Mikael Karlsson

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About me

Mikael Karlsson, Professor of Immunology at the Department of Microbiology, Tumor and Cell Biology, researches the regulation of the immune system and why it sometimes becomes disrupted, leading to disease. He is particularly interested in B cells and macrophages. His research adds to knowledge of autoimmune diseases and is also related to cancer.

Articles

Article: BLOOD ADVANCES. 2024;8(8):1981-1990
In BTK, phosphorylated Y223 in the SH3 domain mirrors catalytic activity, but does not in fl uence biological function
Estupinan HY; Bouderlique T; He C; Berglof A; Cappelleri A; Frengen N; Zain R; Karlsson MCI; Mansson R; Smith CIE
Article: ELIFE. 2023;12:e86454
The role of B cells in immune cell activation in polycystic ovary syndrome
Ascani A; Torstensson S; Risal S; Lu H; Eriksson G; Li C; Teschl S; Menezes J; Sandor K; Ohlsson C; Svensson CI; Karlsson MCI; Stradner MH; Obermayer-Pietsch B; Stener-Victorin E
Article: CANCER RESEARCH. 2023;83(10):1628-1645
FPR2 Shapes an Immune-Excluded Pancreatic Tumor Microenvironment and Drives T-cell Exhaustion in a Sex-Dependent Manner
He F; Tay AHM; Calandigary A; Malki E; Suzuki S; Liu T; Wang Q; Fernandez-Moro C; Kaisso M; Olofsson-Sahl P; Melssen M; Sze SK; Bjornstedt M; Lohr MJ; Karlsson MCI; Heuchel R; Sarhan D
Article: CANCER IMMUNOLOGY RESEARCH. 2023;11(2):217-227
Antigen-Loaded Extracellular Vesicles Induce Responsiveness to Anti-PD-1 and Anti-PD-L1 Treatment in a Checkpoint Refractory Melanoma Model
Veerman RE; Akpinar GG; Offens A; Steiner L; Larssen P; Lundqvist A; Karlsson MCI; Gabrielsson S
Article: ISCIENCE. 2022;25(11):105317
Targeting myeloid suppressive cells revives cytotoxic anti-tumor responses in pancreatic cancer
Sarhan D; Eisinger S; He F; Bergsland M; Pelicano C; Driescher C; Westberg K; Benitez II; Humoud R; Palano G; Li S; Carannante V; Muhr J; Onfelt B; Schlisio S; Ravetch JV; Heuchel R; Lohr MJ; Karlsson MCI
Article: CANCER RESEARCH COMMUNICATIONS. 2022;2(9):1075-1088
The MDM2 Inhibitor Navtemadlin Arrests Mouse Melanoma Growth In Vivo and Potentiates Radiotherapy
Ingelshed K; Spiegelberg D; Kannan P; Pavenius L; Hacheney J; Jiang L; Eisinger S; Lianoudaki D; Lama D; Castillo F; Bosdotter C; Kretzschmar WW; Al-Radi O; Fritz N; Villablanca EJ; Karlsson MCI; Wermeling F; Nestor M; Lane DP; Sedimbi SK
Article: SCIENTIFIC REPORTS. 2022;12(1):12931
Deficiency of mature B cells does not alter the atherogenic response to castration in male mice
Wilhelmson AS; Johansson I; Fogelstrand L; Fagman JB; Arnal J-F; Karlsson MCI; Tivesten A
Article: AUTOPHAGY. 2022;18(1):204-222
LRRK2 is required for CD38-mediated NAADP-Ca²⁺ signaling and the downstream activation of TFEB (transcription factor EB) in immune cells
Nabar NR; Heijjer CN; Shi C-S; Hwang I-Y; Ganesan S; Karlsson MCI; Kehrl JH
Article: AUTOPHAGY. 2021;17(11):3577-3591
CD36 and LC3B initiated autophagy in B cells regulates the humoral immune response
He C; Wang S; Zhou C; He M; Wang J; Ladds M; Lianoudaki D; Sedimbi SK; Lane DP; Westerberg LS; Li S; Karlsson MCI
Article: NATURE COMMUNICATIONS. 2021;12(1):4127
Agonistic CD40 therapy induces tertiary lymphoid structures but impairs responses to checkpoint blockade in glioma
