Suria Jahan

As a postdoctoral researcher at the Karolinska Institutet in Sweden, I am specializing in Transfusion and Regenerative Medicine, with a particular emphasis on Platelet Transfusion, Platelet Storage Lesions, Intracellular Signaling, and Leukemia. My research goal is to improve transfusion outcomes and advance therapeutic strategies in regenerative medicine and hematological malignancies.

My current research focuses on understanding the Platelet function in Transfusion medicine.

Project 1: Therapeutic storage of platelet concentrate is a challenging problem for Transfusion Medicine.

In numerous different clinical conditions, (e.g., upon accidental injury, the treatment of many diseases and in surgery) patients may need transfusion of platelets from healthy blood donors. The platelet concentrates (PC) are purified by different techniques and stored for maximally 5 or 7 days at 22°C temperature. The quality of PC is profoundly affected by the collection, processing methods and ex vivo manipulation (such as pathogen reduction). Similarly, stored platelets undergo deleterious changes, referred to as platelet storage lesions (PSLs), which may prevent transfused platelets to respond to agonists and arrest bleeding after transfusion. However, no reliable techniques are today available to evaluate this. In this project, the aim is to study the activation and function of stored platelet concentrate using flow cytometry, a technique where unique protocols allow to evaluate important platelet subpopulations and their involvement in platelet adhesion, activation, and aggregation upon stimulation with different platelet receptor agonists. The long-term goal is to dissect platelet function during blood bank storage: towards refined platelet production for optimal transfusion outcome.

Project 2: Study different phosphorylated signalling molecules and their role at activated state of platelet upon stimulation with different agonists.

Protein phosphorylation is an important cellular regulatory mechanism. Kinase/phosphatase activity plays crucial role in phosphorylation of platelet 

Project 3: Study the changes in platelets function and membrane receptors in patients with chronic myelomonocytic leukemia (CMML).

Chronic myelomonocytic leukaemia (CMML) is characterised by increased levels of monocyte white blood cells in peripheral blood and bone marrow. Platelet 

Research opportunities:

If you are a master's student and interested to do