Karin Wirdefeldt

About me
Publications
CV
Public outreach and news

About me

I am docent and adjunct professor of neuroepidemiology at the Department of
Medical Epidemiology and Biostatistics [1] and senior neurologist at the
Department of Neurology at the Karolinska University Hospital, Solna.
* MD, Karolinska Institutet, 1996
* Licence to practice as a physician (Swedish "Läkarlegitimation"), 2000
* PhD, Karolinska Institutet, 2004
* Specialist in neurology, 2011
[1] https://ki.se/en/meb

Research

*Current supervision of PhD students*
* Xiaoying Kang [1]
[1] https://staff.ki.se/people/xiaoying-kang

Articles

Article: NEUROEPIDEMIOLOGY. 2024;58(4):256-263
Associations between Sleep Disorders and Impulsive-Compulsive Behaviors in Parkinson's Disease: A Prospective Cohort Study
Ye M; Kang X; Karlsson IK; Wang Y; Ji Q; Liu Q; Xu X; Hagg S; Fang F; Wirdefeldt K; Zhan Y
Article: PARKINSONS DISEASE. 2023;2023:1-7
Sex Differences in the Allele Distribution of PGLYRP2 Variant rs892145 in Parkinson's Disease
Ran C; Wirdefeldt K; Sydow O; Svenningsson P; Diaz Heijtz R
Article: EUROPEAN JOURNAL OF NEUROLOGY. 2023;30(11):3430-3439
Gastrointestinal biopsy of normal mucosa or nonspecific inflammation and risk of neurodegenerative disease: Nationwide matched cohort study
Sun J; Ludvigsson JF; Roelstraete B; Pedersen NL; Pawitan Y; Wirdefeldt K; Fang F
Article: ANNALS OF NEUROLOGY. 2023;94(5):911-916
Risk of Parkinson's Disease in Celiac Disease: A Swedish Population-Based Study
Kang X; Ploner A; Roelstraete B; Ludvigsson JF; Wirdefeldt K
Article: ANNALS OF NEUROLOGY. 2023;93(5):1023-1028
β2-Adrenoreceptor Agonists, Montelukast, and Parkinson Disease Risk
Liu B; Svenningsson P; Ludvigsson JF; Lundholm C; Wallin J; Larsson H; Sjolander A; Williams DM; Pedersen NL; Wirdefeldt K
Article: MOVEMENT DISORDERS. 2023;38(4):604-615
Investigation of Shared Genetic Risk Factors Between Parkinson's Disease and Cancers
Sugier P-E; Lucotte EA; Domenighetti C; Law MH; Iles MM; Brown K; Amos C; McKay JD; Hung RJ; Karimi M; Bacq-Daian D; Boland-Auge A; Olaso R; Deleuze J-F; Lesueur F; Ostroumova E; Kesminiene A; de Vathaire F; Guenel P; Sreelatha AAK; Schulte C; Grover S; May P; Bobbili DR; Radivojkov-Blagojevic M; Lichtner P; Singleton AB; Hernandez DG; Edsall C; Mellick GD; Zimprich A; Pirker W; Rogaeva E; Lang AE; Koks S; Taba P; Lesage S; Brice A; Corvol J-C; Chartier-Harlin M-C; Mutez E; Brockmann K; Deutschlaender AB; Hadjigeorgiou GM; Dardiotis E; Stefanis L; Simitsi AM; Valente EM; Petrucci S; Straniero L; Zecchinelli A; Pezzoli G; Brighina L; Ferrarese C; Annesi G; Quattrone A; Gagliardi M; Matsuo H; Nakayama A; Hattori N; Nishioka K; Chung SJ; Kim YJ; Kolber P; van de Warrenburg BPC; Bloem BR; Aasly J; Toft M; Pihlstrom L; Guedes LC; Ferreira JJ; Bardien S; Carr J; Tolosa E; Ezquerra M; Pastor P; Diez-Fairen M; Wirdefeldt K; Pedersen N; Ran C; Belin AC; Puschmann A; Roedstroem EY; Clarke CE; Morrison KE; Tan M; Krainc D; Burbulla LF; Farrer MJ; Kruger R; Gasser T; Sharma M; Truong T; Elbaz A
Article: BRAIN COMMUNICATIONS. 2022;5(1):fcad002
Genetic overlap between Parkinson's disease and inflammatory bowel disease
Kang X; Ploner A; Wang Y; Ludvigsson JF; Williams DM; Pedersen NL; Wirdefeldt K
Article: MOVEMENT DISORDERS. 2022;37(9):1929-1937
The Interaction between HLA-DRB1 and Smoking in Parkinson's Disease Revisited
Domenighetti C; Douillard V; Sugier P-E; Sreelatha AAK; Schulte C; Grover S; May P; Bobbili DR; Radivojkov-Blagojevic M; Lichtner P; Singleton AB; Hernandez DG; Edsall C; Gourraud P-A; Mellick GD; Zimprich A; Pirker W; Rogaeva E; Lang AE; Koks S; Taba P; Lesage S; Brice A; Corvol J-C; Chartier-Harlin M-C; Mutez E; Brockmann K; Deutschlander AB; Hadjigeorgiou GM; Dardiotis E; Stefanis L; Simitsi AM; Valente EM; Petrucci S; Duga S; Straniero L; Zecchinelli A; Pezzoli G; Brighina L; Ferrarese C; Annesi G; Quattrone A; Gagliardi M; Matsuo H; Nakayama A; Hattori N; Nishioka K; Chung SJ; Kim YJ; Kolber P; van de Warrenburg BPC; Bloem BR; Aasly J; Toft M; Pihlstrom L; Correia Guedes L; Ferreira JJ; Bardien S; Carr J; Tolosa E; Ezquerra M; Pastor P; Diez-Fairen M; Wirdefeldt K; Pedersen NL; Ran C; Belin AC; Puschmann A; Ygland Rodstrom E; Clarke CE; Morrison KE; Tan M; KraincMD D; Burbulla LF; Farrer MJ; Kruger R; Gasser T; Sharma M; Vince N; Elbaz A
Article: PLOS MEDICINE. 2022;19(9):e1004092
