![Researcher pipetting a yellow liquid in a LAF hood](/sites/kise/files/styles/fullsize_bw_no_crop/public/qbank/NextGenNK_360-custom20210616081155.jpg.webp?itok=hvsY28j7)
NextGenNK
NextGenNK is a Competence Center for the development of next generation NK cell-based cancer immunotherapies. The Center is coordinated by Karolinska Institutet and collaborates with the Karolinska University Hospital and prominent national and international industrial partners. The Center was launched in 2020, and is jointly funded by Vinnova, KI, and the Industrial partners.
News
NextGenNK recommended funding for five more years after excellent evaluation
This spring, NextGenNK underwent a comprehensive five-year evaluation. The five-year evaluation included detailed reporting and a one-day visit by an international panel of experts. Their findings, presented on 30 May, praised NextGenNK as a well-functioning and successful Competence Center.
![CAMP-organized ATMP R&D project meeting](/sites/kise/files/styles/article_full_width/public/qbank/Bild1_custom20240527100708.webp?itok=TQSeMMs-)
NextGenNK Directors participated in the national CAMP-organized ATMP R&D project meeting
CAMP, a national competence center within Vinnova's research program for biological medicines, is part of the ATMP Sweden initiative. On May 22nd, 2024 the national CAMP-organized ATMP R&D arranged a project meeting at Karolinska Institutet. NextGenNK Directors Hans-Gustaf Ljunggren and Evren Alici participated.
![Annette Öster Fernström, Andrea Ponzetta, Ashley Moffet, Nicole Marquardt and Hans-Gustaf Ljunggren.](/sites/kise/files/styles/article_full_width/public/qbank/AshleyMoffettlecture_custom20240527110420.webp?itok=n9fgSjDg)
Seminar by Professor Ashley Moffett, recently awarded KI’s honorary doctorate
Ashley Moffett, Professor Emerita at the University of Cambridge, UK, was awarded KI’s honorary doctorate for a lifetime of research that has made groundbreaking discoveries concerning the biological mechanisms behind severe conditions associated with pregnancy.
Hans-Gustaf Ljunggren hosted Ashley Moffett at one of the seminars at Karolinska Institutet, where she gave a presentation entitled “From NK cells to pre-eclampsia: the role of the immune system in pregnancy.”
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Immunotherapy in a new way
Karl-Johan Malmberg receives SEK 19 million to investigate how a subset of NK cells so called “adaptive NK cells”, can be targeted against difficult-to-treat cancer.
This year, The Swedish Cancer Society is making an extra investment in clinical studies and has therefore granted 120 million to 10 research projects. One of the scientists receiving funding is cancer-researcher Karl-Johan Malmberg at Karolinska Institutet, part of the steering group of the NextGenNK competence center.
![A man in speaking from a podium. In the background there is a screen showing presentation slides.](/sites/kise/files/styles/article_full_width/public/qbank/EvrenAdvTherWeek_custom20240212150031.webp?itok=07pGtIGv)
NextGenNK participation in the Advanced Therapies Week Conference, Miami, FL
Evren Alici, co-director of NextGenNK Competence Center was one of the invited speakers at the Advanced Therapies Week, January 16th-19th, Miami, Florida, USA. At the meeting he discussed “Designing optimal clinical trials and clinical operations for advanced therapies”.
Alligator Bioscience Announces Two Presentations on Mitazalimab and ATOR-4066 at the AACR Annual Meeting 2024
1st Presentation supports dosing regimen for mitazalimab in combination with FOLFORINOX and improvement of antitumor response.
2nd Presentation highlights potential of ATOR-4066 to induce tumor localized immune cell activation and strongly support further development of the candidate in clinical trials.
For more information: Alligator Bioscience Announces Two Presentations on Mitazalimab and ATOR-4066 at the AACR Annual Meeting 2024
![About twenty people are sitting around a conference table looking at the camera.](/sites/kise/files/styles/article_full_width/public/qbank/fotoUKKI_custom20240212150518.webp?itok=RXmWqX-w)
NextGenNK interacts with Innovate UK delegation
Innovate UK is the United Kingdom's innovation agency, which provides money and support to organisations to make new products and services. It is a non-departmental public body operating at arm's length from the Government as part of the United Kingdom Research and Innovation organisation.
On January 22nd 2024 Hans-Gustaf Ljunggren, Evren Alici, and parts of the NextGenNK faculty, met a delegation Innovate UK to discuss prospects for collaborations in the intersection between KI and British Biotech Industry.
Awards and recognitions
![info about Innate Killer Summit 2023](/sites/kise/files/styles/article_full_width/public/qbank/InnateKillerSummit2023_custom20230331085215.jpg?itok=4l39MvZ_)
NextGenNK at Innate Killer Summit 2023
co-leader Evren Alici was selected as one of the world-class speakers at Innate Killer Summit 2023.
![woman in green top with dark hair](/sites/kise/files/styles/article_full_width/public/qbank/arnika-custom20220725145047.jpg?itok=WwuxadAS)
Arnika Wagner - KID funding
Arnika Wagner, assistant professor at Karolinska Institutet, was granted KID funding for a new PhD student.
![Anna Pumpe receives Best Poster Prize](/sites/kise/files/styles/article_full_width/public/qbank/fotoAnaforNextGenNKwebpage_custom20240318130417.webp?itok=44xVtU0N)
Anna Pumpe wins Best Poster Prize
NextGenNK congratulates Anna Pumpe (PhD student in Arnika Wagner’s team) who won “Best Poster Prize” at the KI-HERM retreat on 6 March 2024.
Selected Publications
Engineering immune-evasive allogeneic cellular immunotherapies
Martin KE et al, Nature Reviews Immunology, 2024.
Tumor-associated NK cells drive MDSC-mediated tumor immune tolerance through the IL-6/STAT3 axis
Neo SY et al, Science Translational Medicine 2024.
KIR2DS1 and KIR2DL1-C245 Dominantly Repress NK Cell Degranulation Triggered by Monoclonal or Bispecific Antibodies, whereas Education by Uptuning Inhibitory Killer Ig-related Receptors Exerts No Advantage in Ab-dependent Cellular Cytotoxicity
Leijonhufvud C et al, The Journal of Immunology, 2024.