Johan Lindberg

About me
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About me

Senior researcher working at Medical Epidemiology and Biostatistics (MEB), Karolinska Institutet. Heading a team responsible for prospective genomic profiling of cancer in multiple research projects and randomized clinical trials. Close collaboration with Clinical Pathology, KS, with the goal to implement precision medicine for cancer patients in clinical routine.

Research

Cancer genomics, liquid biopsy, assay development, clinical trials.

Teaching

Responsible for the annual course Clinical Cancer Genomics (nr 5534).

Articles

Article: NATURE MEDICINE. 2024;:3291-3302
Androgen receptor pathway inhibitors and taxanes in metastatic prostate cancer: an outcome-adaptive randomized platform trial
De Laere B; Crippa A; Discacciati A; Larsson B; Persson M; Johansson S; D'hondt S; Bergstrom R; Chellappa V; Mayrhofer M; Banijamali M; Kotsalaynen A; Schelstraete C; Vanwelkenhuyzen JP; Hjaelm-Eriksson M; Pettersson L; Ullen A; Lumen N; Enblad G; Thellenberg Karlsson C; Janes E; Sandzen J; Schatteman P; Nyre Vigmostad M; Olsson M; Ghysel C; Sautois B; De Roock W; Van Bruwaene S; Anden M; Verbiene I; De Maeseneer D; Everaert E; Darras J; Aksnessether BY; Luyten D; Strijbos M; Mortezavi A; Oldenburg J; Ost P; Eklund M; Gronberg H; Lindberg J
Article: CLINICAL CANCER RESEARCH. 2024;30(12):2647-2658
Comprehensive Genomic Profiling Alters Clinical Diagnoses in a Significant Fraction of Tumors Suspicious of Sarcoma
Ofverholm I; Wallander K; Haglund C; Chellappa V; Wejde J; Gellerbring A; Wirta V; Renevey A; Caceres E; Tsagkozis P; Mayrhofer M; Papakonstantinou A; Linder-Stragliotto C; Branstrom R; Larsson O; Lindberg J; Lin Y; de Flon FH
Article: NATURE COMMUNICATIONS. 2024;15(1):1828
Prediction of plasma ctDNA fraction and prognostic implications of liquid biopsy in advanced prostate cancer
Fonseca NM; Maurice-Dror C; Herberts C; Tu W; Fan W; Murtha AJ; Kollmannsberger C; Kwan EM; Parekh K; Schonlau E; Bernales CQ; Donnellan G; Ng SWS; Sumiyoshi T; Vergidis J; Noonan K; Finch DL; Zulfiqar M; Miller S; Parimi S; Lavoie J-M; Hardy E; Soleimani M; Nappi L; Eigl BJ; Kollmannsberger C; Taavitsainen S; Nykter M; Tolmeijer SH; Boerrigter E; Mehra N; van Erp NP; De Laere B; Lindberg J; Gronberg H; Khalaf DJ; Annala M; Chi KN; Wyatt AW
Article: EUROPEAN UROLOGY OPEN SCIENCE. 2023;53:63-66
AR and PI3K Genomic Profiling of Cell-free DNA Can Identify Poor Responders to Lutetium-177-PSMA Among Patients with Metastatic Castration-resistant Prostate Cancer
Vanwelkenhuyzen J; Van Bos E; Van Bruwaene S; Lesage K; Maes A; Ustmert S; Lavent F; Beels L; Groenberg H; Ost P; Lindberg J; De Laere B
Article: CLINICAL CHEMISTRY. 2023;69(4):386-398
Prognostic Value of Low-Pass Whole Genome Sequencing of Circulating Tumor DNA in Metastatic Castration-Resistant Prostate Cancer
Norgaard M; Bjerre MT; Fredsoe J; Vang S; Jensen JB; De Laere B; Groenberg H; Borre M; Lindberg J; Sorensen KD
Article: ANNALS OF ONCOLOGY. 2022;33(8):750-768
ESMO recommendations on the use of circulating tumour DNA assays for patients with cancer: a report from the ESMO Precision Medicine Working Group
Pascual J; Attard G; Bidard F-C; Curigliano G; De Mattos-Arruda L; Diehn M; Italiano A; Lindberg J; Merker JD; Montagut C; Normanno N; Pantel K; Pentheroudakis G; Popat S; Reis-Filho JS; Tie J; Seoane J; Tarazona N; Yoshino T; Turner NC
Article: ELIFE. 2022;11:e71569
Unsupervised detection of fragment length signatures of circulating tumor DNA using non-negative matrix factorization
Renaud G; Norgaard M; Lindberg J; Gronberg H; De Laere B; Jensen JB; Borre M; Andersen CL; Sorensen KD; Maretty L; Besenbacher S
Article: ISCIENCE. 2022;25(7):104663
