Jenny Mjösberg group
The purpose of our research is to characterize the role for innate lymphoid cells (ILCs) in intestinal inflammation and cancer.
ILCs are a family of cells that was recently described in humans. The function of these cells is mainly as protectors of mucosal barrier function in the gut, lung and other organs, but more and more data indicate that they might also be involved in disease, such as inflammatory bowel disease (IBD) and cancer in the gut, as well as inflammation in the airways (asthma). We are trying to gain insight into basic ILC biology; how these cells are differentiated, regulated and interact with other cells in the immune system. We perform these studies in the context of gut and lung inflammation and gut cancer with the ultimate aim of increasing the understanding of disease mechanisms, discovering novel treatment targets and strategies for patient stratification in biologics treatment.
Our research is set up in a truly translational fashion, where we address complex immunological questions in unique tissue material from patients with inflammation or tumors. For this, we use advanced single-cell based techniques such as flow cytometric analysis and sorting, in vitro cell assays as well as several molecular techniques such as single-cell RNA-sequencing and ATAC-seq.
Jenny MjösbergPhD, associate professor
During her postdoc period in the laboratory of Hergen Spits at the AMC in Amsterdam, she contributed to a new field in immunology with the identification of two novel subsets of human innate lymphoid cells (ILC1 and ILC2). The Mjösberg group is now focused on the importance of human ILCs in mucosal homeostasis and inflammation, mainly the lung and gastrointestinal tract. Importantly, her group provided the first transcriptional characterization of human ILCs on the single-cell level.
Luca MazzuranaPhD student
He received his Bachelor of Science from the University of Hawaii in 2013 and his master degree from Stockholm University in 2015, where he worked on the functional characterization of a Crohn’s disease associated gene. He joined the group in November 2015 as a PhD student, focusing on the heterogeneity and role of innate lymphoid cells in inflammatory bowel disease
Anna RaoPhD, postdoc
Anna completed her Doctoral studies at the German Rheumatism Research Center in Berlin where she worked on characterizing the immunophenotype, physiology and antigen specificity of memory T cells from the human bone marrow. She joined the group in September 2015 as a postdoc and is working on ILCs and their cross-talk with T cells in human colorectal cancer.
Efthymia KokkinouMSc, PhD student
She completed her Bachelor's Degree in Greece in 2014 and her Master's Degree at Stockholm University and Karolinska Institute in 2016. In her Master's thesis she addressed the characterization and development of regulatory T-cells (Tregs) in premature infants supplemented with probiotics. She joined Jenny Mjösberg's group in June 2016 as a Research Assistant to work on the role of Innate Lymphoid Cells (ILCs) in human colorectal cancer. In May 2017 she started her PhD focused on the regulation of human ILC plasticity in adult and paediatric Inflammatory Bowel Disease.
Tea SoniMD, PhD, postdoc
Tea did her MD and PhD studies in University of Helsinki. In her PhD, she focused on transcriptional regulation in paediatric liver diseases. She joined Jenny Mjösberg’s group in October 2019 as a postdoc and now she studies ILC heterogeneity and function in paediatric inflammatory bowel disease.
Isabel MeiningerPhD, postdoc
studied Biochemistry with a focus on Molecular Medicine at the Friedrich-Schiller-University Jena (Germany). In her PhD at the Helmholtz Center Munich, she analyzed the impact of alternative splicing on T cell signaling and activation. After working as a Trainee at AbbVie, she joined the group in October 2019 as a Postdoc and is now focusing on the mechanisms of ILC plasticity.
Anna CarrascoPhD, postdoc
Anna completed her PhD in the University of Barcelona in 2016, studying in the immune profile in celiac disease and inflammatory bowel disease. She joined the Mjösberg group in June 2017 as a Postdoc and is now focusing on ILC compartmentalization throughout the human gut immune niches.
Whitney WeigelPh.D., Lab manager
Whitney completed her doctoral work at the University of Louisville in 2015 where she worked on the impact of catecholamine hormones on bacteria causing periodontal disease. From 2016-2018, she worked as a postdoctoral fellow at the Helmholtz Center for Infection Research studying the virulence mechanisms of Yersinia pseudotuberculosis. She also a completed a postdoctoral fellowship at the University of Ottawa from 2018-2020 that used organoids as a model for inflammatory bowel disease. From 2020 she has been working as a lab manager in the lab of Jenny Mjosberg at the Karolinska Institute.
Chris TibbittPhD, Postdoc
Chris completed his PhD studies at Newcastle University in 2015 characterizing the influence of TCR signaling on the development of autoimmune Th17 cells. Since joining the Mjösberg group in Feb 2020 his focus has been on understanding ILC heterogeneity across intestinal compartments through the application of single cell technologies.
