Gastrointestinal Surgery KI SÖS

Colorectal surgery

The research at the colorectal department is focused on colorectal cancer, inflammatory bowel diseases and anal fistulas. Since 2005 we have a local register for colorectal cancer (KVALOG). The register also covers patients undergoing surgery for benign conditions (e.g. proctologic procedures, diverticular diseases and colorectal polyps) from 2011 . Since 2017, all patients undergoing rectal surgery are recorded according to a fast track program based on the same principals as ERAS (Enhanced recovery after surgery) called ERASS (ERAS Sös).

Group members

Åsa Hallqvist Everhov, Docent, Head of the colorectal group

Susanne Tumlin Ekelund, PhD

Göran Heinius, PhD

Karolina Eklöv, PhD student

Collaborations

Deborah Saraste, PhD

Martin Janson, PhD

Helene Klinglöf, PhD student

Ulla-Maria Gustafsson, PhD

Anna Lindelius, PhD

Martin Dahlberg, PhD

Emil Pieniowski, PhD

Torbjörn Holm, Professor

Projects

STAR-TREC: Can we Save the rectum by Watchful waiting or TransAnal microsurgery following (chemo) Radiotherapy versus Total mesorectal excision for early Rectal Cancer?
Randomized international multicenter study. Includes patients with rectal cancer cT1-T3bN0M0. Patients are randomized to TME surgery or organ-sparing surgery with chemoradiotherapy or radiotherapy alone. 

EROS: Early intervention and recovery of sexual function in men and women after treatment of rectal cancer– a randomized controlled study with tadalafil compared to standard care. 
Includes patients with rectal cancer stages I-III. Measures change in sexual function from start of treatment to24 months postoperatively with/without Tadalafil. 

PHALIR (ClinicalTrials.gov Identifier: NCT03720262): Sublay mesh or suturing after closure of loop-ileostomy – Karolina Eklöv, Åsa Hallqvist Everhov

Colorectal surgery in Addis Ababa - Karolina Eklöv, Åsa H Everhov

Position of ostomy for deviation in patients with obstructing cancer in descending colon – Karolina Eklöv, Åsa H Everhov

Population-based studies of inflammatory bowel disease – Åsa H Everhov

Is ischemic colitis ischemic? Epidemiological studies of idiopathic colon ischemia - Helene Klinglöf, Åsa Everhov 

Non-operative, antibiotic-free management of children with appendicitis. A cohort study of children aged 10-14 treated for suspected appendicitis - Johan Stormdal-Starck, Martin Dahlberg 

Postoperative complications and acute operations in colorectal cancer patients <50 years - Ida Gutlic, Deborah Saraste, Anna Martling, Caroline Nordenvall, Marie-Louise Lydrup, Pamela Buchwald   

Can increased comorbidity due to inflammatory, metabolic and cancer disease explain the increase in the incidence of CRC in patients under 50 years of age in Sweden? - Erik Lundqvist, Deborah Saraste, Anna Martling, Karin Ekström Smedby, Caroline Nordenvall, Staffan Haapaniemi, Kalle Landerholm, Pär Myrelid   

Evaluation of disease-specific mortality in the screening program for colorectal cancer in the Stockholm-Gotland region - Deborah Saraste, Johannes Blom, Sven Törnberg, Håkan Jonsson 

Participation and experience of colorectal cancer screening - Hanna Heyman, Deborah Saraste, Johannes Blom   

Colorectal cancer in patients ≥ 80 years: quality of life, health care use and survival - Deborah Saraste, Åsa Hallqvist Everhov, Göran Heinius, Torbjörn Holm 

Articles

Characteristics of Early-Onset vs Late-Onset Colorectal Cancer: A Review.
REACCT collaborative
JAMA Surg 2021 09;156(9):865-874

Decompressing Stoma vs Stent in Left-Sided Obstructive Colon Cancer.
Hallqvist-Everhov Å, Asplund J, Dahlberg M
JAMA Surg 2020 08;155(8):788

Interval cancers in a population-based screening program for colorectal cancer with gender-specific cut-off levels for fecal immunochemical test.
Ribbing Wilén H, Saraste D, Blom J
J Med Screen 2022 Sep;29(3):156-165

Trends in Treatment of Colorectal Cancer and Short-term Outcomes During the First Wave of the COVID-19 Pandemic in Sweden.
Eklöv K, Nygren J, Bringman S, Löfgren J, Sjövall A, Nordenvall C, Everhov ÅH
JAMA Netw Open 2022 05;5(5):e2211065

