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Kalle Malmberg group

The group studies the molecular and cellular basis for NK cell differentiation and repertoire formation in health and disease.

A key focus is to gain insights into how killer cell immunoglobulin-like receptors (KIR) influence the function of human NK cells. KIR are HLA class I binding receptors with important functions in reproduction, immunity to infections, and in cell therapy against cancer. We examine the dynamic shaping of human NK cell repertoires during viral infection, tumor transformation and following stem cell transplantation.

We are also seeking to implement new insights into the adaptive-like behaviour of NK cells in the next generation of NK cell-based immunotherapy for patients with refractory or relapsing malignancies.

Keywords: NK cells, killer cell immunoglobulin-like receptors, KIR, allogeneic hematopoietic stem cell transplantation, immunotherapy, cell therapy

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From left to right: Ebba Sohlberg, Aline Pfefferle, Veronika Kremer, Quirin Hammer and Alvaro Haroun-Izquierdo

Collaborative networks

The research group is mainly based at the Norwegian Radium Hospital and Oslo University. However, the group has a node at the Karolinska Institutet and maintain strong interactions with three research networks at the Karolinska Institutet: Immunomodulatory Therapies for Autoimmity and Cancer (IMTAC), Theme Center for Regenerative Medicine and Center for Infectious Medicine (CIM). The PI and some group members have double affiliation to CIM.

Financial support

  • Cancerfonden
  • Vetenskapsrådet
  • Barncancerfonden
  • ALF
  • SSF


Group Leader: Karl-Johan Malmberg

Project managers: Lise Kveberg (OUS), Ebba Sohlberg (KI)

Lab Managers: Hanne Julie Hoel (OUS), Merete Thune Wiiger (OUS)

Senior Scientists: Silje Zandstra Krokeide (OUS)

Post doctoral Fellows: Quirin Hammer (KI), Minoru Kanaya (OUS), Mizuha Kosugi-Kanaya (OUS)

Immune informatics and computational biology: Trevor Clancy (OUS), Herman Netskar (OUS)

Ph.D. Candidates: Dennis Clement (OUS), Alvaro Haroun-Izquierdo (KI), Eivind Heggernes Ask (OUS), Daniel Alfredo Palacios Orellana (OUS), Aline Pfefferle (KI), Michelle Lu Sætersmoen (OUS)

Affiliated Scientists: Marie Schaeffer Co-director HLA Lab (KI), Andreas Björklund, MD, PhD, Specialist in Hematology and Internal medicine

Previous members: Sandra Anderson, Bettina Baumann, Axel Berg-Larsen, Vivien Beziat, Mattias Carlsten, Kishan Kumar Chudasama, Monika Enqvist, Cyril Fauriat, Jodie Peter Goodridge, Benedikt Jakobs, Lisa Liu, Vincent Oei Yi Sheng, Astrid Tschan Plessl, Veronika Kremer 

@MalmbergLab on Twitter

Open positions

We always want to get in touch with highly motivated students and potential post-docs. If you are interested in doing research within our group please contact the group leader Kalle Malmberg.