Using deep learning to detect patients at risk for prostate cancer despite benign biopsies
Liu B; Wang Y; Weitz P; Lindberg J; Hartman J; Wang W; Egevad L; Gronberg H; Eklund M; Rantalainen M
Article: BIOINFORMATICS. 2022;38(13):3462-3469
Transcriptome-wide prediction of prostate cancer gene expression from histopathology images using co-expression-based convolutional neural networks
Weitz P; Wang Y; Kartasalo K; Egevad L; Lindberg J; Gronberg H; Eklund M; Rantalainen M
Article: PROSTATE. 2022;82(5):576-583
Ductal and acinar components of mixed prostatic adenocarcinoma frequently have a common clonal origin
Lindh C; Samaratunga H; Delahunt B; Bergstrom R; Chellappa V; Yaxley J; Lindberg J; Egevad L
Article: NATURE CANCER. 2022;3(2):251-261
The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology
Tamborero D; Dienstmann R; Rachid MH; Boekel J; Lopez-Fernandez A; Jonsson M; Razzak A; Brana I; De Petris L; Yachnin J; Baird RD; Loriot Y; Massard C; Martin-Romano P; Opdam F; Schlenk RF; Vernieri C; Masucci M; Villalobos X; Chavarria E; Balmana J; Apolone G; Caldas C; Bergh J; Ernberg I; Frohling S; Garralda E; Karlsson C; Tabernero J; Voest E; Rodon J; Lehtio J
Article: FRONTIERS IN GENETICS. 2022;13:820493
Fusion Gene Detection Using Whole-Exome Sequencing Data in Cancer Patients
Deng W; Murugan S; Lindberg J; Chellappa V; Shen X; Pawitan Y; Vu TN
Article: CANCERS. 2021;13(7):1588
Increased Pathway Complexity Is a Prognostic Biomarker in Metastatic Castration-Resistant Prostate Cancer
De Laere B; Crippa A; Mortezavi A; Ghysel C; Rajan P; Eklund M; Wyatt A; Dirix L; Ost P; Gronberg H; Lindberg J
Article: BLOOD ADVANCES. 2021;5(4):1003-1016
Challenging conventional karyotyping by next-generation karyotyping in 281 intensively treated patients with AML
Mareschal S; Palau A; Lindberg J; Ruminy P; Nilsson C; Bengtzen S; Engvall M; Eriksson A; Neddermeyer A; Marchand V; Jansson M; Bjorklund M; Jardin F; Rantalainen M; Lennartsson A; Cavelier L; Gronberg H; Lehmann S
Article: TRIALS. 2020;21(1):579
The ProBio trial: molecular biomarkers for advancing personalized treatment decision in patients with metastatic castration-resistant prostate cancer
Crippa A; De Laere B; Discacciati A; Larsson B; Connor JT; Gabriel EE; Thellenberg C; Janes E; Enblad G; Ullen A; Hjalm-Eriksson M; Oldenburg J; Ost P; Lindberg J; Eklund M; Gronberg H
Article: BLOOD CANCER JOURNAL. 2020;10(6):67
Integrated transcriptomic and genomic analysis improves prediction of complete remission and survival in elderly patients with acute myeloid leukemia
Osterroos A; Bjorklund M; Eriksson A; Lindberg J; Nilsson C; Mareschal S; Rantalainen M; Gronberg H; Lehmann S
Article: GENES. 2020;11(3):E314-314
Inherited DNA Repair Gene Mutations in Men with Lethal Prostate Cancer
Rantapero T; Wahlfors T; Kahler A; Hultman C; Lindberg J; Tammela TLJ; Nykter M; Schleutker J; Wiklund F
Article: THE LANCET ONCOLOGY. 2020;21(2):222-232
Artificial intelligence for diagnosis and grading of prostate cancer in biopsies: a population-based, diagnostic study
Strom P; Kartasalo K; Olsson H; Solorzano L; Delahunt B; Berney DM; Bostwick DG; Evans AJ; Grignon DJ; Humphrey PA; Iczkowski KA; Kench JG; Kristiansen G; van der Kwast TH; Leite KRM; McKenney JK; Oxley J; Pan C-C; Samaratunga H; Srigley JR; Takahashi H; Tsuzuki T; Varma M; Zhou M; Lindberg J; Lindskog C; Ruusuvuori P; Wahlby C; Gronberg H; Rantalainen M; Egevad L; Eklund M
Article: PROSTATE. 2019;79(8):920-928
Somatic alterations detected in diagnostic prostate biopsies provide an inadequate representation of multifocal prostate cancer
Kristiansen A; Bergstrom R; Delahunt B; Samaratunga H; Gudjonsdottir J; Gronberg H; Egevad L; Lindberg J
Article: CLINICAL CANCER RESEARCH. 2019;25(6):1766-1773
