Catharina Larsson's Group

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The Medical Genetics research group was started in 1993 within the Department of Molecular Medicine and Surgery of KI. In 2013, the research group moved to the Department of Oncology-Pathology. Our laboratory is located at the Cancer Center Karolinska (CCK) within Karolinska University Hospital, Solna, and we are mainly affiliated to the Clinical Pathology/Cytology Department of the Karolinska University Hospital.

Our research aims to elucidate disease development on the molecular level focusing on certain human cancers, as well as the possibly implications for clinical practice and basic mechanistic principles. The present five research teams are focused on:

- Molecular genetic backgrounds of endocrine tumor development (Catharina Larsson)
- Small RNAs in cancer development (Weng-Onn Lui)
- Genetics of tumor predisposition  and progression in breast cancer and DLBCL (Svetlana Bajalica Lagercrantz)
- Endocrine molecular pathology (Christofer Juhlin)
- Markers of therapy response and outcome in breast cancer (Barbro Linderholm)

Research teams

RESEARCH TEAM CATHARINA LARSSON

The research aims to explain tumor initiation and malignification in endocrine organs (the parathyroid glands, thyroid, and neuroendocrine tumors of the abdomen) focusing on genetic predisposing, initiating and acquired events and their cellular effects and influence of the natural course of the disease. 

RESEARCH TEAM WENG-ONN LUI

The research aims to understand the role of different types of non-coding RNA e.g. miRNA in cancer development and therapy response and their relation to known alterations such as known driver mutations and viral background utilizing both in vitro and in vivo approaches. 

RESEARCH TEAM SVETLANA BAJALICA LAGERCRANTZ

The research aims to understand tumor development to achieve improved patient handling in clinical oncology including: Tumor progression to diffuse large B-cell lymphoma (DLBCL);

Genetic predisposition in hereditary cancer syndromes with focus on breast cancer; and genetic markers for early detection and tumor spread in breast cancer. 

RESEARCH TEAM CHRISTOFER JUHLIN

The research aims to identify key molecular and mutational events in thyroid, adrenal and other endocrine tumors, and their clinical applications in endocrine pathology and molecular pathology for improved decisions in diagnosis, prognosis and treatment.  

RESEARCH TEAM BARBRO LINDERHOLM

The research aims to identify recurrent molecular alterations identified by e.g. miRNA and proteome expression screenings in large groups of breast cancer which significantly influence the response to available oncological therapies and which may be applied to improve therapy decision making for the individual patient.  

Equipment

Fluorescent imaging
Zeiss Axioplan 2
Contact person: Weng-Onn Lui

Micro-array scanning
GenePix 4200A from Axon
Contact person: Omid Fotouhi

Pyrosequencing
Biotage PyroMark Q24
Contact person: Omid Fotouhi

Real-time PCR
StepOnePlus Applied Biosystems
Contact person: Satendra Kumar

RNA in situ equipment
Contact person: Andrew Lee

Tissue imaging
Leica DM 2000
Zeiss Axioskop
Contact person: Adam Stenman

Dissertations

KI RNA Club

The KI RNA club aims to bring together enthusiastic students and researchers interested in RNA biology, to increase the overall awareness of the cutting edge research on RNA biology, and to stimulate scientific exchange and create opportunities for new collaborations among the participants. The club is open to all researchers and students.

KI RNA Club website

Coordinator of the KI RNA Club:

Roger Chang

Phone:
0732021588

E-mail: roger.chang@ki.se

 

RNA