Jonas Frisén's Group

Stem Cells in Tissue Homeostasis and Regenerative Medicine

We are interested in the role of stem cells in cell turnover in healthy and pathological situations. We study the identity of stem cells and the organization of cellular lineages, the molecular regulation of cell production and the role of cell renewal in homeostasis and pathological situations. Many of our projects focus on stem cells in the brain and spinal cord and adult neurogenesis.

We are also interested in cell renewal in the heart and use the intestine as a stem cell and cancer model system. We have developed a method to study cell turnover by analyzing the integration of 14C derived from nuclear bomb tests in DNA, and use this to assess cell renewal in humans.

Group Members

Johanna ClassonPhD student, Graduate Student
Ilke DemirciPhD student, Graduate Student
David DiasGraduate Student
Ionut DumitruPostdoc
Camilla EngblomPostdoc
Jonas FrisénProfessor
Sarantis GiatrellisResearch engineer
Hagen HuttnerAssociated
Joanna HårdPhD student, Graduate Student
Enric LlorensPostdoc
Helena LönnqvistLaboratory engineer
Jens MagnussonAssociated
Jeff MoldSenior lab manager
Marta PaterliniSenior researcher
Michael RatzPostdoc
Giuseppe SantopoloPhD student, Graduate Student
Christian ScharenbergAssociated
Embla SteinerPhD student, Graduate Student
Moa StenuddPhD student, Graduate Student
Mathew TataPostdoc
Marcelo ToroAssociated
Leonie Von BerlinResearch assistant
Maggie YeungPostdoc
Margherita ZamboniPhD student, Graduate Student

Selected Publications

A pericyte origin of spinal cord scar tissue.
Göritz C, Dias D, Tomilin N, Barbacid M, Shupliakov O, Frisén J
Science 2011 Jul;333(6039):238-42

Origin of new glial cells in intact and injured adult spinal cord.
Barnabé-Heider F, Göritz C, Sabelström H, Takebayashi H, Pfrieger F, Meletis K, et al
Cell Stem Cell 2010 Oct;7(4):470-82

Dissociation of EphB2 signaling pathways mediating progenitor cell proliferation and tumor suppression.
Genander M, Halford M, Xu N, Eriksson M, Yu Z, Qiu Z, et al
Cell 2009 Nov;139(4):679-92

Evidence for cardiomyocyte renewal in humans.
Bergmann O, Bhardwaj R, Bernard S, Zdunek S, Barnabé-Heider F, Walsh S, et al
Science 2009 Apr;324(5923):98-102

Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke.
Carlén M, Meletis K, Göritz C, Darsalia V, Evergren E, Tanigaki K, et al
Nat. Neurosci. 2009 Mar;12(3):259-67

Developmental BiologyRegenerative MedicineStem Cell BiologyStem cells