Gastrointestinal Surgery KI SÖS

Colorectal surgery

The research at the colorectal department is focused on colorectal cancer, inflammatory bowel diseases and anal fistulas. Since 2005 we have a local register for colorectal cancer (KVALOG). The register also covers patients undergoing surgery for benign conditions (e.g. proctologic procedures, diverticular diseases and colorectal polyps) from 2011 . Since 2017, all patients undergoing rectal surgery are recorded according to a fast track program based on the same principals as ERAS (Enhanced recovery after surgery) called ERASS (ERAS Sös).

Research group leader

Gabriel Sandblom

Associate professor, senior lecturer

Group members

Åsa Hallqvist Everhov, Head of the colorectal group

Susanne Tumlin Ekelund

Parastou Farahnak

Göran Heinius

Torbjörn Holm

Anna Lindelius

Ulla-Maria Gustafsson

Martin Dahlberg

Karolina Eklöv, Ph D student

Emil Pieniowski, Ph D student

Projects

ALASCCA: Adjuvant Low Dose Aspiring in Colorectal Cancer and mutations in the PIK3 signal pathway - Martin Janson

TAI: transanal irrigation in low anterior resection syndrome (LARS) - Emil Pieniowski

PHALIR (ClinicalTrials.gov Identifier: NCT03720262): Sublay mesh or suturing after closure of loop-ileostomy – Karolina Eklöv, Åsa Hallqvist Everhov

Perirenal fat and prognosis after surgery for colorectal cancer – Sara Eckberg, Åsa H Everhov

Colorectal surgery in Addis Ababa - Karolina Eklöv, Åsa H Everhov

Position of ostomy for deviation in patients with obstructing cancer in descending colon – Karolina Eklöv, Åsa H Everhov

Population-based studies of inflammatory bowel disease – Åsa H Everhov

Preoperative performance status and training in elderly undergoing planned surgery - Parastou Farahnak

Vascular diseases after radiation therapy for rectal cancer - Åsa H Everhov, Peter Gillgren, Jonas Malmstedt, Gabriel Sandblom

Articles

Hernia at the stoma site after loop ileostomy reversal.
Eklöv K, Viktorsson FZ, Frosztega E, Bringman S, Nygren J, Everhov ÅH
Int J Colorectal Dis 2020 May;35(5):887-895

Work Loss in Relation to Pharmacological and Surgical Treatment for Crohn's Disease: A Population-Based Cohort Study.
Everhov ÅH, Sachs MC, Ludvigsson JF, Khalili H, Askling J, Neovius M, et al
Clin Epidemiol 2020 ;12():273-285

Decompressing Stoma vs Stent in Left-Sided Obstructive Colon Cancer.
Hallqvist-Everhov Å, Asplund J, Dahlberg M
JAMA Surg 2020 Jun;():

Prevalence of low anterior resection syndrome and impact on quality of life after rectal cancer surgery: population-based study.
Pieniowski EHA, Nordenvall C, Palmer G, Johar A, Tumlin Ekelund S, Lagergren P, et al
BJS Open 2020 Oct;4(5):935-942

Women's earnings are more affected by inflammatory bowel disease than men's: a register-based Swedish cohort study.
Everhov ÅH, Bruze G, Söderling J, Askling J, Halfvarson J, Westberg K, et al
J Crohns Colitis 2020 Nov;():

Dosing of thromboprophylaxis and mortality in critically ill COVID-19 patients.
Jonmarker S, Hollenberg J, Dahlberg M, Stackelberg O, Litorell J, Everhov ÅH, et al
Crit Care 2020 11;24(1):653

Upper Gastrointestinal Surgery group

The group runs studies aimed at improving diagnostics and treatment of diseases in the upper gastrointestinal canal. The projects are mainly focused on gallstone disease, acute pancreatitis, obesity, peptic ulcer disease and ultrasonographic diagnostics.

Research group leader

Gabriel Sandblom, Associate professor, senior lecturer

Group members

Thorhallur Agustsson, Head of the upper gastrointestinal group

Anders Sondén, Associate Professor, Senior Lecturer

Emma Sverdén, MD, Post-doc

Martin Dahlberg, MD. PhD, Post-doc

Åsa Edergren, MD, Phd student

Camilla Gustafsson, MD, PhD student (”Point-of Care-Ultrasound” and gallstone disease)

Rebecka Zacharias, MD, PhD student (Complications and gallstone surgery)

Collaborations

Ted Leinsköld, MD, Head of upper gastrointestinal department, Södersjukhuset

Magdalena Plecka Östlund, MD. PhD., Post-doc

Jesper Lagergren, Professor, Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery (MMK), K1, KI

Ulf Gunnarsson, Professor, Umeå University

Mikael Rydén, Professor, Unit for Endocrinology and Diabetes, Department of Medicine, Huddinge (MedH), H7, KI

Staffan Holmin, Professor, Department of Clinical Neuroscience, KI

Magnus Nilsson, Professor, Unit of Surgery, Department of Clinical Science, Intervention and Technology, KI

Klara Bolander Laksov, Associate Professor, Department of education, Stockholm University

Bengt Isaksson, Professor, Department of Surgical Sciences, Uppsala University

Cecilia Strömberg, MD, PhD, Unit of Surgery, Department of Clinical Science, Intervention and Technology, KI

Projects

Authentic teawork and interprofessional communication at the clinical training wards - Anders Sondén

”Point-of Care-Ultrasound” and gallstone disease - Anders Sondén

Shortened hospital stay for patients with mild acute pancreatitis – Thorhallur Agustsson

Development of endoscopic treatment methods in acute pancreatitis – Anders Sondén

Complications following gallstone surgery (in collaboration with Professor Nilsson, CLINTEC, KI) – Anders Sondén

