Jan Hillert's research group

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Neuroepidemiology with focus on multiple sclerosis

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system affecting more than two million people world-wide. MS is the second most common cause of neurological disability in young adults. The disease progression varies between patients but often causes different degrees of disability.

In the MS epidemiology research group, we use data from the Swedish MS registry on its own or linked to data from public databases such as Statistics Sweden, National Board of Health and Welfare and Swedish Social Insurance Agency in order to perform epidemiological studies related to MS. Access to these large data collections allows as to conduct research projects into MS outcomes with the aim of describing how MS patients fare over time as regards disease progression, treatment regimens and socioeconomic outcomes. Our studies will hopefully contribute to increased knowledge of factors influencing MS disease and socioeconomic burden of MS with the ultimate ambition of providing the basis for an improved and cost effective healthcare for MS patients.

Our research group consists of molecular biologists, epidemiologists and neurologists. 

Research Projects

  • Basic epidemiology
    Incidence and prevalence of MS in Sweden, MS geographical distribution and changes over time in incidence and prevalence of MS
  • Treatment studies (pharmacoepidemiology)
    Patterns of treatment initiation, switch, escalation and discontinuation, types of treatment, adverse effects and treatment efficacy
  • Health economy and societal consequences of MS
    Cost of MS, sickness absence, disability pension, earnings
  • Clinical course of MS
    Progression of disability and impairment in different types of MS, investigations on causes and course of pediatric MS, and factors influencing disease progression

Selected publications

Age Related Multiple Sclerosis Severity Score: Disability ranked by age.
Manouchehrinia A, Westerlind H, Kingwell E, Zhu F, Carruthers R, Ramanujam R, et al
Mult. Scler. 2017 Dec;23(14):1938-1946

Income in Multiple Sclerosis Patients with Different Disease Phenotypes.
Kavaliunas A, Manouchehrinia A, Danylaite Karrenbauer V, Gyllensten H, Glaser A, Alexanderson K, et al
PLoS ONE 2017 ;12(1):e0169460

Importance of early treatment initiation in the clinical course of multiple sclerosis.
Kavaliunas A, Manouchehrinia A, Stawiarz L, Ramanujam R, Agholme J, Hedström A, et al
Mult. Scler. 2017 Aug;23(9):1233-1240

A significant decrease in diagnosis of primary progressive multiple sclerosis: A cohort study.
Westerlind H, Stawiarz L, Fink K, Hillert J, Manouchehrinia A
Mult. Scler. 2016 07;22(8):1071-9

Earnings and Financial Compensation from Social Security Systems Correlate Strongly with Disability for Multiple Sclerosis Patients.
Kavaliunas A, Wiberg M, Tinghög P, Glaser A, Gyllensten H, Alexanderson K, et al
PLoS ONE 2015 ;10(12):e0145435

Effect of Smoking Cessation on Multiple Sclerosis Prognosis.
Ramanujam R, Hedström A, Manouchehrinia A, Alfredsson L, Olsson T, Bottai M, et al
JAMA Neurol 2015 Oct;72(10):1117-23

The Swedish MS registry – clinical support tool and scientific resource.
Hillert J, Stawiarz L
Acta Neurol. Scand. 2015 ;132(199):11-9

Identity-by-descent mapping in a Scandinavian multiple sclerosis cohort.
Westerlind H, Imrell K, Ramanujam R, Myhr K, Celius E, Harbo H, et al
Eur. J. Hum. Genet. 2015 May;23(5):688-92

Modest familial risks for multiple sclerosis: a registry-based study of the population of Sweden.
Westerlind H, Ramanujam R, Uvehag D, Kuja-Halkola R, Boman M, Bottai M, et al
Brain 2014 Mar;137(Pt 3):770-8

Group members

Sahl Khalid BedriPhD student
Omid BeikiAssociated
Anders BerglundAssociated
Stefanie BinzerPostdoc
Mabel CruzAssociated
Virginija Danylaité KarrenbauerAssociated
Katarina FinkAssociated
Sten FredriksonProfessor/senior physician
Anna GlaserProject manager
Jan HillertResearch team leader, Professor/senior physician
Kerstin ImrellAssociated
Eva-Carin JacobssonAssociated
Andrius KavaliunasPostdoc
Maria LantzAssociated, Postdoc
Jenny LinkDatabase coordinator
Karin LyckeResearch nurse
Ali ManouchehriniaPostdoc
Kyla McKayPostdoc
Ulrik Nilsson RantaGraduate Student
Rayomand PressAssociated
Sven PålhagenAssociated
Ryan RamanujamPostdoc
Kristin SamuelssonGraduate Student
Tim SpelmanAssistant professor
Leszek StawiarzGraduate Student, Project coordinator