Hospital-treated infections in early- and mid-life and risk of Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis: A nationwide nested case-control study in Sweden
Sun J; Ludvigsson JF; Ingre C; Piehl F; Wirdefeldt K; Zagai U; Ye W; Fang F
Article: NEUROLOGY. 2022;99(7):e698-e710
Genome-wide Association and Meta-analysis of Age at Onset in Parkinson Disease Evidence From the COURAGE-PD Consortium
Grover S; Kumar Sreelatha AA; Pihlstrom L; Domenighetti C; Schulte C; Sugier P-E; Radivojkov-Blagojevic M; Lichtner P; Mohamed O; Portugal B; Landoulsi Z; May P; Bobbili D; Edsall C; Bartusch F; Hanussek M; Krueger J; Hernandez DG; Blauwendraat C; Mellick GD; Zimprich A; Pirker W; Tan M; Rogaeva E; Lang A; Koks S; Taba P; Lesage S; Brice A; Corvol J-C; Chartier-Harlin M-C; Mutez E; Brockmann K; Deutschlaender AB; Hadjigeorgiou GM; Dardiotis E; Stefanis L; Simitsi AM; Valente EM; Petrucci S; Straniero L; Zecchinelli A; Pezzoli G; Brighina L; Ferrarese C; Annesi G; Quattrone A; Gagliardi M; Burbulla LF; Matsuo H; Kawamura Y; Hattori N; Nishioka K; Chung SJ; Kim YJ; Pavelka L; van de Warrenburg BPC; Bloem BR; Singleton AB; Aasly J; Toft M; Guedes LC; Ferreira JJ; Bardien S; Carr J; Tolosa E; Ezquerra M; Pastor P; Diez-Fairen M; Wirdefeldt K; Pedersen NL; Ran C; Belin AC; Puschmann A; Hellberg C; Clarke CE; Morrison KE; Krainc D; Farrer MJ; Kruger R; Elbaz A; Gasser T; Sharma M
Article: ANNALS OF NEUROLOGY. 2022;92(2):270-278
Polygenic Resilience Modulates the Penetrance of Parkinson Disease Genetic Risk Factors.
Liu H; Dehestani M; Blauwendraat C; Makarious MB; Leonard H; Kim JJ; Schulte C; Noyce A; Jacobs BM; Foote I; Sharma M; International Parkinson's Disease Genomics Consort; Nalls M; Singleton A; Gasser T; Bandres-Ciga S
Article: NEUROSCIENCE LETTERS. 2022;784:136767
Glucocerebrosidase variant T369M is not a risk factor for Parkinsons disease in Sweden
Ran C; Brodin L; Gellhaar S; Westerlund M; Fardell C; Nissbrandt H; Soderkvist P; Sydow O; Markaki I; Hertz E; Wirdefeldt K; Svenningsson P
Article: MOVEMENT DISORDERS. 2022;37(4):857-864
Dairy Intake and Parkinson's Disease: A Mendelian Randomization Study
Domenighetti C; Sugier P-E; Sreelatha AAK; Schulte C; Grover S; Mohamed O; Portugal B; May P; Bobbili DR; Radivojkov-Blagojevic M; Lichtner P; Singleton AB; Hernandez DG; Edsall C; Mellick GD; Zimprich A; Pirker W; Rogaeva E; Lang AE; Koks S; Taba P; Lesage S; Brice A; Corvol J-C; Chartier-Harlin M-C; Mutez E; Brockmann K; Deutschlaender AB; Hadjigeorgiou GM; Dardiotis E; Stefanis L; Simitsi AM; Valente EM; Petrucci S; Duga S; Straniero L; Zecchinelli A; Pezzoli G; Brighina L; Ferrarese C; Annesi G; Quattrone A; Gagliardi M; Matsuo H; Kawamura Y; Hattori N; Nishioka K; Chung SJ; Kim YJ; Kolber P; van de Warrenburg BPC; Bloem BR; Aasly J; Toft M; Pihlstrom L; Guedes LC; Ferreira JJ; Bardien S; Carr J; Tolosa E; Ezquerra M; Pastor P; Diez-Fairen M; Wirdefeldt K; Pedersen NL; Ran C; Belin AC; Puschmann A; Hellberg C; Clarke CE; Morrison KE; Tan M; Krainc D; Burbulla LF; Farrer MJ; Kruger R; Gasser T; Sharma M; Elbaz A
Article: EBIOMEDICINE. 2022;76:103824
Mendelian randomization study on the causal effects of tumor necrosis factor inhibition on coronary artery disease and ischemic stroke among the general population
Kang X; Jiao T; Wang H; Pernow J; Wirdefeldt K
Article: JOURNAL OF PARKINSONS DISEASE. 2022;12(1):267-282
Mendelian Randomisation Study of Smoking, Alcohol, and Coffee Drinking in Relation to Parkinson's Disease
Domenighetti C; Sugier P-E; Sreelatha AAK; Schulte C; Grover S; Mohamed O; Portugal B; May P; Bobbili DR; Radivojkov-Blagojevic M; Lichtner P; Singleton AB; Hernandez DG; Edsall C; Mellick GD; Zimprich A; Pirker W; Rogaeva E; Lang AE; Koks S; Taba P; Lesage S; Brice A; Corvol J-C; Chartier-Harlin M-C; Mutez E; Brockmann K; Deutschlaender AB; Hadjigeorgiou GM; Dardiotis E; Stefanis L; Simitsi AM; Valente EM; Petrucci S; Duga S; Straniero L; Zecchinelli A; Pezzoli G; Brighina L; Ferrarese C; Annesi G; Quattrone A; Gagliardi M; Matsuo H; Kawamura Y; Hattori N; Nishioka K; Chung SJ; Kim YJ; Kolber P; van de Warrenburg BP; Bloem BR; Aasly J; Toft M; Pihlstrom L; Guedes LC; Ferreira JJ; Bardien S; Carr J; Tolosa E; Ezquerra M; Pastor P; Diez-Fairen M; Wirdefeldt K; Pedersen NL; Ran C; Belin AC; Puschmann A; Hellberg C; Clarke CE; Morrison KE; Tan M; Krainc D; Burbulla LF; Farrer MJ; Krueger R; Gasser T; Sharma M; Elbaz A
Article: EUROPEAN JOURNAL OF EPIDEMIOLOGY. 2021;36(10):1055-1064
