Ebba Sohlberg

About me
Publications
Grants
Public outreach and news

About me

Dedicated PhD with long-standing interest and experience in life sciences. My
current work is focused on cell therapy against cancer, specifically natural
killer (NK) cell based approaches. I have a strong interest in adaptive NK
cells in particular. Specialties include project management, regulatory work,
cell-based in vitro systems assessing the functional capacity of human immune
cells, flow cytometry and subsequent multiparameter analysis and
visualization.

Selected publications

Journal article: MED. 2024;:S2666-6340(24)00377-5
Targeting HLA-E-overexpressing cancers with a NKG2A/C switch receptor.
Sætersmoen M; Kotchetkov IS; Torralba-Raga L; Mansilla-Soto J; Sohlberg E; Krokeide SZ; Hammer Q; Sadelain M; Malmberg K-J
Article: NATURE IMMUNOLOGY. 2024;25(8):1445-1459
Pan-cancer profiling of tumor-infiltrating natural killer cells through transcriptional reference mapping
Netskar H; Pfefferle A; Goodridge JP; Sohlberg E; Dufva O; Teichmann SA; Brownlie D; Michaelsson J; Marquardt N; Clancy T; Horowitz A; Malmberg K-J
Article: BLOOD ADVANCES. 2023;7(16):4492-4504
Allelic variation of KIR and HLA tunes the cytolytic payload and determines functional hierarchy of NK cell repertoires
Philippon C; Tao S; Clement D; Haroun-Izquierdo A; Kichula KM; Netskar H; Brandt L; Oei VS; Kanaya M; Lanuza PM; Schaffer M; Goodridge JP; Horowitz A; Zhu F; Hammer Q; Sohlberg E; Majhi RK; Kveberg L; Onfelt B; Norman PJ; Malmberg K-J
Article: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2022;10(11):e005577
Adaptive single-KIR⁺NKG2C⁺ NK cells expanded from select superdonors show potent missing-self reactivity and efficiently control HLA-mismatched acute myeloid leukemia
Haroun-Izquierdo A; Vincenti M; Netskar H; van Ooijen H; Zhang B; Bendzick L; Kanaya M; Momayyezi P; Li S; Wiiger MT; Hoel HJ; Krokeide SZ; Kremer V; Tjonnfjord G; Berggren S; Wikstroem K; Blomberg P; Alici E; Felices M; oenfelt B; Hoeglund P; Valamehr B; Ljunggren H-G; Bjoerklund A; Hammer Q; Kveberg L; Cichocki F; Miller JS; Malmberg K-J; Sohlberg E
Article: CLINICAL CANCER RESEARCH. 2018;24(8):1834-1844
Complete Remission with Reduction of High-Risk Clones following Haploidentical NK-Cell Therapy against MDS and AML
Bjorklund AT; Carlsten M; Sohlberg E; Liu LL; Clancy T; Karimi M; Cooley S; Miller JS; Klimkowska M; Schaffer M; Watz E; Wikstrom K; Blomberg P; Wahlin BE; Palma M; Hansson L; Ljungman P; Hellstrom-Lindberg E; Ljunggren H-G; Malmberg K-J

