Gonçalo Castelo-Branco Group
Our research group is interested in the molecular mechanisms defining the epigenetic state of cells of the oligodendrocyte lineage.
We are focused on how interplay between transcription factors, non-coding RNAs and chromatin modifying enzymes contribute to the transition between epigenetic states within the oligodendrocyte lineage, with the aim to design epigenetic based-therapies to induce regeneration (remyelination) in demyelinating diseases, such as multiple sclerosis.
Apply as bioinformatician!
Applications for two bioinformatician positions are welcome! One position will be as a core bioinformatician at the our research group and the other position will be for a post-doctoral project, joint with Ana Mendanha Falcao’s group, also at University of Minho.
KAW project funding
KAW project funding
Knut and Alice Wallenberg Foundation grant of SEK 34,000,000 for the project "Insights on the role of oligodendroglia in the origin and progression of multiple sclerosis". The GCB lab is also part of the project "Epigenomic states underlying aggressive inflammation and brain tissue loss in Multiple Sclerosis" that has received funding as well.
KI researcher Gonçalo Castelo-Branco receives SSMF’s Anniversary Prize
KI researcher Gonçalo Castelo-Branco receives SSMF’s Anniversary Prize
He is awarded the Anniversary Prize for influencing and inspiring international research on brain development, glial cells and multiple sclerosis. The prize includes an award of SEK 5 million and will be presented in conjunction with the Swedish Society for Medical Research’s 100th anniversary celebration.
Chan Zuckerberg Initiative grant to Gonçalo Castelo-Branco
Chan Zuckerberg Initiative grant to Gonçalo Castelo-Branco
Gonçalo Castelo-Branco is leading one of 38 projects that received a Chan Zuckerberg Initiative Seed Networks for the Human Cell Atlas grant. The project will investigate how oligodendrocytes can be different in the human brain and spinal cord.
Protein composition changes stimulate brain development and neuronal communication
Protein composition changes stimulate brain development and neuronal communication
Castelo-Branco group shows that the enzyme PAD2, which can alter protein composition by a process called citrullination, plays an important role in brain development and neuronal communication.