Jonas Frisén

About me
Publications
CV
Public outreach and news

About me

Professor of Stem Cell Research.

Research

We are interested in the role of stem cells in cell turnover in healthy and pathological situations. We study the identity of stem cells and the organization of cellular lineages, the molecular regulation of cell production and the role of cell renewal in homeostasis and pathological situations. Many of our projects focus on stem cells in the brain and spinal cord and adult neurogenesis. We are also interested in cell renewal in the heart and use the intestine as a stem cell and cancer model system. We have developed a method to study cell turnover by analyzing the integration of 14C derived from nuclear bomb tests in DNA, and use this to assess cell renewal in humans.

Articles

Article: GENOME BIOLOGY. 2024;25(1):214
Inferring clonal somatic mutations directed by X chromosome inactivation status in single cells
Demirci I; Larsson AJM; Chen X; Hartman J; Sandberg R; Frisen J
Article: CELL SYSTEMS. 2024;15(2):149-165.e10
Clonally heritable gene expression imparts a layer of diversity within cell types
Mold JE; Weissman MH; Ratz M; Hagemann-Jensen M; Hard J; Eriksson C-J; Toosi H; Berghenstrahle J; Ziegenhain C; von Berlin L; Martin M; Blom K; Lagergren J; Lundeberg J; Sandberg R; Michaeeurolsson J; Frisen J
Article: SCIENCE. 2023;382(6675):1137
Spatial transcriptomics of B cell and T cell receptors reveals lymphocyte clonal dynamics
Engblom C; Thrane K; Lin Q; Andersson A; Toosi H; Chen X; Steiner E; Lu C; Mantovani G; Hagemann-Jensen M; Saarenpaa S; Jangard M; Saez-Rodriguez J; Michaelsson J; Hartman J; Lagergren J; Mold JE; Lundeberg J; Frisen J
Journal article: BIORXIV. 2023;:2023.09.14.557681
A latent cardiomyocyte regeneration potential in human heart disease.
Derks W; Rode J; Collin S; Rost F; Heinke P; Hariharan A; Pickel L; Simonova I; Lázár E; Graham E; Jashari R; Andrä M; Jeppsson A; Salehpour M; Alkass K; Druid H; Kyriakopoulos CP; Taleb I; Shankar TS; Selzman CH; Sadek H; Jovinge S; Brusch L; Frisén J; Drakos S; Bergmann O
Article: NATURE BIOTECHNOLOGY. 2023;41(8):1085-1088
Solid-phase capture and profiling of open chromatin by spatial ATAC
Llorens-Bobadilla E; Zamboni M; Marklund M; Bhalla N; Chen X; Hartman J; Frisen J; Stahl PL
Article: NATURE COMMUNICATIONS. 2023;14(1):2184
DRAG in situ barcoding reveals an increased number of HSPCs contributing to myelopoiesis with age
Urbanus J; Cosgrove J; Beltman JBB; Elhanati Y; Moral RAA; Conrad C; van Heijst JWW; Tubeuf E; Velds A; Kok L; Merle C; Magnusson JPP; Guyonnet L; Frisen J; Fre S; Walczak AMM; Mora T; Jacobs H; Schumacher TNN; Perie L
Article: HIPPOCAMPUS. 2023;33(4):391-401
Early fate bias in neuroepithelial progenitors of hippocampal neurogenesis
von Berlin L; Westholm JO; Ratz M; Frisen J
Article: DEVELOPMENTAL CELL. 2023;58(3):239-255.e10
An ependymal cell census identifies heterogeneous and ongoing cell maturation in the adult mouse spinal cord that changes dynamically on injury
Albors AR; Singer GA; Llorens-Bobadilla E; Frisen J; May AP; Ponting CP; Storey KG
Article: MOLECULAR ONCOLOGY. 2022;16(19):3452-3464
Prostate cancer disease recurrence after radical prostatectomy is associated with HLA type and local cytomegalovirus immunity
Classon J; Zamboni M; Engblom C; Alkass K; Mantovani G; Pou C; Nkulikiyimfura D; Brodin P; Druid H; Mold J; Frisen J
Article: NATURE NEUROSCIENCE. 2022;25(3):285-294
Clonal relations in the mouse brain revealed by single-cell and spatial transcriptomics
Ratz M; von Berlin L; Larsson L; Martin M; Westholm JO; La Manno G; Lundeberg J; Frisen J
Article: CELL REPORTS. 2022;38(9):110440
