Research group - Ingemar Björkhem & Ulf Diczfalusy

Oxysterols in health and disease: The role of oxysterols in connection with cholesterol homeostasis in the brain and their importance in relation to neurodegeneration. Oxysterols as biomarkers for neurological diseases, oxidative stress, inflammation and drug metabolism.

Research group leader Ingemar Björkhem

Ingemar Björkhem

Affiliated to research
H5 Department of Laboratory Medicine

Research group leader Ulf Diczfalusy

Ulf Diczfalusy

Affiliated to research
H5 Department of Laboratory Medicine

Group members

Research techniques

  • Gas chromatography
  • Mass spectrometry
  • Molecular biology techniques
  • Transgenic animal models.

External funding

Science Council, Swedish Brain Power, Wallenbergstiftelsen, Stockholm County Council, Alzheimerfonden, Hjärnfonden, Astra Zeneca

Teaching assignments

Study programme in medicine

Selected publications

Enhanced production of 24S-hydroxycholesterol is not sufficient to drive liver X receptor target genes in vivo.
Shafaati M, Olin M, Båvner A, Pettersson H, Rozell B, Meaney S, et al
J. Intern. Med. 2011 Oct;270(4):377-87

4β-Hydroxycholesterol, an endogenous marker of CYP3A4/5 activity in humans.
Diczfalusy U, Nylén H, Elander P, Bertilsson L
Br J Clin Pharmacol 2011 Feb;71(2):183-9

Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharide.
Diczfalusy U, Olofsson KE, Carlsson AM, Gong M, Golenbock DT, Rooyackers O, et al
J. Lipid Res. 2009 Nov;50(11):2258-64

Studies on the transcriptional regulation of cholesterol 24-hydroxylase (CYP46A1): marked insensitivity toward different regulatory axes.
Ohyama Y, Meaney S, Heverin M, Ekström L, Brafman A, Shafir M, et al
J. Biol. Chem. 2006 Feb;281(7):3810-20

Oxysterols: friends, foes, or just fellow passengers?
Björkhem I, Diczfalusy U
Arterioscler. Thromb. Vasc. Biol. 2002 May;22(5):734-42