Articles

Article: JOURNAL OF INFECTIOUS DISEASES. 2024;230(2):e318-e326
Type I Interferon Autoantibodies Correlate With Cellular Immune Alterations in Severe COVID-19
Strunz B; Maucourant C; Mehta A; Wan H; Du L; Sun D; Chen P; Nordlander A; Gao Y; Cornillet M; Bister J; Kvedaraite E; Christ W; Klingstrom J; Geanon D; Parke A; Ekwall-Larson A; Rivino L; MacAry PA; Aleman S; Buggert M; Ljunggren H-G; Pan-Hammarstrom Q; Lund-Johansen F; Stralin K; Bjorkstrom NK
Article: BLOOD ADVANCES. 2024;8(3):571-580
Clinical and immunological features in ACKR1/DARC-associated neutropenia
Palmblad J; Sohlberg E; Nilsson CC; Lindqvist H; Deneberg S; Ratcliffe P; Meinke S; Mortberg A; Klimkowska M; Hoglund P
Article: TRANSPLANTATION AND CELLULAR THERAPY. 2023;29(6):376.e1-376.e11
Effect of mTOR Inhibition with Sirolimus on Natural Killer Cell Reconstitution in Allogeneic Stem Cell Transplantation
Haroun-Izquierdo A; Lanuza PM; Pfefferle A; Netskar H; Ask EH; Torlen J; Bjorklund A; Sohlberg E; Malmberg K-J
Journal article: JOURNAL OF IMMUNOLOGY. 2023;210(1_Supplement):75.20
Pre-existing SARS-CoV-2-reactive CD4 +T cells are established and highly functional in early childhood
Olofsson A; Humbert M; Niessl J; Hodcroft E; Gao Y; Sohlberg E; Malmberg K-J; Lund-Johansen F; Björkhem-Bergman L; Jenmalm MC; Ljunggren H-G; Buggert M; Karlsson AC
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2023;120(12):e2220320120
Functional SARS-CoV-2 cross-reactive CD4⁺ T cells established in early childhood decline with age
Humbert M; Olofsson A; Wullimann D; Niessl J; Hodcroft EB; Cai C; Gao Y; Sohlberg E; Dyrdak R; Mikaeloff F; Neogi U; Albert J; Malmberg K-J; Lund-Johansen F; Aleman S; Bjorkhem-Bergman L; Jenmalm MC; Ljunggren H-G; Buggert M; Karlsson AC
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2022;96(1):e13195
The Karolinska KI/K COVID-19 immune atlas: An open resource for immunological research and educational purposes
Ljunggren H-G; Heggernes Ask E; Cornillet Jeannin M; Strunz B; Chen P; Rao Muvva J; Akber M; Buggert M; Chambers BJ; Cuapio Gomez A; Dzidic M; Filipovic I; Flodstrom-Tullberg M; Garcia M; Gorin J-B; Gredmark-Russ S; Hertwig L; Klingstrom J; Kokkinou E; Kvedaraite E; Lourda M; Mjosberg J; Maucourant C; Norrby-Teglund A; Palma Medina LM; Parrot T; Perez-Potti A; Ponzetta A; Ringqvist E; Rivera-Ballesteros O; Rooyackers O; Sandberg JK; Sandberg JT; Sekine T; Svensson M; Varnaite R; Wullimann D; Eriksson LI; Aleman S; Malmberg K-J; Stralin K; Bjorkstrom NK
Article: CELL REPORTS. 2022;38(10):110503
SARS-CoV-2 Nsp13 encodes for an HLA-E-stabilizing peptide that abrogates inhibition of NKG2A-expressing NK cells
Hammer Q; Dunst J; Christ W; Picarazzi F; Wendorff M; Momayyezi P; Huhn O; Netskar HK; Maleki KT; Garcia M; Sekine T; Sohlberg E; Azzimato V; Aouadi M; Degenhardt F; Franke A; Spallotta F; Mori M; Michaelsson J; Bjorkstrom NK; Rueckert T; Romagnani C; Horowitz A; Klingstrom J; Ljunggren H-G; Malmberg K-J
Article: BLOOD. 2022;139(5):704-716
Perturbed NK-cell homeostasis associated with disease severity in chronic neutropenia
Sohlberg E; Pfefferle A; Ask EH; Tschan-Plessl A; Jacobs B; Netskar H; Lorenz S; Kanaya M; Kosugi-Kanaya M; Meinke S; Mortberg A; Hoglund P; Sundin M; Carlsson G; Palmblad J; Malmberg K-J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(6):e2018587118