Lorenz WirthPhD student
Lorenz studied medical biotechnology at the Technical University of Berlin where he worked on the characterization of a 3d model of the human hematopoietic stem cell niche during his Bachelor’s thesis. He completed his Master’s thesis at the German Rheumatism Research Center in Berlin, focusing on the selective expression and regulation of a specific gene in T helper cell subsets. In May 2020 he joined Jenny Mjösberg’s group for his PhD, studying ILC plasticity in the context of eicosanoid expression and regulation. This project is part a collaboration with AstraZeneca Gothenburg and is performed within the European funded INITIATE training network.
Previous group members
Adrian Carlsson, MD student
Sophie van Tol, master student
Lena Berglin, PhD, postdoc
Viktoria Konya, PhD, postdoc
Marianne Forkel, PhD student
Avinash Ravindran, PhD student
Karin Thourot Nouchi, research nurse
Aline Van Acker, postdoc
- The European Research Council (ERC starting grant 2019)
- Swedish Foundation for Strategic Research (SSF)
- The Swedish Research Council (VR)
- Knut och Alice Wallenberg Foundation (Wallenberg Academy Fellow)
- The Swedish Society for Medical Research (SSMF)
- The Swedish Cancer Society
- Karolinska Institutet
Ten selected publications
- Maric J, Ravindran A, Mazzurana L, Björklund ÅK, van Acker A, Rao A, Kokkinou E, Ekoff M, Thomas D, Fauland A, Nilsson G, Wheelock CE, Dahlén E, Ferreirós N, Geisslinger G, Friberg D, Heinemann A, Konya V and Mjösberg J. Cytokine-induced endogenous production of PGD2 is essential for human ILC2 activation. J Allergy Clin Immunol (JACI). 2019. 143(6): 2202-2214.
- Maric J, Ravindran A, Mazzurana L, Björklund ÅK, van Acker A, Rao A, Friberg D, Dahlén E, Heinemann A, Konya V and Mjösberg J. PGE2 suppresses human group 2 innate lymphoid cell function. J Allergy Clin Immunol (JACI). 2018. 141(5): 1761-1773.
- Konya V, Czarnewski P, Rao A, Forkel M, Villablanca E, Almer S, Lindforss U, Friberg D, Höög C, Bergman P and Mjösberg J. Vitamin D downregulates the IL-23 receptor pathway in human mucosal ILC3. J Allergy Clin Immunol (JACI). 2018. S0091-6749(17)30657-7.
- Björklund ÅK, Forkel M, Picelli S, Konya V, Theorell J, Friberg D, Sandberg R, Mjösberg J. The heterogeneity of human CD127+ innate lymphoid cells revealed by single-cell RNA-sequencing. Nat Immunol. 2016. 17(4):451-60.
- Kløverpris HN, Kazer SW, Mjösberg J, Mabuka JM, Wellmann A, Kamya P, Yadon M, Nhamoyebonde S, Muenchhoff M, Simoni Y, Andersson F, Kuhn W, Garrett N. et al. Irreversible depletion of innate lymphoid cells in early acute HIV-1 infection in the absence of viral suppression. Immunity. 2016. 16;44(2):391-405.
- Munneke JM, Björklund AT, Mjösberg JM, Garming-Legert K, Bernink JH, Blom B, Huisman C, van Oers MH, Spits H, Malmberg KJ, Hazenberg MD. Activated innate lymphoid cells are associated with a reduced susceptibility to graft-versus-host disease. Blood. 2014; Jul 31;124(5):812-21.
- Teunissen MBM, Munneke M, Bernink J, Spuls PI, Res PCM, te Velde A, Cheuk S, Brouwer MWD, Menting SP, Eidsmo L, Spits H, Hazenberg MD and Mjösberg J. Composition of innate lymphoid cell (ILC) subsets in the human skin: Enrichment of NCR+ ILC3 in psoriatic skin inflammation. J Invest Dermatol. 2014; Sep;134(9):2351-60.
- Bernink J, Peters C, Munneke M, te Velde A, Meijer S, Weijer K, Hreggvidsdottir H, Heinsbroek S, Legrand N, Buskens C, Bemelman W, Mjösberg J and Spits H. Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues. Nat Immunol. 2013; 14:221-9.
- Mjösberg J, Bernink J, Golebski K, Karrich JJ, Peters CP, Blom B, Te Velde AA, Fokkens WJ, van Drunen CM, Spits H. The Transcription Factor GATA3 Is Essential for the Function of Human Type 2 Innate Lymphoid Cells. Immunity. 2012; 19;37(4):649-59.
- Mjösberg JM, Trifari S, Crellin NK, Peters CP, van Drunen CM, Piet B, Fokkens WJ, Cupedo T, Spits H. Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161. Nat Immunol. 2011; 11;12(11):1055-62.