Gonçalo Castelo-Branco Group

Our research group is interested in the molecular mechanisms defining the epigenetic state of cells of the oligodendrocyte lineage. 

We are focused on how interplay between transcription factors, non-coding RNAs and chromatin modifying enzymes contribute to the transition between epigenetic states within the oligodendrocyte lineage, with the aim to design epigenetic based-therapies to induce regeneration (remyelination) in demyelinating diseases, such as multiple sclerosis.

Research and publications
Funding
Research Group
Workshops and Conferences
OligoInternode: datasets and resources
Outreach

Latest grants and publications

Artwork from Gonçalo Castelo-Branco’s laboratory, Illustrator Amagoia Agirre

New clues to the origin and progression of multiple sclerosis

Mapping of a certain group of cells, known as oligodendrocytes, in the central nervous system of a mouse model of multiple sclerosis (MS), shows that they might have a significant role in the development of the disease. The discovery can lead to new therapies targeted at other areas than just the immune system. The results are published in Nature Medicine.

StratNeuro research grant received

Our group recently received a StratNeuro Collaborative Neuroscience Pilot Research Project Grant in collaboration with Mats Nilsson's lab at Stockholm University to study oligodendrocyte lineage heterogeneity in development and disease using in situ sequencing. 
Portrait of the researchers in front of their lab. 2 Aug 2018

Oligodendrocytes forget their ancestry in adulthood

The cell type in the brain crucial for the functioning of the nervous system, forget their origins throughout their life, unlike other nerve cells, according to a new study published in Developmental Cell. 
Portrait of the best talk award winners Janina Neufeld, Elisa Floriddia and Sofie Ährlund-Richter.

Elisa Floriddia awarded best talk at StratNeuro retreat

Janina Neufeld, Elisa Floriddia and Sofie Ährlund-Richter were awarded the best talk award the Strategic Research Area Neuroscience's annual retreat.

Gonçalo Castelo-Branco on Twitter

1 Oct 2018 Biomedicum lecture hall, Solnavägen 9

Epigenetics in the nervous system: development and disease

Three day conference on Epigenetics in the nervous system. 
RNA
13 Nov 2018 by Tabea Kemna. Editor: Goncalo Castelo-Branco.