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Gastrointestinal Surgery KI SÖS

Colorectal surgery

The research at the colorectal department is focused on colorectal cancer, inflammatory bowel diseases and anal fistulas. Since 2005 we have a local register for colorectal cancer (KVALOG). The register also covers patients undergoing surgery for benign conditions (e.g. proctologic procedures, diverticular diseases and colorectal polyps) from 2011 . Since 2017, all patients undergoing rectal surgery are recorded according to a fast track program based on the same principals as ERAS (Enhanced recovery after surgery) called ERASS (ERAS Sös).

Projects

ALASCCA: Adjuvant Low Dose Aspiring in Colorectal Cancer and mutations in the PIK3 signal pathway - Martin Janson

TAI: transanal irrigation in low anterior resection syndrome (LARS) - Emil Pieniowski

PHALIR (ClinicalTrials.gov Identifier: NCT03720262): Sublay mesh or suturing after closure of loop-ileostomy – Karolina Eklöv, Åsa Hallqvist Everhov

Perirenal fat and prognosis after surgery for colorectal cancer – Sara Eckberg, Åsa H Everhov

Colorectal surgery in Addis Ababa - Karolina Eklöv, Åsa H Everhov

Position of ostomy for deviation in patients with obstructing cancer in descending colon – Karolina Eklöv, Åsa H Everhov

Population-based studies of inflammatory bowel disease – Åsa H Everhov

Preoperative performance status and training in elderly undergoing planned surgery - Parastou Farahnak

Vascular diseases after radiation therapy for rectal cancer - Åsa H Everhov, Peter Gillgren, Jonas Malmstedt, Gabriel Sandblom

Group members

Åsa Hallqvist Everhov, Head of the colorectal group

Susanne Tumlin Ekelund

Parastou Farahnak

Göran Heinius

Anna Lindelius

Ulla-Maria Gustafsson

Martin Dahlberg

Karolina Eklöv, Ph D student

Emil Pieniowski, Ph D student

Articles

Sick Leave and Disability Pension in Prevalent Patients With Crohn's Disease.
Everhov ÅH, Khalili H, Askling J, Myrelid P, Ludvigsson JF, Halfvarson J, et al
J Crohns Colitis 2018 Nov;12(12):1418-1428

Retained sex toys: an increasing and possibly preventable medical condition.
Dahlberg M, Nordberg M, Pieniowski E, Boström L, Sandblom G, Hallqvist-Everhov Å
Int J Colorectal Dis 2019 Jan;34(1):181-183

Perirenal fat surface area as a risk factor for perioperative difficulties and 30-day postoperative complications in elective colon cancer surgery.
der Hagopian O, Dahlberg M, Heinius G, Nordberg J, Gustafsson J, Nordenvall C, et al
Colorectal Dis 2018 Dec;20(12):1078-1087

Results of collagen plug occlusion of anal fistula: a multicentre study of 126 patients.
Blom J, Husberg-Sellberg B, Lindelius A, Gustafsson UM, Carlens S, Oppelstrup H, et al
Colorectal Dis 2014 Aug;16(8):626-30

miR-185 and miR-133b deregulation is associated with overall survival and metastasis in colorectal cancer.
Akçakaya P, Ekelund S, Kolosenko I, Caramuta S, Ozata DM, Xie H, et al
Int. J. Oncol. 2011 Aug;39(2):311-8

Incidence and Treatment of Patients Diagnosed With Inflammatory Bowel Diseases at 60 Years or Older in Sweden.
Everhov ÅH, Halfvarson J, Myrelid P, Sachs MC, Nordenvall C, Söderling J, et al
Gastroenterology 2018 02;154(3):518-528.e15

Upper Gastrointestinal Surgery group

The group runs studies aimed at improving diagnostics and treatment of diseases in the upper gastrointestinal canal. The projects are mainly focused on gallstone disease, acute pancreatitis, obesity, peptic ulcer disease and ultrasonographic diagnostics.

Projects

”Point-of Care-Ultrasound” and gallstone disease - Anders Sondén

Shortened hospital stay for patients with mild acute pancreatitis – Thorhallur Agustsson

Development of endoscopic treatment methods in acute pancreatitis – Anders Sondén

Complications following gallstone surgery (in collaboration with Professor Nilsson, CLINTEC, KI) – Anders Sondén

Regional anesthesia and surgery – Thorhallur Agustsson

Lipid metabolism - Thorhallur Agustsson

Randomised controlled trial of ultrasonographic dissection versus electrocautery in surgery for acute cholecystitis (clinicaltrials.gov NCT03014817) - Gabriel Sandblom

Study of learning curve during introduction of ultrasonographic dissection in gallstone surgery (clinicaltrials.gov NCT03154164) - Gabriel Sandblom

Randomised controlled trial of percutaneous drainage versus aspiration in acute cholecystitis (clinicaltrials.gov NCT03012243) - Gabriel Sandblom

Group members

Thorhallur Agustsson, Head of the upper gastrointestinal group

Anders Sondén, Associate Professor, Senior Lecturer

Emma Sverdén, MD, Post-doc

Martin Dahlberg, MD. PhD, Post-doc

Camilla Gustafsson, MD, PhD student (”Point-of Care-Ultrasound” and gallstone disease)

Rebecka Zacharias, MD, PhD student (Complications and gallstone surgery)

Collaborations

Ted Leinsköld, MD, Head of upper gastrointestinal department, Södersjukhuset

Magdalena Plecka Östlund, MD. PhD., Post-doc

Jesper Lagergren, Professor, Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery (MMK), K1, KI

