Jonas Frisén's Group

Stem Cells in Tissue Homeostasis and Regenerative Medicine

Microscopic photograph of neural stem cells in the adult mouse spinal cord

We are interested in the role of stem cells in cell turnover in healthy and pathological situations. We study the identity of stem cells and the organization of cellular lineages, the molecular regulation of cell production and the role of cell renewal in homeostasis and pathological situations. Many of our projects focus on stem cells in the brain and spinal cord and adult neurogenesis.

We are also interested in cell renewal in the heart and use the intestine as a stem cell and cancer model system. We have developed a method to study cell turnover by analyzing the integration of 14C derived from nuclear bomb tests in DNA, and use this to assess cell renewal in humans.

Group Members

Selected Publications

Dynamics of oligodendrocyte generation in multiple sclerosis.
Yeung MSY, Djelloul M, Steiner E, Bernard S, Salehpour M, Possnert G, et al
Nature 2019 02;566(7745):538-542

Reducing Pericyte-Derived Scarring Promotes Recovery after Spinal Cord Injury.
Dias DO, Kim H, Holl D, Werne Solnestam B, Lundeberg J, Carlén M, et al
Cell 2018 03;173(1):153-165.e22

Visualization and analysis of gene expression in tissue sections by spatial transcriptomics.
Ståhl PL, Salmén F, Vickovic S, Lundmark A, Navarro JF, Magnusson J, et al
Science 2016 Jul;353(6294):78-82

Dynamics of Cell Generation and Turnover in the Human Heart.
Bergmann O, Zdunek S, Felker A, Salehpour M, Alkass K, Bernard S, et al
Cell 2015 Jun;161(7):1566-75

A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse.
Magnusson JP, Göritz C, Tatarishvili J, Dias DO, Smith EM, Lindvall O, et al
Science 2014 Oct;346(6206):237-41