Colorectal cancer in elderly-onset inflammatory bowel disease: a 1969-2017 Scandinavian register-based cohort study.
Everhov ÅH, Erichsen R, Järås J, Pedersen L, Halfvarson J, Askling J, Ekbom A, Ludvigsson JF, Toft Sørensen H, Olén O
Aliment Pharmacol Ther 2022 Oct;56(7):1168-1182

A Randomized Controlled Clinical Trial of Transanal Irrigation Versus Conservative Treatment in Patients With Low Anterior Resection Syndrome After Rectal Cancer Surgery.
Pieniowski EHA, Bergström CM, Nordenvall CAM, Westberg KS, Johar AM, Tumlin Ekelund SF, Larsson KR, Pekkari KJ, Jansson Palmer GC, Lagergren P, Abraham-Nordling M
Ann Surg 2022 Jul;():

Upper Gastrointestinal Surgery group / Abdominal wall surgery

The group runs studies aimed at improving diagnostics and treatment of diseases in the upper gastrointestinal canal. The projects are mainly focused on gallstone disease, acute pancreatitis, obesity, peptic ulcer disease and ultrasonographic diagnostics.

Group members

Thorhallur Agustsson, Head of the upper gastrointestinal group

Anders Sondén, Associate Professor, Senior Lecturer

Emma Sverdén, MD, Post-doc

Martin Dahlberg, MD, PhD, Post-doc

Åsa Edergren, MD, Phd student

Rebecka Zacharias, MD, PhD student (Complications and gallstone surgery)

Andreas Älgå, MD, Post-doc

Collaborations

Ted Leinsköld, MD, Head of upper gastrointestinal department, Södersjukhuset

Magdalena Plecka Östlund, MD. PhD., Post-doc

Jesper Lagergren, Professor, Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery (MMK), K1, KI

Ulf Gunnarsson, Professor, Umeå University

Mikael Rydén, Professor, Unit for Endocrinology and Diabetes, Department of Medicine, Huddinge (MedH), H7, KI

Staffan Holmin, Professor, Department of Clinical Neuroscience, KI

Magnus Nilsson, Professor, Unit of Surgery, Department of Clinical Science, Intervention and Technology, KI

Klara Bolander Laksov, Associate Professor, Department of education, Stockholm University

Bengt Isaksson, Professor, Department of Surgical Sciences, Uppsala University

Cecilia Strömberg, MD, PhD, Unit of Surgery, Department of Clinical Science, Intervention and Technology, KI

Projects

Authentic teamwork and interprofessional communication at the clinical training wards - Anders Sondén

”Point-of Care-Ultrasound” and gallstone disease - Anders Sondén

Shortened hospital stay for patients with mild acute pancreatitis – Thorhallur Agustsson

Development of endoscopic treatment methods in acute pancreatitis – Anders Sondén

Complications following gallstone surgery (in collaboration with Professor Nilsson, CLINTEC, KI) – Anders Sondén

Regional anesthesia and surgery – Thorhallur Agustsson

Lipid metabolism - Thorhallur Agustsson

Randomised controlled trial of ultrasonographic dissection versus electrocautery in surgery for acute cholecystitis (clinicaltrials.gov NCT03014817) - Gabriel Sandblom

Study of learning curve during introduction of ultrasonographic dissection in gallstone surgery (clinicaltrials.gov NCT03154164) - Gabriel Sandblom

Randomised controlled trial of percutaneous drainage versus aspiration in acute cholecystitis (clinicaltrials.gov NCT03012243) - Gabriel Sandblom

Articles

An interprofessional initiative aimed at creating a common learning resource for the operating room ward.
Torbjörnsson E, Olivecrona C, Sondén A
J Interprof Care 2018 Jul;32(4):501-504

Peptic ulcer disease.
Sverdén E, Agréus L, Dunn JM, Lagergren J
BMJ 2019 Oct;367():l5495

Acute upper gastrointestinal bleeding.
Sverdén E, Markar SR, Agreus L, Lagergren J
BMJ 2018 Oct;363():k4023

Transcatheter Arterial Embolization Compared With Surgery for Uncontrolled Peptic Ulcer Bleeding: A Population-based Cohort Study.
Sverdén E, Mattsson F, Lindström D, Sondén A, Lu Y, Lagergren J
Ann Surg 2019 02;269(2):304-309

Call the On-Call: a study of student learning on an interprofessional training ward.
Ivarson J, Zelic L, Sondén A, Samnegård E, Bolander Laksov K
J Interprof Care 2020 Feb;():1-9

Is out-of-hours cholecystectomy for acute cholecystitis associated with complications?
Gustafsson C, Dahlberg M, Sondén A, Järnbert-Pettersson H, Sandblom G
Br J Surg 2020 Sep;107(10):1313-1323

Acute surgery

At the department of acute surgery and abdominal wall surgery acute abdominal conditions are managed, e.g. appendicitis, acute pancreatitis and cholecystitis. Planned hernia surgery is also performed at the department. A number of studies focused on acute gastrointestinal conditions and abdominal wall surgery are conducted at the section.

