
Mikael Karlsson group
Our research focuses on B Cells and Autoinflammation with a particular interest for the areas of Autoimmunity, Allergy, Cardiovascular Disease, Cancer and Infection.
About us

Our research
In our group we focus research on systemic immunological mechanisms originatingin the spleen. Even though the focus is inflammatory mechanisms in SLE the findings from my group will be central for many inflammatory diseases and conditions.

Our team

Selected publications

Contact us

Collaborations
Current research areas and methods
Autoimmunity
To study the activation and recruitment of B cells in innate autoreactive responses we study the B cell responses to self-antigens using syngeneic apoptotic cells (mimicking the autoimmune disease SLE) and other inflammatory stimuli. In this project we ask which APC and innate or adaptive T cell reactivity that are involved in regulating autoimmune B cell recruitment.
Allergy
Even though much is known about the T cell dependent events leading to IgE production, little is known about the early events in the selection of B cells that produce IgE. We study this in models of both asthma and eczema to evaluate B cell activation.
Cancer
Metastatic cancer develops primarily at secondary sites by interaction with stromal cells within a supporting extra cellular matrix.
Cardiovascular disease
Our studies on the recruitment of B cells in SLE using apoptotic cells as antigen have many connections to atherosclerosis.
Infection
The early innate responsiveness of the immune system is not only important for quick immune responses to pathogens but also to initiate and shape the subsequent adaptive immune response.
Methods
Models for allergy, cancer, autoimmunity and atherosclerosis, flow cytometry and sorting including live signaling, CBA, ELISA, ELISPOT, multiphoton intravital microscopy, confocal laser scanning microscopy, TIRF (Total internal reflection fluorescence microscopy), cell culture (primary cells and cell lines), Antibody production and genetics/molecular biology techniques.