van Hooren L; Vaccaro A; Ramachandran M; Vazaios K; Libard S; van de Walle T; Georganaki M; Huang H; Pietilae I; Lau J; Ulvmar MH; Karlsson MCI; Zetterling M; Mangsbo SM; Jakola AS; Bontell TO; Smits A; Essand M; Dimberg A
Article: CANCER RESEARCH. 2021;81(4):956-967
Targeting MARCO and IL37R on Immunosuppressive Macrophages in Lung Cancer Blocks Regulatory T Cells and Supports Cytotoxic Lymphocyte Function
La Fleur L; Botling J; He F; Pelicano C; Zhou C; He C; Palano G; Mezheyeuski A; Micke P; Ravetch JV; Karlsson MCI; Sarhan D
Article: IMMUNITY. 2021;54(2):259-275.e7
Distinct developmental pathways from blood monocytes generate human lung macrophage diversity
Evren E; Ringqvist E; Tripathi KP; Sleiers N; Rives IC; Alisjahbana A; Gao Y; Sarhan D; Halle T; Sorini C; Lepzien R; Marquardt N; Michaelsson J; Smed-Sorensen A; Botling J; Karlsson MCI; Villablanca EJ; Willinger T
Article: MOLECULAR IMMUNOLOGY. 2021;130:49-54
Reading the room: iNKT cells influence B cell responses
Leadbetter EA; Karlsson MCI
Article: IMMUNOLOGY AND CELL BIOLOGY. 2021;99(2):234-243
GPR43 regulates marginal zone B-cell responses to foreign and endogenous antigens
Rohrbeck L; Adori M; Wang S; He C; Tibbitt CA; Chernyshev M; Sirel M; Ribacke U; Murrell B; Bohlooly-Y M; Karlsson MCI; Karlsson Hedestam GB; Coquet JM
Article: JOURNAL OF AUTOIMMUNITY. 2021;117:102582
The B cell response to both protein and nucleic acid antigens displayed on apoptotic cells are dependent on endosomal pattern recognition receptors
Garimella MG; He C; Chen G; Li Q-Z; Huang X; Karlsson MCI
Article: FRONTIERS IN IMMUNOLOGY. 2021;12:642173
SOCS3 Expression by Thymic Stromal Cells Is Required for Normal T Cell Development
Gao Y; Liu R; He C; Basile J; Vesterlund M; Wahren-Herlenius M; Espinoza A; Hokka-Zakrisson C; Zadjali F; Yoshimura A; Karlsson M; Carow B; Rottenberg ME
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(50):32005-32016
Targeting a scavenger receptor on tumor-associated macrophages activates tumor cell killing by natural killer cells
Eisinger S; Sarhan D; Boura VF; Ibarlucea-Benitez I; Tyystjarvi S; Oliynyk G; Arsenian-Henriksson M; Lane D; Wikstrom SL; Kiessling R; Virgilio T; Gonzalez SF; Kaczynska D; Kanatani S; Daskalaki E; Wheelock CE; Sedimbi S; Chambers BJ; Ravetch JV; Karlsson MCI
Article: BLOOD ADVANCES. 2020;4(16):3971-3976
Platelets mediate serological memory to neutralize viruses in vitro and in vivo
Schrottmaier WC; Salzmann M; Badrnya S; Mussbacher M; Kral-Pointner JB; Morava S; Pirabe A; Brunnthaler L; Yaiw KC; Heber UM; Pereyra D; Andersen JT; Bergthaler A; Soederberg-Naucler C; Karlsson MCI; Assinger A; Forsell MNE
Article: BLOOD ADVANCES. 2020;4(11):2439-2450
Novel mouse model resistant to irreversible BTK inhibitors: a tool identifying new therapeutic targets and side effects
Estupinan HY; Bouderlique T; He C; Berglof A; Gupta D; Saher O; Daza Cruz MA; Pena-Perez L; Yu L; Zain R; Karlsson MCI; Mansson R; Smith CIE
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(16):9054-9063
Combined proinflammatory cytokine and cognate activation of invariant natural killer T cells enhances anti-DNA antibody responses
Sedimbi SK; Hagglof T; Garimella MG; Wang S; Duhlin A; Coelho A; Ingelshed K; Mondoc E; Malin SG; Holmdahl R; Lane DP; Leadbetter EA; Karlsson MCI
Article: JOURNAL OF IMMUNOLOGY. 2019;203(4):825-834
