Roland Fiskesund
Assistant Professor
E-mail: roland.fiskesund@ki.se
Visiting address: NEO Medicinaren 25, HERM plan 7, Hälsovägen 7C (lastkaj), 14157 Huddinge
Postal address: H7 Medicin, Huddinge, H7 Hematologi Höglund Fiskesund, 171 77 Stockholm
About me
- Medical Doctor and Team leader with focus on Transfusion Medicine and Stem
Cell Biology
MD PhD, specializing in Clinical Immunology and Transfusion Medicine.
Research interests in Transfusion Medicine and Stem Cell Biology.
2003-2009 Karolinska Institutet Medical School
2008-2014 PhD in Immunology at Karolinska Institutet
2013-2015 Medical Internship at Karolinska University Hospital
2015 Postdoctoral studies at professor Thomas Helledays lab at SciLife,
Karolinska Institutet
2017-2019 Postdoctoral studies at the Chinese Academy of Medical Sciences,
Beijing
2016-2023 Clinical Specialization in Immunology and Transfusion Medicine at
Karolinska University Hospital
Research
- Transfusion Medicine is a clinically important part of modern medicine and
research in this field has vast translational potential. Platelet transfusion
in thrombocytopenia and erythrocyte transfusion in anemia are well
established and routinely used in the clinic. Our main research interest is
exploring the concept of neutrophil transfusion to neutropenic patients with
antibiotic refractory infections. Neutrophil transfusion is currently
utilized sparingly, mainly due to logistical challenges. We are in the
process of developing "off-the-shelf" neutrophil concentrates, drastically
cutting costs and logistical hassle. Other research areas that we work with
include enzymatic conversion of blood groups, citrate metabolism during
apheresis treatments, harvesting and processing of stem cell grafts.
Our clinic handles the logistics around all Stem Cell Transplantations at
Karolinska University Hospital. This setup provides us with access to large
amounts of human hematopoietic stem cells from healthy donors as well as
cancer patients. We have ethical permit for /ex vivo /culture, running
various experiments including sequencing, CRISPR and animal transplantation
as well as biobanking them. In my group, we are interested in characterizing
the adhesion molecules on stem cells and understanding their role in
maintaining stem cells through integrin signaling.
Teaching
- I teach Transfusion Medicine at Karolinska Institutet to Nursing and Medical
students.
Articles
- Article: NATURE COMMUNICATIONS. 2024;15(1):1405
- Article: NATURE IMMUNOLOGY. 2023;24(12):2042-2052
- Article: CELL DEATH AND DIFFERENTIATION. 2022;29(1):246-261
- Article: CANCER RESEARCH. 2021;81(2):476-488
- Article: ACR OPEN RHEUMATOLOGY. 2020;2(6):344-356
- Article: CANCER IMMUNOLOGY RESEARCH. 2018;6(9):1057-1068
- Article: CANCER RESEARCH. 2018;78(14):3926-3937
- Article: CANCER CELL. 2018;33(3):480-494.e7
- Article: JOURNAL OF CLINICAL INVESTIGATION. 2018;128(3):1057-1073
- Article: NATURE COMMUNICATIONS. 2018;9(1):873
- Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2015;35(1):197-205
- Article: JOURNAL OF IMMUNOLOGY. 2014;192(10):4551-4559
- Article: JOURNAL OF MOLECULAR BIOLOGY. 2012;417(4):279-293
- Article: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2011;29(6):942-950
- Article: STROKE. 2010;41(4):607-612
- Journal article: ATHEROSCLEROSIS PLUS. 2009;10(2):e1290
- Article: JOURNAL OF APPLIED MICROBIOLOGY. 2009;106(2):624-633
All other publications
- Preprint: SSRN ELECTRONIC JOURNAL. 2018
- Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):348
- Review: PLANTA MEDICA. 2010;76(15):1635-1641
- Review: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2006;1760(9):1314-1322
Grants
- Swedish Research Council1 January 2022 - 31 December 2024
- Swedish Research Council1 December 2020 - 31 December 2021
Employments
- Assistant Professor, Department of Medicine, Huddinge, Karolinska Institutet, 2022-2028
Degrees and Education
- Degree Of Doctor Of Philosophy, Institute of Environmental Medicine, Karolinska Institutet, 2014
- University Medical Degree, Karolinska Institutet, 2009