Cancer Genomics – Johan Lindberg's research group

The Cancer Genomics research team is focused on biomarker discovery and assay- and informatics development with a special interest in liquid biopsies. The team is responsible for genomic analysis of prospective research projects and randomized trials.

Sketch of the Wargentin building, KI Campus Solna

The Cancer Genomics team has established a sample- and analysis procedure at KI/SciLife that serves biomarker driven randomized clinical trials and prospective research projects. The procedure encompasses reception and storage of biomaterial, subsequent processing for Illumina sequencing and analysis using an in-house developed bioinformatics pipeline and curation software. The setup is made possible through collaboration with KI biobank and Clinical Genomics at SciLife lab. The sample- and analysis procedure has been in prospective use since 2016 and handled over 5000 samples from ~50 hospitals in 6 European countries. 

The team is devoted to continuous assay- and informatics development. We were first to develop an assay capable of identifying the microsatellite instability phenotype by analysis of dying cancer cell DNA debris extracted from plasma (circulating tumor DNA). In addition, the androgen receptor is the key transcription factor in metastatic prostate cancer. Treatment targeting the androgen receptor gives rise to multiple types of somatic perturbations associated with poor prognosis. These have commonly been investigated individually in retrospective studies with doubtful clinical utility. Therefore, we have established a comprehensive liquid biopsy profile investigating all types of somatic perturbations simultaneously and found that multi-level profiling of the androgen receptor is required for improved patient stratification.


All publications from group members

Staff and contact

Group leader

All members of the group

Visiting address

Karolinska Institutet, Department of Medical Epidemiology and Biostatistics, Nobels väg 12A, Stockholm, 171 77, Sweden

Postal address

Karolinska Institutet, Department of Medical Epidemiology and Biostatistics, PO Box 281, Stockholm, 171 77, Sweden