Allogenicity Boosts Extracellular Vesicle-Induced Antigen-Specific Immunity and Mediates Tumor Protection and Long-Term Memory In Vivo
Larssen P; Veerman RE; Akpinar GG; Hiltbrunner S; Karlsson MCI; Gabrielsson S
Article: NATURE COMMUNICATIONS. 2019;10(1):2870
Actomyosin-driven force patterning controls endocytosis at the immune synapse
Kumari A; Pineau J; Saez PJ; Maurin M; Lankar D; San Roman M; Hennig K; Boura VF; Voituriez R; Karlsson MCI; Balland M; Dumenil A-ML; Pierobon P
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2019;49(3):443-453
Innate and adaptive stimulation of murine diverse NKT cells result in distinct cellular responses
Tripathi P; Sedimbi SK; Singh AK; Lofboml L; Issazadeh-Navikas S; Weiss S; Foerster I; Karlsson MCI; Yrlid U; Kadri N; Cardell SL
Article: JOURNAL OF IMMUNOLOGY. 2019;202(5):1510-1520
Gα_i2 Signaling Regulates Inflammasome Priming and Cytokine Production by Biasing Macrophage Phenotype Determination
Vural A; Nabar NR; Hwang I-Y; Sohn S; Park C; Karlsson MCI; Blumer JB; Kehrl JH
Article: EMBO JOURNAL. 2019;38(2):e100010-19
Precocious expression of Blimp1 in B cells causes autoimmune disease with increased self-reactive plasma cells
Boenelt P; Woehner M; Minnich M; Tagoh H; Fischer M; Jaritz M; Kavirayani A; Garimella M; Karlsson MCI; Busslinger M
Article: CIRCULATION. 2018;138(22):2513-2526
Low-Density Lipoprotein-Reactive T Cells Regulate Plasma Cholesterol Levels and Development of Atherosclerosis in Humanized Hypercholesterolemic Mice
Gistera A; Klement ML; Polyzos KA; Mailer RKW; Duhlin A; Karlsson MCI; Ketelhuth DFJ; Hansson GK
Article: INTERNATIONAL JOURNAL OF CANCER. 2018;143(7):1741-1752
Expression of scavenger receptor MARCO defines a targetable tumor-associated macrophage subset in non-small cell lung cancer
La Fleur L; Boura VF; Alexeyenko A; Berglund A; Ponten V; Mattsson JSM; Djureinovic D; Persson J; Brunnstrom H; Isaksson J; Branden E; Koyi H; Micke P; Karlsson MCI; Botling J
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2018;38(8):e145-e158
Acute Loss of Apolipoprotein E Triggers an Autoimmune Response That Accelerates Atherosclerosis
Centa M; Prokopec KE; Garimella MG; Habir K; Hofste L; Stark JM; Dahdah A; Tibbitt CA; Polyzos KA; Gistera A; Johansson DK; Maeda NN; Hansson GK; Ketelhuth DFJ; Coquet JM; Binder CJ; Karlsson MCI; Malin S
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2018;38(7):1519-1527
Testosterone Protects Against Atherosclerosis in Male Mice by Targeting Thymic Epithelial CellsBrief Report
Wilhelmson AS; Rodriguez ML; Eriksson ES; Johansson I; Fogelstrand P; Stubelius A; Lindgren S; Fagman JB; Hansson GK; Carlsten H; Karlsson MCI; Ekwall O; Tivesten A
Article: NATURE COMMUNICATIONS. 2018;9(1):2067
Testosterone is an endogenous regulator of BAFF and splenic B cell number
Wilhelmson AS; Rodriguez ML; Stubelius A; Fogelstrand P; Johansson I; Buechler MB; Lianoglou S; Kapoor VN; Johansson ME; Fagman JB; Duhlin A; Tripathi P; Camponeschi A; Porse BT; Rolink AG; Nissbrandt H; Turley SJ; Carlsten H; Martensson I-L; Karlsson MCI; Tivesten A
Article: HUMAN MOLECULAR GENETICS. 2018;27(10):1809-1818
A genome-wide association study of IgM antibody against phosphorylcholine: shared genetics and phenotypic relationship to chronic lymphocytic leukemia
