Gonçalo Castelo-Branco Group

Our research group is interested in the molecular mechanisms defining the epigenetic state of cells of the oligodendrocyte lineage. 

We are focused on how interplay between transcription factors, non-coding RNAs and chromatin modifying enzymes contribute to the transition between epigenetic states within the oligodendrocyte lineage, with the aim to design epigenetic based-therapies to induce regeneration (remyelination) in demyelinating diseases, such as multiple sclerosis.