TP53 Outperforms Other Androgen Receptor Biomarkers to Predict Abiraterone or Enzalutamide Outcome in Metastatic Castration-Resistant Prostate Cancer
De Laere B; Oeyen S; Mayrhofer M; Whitington T; van Dam P-J; Van Oyen P; Ghysel C; Ampe J; Ost P; Demey W; Hoekx L; Schrijvers D; Brouwers B; Lybaert W; Everaert EG; De Maeseneer D; Strijbos M; Bols A; Fransis K; Beije N; de Kruijff IE; van Dam V; Brouwer A; Goossens D; Heyrman L; Van den Eynden GG; Rutten A; Del Favero J; Rantalainen M; Rajan P; Sleijfer S; Ullen A; Yachnin J; Gronberg H; Van Laere SJ; Lindberg J; Dirix LY
Article: PLOS ONE. 2019;14(6):e0218280
Are Prostate Specific-Antigen (PSA) and age associated with the risk of ISUP Grade 1 prostate cancer? Results from 72 996 individual biopsy cores in 6 083 men from the Stockholm3 study
Palsdottir T; Nordstrom T; Aly M; Lindberg J; Clements M; Egevad L; Gronberg H; Eklund M
Article: GENOME MEDICINE. 2018;10(1):85
Cell-free DNA profiling of metastatic prostate cancer reveals microsatellite instability, structural rearrangements and clonal hematopoiesis
Mayrhofer M; De Laere B; Whitington T; Van Oyen P; Ghysel C; Ampe J; Ost P; Demey W; Hoekx L; Schrijvers D; Brouwers B; Lybaert W; Everaert E; De Maeseneer D; Strijbos M; Bols A; Fransis K; Oeyen S; van Dam P-J; Van den Eynden G; Rutten A; Aly M; Nordstrom T; Van Laere S; Rantalainen M; Rajan P; Egevad L; Ullen A; Yachnin J; Dirix L; Gronberg H; Lindberg J
Article: JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2018;110(10):1094-1101
Development and Validation of a Novel RNA Sequencing-Based Prognostic Score for Acute Myeloid Leukemia
Wang M; Lindberg J; Klevebring D; Nilsson C; Lehmann S; Gronberg H; Rantalainen M
Article: EUROPEAN UROLOGY FOCUS. 2018;4(5):707-710
The Stockholm-3 (STHLM3) Model can Improve Prostate Cancer Diagnostics in Men Aged 50-69 yr Compared with Current Prostate Cancer Testing
Eklund M; Nordstrom T; Aly M; Adolfsson J; Wiklund P; Brandberg Y; Thompson J; Wiklund F; Lindberg J; Presti JC; StLezin M; Clements M; Egevad L; Gronberg H
Article: JOURNAL OF HEMATOLOGY AND ONCOLOGY. 2018;11(1):52
Expression levels of long non-coding RNAs are prognostic for AML outcome
Mer AS; Lindberg J; Nilsson C; Klevebring D; Wang M; Gronberg H; Lehmann S; Rantalainen M
Article: HISTOPATHOLOGY. 2018;72(3):481-489
A novel technique for biobanking of large sections of radical prostatectomy specimens
Lindh C; Delahunt B; Samaratunga H; Yaxley J; Gudjonsdottir J; Clements M; Lindberg J; Egevad L
Article: JOURNAL OF CLINICAL INVESTIGATION. 2018;128(1):341-358
Differential impact of RB status on E2F1 reprogramming in human cancer
McNair C; Xu K; Mandigo AC; Benelli M; Leiby B; Rodrigues D; Lindberg J; Gronberg H; Crespo M; De laere B; Dirix L; Visakorpi T; Li F; Feng FY; de Bono J; Demichelis F; Rubin MA; Brown M; Knudsen KE
Article: BMC CANCER. 2017;17(1):802
Intra-tumor heterogeneity in breast cancer has limited impact on transcriptomic-based molecular profiling
Karthik G-M; Rantalainen M; Stalhammar G; Lovrot J; Ullah I; Alkodsi A; Ma R; Wedlund L; Lindberg J; Frisell J; Bergh J; Hartman J
Article: HUMAN PATHOLOGY. 2017;69:1-7
Genetic profile of ductal adenocarcinoma of the prostate
Seipel AH; Whitington T; Delahunt B; Samaratunga H; Mayrhofer M; Wiklund P; Gronberg H; Lindberg J; Egevad L
Article: LEUKEMIA. 2017;31(10):2029-2036
Validation of risk stratification models in acute myeloid leukemia using sequencing-based molecular profiling
Wang M; Lindberg J; Klevebring D; Nilsson C; Mer AS; Rantalainen M; Lehmann S; Gronberg H
Article: MOLECULAR ONCOLOGY. 2017;11(10):1413-1429
Bioinformatory-assisted analysis of next-generation sequencing data for precision medicine in pancreatic cancer