Chen X; Gustafsson S; Whitington T; Borne Y; Lorentzen E; Sun J; Almgren P; Su J; Karlsson R; Song J; Lu Y; Zhan Y; Hagg S; Svensson P; Smedby KE; Slager SL; Ingelsson E; Lindgren CM; Morris AP; Melander O; Karlsson T; de Faire U; Caidahl K; Engstrom G; Lind L; Karlsson MCI; Pedersen NL; Frostegard J; Magnusson PKE
Article: JOURNAL OF IMMUNOLOGY. 2018;200(2):775-787
Altered Marginal Zone B Cell Selection in the Absence of IκBNS
Adori M; Pedersen GK; Adori C; Erikson E; Khoenkhoen S; Stark JM; Choi JH; Dosenovic P; Karlsson MCI; Beutler B; Hedestam GBK
Article: FRONTIERS IN IMMUNOLOGY. 2018;9:3033
Differential ACPA Binding to Nuclear Antigens Reveals a PAD-Independent Pathway and a Distinct Subset of Acetylation Cross-Reactive Autoantibodies in Rheumatoid Arthritis
Lloyd KA; Wigerblad G; Sahlstrom P; Garimella MG; Chemin K; Steen J; Titcombe PJ; Marklein B; Zhou D; Stalesen R; Ossipova E; Lundqvist C; Ekwall O; Ronnelid J; Mueller DL; Karlsson MCI; Kaplan MJ; Skriner K; Klareskog L; Wermeling F; Malmstrom V; Gronwall C
Article: JOURNAL OF INFECTIOUS DISEASES. 2017;216(10):1308-1317
A Link Between a Common Mutation in CFTR and Impaired Innate and Adaptive Viral Defense
Svedin E; Utorova R; Huhn MH; Larsson PG; Stone VM; Garimella M; Lind K; Hagglof T; Pincikova T; Laitinen OH; McInerney GM; Scholte B; Hjelte L; Karlsson MCI; Flodstrom-Tullberg M
Article: JOURNAL OF TRANSLATIONAL MEDICINE. 2017;15(1):152
The clinical importance of tumour-infiltrating macrophages and dendritic cells in periampullary adenocarcinoma differs by morphological subtype
Lundgren S; Karnevi E; Elebro J; Nodin B; Karlsson MCI; Eberhard J; Leandersson K; Jirstrom K
Article: MOLECULAR ONCOLOGY. 2017;11(7):781-791
Epithelial-mesenchymal transition in cancer metastasis through the lymphatic system
Karlsson MC; Gonzalez SF; Welin J; Fuxe J
Article: SCIENCE IMMUNOLOGY. 2017;2(9):eaal5196
PPAR-γ promotes type 2 immune responses in allergy and nematode infection
Chen T; Tibbitt CA; Feng X; Stark JM; Rohrbeck L; Rausch L; Sedimbi SK; Karlsson MCI; Lambrecht BN; Hedestam GBK; Hendriks RW; Chambers BJ; Nylen S; Coquet JM
Article: FRONTIERS IN IMMUNOLOGY. 2017;8:738
Regulation of Subunit-Specific Germinal Center B Cell Responses to the HIV-1 Envelope Glycoproteins by Antibody-Mediated Feedback
Forsell MNE; Kvastad L; Sedimbi SK; Andersson J; Karlsson MCI
Article: NATURE IMMUNOLOGY. 2016;17(12):1407-1414
Neutrophils license iNKT cells to regulate self reactive mouse B cell responses
Hagglof T; Sedimbi SK; Yates JL; Parsa R; Salas BH; Harris RA; Leadbetter EA; Karlsson MCI
Article: JOURNAL OF IMMUNOLOGY. 2016;197(7):2618-2626
Selective Memory to Apoptotic Cell-Derived Self-Antigens with Implications for Systemic Lupus Erythematosus Development
Duhlin A; Chen Y; Wermeling F; Sedimbi SK; Lindh E; Shinde R; Halaby MJ; Kaiser Y; Winqvist O; McGaha TL; Karlsson MCI
Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2016;100(4):781-789
Sensitivity of dendritic cells to NK-mediated lysis depends on the inflammatory environment and is modulated by CD54/CD226-driven interactions
Smith LE; Olszewski MA; Georgoudaki A-M; Wagner AK; Hagglof T; Karlsson MCI; Dominguez-Villar M; Garcia-Cozar F; Mueller S; Ravens I; Bernhardt G; Chambers BJ
Article: JOURNAL OF IMMUNOLOGY. 2016;197(6):2063-2068
Cutting Edge: Marginal Zone Macrophages Regulate Antigen Transport by B Cells to the Follicle in the Spleen via CD21
