Gonçalo Castelo-Branco Group
Our research group is interested in the molecular mechanisms defining the epigenetic state of cells of the oligodendrocyte lineage.
We are focused on how interplay between transcription factors, non-coding RNAs and chromatin modifying enzymes contribute to the transition between epigenetic states within the oligodendrocyte lineage, with the aim to design epigenetic based-therapies to induce regeneration (remyelination) in demyelinating diseases, such as multiple sclerosis.
Distinct oligodendrocyte populations have spatial preference and different responses to spinal cord injury
Our latest, from Elisa et al., where we found that specific mature oligodendrocyte populations, MOL2 and MOL5/6, have a different distribution in the mouse brain and spinal cord, and differential susceptibility to spinal cord injury or the MS model EAE.
Crossing boundaries: Interplay between the immune system and oligodendrocyte lineage cells
Crossing boundaries: Interplay between the immune system and oligodendrocyte lineage cells
A new open access review from Leslie and Gonçalo on immune oligodendroglia, part of a special series in Seminars in Cell & Developmental Biology on Myelin, dedicated to the Nobel Mini-Symposium 55 The Dark Side of the Brain.
Gonçalo Castelo-Branco is awarded the Eric K. Fernström prize 2020
Gonçalo Castelo-Branco is awarded the Eric K. Fernström prize 2020
Gonçalo Castelo-Branco receives the 2020 Eric K. Fernström prize for young, especially promising and successful researchers, for his significant research in the oligodendrocyte/myelin field and multiple sclerosis.
KAW project funding
KAW project funding
Knut and Alice Wallenberg Foundation grant of SEK 34,000,000 for the project "Insights on the role of oligodendroglia in the origin and progression of multiple sclerosis". The GCB lab is also part of the project "Epigenomic states underlying aggressive inflammation and brain tissue loss in Multiple Sclerosis" that has received funding as well.
KI researcher Gonçalo Castelo-Branco receives SSMF’s Anniversary Prize
KI researcher Gonçalo Castelo-Branco receives SSMF’s Anniversary Prize
He is awarded the Anniversary Prize for influencing and inspiring international research on brain development, glial cells and multiple sclerosis. The prize includes an award of SEK 5 million and will be presented in conjunction with the Swedish Society for Medical Research’s 100th anniversary celebration.