Heart rate, intelligence in adolescence, and Parkinson's disease later in life
Longinetti E; Zhan Y; Sata M; Larsson H; D'Onofrio BM; Iso H; Wirdefeldt K; Fang F
Article: JOURNAL OF PARKINSONS DISEASE. 2021;11(3):1325-1334
Neuroticism, Smoking, and the Risk of Parkinson's Disease
Sieurin J; Zhan Y; Pedersen NL; Wirdefeldt K
Article: MOVEMENT DISORDERS. 2021;36(8):1919-1926
Association between Microscopic Colitis and Parkinson's Disease in a Swedish Population
Kang X; Ploner A; Roelstraete B; Khalili H; Williams DM; Pedersen NL; Ludvigsson JF; Wirdefeldt K
Article: NEUROLOGY. 2021;96(12):E1672-E1679
Tumor Necrosis Factor Inhibition and Parkinson Disease A Mendelian Randomization Study
Kang X; Ploner A; Pedersen NL; Bandres-Ciga S; Noyce AJ; Wirdefeldt K; Williams DM
Article: NPJ PARKINSONS DISEASE. 2021;7(1):5
Irritable bowel syndrome and Parkinson's disease risk: register-based studies
Liu B; Sjolander A; Pedersen NL; Ludvigsson JF; Chen H; Fang F; Wirdefeldt K
Article: EUROPEAN JOURNAL OF NEUROLOGY. 2020;27(11):2134-2141
Clostridium difficileinfection and risk of Parkinson's disease: a Swedish population-based cohort study
Kang X; Ploner A; Ludvigsson JF; Williams DM; Larsson H; Pedersen NL; Wirdefeldt K
Article: BRAIN COMMUNICATIONS. 2020;2(2):fcaa152
Creatinine and C-reactive protein in amyotrophic lateral sclerosis, multiple sclerosis and Parkinson's disease
Cui C; Sun J; Pawitan Y; Piehl F; Chen H; Ingre C; Wirdefeldt K; Evans M; Andersson J; Carrero J-J; Fang F
Article: ALIMENTARY PHARMACOLOGY & THERAPEUTICS. 2020;51(11):1022-1030
Vagotomy and subsequent risk of inflammatory bowel disease: a nationwide register-based matched cohort study
Liu B; Wanders A; Wirdefeldt K; Sjolander A; Sachs MC; Eberhardson M; Ye W; Ekbom A; Olen O; Ludvigsson JF
Article: JAMA NEUROLOGY. 2020;77(6):700-709
Association of Stress-Related Disorders With Subsequent Neurodegenerative Diseases
Song H; Sieurin J; Wirdefeldt K; Pedersen NL; Almqvist C; Larsson H; Valdimarsdottir UA; Fang F
Article: FRONTIERS IN NEUROLOGY. 2020;11:548
Longitudinal Monitoring of Parkinson's Disease in Different Ethnic Cohorts: The DodoNA and LONG-PD Study
Markopoulou K; Aasly J; Chung SJ; Dardiotis E; Wirdefeldt K; Premkumar AP; Schoneburg B; Kartha N; Wilk G; Wei J; Simon KC; Tideman S; Epshteyn A; Hadsell B; Garduno L; Pham A; Frigerio R; Maraganore D
Article: FRONTIERS IN NEUROLOGY. 2020;11:510
Appendectomy, Tonsillectomy and Parkinson's Disease Risk: A Swedish Register-Based Study
Liu B; Fang F; Ye W; Wirdefeidt K
Article: NEUROLOGY. 2019;93(21):e1964-e1970
Family history increases the risk of late seizures after stroke
Eriksson H; Wirdefeldt K; Asberg S; Zelano J
Article: ACTA NEUROLOGICA SCANDINAVICA. 2019;140(5):342-349
Incidence of osmotic demyelination syndrome in Sweden: A nationwide study
Aegisdottir H; Cooray C; Wirdefeldt K; Piehl F; Sveinsson O
Article: PARKINSONISM & RELATED DISORDERS. 2019;66:158-165
Low prevalence of known pathogenic mutations in dominant PD genes: A Swedish multicenter study
Puschmann A; Jimenez-Ferrer I; Lundblad-Andersson E; Martensson E; Hansson O; Odin P; Widner H; Brolin K; Mzezewa R; Kristensen J; Soller M; Rodstrom EY; Ross OA; Toft M; Breedveld GJ; Bonifati V; Brodin L; Zettergren A; Sydow O; Linder J; Wirdefeldt K; Svenningsson P; Nissbrandt H; Belin AC; Forsgren L; Swanberg M
Article: CIRCULATION RESEARCH. 2019;125(6):643-652
Lipids, Apolipoproteins, and the Risk of Parkinson Disease A Prospective Cohort Study and a Mendelian Randomization Analysis
Fang F; Zhan Y; Hammar N; Shen X; Wirdefeldt K; Walldius G; Mariosa D
Article: ANNALS OF INTERNAL MEDICINE. 2019;170(10):673-681
Relationship Between Poor Olfaction and Mortality Among Community-Dwelling Older Adults A Cohort Study
Liu B; Luo Z; Pinto JM; Shiroma EJ; Tranah GJ; Wirdefeldt K; Fang F; Harris TB; Chen H
Article: MOVEMENT DISORDERS. 2018;33(9):1456-1464
Occupational Stress and Risk for Parkinson's Disease: A Nationwide Cohort Study
Sieurin J; Andel R; Tillander A; Valdes EG; Pedersen NL; Wirdefeldt K
Article: NEUROLOGY. 2018;90(16):E1413-E1417
Body mass index, sitting time, and risk of Parkinson disease
Roos E; Grotta A; Yang F; Bellocco R; Ye W; Adami H-O; Wirdefeldt K; Lagerros YT
Article: MOVEMENT DISORDERS. 2017;32(11):1631-1636
Dietary Antioxidants and Risk of Parkinson's Disease in Two Population-Based Cohorts
Yang F; Wolk A; Hakansson N; Pedersen NL; Wirdefeldt K