Prokopec KE; Georgoudaki A-M; Sohn S; Wermeling F; Gronlund H; Lindh E; Carroll MC; Karlsson MCI
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2016;213(8):1537-1553
BAFF-secreting neutrophils drive plasma cell responses during emergency granulopoiesis
Parsa R; Lund H; Georgoudaki A-M; Zhang X-M; Guerreiro-Cacais AO; Grommisch D; Warnecke A; Croxford AL; Jagodic M; Becher B; Karlsson MCI; Harris RA
Article: NATURE COMMUNICATIONS. 2016;7:12175
Deletion of Wiskott-Aldrich syndrome protein triggers Rac2 activity and increased cross-presentation by dendritic cells
Baptista MAP; Keszei M; Oliveira M; Sunahara KKS; Andersson J; Dahlberg CIM; Worth AJ; Lieden A; Kuo I-C; Wallin RPA; Snapper SB; Eidsmo L; Scheynius A; Karlsson MCI; Bouma G; Burns SO; Forsell MNE; Thrasher AJ; Nylen S; Westerberg LS
Article: ONCOTARGET. 2016;7(25):38707-38717
Exosomal cancer immunotherapy is independent of MHC molecules on exosomes
Hiltbrunner S; Larssen P; Eldh M; Martinez-Bravo M-J; Wagner AK; Karlsson MCI; Gabrielsson S
Article: CELL REPORTS. 2016;15(9):2000-2011
Reprogramming Tumor-Associated Macrophages by Antibody Targeting Inhibits Cancer Progression and Metastasis
Georgoudaki A-M; Prokopec KE; Boura VF; Hellqvist E; Sohn S; Ostling J; Dahan R; Harris RA; Rantalainen M; Klevebring D; Sund M; Brage SE; Fuxe J; Rolny C; Li F; Ravetch JV; Karlsson MCI
Article: ONCOGENE. 2016;35(6):748-760
TGF-β1-induced EMT promotes targeted migration of breast cancer cells through the lymphatic system by the activation of CCR7/CCL21-mediated chemotaxis
Pang M-F; Georgoudaki A-M; Lambut L; Johansson J; Tabor V; Hagikura K; Jin Y; Jansson M; Alexander JS; Nelson CM; Jakobsson L; Betsholtz C; Sunds M; Karlsson MCI; Fuxe J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015;112(40):12474-12479
Cognate interaction with iNKT cells expands IL-10-producing B regulatory cells
Vomhof-DeKrey EE; Yates J; Hagglof T; Lanthier P; Amiel E; Veerapen N; Besra GS; Karlsson MCI; Leadbetter EA
Article: JOURNAL OF AUTOIMMUNITY. 2015;62:81-92
Deletion of WASp and N-WASp in B cells cripples the germinal center response and results in production of IgM autoantibodies
Dahlberg CIM; Torres M-L; Petersen SH; Baptista MAP; Keszei M; Volpi S; Grasset EK; Karlsson MCI; Walter JE; Snapper SB; Notarangelo LD; Westerberg LS
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015;112(16):E2030-E2038
Sterile inflammation in the spleen during atherosclerosis provides oxidation-specific epitopes that induce a protective B-cell response
Grasset EK; Duhlin A; Agardh HE; Ovchinnikova O; Hagglof T; Forsell MN; Paulsson-Berne G; Hansson GK; Ketelhuth DFJ; Karlsson MCI
Article: CELLULAR PHYSIOLOGY AND BIOCHEMISTRY. 2014;34(1):56-70
Invariant Natural Killer T (iNKT) Cells Prevent Autoimmunity, but Induce Pulmonary Inflammation in Cystic Fibrosis
Siegmann N; Worbs D; Effinger F; Bormann T; Gebhardt M; Ulrich M; Wermeling F; Mueller-Hermelink E; Biedermann T; Tighe M; Edwards MJ; Caldwell C; Leadbetter E; Karlsson MCI; Becker KA; Gulbins E; Doering G
Article: CANCER RESEARCH. 2013;73(13):3865-3876
Synergistic Induction of Adaptive Antitumor Immunity by Codelivery of Antigen with α-Galactosylceramide on Exosomes
Gehrmann U; Hiltbrunner S; Georgoudaki A-M; Karlsson MC; Naslund TI; Gabrielsson S