Ulf Gunnarsson, Professor, Umeå University

Mikael Rydén, Professor, Unit for Endocrinology and Diabetes, Department of Medicine, Huddinge (MedH), H7, KI

Staffan Holmin, Professor, Department of Clinical Neuroscience, KI

Magnus Nilsson, Professor, Unit of Surgery, Department of Clinical Science, Intervention and Technology, KI

Klara Bolander Laksov, Associate Professor, Department of education, Stockholm University

Bengt Isaksson, Professor, Department of Surgical Sciences, Uppsala University

Cecilia Strömberg, MD, PhD, Unit of Surgery, Department of Clinical Science, Intervention and Technology, KI

Articles

An interprofessional initiative aimed at creating a common learning resource for the operating room ward.
Torbjörnsson E, Olivecrona C, Sonden A
J Interprof Care 2018 Jul;32(4):501-504

Time latencies of Helicobacter pylori eradication after peptic ulcer and risk of recurrent ulcer, ulcer adverse events, and gastric cancer: a population-based cohort study.
Sverdén E, Brusselaers N, Wahlin K, Lagergren J
Gastrointest. Endosc. 2018 08;88(2):242-250.e1

Transcatheter Arterial Embolization Compared With Surgery for Uncontrolled Peptic Ulcer Bleeding: A Population-based Cohort Study.
Sverdén E, Mattsson F, Lindström D, Sondén A, Lu Y, Lagergren J
Ann. Surg. 2019 Feb;269(2):304-309

Accuracy of Surgeon-Performed Ultrasound in Detecting Gallstones: A Validation Study.
Gustafsson C, McNicholas A, Sondén A, Törngren S, Järnbert-Pettersson H, Lindelius A
World J Surg 2016 07;40(7):1688-94

Risk Factors for Marginal Ulcer After Gastric Bypass Surgery for Obesity: A Population-based Cohort Study.
Sverdén E, Mattsson F, Sondén A, Leinsköld T, Tao W, Lu Y, et al
Ann. Surg. 2016 Apr;263(4):733-7

Increased admission for alcohol dependence after gastric bypass surgery compared with restrictive bariatric surgery.
Ostlund MP, Backman O, Marsk R, Stockeld D, Lagergren J, Rasmussen F, et al
JAMA Surg 2013 Apr;148(4):374-7

Acute surgery / Abdominal wall surgery

At the department of acute surgery and abdominal wall surgery acute abdominal conditions are managed, e.g. appendicitis, acute pancreatitis and cholecystitis. Planned hernia surgery is also performed at the department. A number of studies focused on acute gastrointestinal conditions and abdominal wall surgery are conducted at the section.

Projects

Randomised controlled trial comparing conventional closure with reinforcement with resorbable mesh (PrevMesh, clincaltrials.gov NCT02487134)

Randomised controlled trial comparing conventional closure of the defect with peritoneal bridging in laparoscopic surgery for ventral hernias (clinicaltrials.gov NCT03344575)

Studies of conventional versus robot-assisted laparoscopic surgery for ventral hernias and groin hernias

Randomised controlled trial for evaluating the benefit of intraoperative cholangiography in uncomplicated gallstone surgery

Prospective registration of pancreatic cysts and premalignant lesions incidentally detected at computer tomography

Artificial intelligence for assessing the course of acute pancreatitis

Full-thickness skin graft in surgery for ventral hernias

Register-based studies of cardiovascular complications in hernia surgery

Studies of risk factors and incidence of incisional hernias and wound dehiscence following abdominal surgery

Study of a smartphone application and virtual simulators for enhancing surgical skills training

Studies of surgery for abdominal rectus diastasis

Register-based studies of complications following hernia surgery

Prospective registration of patients undergoing surgery for appendicitis

Validation of a patient reported outcome measure intended for patients with acute pancreatitis

Research group leader

Gabriel Sandblom, Associate professor, senior lecturer

Collaborations

Leonard Clay, Registrar, Department of surgery, Södersjukhuset

Per Lindström, Surgeon specialist, Södersjukhuset

Göran Rietz, Registrar, Department of surgery, Södersjukhuset

Ruth Kalvelage, Surgeon specialist, Södersjukhuset

Articles

Index versus delayed cholecystectomy in mild gallstone pancreatitis: results of a randomized controlled trial.
Noel R, Arnelo U, Lundell L, Hammarqvist F, Jumaa H, Enochsson L, et al
HPB (Oxford) 2018 Oct;20(10):932-938

The Impact of Groin Surgery during Childhood on the Incidence of Inguinal Hernia Repair and Its Postoperative Complications in Adult Life.
Sokratous A, Österberg J, Sandblom G
Eur J Pediatr Surg 2019 Jun;29(3):271-275

Inversed relationship between completeness of follow-up and coverage of postoperative complications in gallstone surgery and ERCP: a potential source of bias in patient registers.
Enochsson L, Blohm M, Sandblom G, Jonas E, Hallerbäck B, Lundell L, et al
BMJ Open 2018 01;8(1):e01955

Disparities in the regional, hospital and individual levels of antibiotic use in gallstone surgery in Sweden.
Jaafar G, Darkahi B, Lindhagen L, Persson G, Sandblom G
BMC Surg 2017 Dec;17(1):128

Morbidity of cholecystectomy and gastric bypass in a national database.
Wanjura V, Szabo E, Österberg J, Ottosson J, Enochsson L, Sandblom G
Br J Surg 2018 Jan;105(1):121-127

Full-thickness skin graft vs. synthetic mesh in the repair of giant incisional hernia: a randomized controlled multicenter study.
Clay L, Stark B, Gunnarsson U, Strigård K
Hernia 2018 04;22(2):325-332