Kalle Malmberg group
The group studies the molecular and cellular basis for NK cell differentiation and repertoire formation in health and disease.
A key focus is to gain insights into how killer cell immunoglobulin-like receptors (KIR) influence the function of human NK cells. KIR are HLA class I binding receptors with important functions in reproduction, immunity to infections, and in cell therapy against cancer. We examine the dynamic shaping of human NK cell repertoires during viral infection, tumor transformation and following stem cell transplantation.
We are also seeking to implement new insights into the adaptive-like behaviour of NK cells in the next generation of NK cell-based immunotherapy for patients with refractory or relapsing malignancies.
Keywords: NK cells, killer cell immunoglobulin-like receptors, KIR, allogeneic hematopoietic stem cell transplantation, immunotherapy, cell therapy
The research group is mainly based at the Norwegian Radium Hospital and Oslo University. However, the group has a node at the Karolinska Institutet and maintain strong interactions with three research networks at the Karolinska Institutet: Immunomodulatory Therapies for Autoimmity and Cancer (IMTAC), Theme Center for Regenerative Medicine and Center for Infectious Medicine (CIM). The PI and some group members have double affiliation to CIM.
Group Leader: Karl-Johan Malmberg
Project managers: Lise Kveberg (OUS), Ebba Sohlberg (KI)
Lab Managers: Hanne Julie Hoel (OUS), Merete Thune Wiiger (OUS)
Senior Scientists: Silje Zandstra Krokeide (OUS)
Immune informatics and computational biology: Trevor Clancy (OUS), Herman Netskar (OUS)
Previous members: Sandra Anderson, Bettina Baumann, Axel Berg-Larsen, Vivien Beziat, Mattias Carlsten, Kishan Kumar Chudasama, Monika Enqvist, Cyril Fauriat, Jodie Peter Goodridge, Benedikt Jakobs, Lisa Liu, Vincent Oei Yi Sheng, Astrid Tschan Plessl
@MalmbergLab on Twitter
[embed]<blockquote class="twitter-tweet" data-lang="sv"><p lang="en" dir="ltr">Enabling MHC-mismatched hematopoietic stem cell transplants and organ graft tolerance without chemotherapy or radiation <a href="https://t.co/i1YM1itiV5">https://t.co/i1YM1itiV5</a></p>— MalmbergLab (@MalmbergLab) <a href="https://twitter.com/MalmbergLab/status/1087524750111367168?ref_src=twsr…">22 januari 2019</a></blockquote>
<script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script>[/embed].
We always want to get in touch with highly motivated students and potential post-docs. If you are interested in doing research within our group please contact the group leader Kalle Malmberg.