Translational cardiac and skeletal muscle physiology

We perform translational studies on heart and skeletal muscle diseases. An important focus of the research is to understand the mechanisms that link rheumatic diseases and heart failure.

The studies utilize mouse models, patient materials and clinical data to better understand the disease processes of heart dysfunction in rheumatic disease.

The experimental studies are performed at FYFA in collaboration with the rheumatology clinic and the Heart and vascular theme at Karolinska University Hospital.

Group members

Daniel Andersson, Associate Professor, Research group leader

Arturo Eduardo Uribe Gonzales, PhD student

Cecilia Landberg, PhD student

Gianluigi Pironti, Researcher

Victoria Wyckelsma, Postdoc

Selected Publications

Maternal androgen excess induces cardiac hypertrophy and left ventricular dysfunction in female mice offspring.
Manti M, Fornes R, Pironti G, McCann Haworth S, Zhengbing Z, Benrick A, et al
Cardiovascular Research, August 2019;

Three weeks of sprint interval training improved high-intensity cycling performance and limited ryanodine receptor modifications in recreationally active human subjects.
Schlittler M, Neyroud D, Tanga C, Zanou N, Kamandulis S, Skurvydas A, et al
European Journal of Applied Physiology, June 2019;119(9):1951-1958

Intact single muscle fibres from SOD1G93A amyotrophic lateral sclerosis mice display preserved specific force, fatigue resistance and training-like adaptations.
Cheng AJ, Allodi I, Chaillou T, Schlittler M, Ivarsson N, Lanner JT, et al
The Journal of Physiology (London), May 2019;597(12):3133-3146

Cardiomyopathy, oxidative stress and impaired contractility in a rheumatoid arthritis mouse model.
Pironti G, Bersellini-Farinotti A, Agalave NM, Sandor K, Fernandez-Zafra T, Jurczak A, et al
Heart (British Cardiac Society), May 2018;104(24):2026-2034

Association Between Rheumatoid Arthritis and Risk of Ischemic and Nonischemic Heart Failure.
Mantel Ä, Holmqvist M, Andersson DC, Lund LH, Askling J
Journal of the American College of Cardiology, March 2017;69(10):1275-1285