Gastrointestinal Surgery KI SÖS
Research group leader
Gabriel Sandblom
Associate professor, senior lecturerColorectal surgery
The research at the colorectal department is focused on colorectal cancer, inflammatory bowel diseases and anal fistulas. Since 2005 we have a local register for colorectal cancer (KVALOG). The register also covers patients undergoing surgery for benign conditions (e.g. proctologic procedures, diverticular diseases and colorectal polyps) from 2011 . Since 2017, all patients undergoing rectal surgery are recorded according to a fast track program based on the same principals as ERAS (Enhanced recovery after surgery) called ERASS (ERAS Sös).
Group members
Åsa Hallqvist Everhov, Docent, Head of the colorectal group
Göran Heinius, PhD
Deborah Saraste, PhD
Karolina Eklöv, PhD student
Collaborations
Martin Janson, PhD
Helene Klinglöf, PhD student
Ulla-Maria Gustafsson, PhD
Anna Lindelius, PhD
Martin Dahlberg, PhD
Emil Pieniowski, PhD
Torbjörn Holm, Professor
Projects
STAR-TREC: Can we Save the rectum by Watchful waiting or TransAnal microsurgery following (chemo) Radiotherapy versus Total mesorectal excision for early Rectal Cancer?
Randomized international multicenter study. Includes patients with rectal cancer cT1-T3bN0M0. Patients are randomized to TME surgery or organ-sparing surgery with chemoradiotherapy or radiotherapy alone.
EROS: Early intervention and recovery of sexual function in men and women after treatment of rectal cancer– a randomized controlled study with tadalafil compared to standard care.
Includes patients with rectal cancer stages I-III. Measures change in sexual function from start of treatment to24 months postoperatively with/without Tadalafil.
PHALIR (ClinicalTrials.gov Identifier: NCT03720262): Sublay mesh or suturing after closure of loop-ileostomy – Karolina Eklöv, Åsa Hallqvist Everhov
Colorectal surgery in Addis Ababa - Karolina Eklöv, Åsa H Everhov
Position of ostomy for deviation in patients with obstructing cancer in descending colon – Karolina Eklöv, Åsa H Everhov
Population-based studies of inflammatory bowel disease – Åsa H Everhov
Is ischemic colitis ischemic? Epidemiological studies of idiopathic colon ischemia - Helene Klinglöf, Åsa Everhov
Non-operative, antibiotic-free management of children with appendicitis. A cohort study of children aged 10-14 treated for suspected appendicitis - Johan Stormdal-Starck, Martin Dahlberg
Postoperative complications and acute operations in colorectal cancer patients <50 years - Ida Gutlic, Deborah Saraste, Anna Martling, Caroline Nordenvall, Marie-Louise Lydrup, Pamela Buchwald
Can increased comorbidity due to inflammatory, metabolic and cancer disease explain the increase in the incidence of CRC in patients under 50 years of age in Sweden? - Erik Lundqvist, Deborah Saraste, Anna Martling, Karin Ekström Smedby, Caroline Nordenvall, Staffan Haapaniemi, Kalle Landerholm, Pär Myrelid
Evaluation of disease-specific mortality in the screening program for colorectal cancer in the Stockholm-Gotland region - Deborah Saraste, Johannes Blom, Sven Törnberg, Håkan Jonsson
Participation and experience of colorectal cancer screening - Hanna Heyman, Deborah Saraste, Johannes Blom
Colorectal cancer in patients ≥ 80 years: quality of life, health care use and survival - Deborah Saraste, Åsa Hallqvist Everhov, Göran Heinius, Torbjörn Holm
Articles
Characteristics of Early-Onset vs Late-Onset Colorectal Cancer: A Review.
REACCT collaborative
JAMA Surg 2021 09;156(9):865-874
Decompressing Stoma vs Stent in Left-Sided Obstructive Colon Cancer.
Hallqvist-Everhov Å, Asplund J, Dahlberg M
JAMA Surg 2020 08;155(8):788
Interval cancers in a population-based screening program for colorectal cancer with gender-specific cut-off levels for fecal immunochemical test.
Ribbing Wilén H, Saraste D, Blom J
J Med Screen 2022 Sep;29(3):156-165
Trends in Treatment of Colorectal Cancer and Short-term Outcomes During the First Wave of the COVID-19 Pandemic in Sweden.
