Colorectal surgery
The research at the colorectal department is focused on colorectal cancer, inflammatory bowel diseases and anal fistulas. Since 2005 we have a local register for colorectal cancer (KVALOG). The register also covers patients undergoing surgery for benign conditions (e.g. proctologic procedures, diverticular diseases and colorectal polyps) from 2011 . Since 2017, all patients undergoing rectal surgery are recorded according to a fast track program based on the same principals as ERAS (Enhanced recovery after surgery) called ERASS (ERAS Sös).
Collaborations
Martin Janson, PhD
Helene Klinglöf, PhD student
Ulla-Maria Gustafsson, PhD
Anna Lindelius, PhD
Martin Dahlberg, PhD
Emil Pieniowski, PhD
Torbjörn Holm, Professor
Projects
STAR-TREC: Can we Save the rectum by Watchful waiting or TransAnal microsurgery following (chemo) Radiotherapy versus Total mesorectal excision for early Rectal Cancer?
Randomized international multicenter study. Includes patients with rectal cancer cT1-T3bN0M0. Patients are randomized to TME surgery or organ-sparing surgery with chemoradiotherapy or radiotherapy alone.
EROS: Early intervention and recovery of sexual function in men and women after treatment of rectal cancer– a randomized controlled study with tadalafil compared to standard care.
Includes patients with rectal cancer stages I-III. Measures change in sexual function from start of treatment to24 months postoperatively with/without Tadalafil.
PHALIR (ClinicalTrials.gov Identifier: NCT03720262): Sublay mesh or suturing after closure of loop-ileostomy – Karolina Eklöv, Åsa Hallqvist Everhov
Colorectal surgery in Addis Ababa - Karolina Eklöv, Åsa H Everhov
Position of ostomy for deviation in patients with obstructing cancer in descending colon – Karolina Eklöv, Åsa H Everhov
Population-based studies of inflammatory bowel disease – Åsa H Everhov
Is ischemic colitis ischemic? Epidemiological studies of idiopathic colon ischemia - Helene Klinglöf, Åsa Everhov
Non-operative, antibiotic-free management of children with appendicitis. A cohort study of children aged 10-14 treated for suspected appendicitis - Johan Stormdal-Starck, Martin Dahlberg
Postoperative complications and acute operations in colorectal cancer patients <50 years - Ida Gutlic, Deborah Saraste, Anna Martling, Caroline Nordenvall, Marie-Louise Lydrup, Pamela Buchwald
Can increased comorbidity due to inflammatory, metabolic and cancer disease explain the increase in the incidence of CRC in patients under 50 years of age in Sweden? - Erik Lundqvist, Deborah Saraste, Anna Martling, Karin Ekström Smedby, Caroline Nordenvall, Staffan Haapaniemi, Kalle Landerholm, Pär Myrelid
Evaluation of disease-specific mortality in the screening program for colorectal cancer in the Stockholm-Gotland region - Deborah Saraste, Johannes Blom, Sven Törnberg, Håkan Jonsson
Participation and experience of colorectal cancer screening - Hanna Heyman, Deborah Saraste, Johannes Blom
Colorectal cancer in patients ≥ 80 years: quality of life, health care use and survival - Deborah Saraste, Åsa Hallqvist Everhov, Göran Heinius, Torbjörn Holm
Upper Gastrointestinal Surgery group / Abdominal wall surgery
The group runs studies aimed at improving diagnostics and treatment of diseases in the upper gastrointestinal canal. The projects are mainly focused on gallstone disease, acute pancreatitis, obesity, peptic ulcer disease and ultrasonographic diagnostics.
Collaborations
Magdalena Plecka Östlund, MD. PhD., Post-doc
Jesper Lagergren, Professor, Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery (MMK), K1, KI
Ulf Gunnarsson, Professor, Umeå University
Mikael Rydén, Professor, Unit for Endocrinology and Diabetes, Department of Medicine, Huddinge (MedH), H7, KI
Staffan Holmin, Professor, Department of Clinical Neuroscience, KI
Magnus Nilsson, Professor, Unit of Surgery, Department of Clinical Science, Intervention and Technology, KI
Klara Bolander Laksov, Associate Professor, Department of education, Stockholm University
Bengt Isaksson, Professor, Department of Surgical Sciences, Uppsala University
Cecilia Strömberg, MD, PhD, Unit of Surgery, Department of Clinical Science, Intervention and Technology, KI
Projects
Authentic teamwork and interprofessional communication at the clinical training wards - Anders Sondén
”Point-of Care-Ultrasound” and gallstone disease - Anders Sondén
Shortened hospital stay for patients with mild acute pancreatitis – Thorhallur Agustsson
Development of endoscopic treatment methods in acute pancreatitis – Anders Sondén
Complications following gallstone surgery (in collaboration with Professor Nilsson, CLINTEC, KI) – Anders Sondén
Regional anesthesia and surgery – Thorhallur Agustsson
Lipid metabolism - Thorhallur Agustsson
Randomised controlled trial of ultrasonographic dissection versus electrocautery in surgery for acute cholecystitis (clinicaltrials.gov NCT03014817) - Gabriel Sandblom
Study of learning curve during introduction of ultrasonographic dissection in gallstone surgery (clinicaltrials.gov NCT03154164) - Gabriel Sandblom
Randomised controlled trial of percutaneous drainage versus aspiration in acute cholecystitis (clinicaltrials.gov NCT03012243) - Gabriel Sandblom
Acute surgery
At the department of acute surgery and abdominal wall surgery acute abdominal conditions are managed, e.g. appendicitis, acute pancreatitis and cholecystitis. Planned hernia surgery is also performed at the department. A number of studies focused on acute gastrointestinal conditions and abdominal wall surgery are conducted at the section.
Projects
Randomised controlled trial comparing conventional closure with reinforcement with resorbable mesh (PrevMesh, clincaltrials.gov NCT02487134)
Randomised controlled trial comparing conventional closure of the defect with peritoneal bridging in laparoscopic surgery for ventral hernias (clinicaltrials.gov NCT03344575)
Studies of conventional versus robot-assisted laparoscopic surgery for ventral hernias and groin hernias
Randomised controlled trial for evaluating the benefit of intraoperative cholangiography in uncomplicated gallstone surgery
Prospective registration of pancreatic cysts and premalignant lesions incidentally detected at computer tomography
Artificial intelligence for assessing the course of acute pancreatitis
Full-thickness skin graft in surgery for ventral hernias
Register-based studies of cardiovascular complications in hernia surgery
Studies of risk factors and incidence of incisional hernias and wound dehiscence following abdominal surgery
Study of a smartphone application and virtual simulators for enhancing surgical skills training
Studies of surgery for abdominal rectus diastasis
Register-based studies of complications following hernia surgery
Prospective registration of patients undergoing surgery for appendicitis
Validation of a patient reported outcome measure intended for patients with acute pancreatitis
Trauma in elderly. Study based on the Swedish National Trauma Register (SweTrau) - Martin Nordberg, Andreas Älgå, Lennart Boström
Long-term effects of traumatic brain injury - Olivia Kiwanuka, Lennart Boström
Traumatic brain injury and multitrauma in combination - Olivia Kiwanuka, Lennart Boström
Complications after appendectomy - Petter Nyström, Martin Dahlberg, Martin Nordberg, Lennart Boström
Outcome after out-of-hours appendectomy - Petter Nyström, Martin Dahlberg, Martin Nordberg, Lennart Boström
Hyponatremia and appendectomy in young patients - Petter Nyström, Martin Dahlberg