Major alterations in the mononuclear phagocyte landscape associated with COVID-19 severity
Kvedaraite E; Hertwig L; Sinha I; Ponzetta A; Myrberg IH; Lourda M; Dzidic M; Akber M; Klingstrom J; Folkesson E; Muvva JR; Chen P; Gredmark-Russ S; Brighenti S; Norrby-Teglund A; Eriksson LI; Rooyackers O; Aleman S; Stralin K; Ljunggren H-G; Ginhoux F; Bjorkstrom NK; Henter J-I; Svensson M
Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2021;10(7):e1306
SARS-CoV-2-specific humoral and cellular immunity persists through 9 months irrespective of COVID-19 severity at hospitalisation
Sandberg JT; Varnaite R; Christ W; Chen P; Muvva JR; Maleki KT; Garcia M; Dzidic M; Folkesson E; Skagerberg M; Ahlen G; Frelin L; Sallberg M; Eriksson LI; Rooyackers O; Sonnerborg A; Buggert M; Bjorkstrom NK; Aleman S; Stralin K; Klingstrom J; Ljunggren H-G; Blom K; Gredmark-Russ S
Article: CELL. 2020;183(1):158-168.e14
Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19
Sekine T; Perez-Potti A; Rivera-Ballesteros O; Stralin K; Gorin J-B; Olsson A; Llewellyn-Lacey S; Kamal H; Bogdanovic G; Muschiol S; Wullimann DJ; Kammann T; Emgard J; Parrot T; Folkesson E; Rooyackers O; Eriksson LI; Henter J-I; Sonnerborg A; Allander T; Albert J; Nielsen M; Klingstrom J; Gredmark-Russ S; Bjorkstrom NK; Sandberg JK; Price DA; Ljunggren H-G; Aleman S; Buggert M
Article: SCIENCE IMMUNOLOGY. 2020;5(51):eabe1670
MAIT cell activation and dynamics associated with COVID-19 disease severity
Parrot T; Gorin J-B; Ponzetta A; Maleki KT; Kammann T; Emgard J; Perez-Potti A; Sekine T; Rivera-Ballesteros O; Gredmark-Russ S; Rooyackers O; Folkesson E; Eriksson LI; Norrby-Teglund A; Ljunggren H-G; Bjorkstrom NK; Aleman S; Buggert M; Klingstrom J; Stralin K; Sandberg JK
Article: SCIENCE IMMUNOLOGY. 2020;5(50):eabd6832
Natural killer cell immunotypes related to COVID-19 disease severity
Maucourant C; Filipovic I; Ponzetta A; Aleman S; Cornillet M; Hertwig L; Strunz B; Lentini A; Reinius B; Brownlie D; Cuapio A; Ask EH; Hull RM; Haroun-Izquierdo A; Schaffer M; Klingstrom J; Folkesson E; Buggert M; Sandberg JK; Eriksson LI; Rooyackers O; Ljunggren H-G; Malmberg K-J; Michaelsson J; Marquardt N; Hammer Q; Stralin K; Bjorkstrom NK
Article: CELL REPORTS. 2019;29(8):2284-2294.e4
Intra-lineage Plasticity and Functional Reprogramming Maintain Natural Killer Cell Repertoire Diversity
Pfefferle A; Jacobs B; Netskar H; Ask EH; Lorenz S; Clancy T; Goodridge JP; Sohlberg E; Malmberg K-J
Article: CELL REPORTS. 2016;15(5):1088-1099
Critical Role of CD2 Co-stimulation in Adaptive Natural Killer Cell Responses Revealed in NKG2C-Deficient Humans
Liu LL; Landskron J; Ask EH; Enqvist M; Sohlberg E; Traherne JA; Hammer Q; Goodridge JP; Larsson S; Jayaraman J; Oei VYS; Schaffer M; Tasken K; Ljunggren H-G; Romagnani C; Trowsdale J; Malmberg K-J; Beziat V
Article: ONCOTARGET. 2015;6(33):34178-34190
Imprint of 5-azacytidine on the natural killer cell repertoire during systemic treatment for high-risk myelodysplastic syndrome
Sohlberg E; Pfefferle A; Andersson S; Baumann BC; Hellstrom-Lindberg E; Malmberg K-J
Article: JOURNAL OF IMMUNOLOGY. 2015;195(7):3374-3381
