
Cephalalgia 2018 03;38(3):496-502
Screening of Two ADH4 Variations in a Swedish Cluster Headache Case-Control Material.
Fourier C, Ran C, Steinberg A, Sjöstrand C, Waldenlind E, Carmine Belin A
Headache 2016 May;56(5):835-840
ReMo-SNPs: a new software tool for identification of polymorphisms in regions and motifs genome-wide.
Graae L, Paddock S, Belin AC
Genet Res (Camb) 2015 Apr;97():e8
A replication study of GWAS findings in migraine identifies association in a Swedish case-control sample.
Ran C, Graae L, Magnusson PK, Pedersen NL, Olson L, Belin AC
BMC Med. Genet. 2014 Mar;15():38
The HLA-DRA variation rs3129882 is not associated with Parkinson's disease in Sweden.
Ran C, Willows T, Sydow O, Johansson A, Söderkvist P, Dizdar N, et al
Parkinsonism Relat. Disord. 2013 Jul;19(7):701-2
Adh1 and Adh1/4 knockout mice as possible rodent models for presymptomatic Parkinson's disease.
Anvret A, Ran C, Westerlund M, Gellhaar S, Lindqvist E, Pernold K, et al
Behav. Brain Res. 2012 Feb;227(1):252-7