Article: BRAIN. 2017;140(10):2653-2662
Migraine and risk of stroke: a national population-based twin study
Lantz M; Sieurin J; Sjolander A; Waldenlind E; Sjostrand C; Wirdefeldt K
Article: INTERNATIONAL JOURNAL OF EPIDEMIOLOGY. 2017;46(3):872-880
Moist smokeless tobacco (Snus) use and risk of Parkinson's disease
Yang F; Pedersen NL; Ye W; Liu Z; Norberg M; Forsgren L; Lagerros YT; Bellocco R; Alfredsson L; Knutsson A; Jansson J-H; Wennberg P; Galanti MR; Lager ACJ; Araghi M; Lundberg M; Magnusson C; Wirdefeldt K
Article: NEUROLOGY. 2017;88(21):1996-2002
Vagotomy and Parkinson disease A Swedish register-based matched-cohort study
Liu B; Fang F; Pedersen NL; Tillander A; Ludvigsson JF; Ekbom A; Svenningsson P; Chen H; Wirdefeldt K
Article: NEUROBIOLOGY OF AGING. 2017;49:217.e1-217.e4
Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study
Wang L; Heckman MG; Aasly JO; Annesi G; Bozi M; Chung SJ; Clarke C; Crosiers D; Eckstein G; Garraux G; Hadjigeorgiou GM; Hattori N; Jeon B; Kim YJ; Kubo M; Lesage S; Lin JJ; Lynch T; Lichtner P; Mellick GD; Mok V; Morrison KE; Quattrone A; Satake W; Silburn PA; Stefanis L; Stockton JD; Tan EK; Toda T; Brice A; Van Broeckhoven C; Uitti RJ; Wirdefeldt K; Wszolek Z; Xiromerisiou G; Maraganore DM; Gasser T; Krueger R; Farrer MJ; Ross OA; Sharma M
Article: PARKINSONS DISEASE. 2017;2017:4020198-7
Genetic Variations and mRNA Expression of NRF2 in Parkinson's Disease
Ran C; Wirdefeldt K; Brodin L; Ramezani M; Westerlund M; Xiang F; Anvret A; Willows T; Sydow O; Johansson A; Galter D; Svenningsson P; Belin AC
Article: PLOS ONE. 2017;12(5):e0173565
A KCNC3 mutation causes a neurodevelopmental, non-progressive SCA13 subtype associated with dominant negative effects and aberrant EGFR trafficking
Khare S; Nick JA; Zhang Y; Galeano K; Butler B; Khoshbouei H; Rayaprolu S; Hathorn T; Ranum LPW; Smithson L; Golde TE; Paucar M; Morse R; Raff M; Simon J; Ld MNE; Wirdefeldt K; Rincon-Limas DE; Lewis J; Kaczmarek LK; Fernandez-Funez P; Nick HS; Waters MF
Article: NEUROBIOLOGY OF AGING. 2016;45:212.e5-212.e11
Strong association between glucocerebrosidase mutations and Parkinson's disease in Sweden
Ran C; Brodin L; Forsgren L; Westerlund M; Ramezani M; Gellhaar S; Xiang F; Fardell C; Nissbrandt H; Soderkvist P; Puschmann A; Ygland E; Olson L; Willows T; Johansson A; Sydow O; Wirdefeldt K; Galter D; Svenningsson P; Belin AC
Article: MEDICINE. 2016;95(30):e4337
Socioeconomic status in relation to Parkinson's disease risk and mortality A population-based prospective study
Yang F; Johansson ALV; Pedersen NL; Fang F; Gatz M; Wirdefeldt K
Article: OPEN NEUROLOGY JOURNAL. 2016;10:25-29
No Association Between rs7077361 in ITGA8 and Parkinson's Disease in Sweden.
Ran C; Mehdi RN; Fardell C; Xiang F; Nissbrandt H; Sydow O; Wirdefeldt K; Belin AC
Article: NEUROLOGY. 2016;86(24):2271-2277
Depression in amyotrophic lateral sclerosis
Roos E; Mariosa D; Ingre C; Lundholm C; Wirdefeldt K; Roos PM; Fang F
Article: EUROPEAN JOURNAL OF EPIDEMIOLOGY. 2016;31(2):169-175
Personality traits and the risk for Parkinson disease: a prospective study
Sieurin J; Gustavsson P; Weibull CE; Feldman AL; Petzinger GM; Gatz M; Pedersen NL; Wirdefeldt K
Article: PLOS ONE. 2016;11(4):e0152841
Early-Life Factors and Risk of Parkinson's Disease: A Register-Based Cohort Study
Liu B; Chen H; Fang F; Tillander A; Wirdefeldt K
Article: NEUROLOGY. 2015;85(15):1283-1292
Large-scale assessment of polyglutamine repeat expansions in Parkinson disease
Wang L; Aasly JO; Annesi G; Bardien S; Bozi M; Brice A; Carr J; Chung SJ; Clarke C; Crosiers D; Deutschlaender A; Eckstein G; Farrer MJ; Goldwurm S; Garraux G; Hadjigeorgiou GM; Hicks AA; Hattori N; Klein C; Jeon B; Kim YJ; Lesage S; Lin J-J; Lynch T; Lichtner P; Lang AE; Mok V; Jasinska-Myga B; Mellick GD; Morrison KE; Opala G; Pihlstrom L; Pramstaller PP; Park SS; Quattrone A; Rogaeva E; Ross OA; Stefanis L; Stockton JD; Silburn PA; Theuns J; Tan EK; Tomiyama H; Toft M; Van Broeckhoven C; Uitti RJ; Wirdefeldt K; Wszolek Z; Xiromerisiou G; Yueh K-C; Zhao Y; Gasser T; Maraganore DM; Krueger R; Sharma M
Article: BRAIN. 2015;138(Pt 2):269-275
Physical activity and risk of Parkinson's disease in the Swedish National March Cohort
Yang F; Lagerros YT; Bellocco R; Adami H-O; Fang F; Pedersen NL; Wirdefeldt K
Article: PLOS ONE. 2015;10(4):e0122960
Is a Cancer Diagnosis Associated with Subsequent Risk of Transient Global Amnesia?