Article: JOURNAL OF IMMUNOLOGY. 2013;191(1):44-51
Independent Expansion of Epitope-Specific Plasma Cell Responses upon HIV-1 Envelope Glycoprotein Immunization
Forsell MNE; Soldemo M; Dosenovic P; Wyatt RT; Karlsson MCI; Hedestam GBK
Article: JOURNAL OF AUTOIMMUNITY. 2013;42:62-70
AIRE expressing marginal zone dendritic cells balances adaptive immunity and T-follicular helper cell recruitment
Lindmark E; Chen Y; Georgoudaki A-M; Dudziak D; Lindh E; Adams WC; Lore K; Winqvist O; Chambers BJ; Karlsson MCI
Article: JOURNAL OF AUTOIMMUNITY. 2013;42:1-6
Autoimmunity and cystatin SA1 deficiency behind chronic mucocutaneous candidiasis in autoimmune polyendocrine syndrome type 1
Lindh E; Brannstrom J; Jones P; Wermeling F; Hassler S; Betterle C; Garty BZ; Stridsberg M; Herrmann B; Karlsson MCI; Winqvist O
Article: JOURNAL OF IMMUNOLOGY. 2013;190(6):2712-2719
Dendritic Cell-Derived Exosomes Need To Activate Both T and B Cells To Induce Antitumor Immunity
Naslund TI; Gehrmann U; Qazi KR; Karlsson MCI; Gabrielsson S
Article: JOURNAL OF IMMUNOLOGY. 2012;188(12):6018-6026
BLyS-Mediated Modulation of Naive B Cell Subsets Impacts HIV Env-Induced Antibody Responses
Dosenovic P; Soldemo M; Scholz JL; O'Dell S; Grasset EK; Pelletier N; Karlsson MCI; Mascola JR; Wyatt RT; Cancro MP; Hedestam GBK
Article: PARTICLE AND FIBRE TOXICOLOGY. 2012;9:16
Pulmonary exposure to single-walled carbon nanotubes does not affect the early immune response against Toxoplasma gondii
Swedin L; Arrighi R; Andersson-Willman B; Murray A; Chen Y; Karlsson MCI; Georen SK; Tkach AV; Shvedova AA; Fadeel B; Barragan A; Scheynius A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(10):3909-3914
Tolerance to apoptotic cells is regulated by indoleamine 2,3-dioxygenase
Ravishankar B; Liu H; Shinde R; Chandler P; Baban B; Tanaka M; Munn DH; Mellor AL; Karlsson MCI; McGaha TL
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2011;108(51):E1399-E1407
The inflammatory cytokine IL-18 induces self-reactive innate antibody responses regulated by natural killer T cells
Enoksson SL; Grasset EK; Hagglof T; Mattsson N; Kaiser Y; Gabrielsson S; McGaha TL; Scheynius A; Karlsson MCI
Article: JOURNAL OF IMMUNOLOGY. 2011;187(7):3641-3652
Complement Activation and Complement Receptors on Follicular Dendritic Cells Are Critical for the Function of a Targeted Adjuvant
Mattsson J; Yrlid U; Stensson A; Schon K; Karlsson MCI; Ravetch JV; Lycke NY
Article: CELLULAR AND MOLECULAR IMMUNOLOGY. 2011;8(4):296-304
Marginal zone B cells are naturally reactive to collagen type II and are involved in the initiation of the immune response in collagen-induced arthritis
Carnrot C; Prokopec KE; Rasbo K; Karlsson MCI; Kleinau S
Article: BLOOD. 2011;117(20):5403-5412
Marginal zone macrophages suppress innate and adaptive immunity to apoptotic cells in the spleen
McGaha TL; Chen Y; Ravishankar B; van Rooijen N; Karlsson MCI
Article: PLOS ONE. 2011;6(7):e22202
The Expression of BAFF, APRIL and TWEAK Is Altered in Eczema Skin but Not in the Circulation of Atopic and Seborrheic Eczema Patients
Chen Y; Enoksson SL; Johansson C; Karlsson MA; Lundeberg L; Nilsson G; Scheynius A; Karlsson MCI
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2010;207(5):943-952
Invariant NKT cells limit activation of autoreactive CD1d-positive B cells