Malgerud L; Lindberg J; Wirta V; Gustafsson-Liljefors M; Karimi M; Moro CF; Stecker K; Picker A; Huelsewig C; Stein M; Bohnert R; Del Chiaro M; Haas SL; Heuchel RL; Permert J; Maeurer MJ; Brock S; Verbeke CS; Engstrand L; Jackson DB; Gronberg H; Lohr J-M
Article: EUROPEAN UROLOGY. 2017;72(2):192-200
Comprehensive Profiling of the Androgen Receptor in Liquid Biopsies from Castration-resistant Prostate Cancer Reveals Novel Intra-AR Structural Variation and Splice Variant Expression Patterns
De laere B; van Dam P-J; Whitington T; Mayrhofer M; Diaz EH; Van den Eynden G; Vandebroek J; Del-Favero J; Van Laere S; Dirix L; Gronberg H; Lindberg J
Article: EUROPEAN UROLOGY. 2017;72(1):22-31
Translating a Prognostic DNA Genomic Classifier into the Clinic: Retrospective Validation in 563 Localized Prostate Tumors
Lalonde E; Alkallas R; Chua MLK; Fraser M; Haider S; Meng A; Zheng J; Yao CQ; Picard V; Orain M; Hovington H; Murgic J; Berlin A; Lacombe L; Bergeron A; Fradet Y; Tetu B; Lindberg J; Egevad L; Gronberg H; Ross-Adams H; Lamb AD; Halim S; Dunning MJ; Neal DE; Pintilie M; van der Kwast T; Bristow RG; Boutros PC
Article: CLINICAL CANCER RESEARCH. 2017;23(10):2584-2592
Molecular Differences between Screen-Detected and Interval Breast Cancers Are Largely Explained by PAM50 Subtypes
Li J; Ivansson E; Klevebring D; Tobin NP; Lindstrom LS; Holm J; Prochazka G; Cristando C; Palmgren J; Tornberg S; Humphreys K; Hartman J; Frisell J; Rantalainen M; Lindberg J; Hall P; Bergh J; Gronberg H; Czene K
Article: SCIENTIFIC REPORTS. 2016;6:38037
Sequencing-based breast cancer diagnostics as an alternative to routine biomarkers.
Rantalainen M; Klevebring D; Lindberg J; Ivansson E; Rosin G; Kis L; Celebioglu F; Fredriksson I; Czene K; Frisell J; Hartman J; Bergh J; Grönberg H
Article: MOLECULAR ONCOLOGY. 2016;10(6):825-837
Large-scale evaluation of SLC18A2 in prostate cancer reveals diagnostic and prognostic biomarker potential at three molecular levels
Haldrup C; Lynnerup A-S; Storebjerg TM; Vang S; Wild P; Visakorpi T; Arsov C; Schulz WA; Lindberg J; Groenberg H; Egevad L; Borre M; Orntoft TF; Hoyer S; Sorensen KD
Article: BREAST CANCER RESEARCH. 2016;18(1):48
Determining breast cancer histological grade from RNA-sequencing data.
Wang M; Klevebring D; Lindberg J; Czene K; Grönberg H; Rantalainen M
Article: NATURE GENETICS. 2016;48(4):387-397
Gene regulatory mechanisms underpinning prostate cancer susceptibility
Whitington T; Gao P; Song W; Ross-Adams H; Lamb AD; Yang Y; Svezia I; Klevebring D; Mills IG; Karlsson R; Halim S; Dunning MJ; Egevad L; Warren AY; Neal DE; Gronberg H; Lindberg J; Wei G-H; Wiklund F
Article: PLOS ONE. 2016;11(12):e0168153
The In Vitro Stability of Circulating Tumour DNA
Diaz EH; Yachnin J; Gronberg H; Lindberg J
Article: THE LANCET ONCOLOGY. 2015;16(16):1667-1676
Prostate cancer screening in men aged 50-69 years (STHLM3): a prospective population-based diagnostic study
Gronberg H; Adolfsson J; Aly M; Nordstrom T; Wiklund P; Brandberg Y; Thompson J; Wiklund F; Lindberg J; Clements M; Egevad L; Eklund M
Article: EBIOMEDICINE. 2015;2(9):1133-1144
Integration of copy number and transcriptomics provides risk stratification in prostate cancer: A discovery and validation cohort study
Ross-Adams H; Lamb AD; Dunning MJ; Halim S; Lindberg J; Massie CM; Egevad LA; Russell R; Ramos-Montoya A; Vowler SL; Sharma NL; Kay J; Whitaker H; Clark J; Hurst R; Gnanapragasam VJ; Shah NC; Warren AY; Cooper CS; Lynch AG; Stark R; Mills IG; Groenberg H; Neal DE
Article: SCIENTIFIC REPORTS. 2015;5:13426
The RNA-binding protein Sam68 regulates expression and transcription function of the androgen receptor splice variant AR-V7
Stockley J; Markert E; Zhou Y; Robson CN; Elliott DJ; Lindberg J; Leung HY; Rajan P