Eklöv K, Nygren J, Bringman S, Löfgren J, Sjövall A, Nordenvall C, Everhov ÅH
JAMA Netw Open 2022 05;5(5):e2211065
Colorectal cancer in elderly-onset inflammatory bowel disease: a 1969-2017 Scandinavian register-based cohort study.
Everhov ÅH, Erichsen R, Järås J, Pedersen L, Halfvarson J, Askling J, Ekbom A, Ludvigsson JF, Toft Sørensen H, Olén O
Aliment Pharmacol Ther 2022 Oct;56(7):1168-1182
A Randomized Controlled Clinical Trial of Transanal Irrigation Versus Conservative Treatment in Patients With Low Anterior Resection Syndrome After Rectal Cancer Surgery.
Pieniowski EHA, Bergström CM, Nordenvall CAM, Westberg KS, Johar AM, Tumlin Ekelund SF, Larsson KR, Pekkari KJ, Jansson Palmer GC, Lagergren P, Abraham-Nordling M
Ann Surg 2022 Jul;():
Upper Gastrointestinal Surgery group / Abdominal wall surgery
The group runs studies aimed at improving diagnostics and treatment of diseases in the upper gastrointestinal canal. The projects are mainly focused on gallstone disease, acute pancreatitis, obesity, peptic ulcer disease and ultrasonographic diagnostics.
Group members
Thorhallur Agustsson, Head of the upper gastrointestinal group
Anders Sondén, Associate Professor, Senior Lecturer
Emma Sverdén, MD, Post-doc
Martin Dahlberg, MD, PhD, Post-doc
Åsa Edergren, MD, Phd student
Rebecka Zacharias, MD, PhD student (Complications and gallstone surgery)
Andreas Älgå, MD, Post-doc
Göran Rietz, PhD Student
Ivan Ernudd, PhD Student
Blend Fathalla Ali, PhD Student
Collaborations
Magdalena Plecka Östlund, MD. PhD., Post-doc
Jesper Lagergren, Professor, Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery (MMK), K1, KI
Ulf Gunnarsson, Professor, Umeå University
Mikael Rydén, Professor, Unit for Endocrinology and Diabetes, Department of Medicine, Huddinge (MedH), H7, KI
Staffan Holmin, Professor, Department of Clinical Neuroscience, KI
Magnus Nilsson, Professor, Unit of Surgery, Department of Clinical Science, Intervention and Technology, KI
Klara Bolander Laksov, Associate Professor, Department of education, Stockholm University
Bengt Isaksson, Professor, Department of Surgical Sciences, Uppsala University
Cecilia Strömberg, MD, PhD, Unit of Surgery, Department of Clinical Science, Intervention and Technology, KI
Projects
Authentic teamwork and interprofessional communication at the clinical training wards - Anders Sondén
”Point-of Care-Ultrasound” and gallstone disease - Anders Sondén
Shortened hospital stay for patients with mild acute pancreatitis – Thorhallur Agustsson
Development of endoscopic treatment methods in acute pancreatitis – Anders Sondén
Complications following gallstone surgery (in collaboration with Professor Nilsson, CLINTEC, KI) – Anders Sondén
Regional anesthesia and surgery – Thorhallur Agustsson
Lipid metabolism - Thorhallur Agustsson
Randomised controlled trial of ultrasonographic dissection versus electrocautery in surgery for acute cholecystitis (clinicaltrials.gov NCT03014817) - Gabriel Sandblom
Study of learning curve during introduction of ultrasonographic dissection in gallstone surgery (clinicaltrials.gov NCT03154164) - Gabriel Sandblom
Randomised controlled trial of percutaneous drainage versus aspiration in acute cholecystitis (clinicaltrials.gov NCT03012243) - Gabriel Sandblom
Articles
An interprofessional initiative aimed at creating a common learning resource for the operating room ward.
Torbjörnsson E, Olivecrona C, Sondén A
J Interprof Care 2018 Jul;32(4):501-504
Peptic ulcer disease.
Sverdén E, Agréus L, Dunn JM, Lagergren J
BMJ 2019 Oct;367():l5495
Acute upper gastrointestinal bleeding.
Sverdén E, Markar SR, Agreus L, Lagergren J
BMJ 2018 Oct;363():k4023
Transcatheter Arterial Embolization Compared With Surgery for Uncontrolled Peptic Ulcer Bleeding: A Population-based Cohort Study.
Sverdén E, Mattsson F, Lindström D, Sondén A, Lu Y, Lagergren J
Ann Surg 2019 02;269(2):304-309
Call the On-Call: a study of student learning on an interprofessional training ward.
