Petter Höglund group -Immunological tolerance and transfusion immunology

One research focus in the group is to understand the molecular mechanisms responsible for immunological tolerance.

In particular, we study natural killer cells in the mouse using a combination of cellular immunology, biophysical imaging and mathematical modeling. The intracellular signals that control functional responses and development under various conditions are studied.

A second question is to ask how various components of the immune system impact on the outcome of erythrocyte and platelet transfusion in humans.

One aim is to understand how antibodies to HLA molecules makes patients refractory to platelet transfusions and another is to study natural killer cells in transfusion reactions. The aim is to develop means to avoid such reactions and to improve transfusion practices.

Keywords:

immunology, natural killer cells, tolerance, platelet transfusions, HLA, intracellular signaling

Group leader

Petter Höglund

Professor/specialist physician
H7 Department of Medicine, Huddinge

Group members

Sophia Hald

PhD student
H7 Department of Medicine, Huddinge

Suria Jahan

Postdoctoral researcher
H7 Department of Medicine, Huddinge

Maaike Jongen

Postdoctoral studies
H7 Department of Medicine, Huddinge

Thuy Luu Thanh

Research Specialist
H7 Department of Medicine, Huddinge

Stephan Meinke

Research Specialist
H7 Department of Medicine, Huddinge

Peter Norris

Postdoctoral studies
H7 Department of Medicine, Huddinge

Bhavna Rani

Postdoctoral researcher
H7 Department of Medicine, Huddinge

Paul Ratcliffe

Affiliated to research
H7 Department of Medicine, Huddinge

Jenny Rydén

Affiliated to research
H7 Department of Medicine, Huddinge

Laurent Schmied

Affiliated to research
H7 Department of Medicine, Huddinge

Luana Tomaipitinca

Postdoctoral studies
H7 Department of Medicine, Huddinge

Team leader

Roland Fiskesund

Assistant professor
H7 Department of Medicine, Huddinge