Article: BREAST CANCER RESEARCH AND TREATMENT. 2015;151(2):319-324
Exome sequencing of contralateral breast cancer identifies metastatic disease.
Klevebring D; Lindberg J; Rockberg J; Hilliges C; Hall P; Sandberg M; Czene K
Article: EUROPEAN UROLOGY. 2015;67(5):819-822
Tracking the Origin of Metastatic Prostate Cancer
Lindberg J; Kristiansen A; Wiklund P; Gronberg H; Egevad L
Article: NEW ENGLAND JOURNAL OF MEDICINE. 2014;371(26):2477-2487
Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence
Genovese G; Kaehler AK; Handsaker RE; Lindberg J; Rose SA; Bakhoum SF; Chambert K; Mick E; Neale BM; Fromer M; Purcell SM; Svantesson O; Landen M; Hoeglund M; Lehmann S; Gabriel SB; Moran JL; Lander ES; Sullivan PF; Sklar P; Groenberg H; Hultman CM; McCarroll SA
Article: VIRCHOWS ARCHIV. 2014;465(5):559-565
Immunohistochemical profile of ductal adenocarcinoma of the prostate
Seipel AH; Samaratunga H; Delahunt B; Wiklund F; Wiklund P; Lindberg J; Gronberg H; Egevad L
Article: BREAST CANCER RESEARCH. 2014;16(4):R72
Sequencing of breast cancer stem cell populations indicates a dynamic conversion between differentiation states in vivo
Klevebring D; Rosin G; Ma R; Lindberg J; Czene K; Kere J; Fredriksson I; Bergh J; Hartman J
Article: CLINICAL CANCER RESEARCH. 2014;20(8):2169-2181
Hypermethylation of the GABRE∼miR-452∼miR-224 Promoter in Prostate Cancer Predicts Biochemical Recurrence after Radical Prostatectomy
Kristensen H; Haldrup C; Strand S; Mundbjerg K; Mortensen MM; Thorsen K; Ostenfeld MS; Wild PJ; Arsov C; Goering W; Visakorpi T; Egevad L; Lindberg J; Groenberg H; Hoyer S; Borre M; Orntoft TF; Sorensen KD
Article: NATURE GENETICS. 2014;46(2):126-135
A prostate cancer susceptibility allele at 6q22 increases RFX6 expression by modulating HOXB13 chromatin binding
Huang Q; Whitington T; Gao P; Lindberg JF; Yang Y; Sun J; Vaisanen M-R; Szulkin R; Annala M; Yan J; Egevad LA; Zhang K; Lin R; Jolma A; Nykter M; Manninen A; Wiklund F; Vaarala MH; Visakorpi T; Xu J; Taipale J; Wei G-H
Article: PLOS ONE. 2014;9(8):e104417
Evaluation of Exome Sequencing to Estimate Tumor Burden in Plasma
Klevebring D; Neiman M; Sundling S; Eriksson L; Ramqvist ED; Celebioglu F; Czene K; Hall P; Egevad L; Groenberg H; Lindberg J
Article: CANCER. 2013;119(13):2405-2412
Genetic markers associated with early cancer-specific mortality following prostatectomy
Liu W; Xie CC; Thomas CY; Kim S-T; Lindberg J; Egevad L; Wang Z; Zhang Z; Sun J; Sun J; Koty PP; Kader AK; Cramer SD; Bova GS; Zheng SL; Groenberg H; Isaacs WB; Xu J
Article: EUROPEAN UROLOGY. 2013;63(4):702-708
The Mitochondrial and Autosomal Mutation Landscapes of Prostate Cancer
Lindberg J; Mills IG; Klevebring D; Liu W; Neiman M; Xu J; Wikstrom P; Wiklund P; Wiklund F; Egevad L; Gronberg H
Article: EUROPEAN UROLOGY. 2013;63(2):347-353
Exome Sequencing of Prostate Cancer Supports the Hypothesis of Independent Tumour Origins
Lindberg J; Klevebring D; Liu W; Neiman M; Xu J; Wiklund P; Wiklund F; Mills IG; Egevad L; Gronberg H
Article: ONCOGENE. 2012;31(35):3939-3948
Identification of novel CHD1-associated collaborative alterations of genomic structure and functional assessment of CHD1 in prostate cancer
Liu W; Lindberg J; Sui G; Luo J; Egevad L; Li T; Xie C; Wan M; Kim S-T; Wang Z; Turner AR; Zhang Z; Feng J; Yan Y; Sun J; Bova GS; Ewing CM; Yan G; Gielzak M; Cramer SD; Vessella RL; Zheng SL; Gronberg H; Isaacs WB; Xu J
Article: CYTOKINE. 2012;57(3):406-416
Signaling pathways involved in the regulation of TNFα-induced toll-like receptor 2 expression in human gingival fibroblasts
Davanian H; Bage T; Lindberg J; Lundeberg J; Concha HQ; Chen MS; Yucel-Lindberg T
Article: PLOS ONE. 2012;7(11):e48616
Library Preparation and Multiplex Capture for Massive Parallel Sequencing Applications Made Efficient and Easy