Wermeling F; Lind SM; Jordo ED; Cardell SL; Karlsson MCI
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2010;40(5):1451-1460
A regulatory role for macrophage class A scavenger receptors in TLR4-mediated LPS responses
Chen Y; Wermeling F; Sundqvist J; Jonsson A-B; Tryggvason K; Pikkarainen T; Karlsson MCI
Article: JOURNAL OF AUTOIMMUNITY. 2010;34(1):66-72
AIRE deficiency leads to impaired iNKT cell development
Lindh E; Rosmaraki E; Berg L; Brauner H; Karlsson MCI; Peltonen L; Hoglund P; Winqvist O
Article: AUTOIMMUNITY REVIEWS. 2009;9(1):49-52
An anatomical view on macrophages in tolerance
Wermeling F; Karlsson MCI; McGaha TL
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2009;39(8):2293-2301
IL-18 skews the invariant NKT-cell population via autoreactive activation in atopic eczema
Lind SM; Kuylenstierna C; Moll M; Jordo ED; Winqvist O; Lundeberg L; Karlsson MA; Linder MT; Johansson C; Scheynius A; Sandberg JK; Karlsson MCI
Article: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2009;64(6):919-926
Prolonged antigen-exposure with carbohydrate particle based vaccination prevents allergic immune responses in sensitized mice
Thunberg S; Neimert-Andersson T; Cheng Q; Wermeling F; Bergstrom U; Swedin L; Dahlen S-E; Arner E; Scheynius A; Karlsson MCI; Gafvelin G; van Hage M; Gronlund H
Article: BLOOD. 2009;113(12):2673-2683
Antigen-loaded exosomes alone induce Th1-type memory through a B cell-dependent mechanism
Qazi KR; Gehrmann U; Jordo ED; Karlsson MCI; Gabrielsson S
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(50):19571-19578
Identification of a receptor required for the anti-inflammatory activity of IVIG
Anthony RM; Wermeling F; Karlsson MCI; Ravetch JV
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(47):18466-18471
AIRE regulates T-cell-independent B-cell responses through BAFF
Lindh E; Lind SM; Lindmark E; Hassler S; Perheentupa J; Peltonen L; Winqvist O; Karlsson MCI
Article: BLOOD. 2008;112(10):4139-4147
WASP confers selective advantage for specific hematopoietic cell populations and serves a unique role in marginal zone B-cell homeostasis and function
Westerberg LS; de la Fuente MA; Wermeling F; Ochs HD; Karlsson MCI; Snapper SB; Notarangelo LD
Article: JOURNAL OF IMMUNOLOGY. 2008;180(10):6604-6610
A novel B cell-mediated transport of IgE-immune complexes to the follicle of the spleen
Hjelm F; Karlsson MCI; Heyman B
Article: JOURNAL OF IMMUNOLOGY. 2008;180(8):5670-5679
FcγRIIB deficiency leads to autoimmunity and a defective response to apoptosis in Mrl-MpJ mice
McGaha TL; Karlsson MCI; Ravetch JV
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2007;204(10):2259-2265
Class A scavenger receptors regulate tolerance against apoptotic cells, and autoantibodies against these receptors are predictive of systemic lupus
Wermeling F; Chen Y; Pikkarainen T; Scheynius A; Winqvist O; Izui S; Ravetch JRV; Tryggvason K; Karlsson MCI
Article: BLOOD. 2006;108(6):1941-1948
Aire-deficient mice develop hematopoetic irregularities and marginal zone B-cell lymphoma
Hassler S; Ramsey C; Karlsson MC; Larsson D; Herrmann B; Rozell B; Backheden M; Peltonen L; Kampe O; Winqvist O
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2003;198(2):333-340
Macrophages control the retention and trafficking of B lymphocytes in the splenic marginal zone.