Zhu J; Lu D; Sveinsson O; Wirdefeldt K; Fall K; Piehl F; Valdimarsdottir U; Fang F
Article: NEUROEPIDEMIOLOGY. 2015;45(4):282-297
Methods in Neuroepidemiology Characterization of European Longitudinal Cohort Studies in Parkinson's Disease - Report of the JPND Working Group BioLoC-PD
Lerche S; Liepelt-Scarfone I; Alves G; Barone P; Behnke S; Ben-Shlomo Y; Berendse H; Burn D; Dodel R; Grosset D; Heinzel S; Hu M; Kasten M; Krueger R; Maetzler W; Moccia M; Mollenhauer B; Oertel W; Roeben B; Suenkel U; Walter U; Wirdefeldt K; Berg D
Article: NEUROLOGY. 2014;83(21):1906-1913
Global investigation and meta-analysis of the C9orf72 (G4C2)n repeat in Parkinson disease.
Theuns J; Verstraeten A; Sleegers K; Wauters E; Gijselinck I; Smolders S; Crosiers D; Corsmit E; Elinck E; Sharma M; Krüger R; Lesage S; Brice A; Chung SJ; Kim M-J; Kim YJ; Ross OA; Wszolek ZK; Rogaeva E; Xi Z; Lang AE; Klein C; Weissbach A; Mellick GD; Silburn PA; Hadjigeorgiou GM; Dardiotis E; Hattori N; Ogaki K; Tan E-K; Zhao Y; Aasly J; Valente EM; Petrucci S; Annesi G; Quattrone A; Ferrarese C; Brighina L; Deutschländer A; Puschmann A; Nilsson C; Garraux G; LeDoux MS; Pfeiffer RF; Boczarska-Jedynak M; Opala G; Maraganore DM; Engelborghs S; De Deyn PP; Cras P; Cruts M; Van Broeckhoven C; GEO-PD Consortium
Article: MOVEMENT DISORDERS. 2014;29(8):1053-1057
Alpha-Synuclein Repeat Variants and Survival in Parkinson's Disease
Chung SJ; Biernacka JM; Armasu SM; Anderson K; Frigerio R; Aasly JO; Annesi G; Bentivoglio AR; Brighina L; Chartier-Harlin M-C; Goldwurm S; Hadjigeorgiou G; Jasinska-Myga B; Jeon BS; Kim YJ; Krueger R; Lesage S; Markopoulou K; Mellick G; Morrison KE; Puschmann A; Tan E-K; Crosiers D; Theuns J; Van Broeckhoven C; Wirdefeldt K; Wszolek ZK; Elbaz A; Maraganore DM
Article: AMERICAN JOURNAL OF EPIDEMIOLOGY. 2014;179(1):85-94
Parkinson's Disease and Cancer: A Register-based Family Study
Wirdefeldt K; Weibull CE; Chen H; Kamel F; Lundholm C; Fang F; Ye W
Article: EUROPEAN JOURNAL OF EPIDEMIOLOGY. 2014;29(1):49-56
Evidence for modest familial co-aggregation between dementia and parkinsonism
Feldman AL; Wirdefeldt K; Johansson ALV; Gatz M; Pedersen NL
Article: PLOS ONE. 2014;9(9):e106676
Occupational Complexity and Risk of Parkinson's Disease
Valdes EG; Andel R; Sieurin J; Feldman AL; Edwards JD; Langstrom N; Gatz M; Wirdefeldt K
Article: NEUROBIOLOGY OF AGING. 2014;35(1):266.e5-266.e14
The protective effect of LRRK2 p.R1398H on risk of Parkinson's disease is independent of MAPT and SNCA variants
Heckman MG; Elbaz A; Soto-Ortolaza AI; Serie DJ; Aasly JO; Annesi G; Auburger G; Bacon JA; Boczarska-Jedynak M; Bozi M; Brighina L; Chartier-Harlin M-C; Dardiotism E; Destee A; Ferrarese C; Ferraris A; Fiske B; Gispert S; Hadjigeorgioum GM; Hattori N; Ioannidis JPA; Jasinska-Myga B; Jeon BS; Kim YJ; Klein C; Kruger R; Kyratzi E; Lin C-H; Lohmann K; Loriot M-A; Lynch T; Mellick GD; Mutez E; Opala G; Park SS; Petrucci S; Quattrone A; Sharma M; Silburn PA; Sohn YH; Stefanis L; Tadic V; Tomiyama H; Uitti RJ; Valente EM; Vassilatis DK; Vilarino-Guell C; White LR; Wirdefeldt K; Wszolek ZK; Wu R-M; Xiromerisiou G; Maraganore DM; Farrer MJ; Ross OA
Article: MOVEMENT DISORDERS. 2013;28(12):1740-1744
Population-specific Frequencies for LRRK2 Susceptibility Variants in the Genetic Epidemiology of Parkinson's Disease (GEO-PD) Consortium
Heckman MG; Soto-Ortolaza AI; Aasly JO; Abahuni N; Annesi G; Bacon JA; Bardien S; Bozi M; Brice A; Brighina L; Carr J; Chartier-Harlin M-C; Dardiotis E; Dickson DW; Diehl NN; Elbaz A; Ferrarese C; Fiske B; Gibson JM; Gibson R; Hadjigeorgiou GM; Hattori N; Ioannidis JPA; Boczarska-Jedynak M; Jasinska-Myga B; Jeon BS; Kim YJ; Klein C; Kruger R; Kyratzi E; Lesage S; Lin C-H; Lynch T; Maraganore DM; Mellick GD; Mutez E; Nilsson C; Opala G; Park SS; Petrucci S; Puschmann A; Quattrone A; Sharma M; Silburn PA; Sohn YH; Stefanis L; Tadic V; Theuns J; Tomiyama H; Uitti RJ; Valente EM; Van Broeckhoven C; van de Loo S; Vassilatis DK; Vilarino-Gueell C; White LR; Wirdefeldt K; Wszolek ZK; Wu R-M; Hentati F; Farrer MJ; Ross OA