Microchip-Based Single-Cell Imaging Reveals That CD56^dim CD57^-KIR^-NKG2A⁺ NK Cells Have More Dynamic Migration Associated with Increased Target Cell Conjugation and Probability of Killing Compared to CD56^dimCD57^-KIR^-NKG2A^- NK Cells
Forslund E; Sohlberg E; Enqvist M; Olofsson PE; Malmberg K-J; Onfelt B
Article: AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY. 2014;71(2):178-188
Pre-Eclampsia Affects Cord Blood NK Cell Expression of Activation Receptors and Serum Cytokine Levels but Not CB Monocyte Characteristics
Sohlberg E; Saghafian-Hedengren S; Bachmayer N; Hamad RR; Bremme K; Holmlund U
Journal article: BIO-PROTOCOL. 2014;4(14)
In vitro EBV Infection of Mononuclear Cells that Have Been Cryo-preserved
Saghafian-Hedengren S; Sohlberg E; Theorell J; Carvalho-Queiroz C; Nagy N; Persson J-O; Nilsson C; Bryceson Y; Sverremark-Ekström E
Article: JOURNAL OF VIROLOGY. 2013;87(24):13446-13455
Epstein-Barr Virus Coinfection in Children Boosts Cytomegalovirus-Induced Differentiation of Natural Killer Cells
Saghafian-Hedengren S; Sohlberg E; Theorell J; Carvalho-Queiroz C; Nagy N; Persson J-O; Nilsson C; Bryceson YT; Sverremark-Ekstrom E
Article: JOURNAL OF IMMUNOLOGY. 2013;191(11):5669-5676
Cytomegalovirus-Seropositive Children Show Inhibition of In Vitro EBV Infection That Is Associated with CD8⁺CD57⁺ T Cell Enrichment and IFN-γ
Sohlberg E; Saghafian-Hedengren S; Rasul E; Marchini G; Nilsson C; Klein E; Nagy N; Sverremark-Ekstrom E
Article: BLOOD. 2013;121(14):2678-2688
NK cell responses to cytomegalovirus infection lead to stable imprints in the human KIR repertoire and involve activating KIRs
Beziat V; Liu LL; Malmberg J-A; Ivarsson MA; Sohlberg E; Bjorklund AT; Retiere C; Sverremark-Ekstrom E; Traherne J; Ljungman P; Schaffer M; Price DA; Trowsdale J; Michaelsson J; Ljunggren H-G; Malmberg K-J
Article: JOURNAL OF IMMUNOLOGICAL METHODS. 2012;385(1-2):60-70
Simultaneous detection of the two main proliferation driving EBV encoded proteins, EBNA-2 and LMP-1 in single B cells
Rasul AE; Nagy N; Sohlberg E; Adori M; Claesson H-E; Klein G; Klein E
Article: IMMUNOLOGY. 2011;133(1):41-50
Cord blood monocyte subsets are similar to adult and show potent peptidoglycan-stimulated cytokine responses
Sohlberg E; Saghafian-Hedengren S; Bremme K; Sverremark-Ekstrom E
Journal article: AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY. 2009;62(5):348
Women with Pre-Eclampsia have an Altered NKG2A and NKG2C Receptor Expression on Peripheral Blood Natural Killer Cells (vol 62, pg 147, 2009)
Bachmayer N; Sohlberg E; Sundstrom Y; Hamad RR; Berg L; Bremme K; Sverremark-Ekstrom E
Article: AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY. 2009;62(3):147-157
Women with Pre-Eclampsia Have an Altered NKG2A and NKG2C Receptor Expression on Peripheral Blood Natural Killer Cells
Bachmayer N; Sohlberg E; Sundstrom Y; Hamad RR; Berg L; Bremme K; Sverremark-Ekstrom E
Article: JOURNAL OF IMMUNOLOGY. 2009;182(4):2511-2517
Herpesvirus Seropositivity in Childhood Associates with Decreased Monocyte-Induced NK Cell IFN-γ Production
Saghafian-Hedengren S; Sundstrom Y; Sohlberg E; Nilsson C; Linde A; Troye-Blomberg M; Berg L; Sverremark-Ekstrom E
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All other publications

