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Human memory CD8+ T cells

We conduct innovative human immunology to study recirculating and resident memory CD8+ T cells in health and disease.

It is an exciting time to work on memory CD8+ T cells. These cells are absolutely critical for immune control of multiple chronic viral infections, such as HIV, and also represent a major cellular target of immune checkpoint therapies that have entirely revolutionized the treatment outcome in cancer care. However, many still view CD8+ T cells solely as killer T cells eliminating HIV-infected or tumor cells based on concepts from studies of peripheral blood. With emerging data from us and others demonstrating that many CD8+ T cells in tissues are non-cytolytic resident cells expressing multiple checkpoint molecules, such as PD-1, also in healthy subjects, it is tempting to speculate that these cells are designed to contain rather than eliminate tumors and virus-infected cells. This could be an evolutionary conserved process of the human body to minimize collateral tissue damage. Our group focus its work on many of these concepts with the aim to i) study the heterogeneity of circulating and resident memory CD8+ T cells in human donors, ii) identify alternative functions of memory CD8+ T cell in human tissues, iii) understand how memory CD8+ T cells maintain tumor and HIV control.

We use cutting-edge bulk- and single-cell technologies including 30-parameter flow cytometry, gene-expression, RNA-seq, ATAC-seq and proteomics analysis to dissect the heterogeneity and function of memory CD8+ T cells. Our lab is located in a vibrant research environment at the Center for Infectious Medicine (CIM) in the top modern ANA Futura laboratories. Here, we function in close conjunction with other research groups at CIM, and also collaborate with clinicians and surgeons at the Karolinska University Hospital Huddinge to receive valuable samples. We also collaborate with other researchers at Karolinska Institutet and Science for Life laboratories in Sweden as well with leading researchers in our field from universities in Denmark, Germany, Great Britain, Spain, and USA.

Members

Marcus Buggert, Group leader, Assistant Professor

André Perez Potti, PhD, Postdoc

Takuya Sekine, PhD, Postdoc 

Open positions 

We are constantly looking for talented post docs with an ambition to explore new and unique aspects of human T cell immunology, tissue immunology, and related questions. Contact Group leader: Marcus Buggert (marcus.buggert@ki.se)