Article: AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION. 2013;14(5-6):362-368
Amyotrophic lateral sclerosis and cancer: A register-based study in Sweden
Fang F; Al-Chalabi A; Ronnevi L-O; Turner MR; Wirdefeldt K; Kamel F; Ye W
Article: MOVEMENT DISORDERS. 2012;27(13):1632-1635
Head injury and Parkinson's disease: A population-based study
Fang F; Chen H; Feldman AL; Kamel F; Ye W; Wirdefeldt K
Article: JOURNAL OF MEDICAL GENETICS. 2012;49(11):721-726
A multi-centre clinico-genetic analysis of the VPS35 gene in Parkinson disease indicates reduced penetrance for disease-associated variants
Sharma M; Ioannidis JPA; Aasly JO; Annesi G; Brice A; Bertram L; Bozi M; Barcikowska M; Crosiers D; Clarke CE; Facheris MF; Farrer M; Garraux G; Gispert S; Auburger G; Vilarino-Guell C; Hadjigeorgiou GM; Hicks AA; Hattori N; Jeon BS; Jamrozik Z; Krygowska-Wajs A; Lesage S; Lill CM; Lin J-J; Lynch T; Lichtner P; Lang AE; Libioulle C; Murata M; Mok V; Jasinska-Myga B; Mellick GD; Morrison KE; Meitnger T; Zimprich A; Opala G; Pramstaller PP; Pichler I; Park SS; Quattrone A; Rogaeva E; Ross OA; Stefanis L; Stockton JD; Satake W; Silburn PA; Strom TM; Theuns J; Tan E-K; Toda T; Tomiyama H; Uitti RJ; Van Broeckhoven C; Wirdefeldt K; Wszolek Z; Xiromerisiou G; Yomono HS; Yueh K-C; Zhao Y; Gasser T; Maraganore D; Krueger R
Article: NEUROLOGY. 2012;79(7):659-667
Large-scale replication and heterogeneity in Parkinson disease genetic loci
Sharma M; Ioannidis JPA; Aasly JO; Annesi G; Brice A; Van Broeckhoven C; Bertram L; Bozi M; Crosiers D; Clarke C; Facheris M; Farrer M; Garraux G; Gispert S; Auburger G; Vilarino-Gueell C; Hadjigeorgiou GM; Hicks AA; Hattori N; Jeon B; Lesage S; Lill CM; Lin J-J; Lynch T; Lichtner P; Lang AE; Mok V; Jasinska-Myga B; Mellick GD; Morrison KE; Opala G; Pramstaller PP; Pichler I; Park SS; Quattrone A; Rogaeva E; Ross OA; Stefanis L; Stockton JD; Satake W; Silburn PA; Theuns J; Tan E-K; Toda T; Tomiyama H; Uitti RJ; Wirdefeldt K; Wszolek Z; Xiromerisiou G; Yueh K-C; Zhao Y; Gasser T; Maraganore D; Krueger R
Article: INTERNATIONAL JOURNAL OF EPIDEMIOLOGY. 2012;41(4):1042-1049
CNS infections, sepsis and risk of Parkinson's disease
Fang F; Wirdefeldt K; Jacks A; Kamel F; Ye W; Chen H
Article: NEUROEPIDEMIOLOGY. 2012;38(3):186-193
Accuracy and Sensitivity of Parkinsonian Disorder Diagnoses in Two Swedish National Health Registers
Feldman AL; Johansson ALV; Gatz M; Flensburg M; Petzinger GM; Widner H; Lew MF; Pedersen NL; Wirdefeldt K
Article: NEUROBIOLOGY OF AGING. 2011;32(11):2108.e1-2108.e5
Role of sepiapterin reductase gene at the PARK3 locus in Parkinson's disease
Sharma M; Maraganore DM; Ioannidis JPA; Riess O; Aasly JO; Annesi G; Abahuni N; Bentivoglio AR; Brice A; Van Broeckhoven C; Chartier-Harlin M-C; Destee A; Djarmati A; Elbaz A; Farrer M; Ferrarese C; Gibson JM; Gispert S; Hattori N; Jasinska-Myga B; Klein C; Lesage S; Lynch T; Lichtner P; Lambert J-C; Lang AE; Mellick GD; De Nigris F; Opala G; Quattrone A; Riva C; Rogaeva E; Ross OA; Satake W; Silburn PA; Theuns J; Toda T; Tomiyama H; Uitti RJ; Wirdefeldt K; Wszolek Z; Gasser T; Krueger R
Article: PARKINSONISM & RELATED DISORDERS. 2011;17(9):677-682
Occupational exposure in Parkinsonian disorders: A 43-year prospective cohort study in men
Feldman AL; Johansson ALV; Nise G; Gatz M; Pedersen NL; Wirdefeldt K
Article: LANCET NEUROLOGY. 2011;10(10):898-908
Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case-control study
Ross OA; Soto-Ortolaza AI; Heckman MG; Aasly JO; Abahuni N; Annesi G; Bacon JA; Bardien S; Bozi M; Brice A; Brighina L; Van Broeckhoven C; Carr J; Chartier-Harlin M-C; Dardiotis E; Dickson DW; Diehl NN; Elbaz A; Ferrarese C; Ferraris A; Fiske B; Gibson JM; Gibson R; Hadjigeorgiou GM; Hattori N; Ioannidis JPA; Jasinska-Myga B; Jeon BS; Kim YJ; Klein C; Kruger R; Kyratzi E; Lesage S; Lin C-H; Lynch T; Maraganore DM; Mellick GD; Mutez E; Nilsson C; Opala G; Park SS; Puschmann A; Quattrone A; Sharma M; Silburn PA; Sohn YH; Stefanis L; Tadic V; Theuns J; Tomiyama H; Uitti RJ; Valente EM; van de Loo S; Vassilatis DK; Vilarino-Gueell C; White LR; Wirdefeldt K; Wszolek ZK; Wu R-M; Farrer MJ
