Gianluigi Pironti
About me
Leading research projects aimed to develop new therapies for Heart Failure (HF) and cardiovascular diseases (CVDs) using the state-of-the-art methodologies in preclinical research to assess cardiac function both invasively (PV-loop) and not invasively (echocardiography) in small and large animal models of HF and CVDs. Investigating at cellular level the excitation-contraction coupling by measuring Ca2+ signaling and electrophysiology in cardiomyocytes.
The research activity is carried out through collaborative work between different research groups located within and outside Karolinska Institutet.
Research
Research focused on investigating the molecular mechanisms and pathophysiology underlying heart failure,
- ischemic heart disease,
- diabetic and inflammatory cardiomyopathies. The aim is to uncover novel therapeutic targets enabling the development of therapies able to modulate cardiac inotropy, fibrosis and inflammation.
Teaching
Lead teacher of Cardiovascular module in Translational Physiology and Pharmacology Master program (MTPP) and lead teacher of Cardiovascular pharmacology in project work in Translational Physiology and Pharmacology.
Teaching Physiology, Cardiovascular Pharmacology and local anesthetics classes to medical, biomedicine and undergraduate students.
Articles
- Article: ESC HEART FAILURE. 2024;11(1):601-605
- Journal article: EUROPEAN HEART JOURNAL. 2023;44:ehad655.760
- Article: EUROPEAN HEART JOURNAL. 2023;44(22):2009-2025
- Article: ACTA PHYSIOLOGICA. 2022;236(3):e13869
- Article: THE FASEB JOURNAL. 2021;35(12):e22010
- Article: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2021;9:640723
- Article: CARDIOVASCULAR RESEARCH (CVR). 2020;116(3):619-632
- Journal article: JOURNAL OF THE ENDOCRINE SOCIETY. 2019;3(Supplement_1):mon-217
- Article: HEART. 2018;104(24):2026-2034
- Article: HYPERTENSION. 2018;71(3):507-517
- Article: BASIC RESEARCH IN CARDIOLOGY. 2016;111(3):34
- Article: SCIENCE TRANSLATIONAL MEDICINE. 2015;7(319):319ra207
- Article: CARDIOVASCULAR RESEARCH (CVR). 2015;107(4):431-441
- Journal article: CIRCULATION RESEARCH. 2015;117(suppl_1)
- Article: CIRCULATION. 2015;131(24):2120-2130
- Journal article: CIRCULATION RESEARCH. 2014;115(suppl_1)
- Article: CIRCULATION RESEARCH. 2014;115(2):273-283
- Article: CIRCULATION RESEARCH. 2014;114(5):833-844
- Article: PLOS ONE. 2014;9(9):e106024
- Article: APOPTOSIS : AN INTERNATIONAL JOURNAL ON PROGRAMMED CELL DEATH. 2013;18(10):1252-1261
- Article: JOURNAL OF THE AMERICAN HEART ASSOCIATION. 2013;2(3):e000086
- Article: BIOINSPIRED, BIOMIMETIC AND NANOBIOMATERIALS. 2013;2(1):20-27
- Article: BASIC RESEARCH IN CARDIOLOGY. 2012;107(5):296
- Article: BASIC RESEARCH IN CARDIOLOGY. 2011;106(4):577-589
- Article: HYPERTENSION. 2010;55(1):137-143
- Article: JOURNAL OF CARDIOVASCULAR MEDICINE. 2009;10(11):861-865
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All other publications
- Letter: EUROPEAN JOURNAL OF HEART FAILURE. 2023;25(11):2093-2095
- Review: FRONTIERS IN CARDIOVASCULAR MEDICINE. 2023;10:1228789
- Conference publication: EUROPEAN JOURNAL OF HEART FAILURE. 2021;23:31
- Conference publication: EUROPEAN JOURNAL OF HEART FAILURE. 2020;22:4
- Editorial comment: FRONTIERS IN PHYSIOLOGY. 2020;11:641771
- Conference publication: ACTA PHYSIOLOGICA. 2017;219:20-21
- Conference publication: ACTA PHYSIOLOGICA. 2017;219:16-17
- Meeting abstract: FREE RADICAL BIOLOGY AND MEDICINE. 2016;100:S186
- Conference publication: BIOPHYSICAL JOURNAL. 2016;110(3):598A-599A
- Conference publication: EUROPEAN HEART JOURNAL. 2016;37:707
- Conference publication: CIRCULATION RESEARCH. 2015;117
- Conference publication: CIRCULATION RESEARCH. 2014;115
- Review: AMERICAN JOURNAL OF PHYSIOLOGY. HEART AND CIRCULATORY PHYSIOLOGY. 2011;300(6):H1983-H1989
- Conference publication: CIRCULATION. 2011;124(21)
- Conference publication: CIRCULATION. 2011;124(21)
- Conference publication: CIRCULATION. 2011;124(21)
- Conference publication: CIRCULATION. 2009;120(18):S814
- Conference publication: CIRCULATION. 2009;120(18):S1167
Employments
- Senior Research Specialist, Department of Medicine, Karolinska Institutet, 2022-
- Senior Research Specialist, Department of Physiology and Pharmacology, Karolinska Institutet, 2023-2025