Gonçalo Castelo-Branco Group

Our research group is interested in the molecular mechanisms defining the epigenetic state of cells of the oligodendrocyte lineage. 

We are focused on how interplay between transcription factors, non-coding RNAs and chromatin modifying enzymes contribute to the transition between epigenetic states within the oligodendrocyte lineage, with the aim to design epigenetic based-therapies to induce regeneration (remyelination) in demyelinating diseases, such as multiple sclerosis.

Research and publications
Funding
Research Group
Workshops and Conferences
OligoInternode: datasets and resources
Outreach

Latest grants and publications

Single-cell transcriptomic analysis of oligodendrocyte lineage cells

Open access review on single cell transcriptomics on oligodendrocytes in Current Opinion in Neurobiology by group members David van Bruggen and Eneritz Agirre.

Birth, coming of age and death: The intriguing life of long noncoding RNAs

Review on the intriguing life of long ncRNAs in Seminars in Cell and Developmental Biology by group members Alessandro Bonetti and Samudyata.

Gonçalo Castelo-Branco on Twitter

Upcoming events

Microscope picture of the structures 1K9W and 2N6Q.

EMBO Workshop "RNA: Structure meets function"

Workshop on July 1 - 4, 2018, organized by Gonçalo Castelo-Branco, Katja Petzold, Alessandra Villa and Claudia Kutter.
Brain made out of colored marbles. 6 Sep 2018

Developing Brains 2018

The 5th edition of the KI Conference “Developing Brains" gathers some of the leading scientists working on critical questions ranging from transcriptional heterogeneity of neural cell types, their specification, to myelination and creation of mature neural circuits. 
1 Oct 2018

Epigenetics in the nervous system: development and disease

Three day conference on Epigenetics in the nervous system. 
RNA
17 Apr 2018 by Tabea Kemna. Editor: Goncalo Castelo-Branco.