Karlsson MCI; Guinamard R; Bolland S; Sankala M; Steinman RM; Ravetch JV
Article: CANCER RESEARCH. 2002;62(23):6891-6900
Disruption of cell-cell adhesion enhances antibody-dependent cellular cytotoxicity: implications for antibody-based therapeutics of cancer.
Green SK; Karlsson MCI; Ravetch JV; Kerbel RS
Article: JOURNAL OF IMMUNOLOGY. 2001;167(10):5558-5564
FcgammaRIIB in IgG-mediated suppression of antibody responses: different impact in vivo and in vitro.
Karlsson MC; Getahun A; Heyman B
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2001;53(4):381-385
IgE-mediated suppression of primary antibody responses in vivo.
Karlsson MC; Diaz de Ståhl T; Heyman B
Article: JOURNAL OF IMMUNOLOGY. 1999;163(2):618-622
IgG-mediated enhancement of antibody responses is low in Fc receptor gamma chain-deficient mice and increased in Fc gamma RII-deficient mice.
Wernersson S; Karlsson MC; Dahlström J; Mattsson R; Verbeek JS; Heyman B
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1999;96(5):2244-2249
Efficient IgG-mediated suppression of primary antibody responses in Fcgamma receptor-deficient mice.
Karlsson MC; Wernersson S; Diaz de Ståhl T; Gustavsson S; Heyman B
Article: IMMUNOGENETICS. 1998;48(5):344-349
Limited polymorphism in the first domain of the rat MHC class II RT1-D molecule
Vestberg M; Brunsberg U; Bergsteinsdottir K; Karlsson M; Gustafsson K; Wedekind D; Hedrich H; Holmdahl R
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Letter: CELLULAR AND MOLECULAR IMMUNOLOGY. 2024;21(1):91-94
Cancer-associated fibroblasts express CD1d and activate invariant natural killer T cells under cellular stress
Pei S; Sjolund J; Pan Y; Pietras K; Karlsson MCI
Review: JOURNAL OF CLINICAL MEDICINE. 2023;12(19):6268
B Cell Tolerance and Targeted Therapies in SLE
Parodis I; Long X; Karlsson MCI; Huang X
Editorial comment: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2021;148(3):702-705
IgE autoantibodies: An innate connection to adaptive immunity
Huang X; Karlsson MCI
Review: IMMUNOLOGICAL REVIEWS. 2021;299(1):93-107
Invariant natural killer T cells balance B cell immunity
Leadbetter EA; Karlsson MCI
Review: IMMUNOLOGICAL REVIEWS. 2016;269(1):26-43
Apoptotic cell responses in the splenic marginal zone: a paradigm for immunologic reactions to apoptotic antigens with implications for autoimmunity
McGaha TL; Karlsson MCI
Review: CELLULAR AND MOLECULAR LIFE SCIENCES. 2013;70(24):4795-4808
IL-18 in inflammatory and autoimmune disease
Sedimbi SK; Hagglof T; Karlsson MCI
Review: SEMINARS IN CANCER BIOLOGY. 2012;22(5-6):455-461
TGF-β-induced epithelial-mesenchymal transition: A link between cancer and inflammation
Fuxe J; Karlsson MCI
Review: MOLECULAR IMMUNOLOGY. 2011;48(11):1307-1318
Scavenger receptors as regulators of natural antibody responses and B cell activation in autoimmunity
Jordo ED; Wermeling F; Chen Y; Karlsson MCI
Meeting abstract: CLINICAL IMMUNOLOGY. 2008;127:S64
The Wiskott-Aldrich syndrome protein is essential for development and correct function of the marginal zone
Westerberg L; De La Fuente M; Wermeling F; Ochs H; Karlsson M; Notarangelo L; Snapper S
Editorial comment: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2001;53(4):331-334
No evidence for a role of FcgammaRIIB in suppression of in vivo antibody responses to erythrocytes by passively administered IgG.
Heyman B; Dahlström J; Diaz De Ståhl T; Getahun A; Wernersson S; Karlsson MC

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Professor, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 2016-

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Docent, Karolinska Institutet, 2009

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