Neiman M; Sundling S; Gronberg H; Hall P; Czene K; Lindberg J; Klevebring D
Article: PLOS ONE. 2012;7(10):e48455
Identification of New Differentially Methylated Genes That Have Potential Functional Consequences in Prostate Cancer
Kim JW; Kim S-T; Turner AR; Young T; Smith S; Liu W; Lindberg J; Egevad L; Gronberg H; Isaacs WB; Xu J
Article: PLOS ONE. 2010;5(6):e11310
The Gene Expression Profile in the Synovium as a Predictor of the Clinical Response to Infliximab Treatment in Rheumatoid Arthritis
Lindberg J; Wijbrandts CA; van Baarsen LG; Nader G; Klareskog L; Catrina A; Thurlings R; Vervoordeldonk M; Lundeberg J; Tak PP
Article: BMC GENOMICS. 2010;11:241
Signal pathways JNK and NF-κB, identified by global gene expression profiling, are involved in regulation of TNFα-induced mPGES-1 and COX-2 expression in gingival fibroblasts
Bage T; Lindberg J; Lundeberg J; Modeer T; Yucel-Lindberg T
Article: ARTHRITIS & RHEUMATOLOGY. 2010;62(1):44-52
Antibodies to Several Citrullinated Antigens Are Enriched in the Joints of Rheumatoid Arthritis Patients
Snir O; Widhe M; Hermansson M; von Spee C; Lindberg J; Hensen S; Lundberg K; Engstrom A; Venables PJW; Toes REM; Holmdahl R; Klareskog L; Malmstrom V
Article: ANNALS OF THE RHEUMATIC DISEASES. 2009;68(5):736-743
Multiple antibody reactivities to citrullinated antigens in sera from patients with rheumatoid arthritis: association with HLA-DRB1 alleles
Snir O; Widhe M; von Spee C; Lindberg J; Padyukov L; Lundberg K; Engstrom A; Venables PJ; Lundeberg J; Holmdahl R; Klareskog L; Malmstrom V
Article: JOURNAL OF NEUROENDOCRINOLOGY. 2009;21(3):208-216
Extremely Different Behaviours in High and Low Body Weight Lines of Chicken are Associated with Differential Expression of Genes Involved in Neuronal Plasticity
Ka S; Lindberg J; Stromstedt L; Fitzsimmons C; Lindqvist N; Lundeberg J; Siegel PB; Andersson L; Hallbook F
Article: JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY. 2009;2009:396808
Automation of cDNA Synthesis and Labelling Improves Reproducibility
Klevebring D; Gry M; Lindberg J; Eidefors A; Lundeberg J
Article: ARTHRITIS RESEARCH & THERAPY. 2008;10(2):R33
Systemic TNF blockade does not modulate synovial expression of the pro-inflammatory mediator HMGB1 in rheumatoid arthritis patients - a prospective clinical study
Sundberg E; Grundtman C; Klint EAF; Lindberg J; Ernestam S; Ulfgren A-K; Harris HE; Andersson U
Article: BMC GENOMICS. 2007;8:208
Differential gene expression in femoral bone from red junglefowl and domestic chicken, differing for bone phenotypic traits
Rubin C-J; Lindberg J; Fitzsimmons C; Savolainen P; Jensen P; Lundeberg J; Andersson L; Kindmark A
Article: PLOS ONE. 2007;2(4):e364
Transmission of Stress-Induced Learning Impairment and Associated Brain Gene Expression from Parents to Offspring in Chickens
Lindqvist C; Janczak AM; Natt D; Baranowska I; Lindqvist N; Wichman A; Lundeberg J; Lindberg J; Torjesen PA; Jensen P
Article: MOLECULAR & CELLULAR PROTEOMICS. 2007;6(1):125-132
Determination of binding specificities in highly multiplexed bead-based assays for antibody proteomics
Schwenk JM; Lindberg J; Sundberg M; Uhlen M; Nilsson P
Article: ARTHRITIS RESEARCH & THERAPY. 2006;8(6):R179
Effect of infliximab on mRNA expression profiles in synovial tissue of rheumatoid arthritis patients
Lindberg J; af Klint E; Catrina AI; Nilsson P; Klareskog L; Ulfgren A-K; Lundeberg J
Article: ARTHRITIS RESEARCH & THERAPY. 2006;8(2):R47
Variability in synovial inflammation in rheumatoid arthritis investigated by microarray technology
Lindberg J; af Klint E; Ulfgren A-K; Stark A; Andersson T; Nilsson P; Klareskog L; Lundeberg J
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All other publications

