Skin wound healing – Research group Ning Xu Landén

Chronic wounds are major and rising health and economic burdens worldwide and lack effective treatment. Understanding the roles of novel non-protein-coding RNAs may open a new avenue for treating hard-to-heal wounds.

Skin wound healing

Chronic wounds are a common and severe medical problem lacking efficient treatments. They are trapped in a constant inflammatory state and fail to progress through the normal stages of wound healing. Although constituting the majority of the transcriptional output of the human genome, the functional importance of non-protein-coding RNA (ncRNAs) has only recently been recognized. Compared to protein-coding genes, ncRNAs' expression and function are more tissue- and cell-type-specific, underscoring their great potential as precise therapeutic and diagnostic entities.

Our research aims to understand the role of ncRNAs in the skin immune system in response to injury and identify ncRNAs capable of resolving chronic wound inflammation and reactivating the healing program. For this, we are making efforts to (i) establish a gene expression map of human acute, and chronic wounds with single-cell resolution; (ii) identify the biological functions and the underlying molecular mechanisms of wound-related ncRNAs; (iii) develop RNA-based wound treatments. From a new angle, our study will add to the understanding of wound biology and chronic wound pathogenesis, which will open new avenues for disease stratification and highlight novel drug targets for clinical studies.

från vänster till höger, Zhuang Liu, Letian Zhang, Guanglin Niu, Maria Toma, Minna Piipponen, Xiaowei Bian, Jennifer Geara, Monica Maselli , Ning Xu Landén (PI).
From left: Zhuang Liu (Bioinformatician), Letian Zhang (Ph.D. student), Guanglin Niu (Postdoc fellow), Maria Toma (Ph.D. student), Minna Piipponen (Postdoc fellow), Xiaowei Bian (Ph.D. student), Jennifer Geara (PhD student), Monica Maselli (master student), Ning Xu Landén (PI). Photo: Kunal Das Mahapatra.

Publications

Selected publications

Funding

  • The Swedish Research Council.
  • Cancerfonden.
  • Ragnar Söderbergs Foundation.
  • Welander and Finsens Foundation (Hudfonden).
  • LEO foundation.
  • Ming Wai Lau Centre for Reparative Medicine.
  • Karolinska Institutet.

Members and contact

Group leader

All members of the group