Research group leader

Gabriel Sandblom, Associate professor, senior lecturer

Group members

Martin Nordberg, Registrar, Section manager

Leonard Clay, Registrar, Department of surgery, Södersjukhuset

Per Lindström, Surgeon specialist, Södersjukhuset

Göran Rietz, Registrar, Department of surgery, Södersjukhuset

Ruth Kalvelage, Surgeon specialist, Södersjukhuset

Lennart Boström, Chief physician, Docent

Projects

Randomised controlled trial comparing conventional closure with reinforcement with resorbable mesh (PrevMesh, clincaltrials.gov NCT02487134)

Randomised controlled trial comparing conventional closure of the defect with peritoneal bridging in laparoscopic surgery for ventral hernias (clinicaltrials.gov NCT03344575)

Studies of conventional versus robot-assisted laparoscopic surgery for ventral hernias and groin hernias

Randomised controlled trial for evaluating the benefit of intraoperative cholangiography in uncomplicated gallstone surgery

Prospective registration of pancreatic cysts and premalignant lesions incidentally detected at computer tomography

Artificial intelligence for assessing the course of acute pancreatitis

Full-thickness skin graft in surgery for ventral hernias

Register-based studies of cardiovascular complications in hernia surgery

Studies of risk factors and incidence of incisional hernias and wound dehiscence following abdominal surgery

Study of a smartphone application and virtual simulators for enhancing surgical skills training

Studies of surgery for abdominal rectus diastasis

Register-based studies of complications following hernia surgery

Prospective registration of patients undergoing surgery for appendicitis

Validation of a patient reported outcome measure intended for patients with acute pancreatitis

Trauma in elderly. Study based on the Swedish National Trauma Register (SweTrau) - Martin Nordberg, Andreas Älgå, Lennart Boström

Long-term effects of traumatic brain injury - Olivia Kiwanuka, Lennart Boström

Traumatic brain injury and multitrauma in combination - Olivia Kiwanuka, Lennart Boström

Complications after appendectomy - Petter Nyström, Martin Dahlberg, Martin Nordberg, Lennart Boström

Outcome after out-of-hours appendectomy - Petter Nyström, Martin Dahlberg, Martin Nordberg, Lennart Boström

Hyponatremia and appendectomy in young patients - Petter Nyström, Martin Dahlberg

Articles

Intervention versus surveillance in patients with common bile duct stones detected by intraoperative cholangiography: a population-based registry study.
Johansson E, Österberg J, Sverdén E, Enochsson L, Sandblom G
Br J Surg 2021 12;108(12):1506-1512

Learning by doing: an observational study of the learning curve for ultrasonic fundus-first dissection in elective cholecystectomy.
Blohm M, Sandblom G, Enochsson L, Cengiz Y, Austrums E, Abdon E, Hennings J, Hedberg M, Gustafsson U, Diaz-Pannes A, Österberg J
Surg Endosc 2022 06;36(6):4602-4613

Negative pressure wound therapy versus standard treatment in patients with acute conflict-related extremity wounds: a pragmatic, multisite, randomised controlled trial.
Älgå A, Haweizy R, Bashaireh K, Wong S, Lundgren KC, von Schreeb J, et al
Lancet Glob Health 2020 03;8(3):e423-e429

Antibiotic prophylaxis in acute cholecystectomy revisited: results of a double-blind randomised controlled trial.
Jaafar G, Sandblom G, Lundell L, Hammarqvist F
Langenbecks Arch Surg 2020 Dec;405(8):1201-1207

Analysis of Scientific Publications During the Early Phase of the COVID-19 Pandemic: Topic Modeling Study.
Älgå A, Eriksson O, Nordberg M
J Med Internet Res 2020 11;22(11):e21559

Plasma Sodium and Age Are Important Markers of Risk of Perforation in Acute Appendicitis.
Heymowski A, Boström L, Dahlberg M
J Gastrointest Surg 2020 Aug;():