Corrigendum: NATURE MEDICINE. 2024;:1
Androgen receptor pathway inhibitors and taxanes in metastatic prostate cancer: an outcome-adaptive randomized platform trial (Aug, 10.1038/s41591-024-03204-2, 2024)
De Laere B; Crippa A; Discacciati A; Larsson B; Persson M; Johansson S; D'hondt S; Bergstrom R; Chellappa V; Mayrhofer M; Banijamali M; Kotsalaynen A; Schelstraete C; Vanwelkenhuyzen JP; Hjalm-Eriksson M; Pettersson L; Ullen A; Lumen N; Enblad G; Karlsson CT; Janes E; Sandzen J; Schatteman P; Vigmostad MN; Olsson M; Ghysel C; Sautois B; De Roock W; Van Bruwaene S; Anden M; Verbiene I; De Maeseneer D; Everaert E; Darras J; Aksnessether BY; Luyten D; Strijbos M; Mortezavi A; Oldenburg J; Ost P; Eklund M; Gronberg H; Lindberg J
Editorial comment: EUROPEAN UROLOGY FOCUS. 2022;8(6):1617-1621
Clinical Trial Protocol for ProBio: An Outcome-adaptive and Randomised Multiarm Biomarker-driven Study in Patients with Metastatic Prostate Cancer
De laere B; Crippa A; Discacciati A; Larsson B; Oldenburg J; Mortezavi A; Ost P; Eklund M; Lindberg J; Gronberg H
Review: ACTA ONCOLOGICA. 2022;61(4):523-530
Circulating tumor DNA (ctDNA) in adjuvant therapy of early stage colon cancer: current status and future perspectives
Merk C; Martling A; Lindberg J; Benhaim L; Taieb J; Lind P
Review: EUROPEAN UROLOGY FOCUS. 2021;7(4):687-691
Artificial Intelligence for Diagnosis and Gleason Grading of Prostate Cancer in Biopsies-Current Status and Next Steps
Kartasalo K; Bulten W; Delahunt B; Chen P-HC; Pinckaers H; Olsson H; Ji X; Mulliqi N; Samaratunga H; Tsuzuki T; Lindberg J; Rantalainen M; Wahlby C; Litjens G; Ruusuvuori P; Egevad L; Eklund M
Letter: JOURNAL OF CLINICAL ONCOLOGY. 2019;37(24):2181-2182
Has the PROPHECY of AR-V7 Been Fulfilled?
De Laere B; Ost P; Gronberg H; Lindberg J
Letter: JAMA ONCOLOGY. 2019;5(7):1060-1062
Androgen Receptor Burden and Poor Response to Abiraterone or Enzalutamide in TP53 Wild-Type Metastatic Castration-Resistant Prostate Cancer
De Laere B; Rajan P; Gronberg H; Dirix L; Lindberg J; Mayrhofer M; Whitington T; van Dam P-J; Van Oyen P; Ghysel C; Ampe J; Ost P; Demey W; Hoela L; Schrijvers D; Brouwers B; Lybaert W; Everaert E; De Maeseneer D; Strijbos M; Bols A; Fransis K; Beije N; de Kruijff I; van Dam V; Brouwer A; Goossens D; Heyrman L; Van den Eynden G; Rutten A; Del Favero J; Rantalainen M; Sleijfer S; Ullen A; Yachnin J; Van Laere S; De laere L; Develter T; Vantieghem S; Herman S; Coifs G; Lamotte V; Boumans A; Baitar A; Haeck R; Wallays G
Editorial comment: EUROPEAN UROLOGY. 2018;74(6):739-740
Towards Next-generation Urine-based Prostate Cancer Risk Stratification
Nordstrom T; Lindberg J; Eklund M
Corrigendum: EBIOMEDICINE. 2017;17:238
Integration of Copy Number and Transcriptomics Provides Risk Stratification in Prostate Cancer: A Discovery and Validation Cohort Study (vol 2, pg 1133, 2015)
Ross-Adams H; Lamb AD; Dunning MJ; Halim S; Lindberg J; Massie CM; Egevad LA; Russell R; Ramos-Montoya A; Vowler SL; Sharma NL; Kay J; Whitaker H; Clarkh J; Hurst R; Gnanapragasam VJ; Shah NC; Warren AY; Cooper CS; Lynch AG; Stark R; Mills IG; Gronberg H; Neal DE
Review: GENOMICS. 2010;95(1):1-6
The plasticity of the mammalian transcriptome
Lindberg J; Lundeberg J