Preprint: BIORXIV. 2024;BIORXIV
A genetically engineered therapeutic lectin inhibits human influenza A virus infection and sustains robust virus-specific CD8 T cell expansion.
Yu M; Lin A; Baharom F; Li S; Legendre M; Covés-Datson E; Sohlberg E; Schlisio S; Loré K; Markovitz DM; Smed-Sörensen A
Preprint: BIORXIV. 2023
Targeting HLA-E Positive Cancers with a Novel NKG2A/C Switch Receptor
Sætersmoen M; Kotchetkov I; Torralba-Raga L; Mansilla-Soto J; Sohlberg E; Krokeide SZ; Hammer Q; Sadelain M; Malmberg K-J
Preprint: BIORXIV. 2023
Pan-cancer profiling of tumor-infiltrating natural killer cells through transcriptional reference mapping
Netskar H; Pfefferle A; Goodridge J; Sohlberg E; Dufva O; Teichmann S; Clancy T; Horowitz A; Malmberg K-J
Conference publication: JOURNAL OF IMMUNOLOGY. 2023;210(1)
Pre-existing SARS-CoV-2-reactive CD4⁺ T cells are established and highly functional in early childhood
Olofsson A; Humbert M; Niessl J; Hodcroft E; Gao Y; Sohlberg E; Malmberg K-J; Lund-Johansen F; Bjorkhem-Bergman L; Jenmalm MC; Ljunggren H-G; Buggert M; Karlsson AC
Conference publication: BLOOD. 2020;136:24-25
Systems-Level Analysis of the Immune Repertoire in Neutropenia Reveal Arrested NK Cell Differentiation and Exhaustion
Sohlberg E; Pfefferle A; Ask EH; Tschan-Plessl A; Jacobs B; Lorenz S; Meinke S; Hoglund P; Sundin M; Karlsson G; Palmblad J; Malmberg K-J
Review: FRONTIERS IN IMMUNOLOGY. 2020;11:812
Deciphering Natural Killer Cell Homeostasis
Pfefferle A; Jacobs B; Haroun-Izquierdo A; Kveberg L; Sohlberg E; Malmberg K-J
Preprint: BIORXIV. 2019
A Temporal Transcriptional Map of Human Natural Killer Cell Differentiation
Pfefferle A; Netskar H; Ask EH; Lorenz S; Goodridge JP; Sohlberg E; Clancy T; Malmberg K-J
Preprint: BIORXIV. 2019
Intra-lineage Plasticity and Functional Reprogramming Maintain Natural Killer Cell Repertoire Diversity
Pfefferle A; Jacobs B; Ask EH; Lorenz S; Clancy T; Goodridge JP; Sohlberg E; Malmberg K-J
Preprint: SSRN ELECTRONIC JOURNAL. 2019
Intra-Lineage Plasticity and Functional Reprogramming Maintain Natural Killer Cell Repertoire Diversity
Pfefferle A; Jacobs B; Ask EH; Lorenz S; Clancy T; Goodridge JP; Sohlberg E; Malmberg K-J
Meeting abstract: BLOOD. 2018;132:195
Efficient Scale-up and Pre-Clinical Evaluation of NKG2C+Adaptive NK Cell Expansion for Therapy Against High-Risk AML/MDS
Sohlberg E; Haroun-Izquierdo A; Bjorklund AT; Cooley S; Wiiger MT; Goodridge P; Hoel HJ; Pfefferle A; Chrobook M; Kremer V; Hellstrom-Lindberg E; Ask EH; Pontus B; Valamehr B; Guldevall K; van Ooijen H; Onfelt B; Alici E; Ljunggren H-G; Miller JS; Malmberg K-J
Review: IMMUNOGENETICS. 2017;69(8-9):547-556
Immune selection during tumor checkpoint inhibition therapy paves way for NK-cell "missing self" recognition
Malmberg K-J; Sohlberg E; Goodridge JP; Ljunggren H-G
Review: SEMINARS IN IMMUNOLOGY. 2017;31:20-29
Natural killer cell-mediated immunosurveillance of human cancer
Malmberg K-J; Carlsten M; Bjorklund A; Sohlberg E; Bryceson YT; Ljunggren H-G
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):266
Donor intrinsic metabolic set points determine proliferation in human NK cells
Pfefferle A; Jacobs B; Clancy T; Sohlberg E; Goodridge JP; Malmberg K-J