Article: NEUROBIOLOGY OF AGING. 2011;32(10):1923.e1-1923.e8
Heritability of Parkinson disease in Swedish twins: a longitudinal study
Wirdefeldt K; Gatza M; Reynolds CA; Prescott CA; Pedersen NL
Article: ANNALS OF NEUROLOGY. 2011;69(5):778-792
Independent and Joint Effects of the MAPT and SNCA Genes in Parkinson Disease
Elbaz A; Ross OA; Ioannidis JPA; Soto-Ortolaza AI; Moisan F; Aasly J; Annesi G; Bozi M; Brighina L; Chartier-Harlin M-C; Destee A; Ferrarese C; Ferraris A; Gibson JM; Gispert S; Hadjigeorgiou GM; Jasinska-Myga B; Klein C; Krueger R; Lambert J-C; Lohmann K; van de Loo S; Loriot M-A; Lynch T; Mellick GD; Mutez E; Nilsson C; Opala G; Puschmann A; Quattrone A; Sharma M; Silburn PA; Stefanis L; Uitti RJ; Valente EM; Vilarino-Gueell C; Wirdefeldt K; Wszolek ZK; Xiromerisiou G; Maraganore DM; Farrer MJ
Article: NEUROBIOLOGY OF AGING. 2011;32(3):548.e9-548.18
A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease
Krueger R; Sharma M; Riess O; Gasser T; Van Broeckhoven C; Theuns J; Aasly J; Annesi G; Bentivoglio AR; Brice A; Djarmati A; Elbaz A; Farrer M; Ferrarese C; Gibson JM; Hadjigeorgiou GM; Hattori N; Ioannidis JPA; Jasinska-Myga B; Klein C; Lambert J-C; Lesage S; Lin J-J; Lynch T; Mellick GD; de Nigris F; Opala G; Prigione A; Quattrone A; Ross OA; Satake W; Silburn PA; Tan EK; Toda T; Tomiyama H; Wirdefeldt K; Wszolek Z; Xiromerisiou G; Maraganore DM
Article: PLOS ONE. 2011;6(12):e29749
Infection of the Central Nervous System, Sepsis and Amyotrophic Lateral Sclerosis
Fang F; Chen H; Wirdefeldt K; Ronnevi L-O; Al-Chalabi A; Peters TL; Kamel F; Ye W
Article: AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS. 2010;153B(1):220-228
Non-Replication of Association for Six Polymorphisms From Meta-Analysis of Genome-Wide Association Studies of Parkinson's Disease: Large-Scale Collaborative Study
Evangelou E; Maraganore DM; Annesi G; Brijhina L; Brice A; Elbaz A; Ferrarese C; Hadjigeorgiou GM; Krueger R; Lambert J-C; Lesage S; Markopoulou K; Mellick GD; Meeus B; Pedersen NL; Quattrone A; Van Broeckhoven C; Sharma M; Silburn PA; Tan E-K; Wirdefeldt K; Ioannidis JPA
Article: NEUROBIOLOGY OF AGING. 2008;29(12):1765-1773
Complete ascertainment of Parkinson disease in the Swedish Twin Registry
Wirdefeldt K; Gatz M; Bakaysa SL; Fiske A; Flensburg M; Petzinger GM; Widner H; Lew MF; Welsh M; Pedersen NL
Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2008;82(3):763-771
Phenotypically concordant and discordant monozygotic twins display different DNA copy-number-variation profiles
Bruder CEG; Piotrowski A; Gijsbers AACJ; Andersson R; Erickson S; de Stahl TD; Menzel U; Sandgren J; von Tell D; Poplawski A; Crowley M; Crasto C; Partridge EC; Tiwari H; Allison DB; Komorowski J; van Ommen G-JB; Boomsma DI; Pedersen NL; den Dunnen JT; Wirdefeldt K; Dumanski JP
Article: LANCET NEUROLOGY. 2006;5(11):917-923
Lack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson's disease:: a large-scale international study
Elbaz A; Nelson LM; Payami H; Ioannidis JPA; Fiske BK; Annesi G; Belin AC; Factor SA; Ferrarese C; Hadjigeorgiou GM; Higgins DS; Kawakami H; Krueger R; Marder KS; Mayeux RP; Mellick GD; Nutt JG; Ritz B; Samii A; Tanner CM; Van Broeckhoven C; Van Den Eeden SK; Wirdefeldt K; Zabetian CP; Dehem M; Montimurro JS; Southwick A; Myers RM; Trikalinos TA
Article: ANNALS OF NEUROLOGY. 2005;57(1):27-33
Risk and protective factors for Parkinson's disease: A study in Swedish twins
Wirdefeldt K; Gatz M; Pawitan Y; Pedersen NL
Article: NEUROLOGY. 2004;63(2):305-311
No evidence for heritability of Parkinson disease in Swedish twins
Wirdefeldt K; Gatz M; Schalling M; Pedersen NL
Article: BMC NEUROLOGY. 2003;3:6
A linkage study of candidate loci in familial Parkinson's Disease.
