Research focus
We study the genetics and neuropathology of neurodegenerative diseases in particular Alzheimer disease (AD), Frontotemporal lobar degeneration (FTLD) and FTLD associated with amyotrophic lateral sclerosis (ALS). Our research is translational from patients and families to the laboratory and back. If you are interested to participate in research please contact us via NVS Kliniskforskning Graff (kliniskforskning-graff@nvs.ki.se) or contact one of the group members directly.
Activities
Our activities include:
- Clinical follow-up studies of families with inherited neurodegenerative diseases to describe the pathological staging of disease in particular
- the GENFI study (genfi.org) and
- a study on dominantly inherited Alzheimer disease
- Recruit clinical treatment trials for genetic forms of FTD within the framework of (thefpi.org)
- Whole genome sequencing to identify known and unknown genetic factors in early onset cognitive diseases
- We host a webpage for and organize the activites in the Swedish FTD Initiative (frontallobsdemens.se)
- We participate in global association studies in case-control cohorts in AD and
- Neuropathological studies of human brain tissue
- We imnplement our research in close collaboration with the out-patient clinic at the Unit for hereditary dementia, (Mottagning för ärftliga demenssjukdomar) Clinical Genetics, Karolinska University Hospital, Solna.
- We have large sample collections of DNA, fibroblasts, RNA, plasma, serum and CSF.
- FTD such as IGAP (International Genomics of Alzheimer’s Project), ECEOD (European Consortium on Early Onset Dementia, EADC (European Alzheimer Disease Consortium) and FTD-GWAS, ICFGC and whole genome sequencing projects such as the FTLD-TDP WGS Consortium, FTDGSC