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):303
Profound NK cell differentiation block in a subgroup of neutropenic patients
Sohlberg E; Pfefferle A; Clancy T; Sundin M; Carlsson G; Palmblad J; Malmberg K-J
Conference publication: BLOOD. 2017;130
Complete Remission and Signs of Immunoediting Following Haploidentical NK Cell Therapy in Refractory High-Risk MDS and AML Ell Therapy in Refractory High-Risk MDS and AML
Bjorklund AT; Carlsten M; Sohlberg E; Clancy T; Liu L; Karimi M; Cooley S; Miller JS; Watz E; Wahlin BE; Palma M; Hansson L; Ljungman P; Hellstrom-Lindberg E; Ljunggren H-G; Malmberg K-J
Conference publication: BONE MARROW TRANSPLANTATION. 2016;51:S97-S98
ADOPTIVELY TRANSFERRED HAPLOIDENTICAL NK CELLS AGAINST REFRACTORY MDS, HIGH-RISK MDS AND REFRACTORY AML AS A BRIDGE TO TRANSPLANTATION. COMPLETE REMISSION ASSOCIATED WITH DETECTABLE NK CELLS
Bjorklund AT; Carlsten M; Sohlberg E; Liu L; Schaffer M; Watz E; Ljungman P; Hellstrom-Lindberg E; Ljunggren H-G; Malmberg K-J
Meeting abstract: LEUKEMIA RESEARCH. 2015;39:S25-S26
ADOPTIVELY TRANSFERRED HAPLOIDENTICAL NK CELLS AGAINST REFRACTORY MDS, HIGH-RISK MDS AND REFRACTORY AML AS A BRIDGE TO TRANSPLANTATION. COMPLETE REMISSION ASSOCIATED WITH DETECTABLE NK CELLS
Bjorklund AT; Carlsten M; Liu L; Schaffer M; Watz E; Palma M; Hansson L; Mollgard L; Cooley SA; Miller JS; Ljungman PT; Hellstrom-Lindberg E; Ljunggren HG; Malmberg KJ
Conference publication: JOURNAL OF IMMUNOLOGY. 2013;190:183.15
NKG2C+CD57+CD56dim NK cells are enriched following Epstein-Barr virus transformed lymphoblastoid cell line co-culture with peripheral blood mononuclear cells from cytomegalovirus plus donors
Saghafian-Hedengren S; Sohlberg E; Theorell J; Queiroz-Carvalho C; Nagy N; Nilsson C; Bryceson Y; Sverremark-Ekstrom E
Conference publication: IMMUNOLOGY. 2012;137:128-129
Mapping the diversity of human KIR repertoires and their adaptation to infection
Beziat V; Liu L; Sohlberg E; Retiere C; Traherne JA; Sverremark-Ekstrom E; Trowsdale J; Michaelsson J; Ljunggren HG; Malmberg KJ
Conference publication: IMMUNOLOGY. 2011;135:97
Epstein-Barr virus latency and weaker NK-cell responses in children - exploring the immune modulating potential of EBV
Saghafian-Hedengren S; Sohlberg E; Nilsson C; Sverremark-Ekstrom E
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2008;68(2):231
Inverse association between herpesvirus seropositivity and activation of innate immunity in children
Saghafian-Hedengren S; Sundstrom Y; Sohlberg E; Nilsson C; Lilja G; Marita T-B; Louise B; Eva S-E
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2008;68(2):225-226
Pre-eclampsia does not influence the peripheral natural killer cell population with regard to their subpopulations and receptor expression
Bachmayer N; Sundstrom Y; Berg L; Sohlberg E; Hamad RR; Bremme K; Sverremark-Ekstrom E
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Grants

Lysosomal Remodelling in Natural Killer Cells – New Targets for Immune-Gene Therapy
Swedish Research Council
1 January 2021 - 31 December 2024

About me

Selected publications

Articles

All other publications

Grants

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