Grants

Lindberg, Johan Fredrik – Liquid biopsies in metastatic prostate cancer
Swedish Cancer Society
1 January 2024
ProBio: An outcome-adaptive and randomised multi-arm biomarker driven study in patients with metastatic prostate cancer
Swedish Research Council
1 January 2022 - 31 December 2025
Artificial intelligence, game-based learning, and DNA-profiling to differentiate benign from malignant ovarian tumours, and to predict the prognosis in women with ovarian cancer.
Swedish Research Council
1 January 2021 - 31 December 2023
Clinical implementation of the Individualized Prostate Cancer Diagnosis Pipeline
Swedish Research Council
1 January 2021 - 31 December 2024
Lindberg, Johan Fredrik – Liquid biopsies in localized prostate cancer
Swedish Cancer Society
1 January 2021
CITCCA-Circulating Tumour DNA in Colorectal Cancer- a pilot study
Swedish Research Council
1 January 2020 - 31 December 2020
The prostate cancer image epidemiology project: development and validation of model-based histopathology
Swedish Research Council
1 January 2019 - 31 December 2022
Clinical implementation of the Individualized Prostate Cancer Diagnosis Pipeline
Swedish Research Council
1 January 2018 - 31 December 2020
ProBio II – An adaptive and randomized multi-arm biomarker driven phase 2 study in men with castrate resistant prostate cancer (CRPC)
Swedish Research Council
1 December 2017 - 31 December 2020
Genomics of prostate cancer: From gene identification to clinical applications
Swedish Research Council
1 January 2013 - 31 December 2016
Genetic susceptibility of prostate cancer: From gene identification to clinical applications
Swedish Research Council
1 January 2010 - 31 December 2012

Employments

Principal Researcher, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 2022-

Supervisor

Cecilia Merk, 2022

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