Regional anesthesia and surgery – Thorhallur Agustsson

Lipid metabolism - Thorhallur Agustsson

Randomised controlled trial of ultrasonographic dissection versus electrocautery in surgery for acute cholecystitis (clinicaltrials.gov NCT03014817) - Gabriel Sandblom

Study of learning curve during introduction of ultrasonographic dissection in gallstone surgery (clinicaltrials.gov NCT03154164) - Gabriel Sandblom

Randomised controlled trial of percutaneous drainage versus aspiration in acute cholecystitis (clinicaltrials.gov NCT03012243) - Gabriel Sandblom

Articles

An interprofessional initiative aimed at creating a common learning resource for the operating room ward.
Torbjörnsson E, Olivecrona C, Sondén A
J Interprof Care 2018 Jul;32(4):501-504

Peptic ulcer disease.
Sverdén E, Agréus L, Dunn JM, Lagergren J
BMJ 2019 Oct;367():l5495

Acute upper gastrointestinal bleeding.
Sverdén E, Markar SR, Agreus L, Lagergren J
BMJ 2018 Oct;363():k4023

Transcatheter Arterial Embolization Compared With Surgery for Uncontrolled Peptic Ulcer Bleeding: A Population-based Cohort Study.
Sverdén E, Mattsson F, Lindström D, Sondén A, Lu Y, Lagergren J
Ann Surg 2019 02;269(2):304-309

Call the On-Call: a study of student learning on an interprofessional training ward.
Ivarson J, Zelic L, Sondén A, Samnegård E, Bolander Laksov K
J Interprof Care 2020 Feb;():1-9

Is out-of-hours cholecystectomy for acute cholecystitis associated with complications?
Gustafsson C, Dahlberg M, Sondén A, Järnbert-Pettersson H, Sandblom G
Br J Surg 2020 Sep;107(10):1313-1323

Acute surgery / Abdominal wall surgery

At the department of acute surgery and abdominal wall surgery acute abdominal conditions are managed, e.g. appendicitis, acute pancreatitis and cholecystitis. Planned hernia surgery is also performed at the department. A number of studies focused on acute gastrointestinal conditions and abdominal wall surgery are conducted at the section.

Research group leader

Gabriel Sandblom, Associate professor, senior lecturer

Collaborations

Leonard Clay, Registrar, Department of surgery, Södersjukhuset

Per Lindström, Surgeon specialist, Södersjukhuset

Göran Rietz, Registrar, Department of surgery, Södersjukhuset

Ruth Kalvelage, Surgeon specialist, Södersjukhuset

Projects

Randomised controlled trial comparing conventional closure with reinforcement with resorbable mesh (PrevMesh, clincaltrials.gov NCT02487134)

Randomised controlled trial comparing conventional closure of the defect with peritoneal bridging in laparoscopic surgery for ventral hernias (clinicaltrials.gov NCT03344575)

Studies of conventional versus robot-assisted laparoscopic surgery for ventral hernias and groin hernias

Randomised controlled trial for evaluating the benefit of intraoperative cholangiography in uncomplicated gallstone surgery

Prospective registration of pancreatic cysts and premalignant lesions incidentally detected at computer tomography

Artificial intelligence for assessing the course of acute pancreatitis

Full-thickness skin graft in surgery for ventral hernias

Register-based studies of cardiovascular complications in hernia surgery

Studies of risk factors and incidence of incisional hernias and wound dehiscence following abdominal surgery

Study of a smartphone application and virtual simulators for enhancing surgical skills training

Studies of surgery for abdominal rectus diastasis

Register-based studies of complications following hernia surgery

Prospective registration of patients undergoing surgery for appendicitis

Validation of a patient reported outcome measure intended for patients with acute pancreatitis

Trauma in elderly. Study based on the Swedish National Trauma Register (SweTrau) - Martin Nordberg, Andreas Älgå, Lennart Boström

Long-term effects of traumatic brain injury - Olivia Kiwanuka, Lennart Boström

Traumatic brain injury and multitrauma in combination - Olivia Kiwanuka, Lennart Boström

Complications after appendectomy - Petter Nyström, Martin Dahlberg, Martin Nordberg, Lennart Boström

Outcome after out-of-hours appendectomy - Petter Nyström, Martin Dahlberg, Martin Nordberg, Lennart Boström

Hyponatremia and appendectomy in young patients - Petter Nyström, Martin Dahlberg

Articles

Negative pressure wound therapy versus standard treatment in patients with acute conflict-related extremity wounds: a pragmatic, multisite, randomised controlled trial.
Älgå A, Haweizy R, Bashaireh K, Wong S, Lundgren KC, von Schreeb J, et al
Lancet Glob Health 2020 03;8(3):e423-e429

Incisional hernias following gallstone surgery. A population-based study.
Howie A, Sandblom G, Enochsson L, Österberg J
HPB (Oxford) 2020 Dec;22(12):1775-1781

Cardiovascular complications after common bile duct stone extractions.
Syrén EL, Enochsson L, Eriksson S, Eklund A, Isaksson B, Sandblom G
Surg Endosc 2020 Jul;():

Antibiotic prophylaxis in acute cholecystectomy revisited: results of a double-blind randomised controlled trial.
Jaafar G, Sandblom G, Lundell L, Hammarqvist F
Langenbecks Arch Surg 2020 Dec;405(8):1201-1207

Analysis of Scientific Publications During the Early Phase of the COVID-19 Pandemic: Topic Modeling Study.
Älgå A, Eriksson O, Nordberg M
J Med Internet Res 2020 11;22(11):e21559

Plasma Sodium and Age Are Important Markers of Risk of Perforation in Acute Appendicitis.
Heymowski A, Boström L, Dahlberg M
J Gastrointest Surg 2020 Aug;():