Gonçalo Castelo-Branco Group

Our research group is interested in the molecular mechanisms defining the epigenetic state of cells of the oligodendrocyte lineage. 

We are focused on how interplay between transcription factors, non-coding RNAs and chromatin modifying enzymes contribute to the transition between epigenetic states within the oligodendrocyte lineage, with the aim to design epigenetic based-therapies to induce regeneration (remyelination) in demyelinating diseases, such as multiple sclerosis.

Research and publications
Funding
Research Group
Workshops and Conferences
OligoInternode: datasets and resources
Outreach

Latest grants and publications

Portrait of the researchers in front of their lab. 2 Aug 2018

Oligodendrocytes forget their ancestry in adulthood

The cell type in the brain crucial for the functioning of the nervous system, forget their origins throughout their life, unlike other nerve cells, according to a new study published in Developmental Cell. 
Portrait of the best talk award winners Janina Neufeld, Elisa Floriddia and Sofie Ährlund-Richter.

Elisa Floriddia awarded best talk at StratNeuro retreat

Janina Neufeld, Elisa Floriddia and Sofie Ährlund-Richter were awarded the best talk award the Strategic Research Area Neuroscience's annual retreat.

Birth, coming of age and death: The intriguing life of long noncoding RNAs

Review on the intriguing life of long ncRNAs in Seminars in Cell and Developmental Biology by group members Alessandro Bonetti and Samudyata.

Gonçalo Castelo-Branco on Twitter

Upcoming events

Brain made out of colored marbles.
6 Sep 2018

Developing Brains 2018

The 5th edition of the KI Conference “Developing Brains" gathers some of the leading scientists working on critical questions ranging from transcriptional heterogeneity of neural cell types, their specification, to myelination and creation of mature neural circuits. 
1 Oct 2018

Epigenetics in the nervous system: development and disease

Three day conference on Epigenetics in the nervous system. 
RNA
03 Aug 2018 by Tabea Kemna. Editor: Goncalo Castelo-Branco.