Wirdefeldt K; Burgess CE; Westerberg L; Payami H; Schalling M
Article: BRAIN RESEARCH. 2001;92(1-2):58-65
Expression of α-synuclein in the human brain:: relation to Lewy body disease
Wirdefeldt K; Bogdanovic N; Westerberg L; Payami H; Schalling M; Murdoch G
Article: NEUROSCIENCE LETTERS. 1999;272(2):140-142
Exclusion of dominant mutations within the FTDP-17 locus on chromosome 17 for Parkinson's disease
Zareparsi S; Wirdefeldt K; Burgess CE; Nutt J; Kramer P; Schalling M; Payami H
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Letter: GUT. 2024;:gutjnl-2024-332352
Gastrointestinal syndromes in Parkinson's disease: risk factors or comorbidities?
Sun J; Yan D; Wirdefeldt K; Yao J; Ludvigsson JF
Letter: MOVEMENT DISORDERS. 2021;36(10):2453
Reply to: "Association between Microscopic Colitis and Parkinson's Disease in a Swedish Population".
Kang X; Ploner A; Roelstraete B; Khalili H; Williams DM; Pedersen NL; Ludvigsson JF; Wirdefeldt K
Letter: CNS DRUGS. 2016;30(10):1009-1010
Authors' Reply to Lambarth: "Levodopa-Carbidopa Intestinal Gel in Patients with Parkinson's Disease: A Systematic Review"
Wirdefeldt K; Odin P; Nyholm D
Letter: MOVEMENT DISORDERS. 2016;31(9):1422-1423
Reduced incidence of Parkinson's disease after dipeptidyl peptidase-4 inhibitorsA nationwide case-control study
Svenningsson P; Wirdefeldt K; Yin L; Fang F; Markaki I; Efendic S; Ludvigsson JF
Review: CNS DRUGS. 2016;30(5):381-404
Levodopa-Carbidopa Intestinal Gel in Patients with Parkinson's Disease: A Systematic Review
Wirdefeldt K; Odin P; Nyholm D
Review: FRONTIERS IN AGING NEUROSCIENCE. 2016;8:147
Prodromal Markers in Parkinson's Disease: Limitations in Longitudinal Studies and Lessons Learned
Heinzel S; Roeben B; Ben-Shlomo Y; Lerche S; Alves G; Barone P; Behnke S; Berendse HW; Bloem BR; Burn D; Dodel R; Grosset DG; Hu M; Kasten M; Krueger R; Moccia M; Mollenhauer B; Oertel W; Suenkel U; Walter U; Wirdefeldt K; Liepelt-Scarfone I; Maetzler W; Berg D
Editorial comment: FRONTIERS IN AGING NEUROSCIENCE. 2016;8:121
Aiming for Study Comparability in Parkinson's Disease: Proposal for a Modular Set of Biomarker Assessments to be Used in Longitudinal Studies
Lerche S; Heinzel S; Alves G; Barone P; Behnke S; Ben-Shlomo Y; Berendse H; Bloem BR; Burn D; Dodel R; Grosset DG; Hipp G; Hu MT; Kasten M; Kruger R; Liepelt-Scarfone I; Maetzler W; Moccia M; Mollenhauer B; Oertel W; Roeben B; Walter U; Wirdefeldt K; Berg D
Review: NEUROEPIDEMIOLOGY. 2014;42(2):69-80
Familial Coaggregation of Alzheimer's Disease and Parkinson's Disease: Systematic Review and Meta-Analysis
Feldman AL; Johansson ALV; Lambert PC; Sieurin J; Yang F; Pedersen NL; Wirdefeldt K
Corrigendum: JOURNAL OF MEDICAL GENETICS. 2013;50(3):202
A multi-centre clinico-genetic analysis of the VPS35 gene in Parkinson disease indicates reduced penetrance for disease-associated variants (vol 49, pg 721, 2012)
Sharma M; Ioannidis JP; Aasly JO; Annesi G; Brice A; Bertram L; Bozi M; Barcikowska M; Crosiers D; Clarke CE; Facheris MF; Farrer M; Garraux G; Gispert S; Auburger G; Vilarino-Gueell C; Hadjigeorgiou GM; Hicks AA; Hattori N; Jeon BS; Jamrozik Z; Krygowska-Wajs A; Lesage S; Lill CM; Lin JJ; Lynch T; Lichtner P; Lang AE; Libioulle C; Murata M; Mok V; Jasinska-Myga B; Mellick GD; Morrison KE; Meitnger T; Zimprich A; Opala G; Pramstaller PP; Pichler I; Park SS; Quattrone A; Rogaeva E; Ross OA; Stefanis L; Stockton JD; Satake W; Silburn PA; Strom TM; Theuns J; Tan EK; Toda T; Tomiyama H; Uitti RJ; Van Broeckhoven C; Wirdefeldt K; Wszolek Z; Xiromerisiou G; Yomono HS; Yueh KC; Zhao Y; Gasser T; Maraganore D; Krueger R
Review: EUROPEAN JOURNAL OF EPIDEMIOLOGY. 2011;26:S1-S58
Epidemiology and etiology of Parkinson's disease: a review of the evidence
Wirdefeldt K; Adami H-O; Cole P; Trichopoulos D; Mandel J
Letter: NEUROLOGY. 2005;64(5):932
No evidence for heritability of Parkinson disease in Swedish twins - Repl
Pedersen NL; Wirdefeldt K; Gatz M; Schalling M
Thesis / dissertation: 2004
Studies of genetic and environmental influences on Parkinson’s disease
Wirdefeldt, Karin

Employments

Adjunct Professor, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 2023-2026
Adjunct Professor, Department of Clinical Neuroscience, Karolinska Institutet, 2023-2026

Degrees and Education

Docent, Karolinska Institutet, 2015
Doctor Of Philosophy, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 2004
University Medical Degree, Karolinska Institutet, 1996

Supervisor

Sara Licaj
Katalin Vincze

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