Ivarson J, Zelic L, Sondén A, Samnegård E, Bolander Laksov K
J Interprof Care 2020 Feb;():1-9
Is out-of-hours cholecystectomy for acute cholecystitis associated with complications?
Gustafsson C, Dahlberg M, Sondén A, Järnbert-Pettersson H, Sandblom G
Br J Surg 2020 Sep;107(10):1313-1323
Acute surgery
At the department of acute surgery and abdominal wall surgery acute abdominal conditions are managed, e.g. appendicitis, acute pancreatitis and cholecystitis. Planned hernia surgery is also performed at the department. A number of studies focused on acute gastrointestinal conditions and abdominal wall surgery are conducted at the section.
Research group leader
Gabriel Sandblom, Associate professor, senior lecturer
Group members
Leonard Clay, Registrar, Department of surgery, Södersjukhuset
Lennart Boström, Chief physician, Docent
Carl-Jacob Khailat Holmberg, PhD Student
Olivia Kiwanuka, PhD Student
Projects
Randomised controlled trial comparing conventional closure with reinforcement with resorbable mesh (PrevMesh, clincaltrials.gov NCT02487134)
Randomised controlled trial comparing conventional closure of the defect with peritoneal bridging in laparoscopic surgery for ventral hernias (clinicaltrials.gov NCT03344575)
Studies of conventional versus robot-assisted laparoscopic surgery for ventral hernias and groin hernias
Randomised controlled trial for evaluating the benefit of intraoperative cholangiography in uncomplicated gallstone surgery
Prospective registration of pancreatic cysts and premalignant lesions incidentally detected at computer tomography
Artificial intelligence for assessing the course of acute pancreatitis
Full-thickness skin graft in surgery for ventral hernias
Register-based studies of cardiovascular complications in hernia surgery
Studies of risk factors and incidence of incisional hernias and wound dehiscence following abdominal surgery
Study of a smartphone application and virtual simulators for enhancing surgical skills training
Studies of surgery for abdominal rectus diastasis
Register-based studies of complications following hernia surgery
Prospective registration of patients undergoing surgery for appendicitis
Validation of a patient reported outcome measure intended for patients with acute pancreatitis
Trauma in elderly. Study based on the Swedish National Trauma Register (SweTrau) - Martin Nordberg, Andreas Älgå, Lennart Boström
Long-term effects of traumatic brain injury - Olivia Kiwanuka, Lennart Boström
Traumatic brain injury and multitrauma in combination - Olivia Kiwanuka, Lennart Boström
Complications after appendectomy - Petter Nyström, Martin Dahlberg, Martin Nordberg, Lennart Boström
Outcome after out-of-hours appendectomy - Petter Nyström, Martin Dahlberg, Martin Nordberg, Lennart Boström
Hyponatremia and appendectomy in young patients - Petter Nyström, Martin Dahlberg
Articles
Intervention versus surveillance in patients with common bile duct stones detected by intraoperative cholangiography: a population-based registry study.
Johansson E, Österberg J, Sverdén E, Enochsson L, Sandblom G
Br J Surg 2021 12;108(12):1506-1512
Learning by doing: an observational study of the learning curve for ultrasonic fundus-first dissection in elective cholecystectomy.
Blohm M, Sandblom G, Enochsson L, Cengiz Y, Austrums E, Abdon E, Hennings J, Hedberg M, Gustafsson U, Diaz-Pannes A, Österberg J
Surg Endosc 2022 06;36(6):4602-4613
Negative pressure wound therapy versus standard treatment in patients with acute conflict-related extremity wounds: a pragmatic, multisite, randomised controlled trial.
Älgå A, Haweizy R, Bashaireh K, Wong S, Lundgren KC, von Schreeb J, et al
Lancet Glob Health 2020 03;8(3):e423-e429
Antibiotic prophylaxis in acute cholecystectomy revisited: results of a double-blind randomised controlled trial.
Jaafar G, Sandblom G, Lundell L, Hammarqvist F
Langenbecks Arch Surg 2020 Dec;405(8):1201-1207
Analysis of Scientific Publications During the Early Phase of the COVID-19 Pandemic: Topic Modeling Study.
Älgå A, Eriksson O, Nordberg M
J Med Internet Res 2020 11;22(11):e21559
Plasma Sodium and Age Are Important Markers of Risk of Perforation in Acute Appendicitis.
Heymowski A, Boström L, Dahlberg M
J Gastrointest Surg 2020 Aug;():