Identification of a discrete subpopulation of spinal cord ependymal cells with neural stem cell properties
Stenudd M; Sabelstrom H; Llorens-Bobadilla E; Zamboni M; Blom H; Brismar H; Zhang S; Basak O; Clevers H; Goritz C; Barnabe-Heider F; Frisen J
Article: NATURE COMMUNICATIONS. 2021;12(1):6012
Spatial deconvolution of HER2-positive breast cancer delineates tumor-associated cell type interactions
Andersson A; Larsson L; Stenbeck L; Salmen F; Ehinger A; Wu SZ; Al-Eryani G; Roden D; Swarbrick A; Borg A; Frisen J; Engblom C; Lundeberg J
Article: NATURE COMMUNICATIONS. 2021;12(1):5501
Pericyte-derived fibrotic scarring is conserved across diverse central nervous system lesions
Dias DO; Kalkitsas J; Kelahmetoglu Y; Estrada CP; Tatarishvili J; Holl D; Jansson L; Banitalebi S; Amiry-Moghaddam M; Ernst A; Huttner HB; Kokaia Z; Lindvall O; Brundin L; Frisen J; Goritz C
Article: CELL REPORTS. 2021;35(8):109174
Divergent clonal differentiation trajectories establish CD8⁺ memory T cell heterogeneity during acute viral infections in humans
Mold JE; Modolo L; Hard J; Zamboni M; Larsson AJM; Stenudd M; Eriksson C-J; Durif G; Stahl PL; Borgstrom E; Picelli S; Reinius B; Sandberg R; Reu P; Talavera-Lopez C; Andersson B; Blom K; Sandberg JK; Picard F; Michaelsson J; Frisen J
Article: NATURE GENETICS. 2021;53(5):694-706
Single-cell transcriptomics of human embryos identifies multiple sympathoblast lineages with potential implications for neuroblastoma origin
Kameneva P; Artemov AV; Kastriti ME; Faure L; Olsen TK; Otte J; Erickson A; Semsch B; Andersson ER; Ratz M; Frisen J; Tischler AS; de Krijger RR; Bouderlique T; Akkuratova N; Vorontsova M; Gusev O; Fried K; Sundstrom E; Mei S; Kogner P; Baryawno N; Kharchenko PV; Adameyko I
Article: ONCOGENE. 2021;40(16):2830-2841
The age of adult pilocytic astrocytoma cells
Voronina N; Aichmueller C; Kolb T; Korshunov A; Ryzhova M; Barnholtz-Sloan J; Cioffi G; Sill M; von Deimling A; Pfister SM; Gronych J; Jones DTW; Frisen J; Zapatka M; Ernst A
Article: NATURE COMMUNICATIONS. 2020;11(1):5860
Distinct oligodendrocyte populations have spatial preference and different responses to spinal cord injury
Floriddia EM; Lourenco T; Zhang S; van Bruggen D; Hilscher MM; Kukanja P; dos Santos JPG; Altinkok M; Yokota C; Llorens-Bobadilla E; Mulinyawe SB; Graos M; Sun LO; Frisen J; Nilsson M; Castelo-Branco G
Article: SCIENCE. 2020;370(6512):73
A latent lineage potential in resident neural stem cells enables spinal cord repair
Llorens-Bobadilla E; Chell JM; Le Merre P; Wu Y; Zamboni M; Bergenstrahle J; Stenudd M; Sopova E; Lundeberg J; Shupliakov O; Carlen M; Frisen J
Article: CELL STEM CELL. 2020;27(4):605-617.e5
A Widespread Neurogenic Potential of Neocortical Astrocytes Is Induced by Injury
Zamboni M; Llorens-Bobadilla E; Magnusson JP; Frisen J
Article: ELIFE. 2020;9:e59733
Activation of a neural stem cell transcriptional program in parenchymal astrocytes
Magnusson JP; Zamboni M; Santopolo G; Mold JE; Barrientos-Somarribas M; Talavera-Lopez C; Andersson B; Frisen J
Article: CELLS. 2020;9(7):E1732-1732
Blocking Notch-Signaling Increases Neurogenesis in the Striatum after Stroke
Santopolo G; Magnusson JP; Lindvall O; Kokaia Z; Frisen J
Journal article: JOURNAL OF VISUALIZED EXPERIMENTS. 2020;(159)
Induction of Leptomeningeal Cells Modification Via Intracisternal Injection
Zamboni M; Santopolo G; Frisén J
Article: JOURNAL OF VISUALIZED EXPERIMENTS. 2020;(159)
Induction of Leptomeningeal Cells Modification Via Intracisternal Injection
Zamboni M; Santopolo G; Frisen J
Article: NATURE METHODS. 2019;16(10):987-990
High-definition spatial transcriptomics for in situ tissue profiling
Vickovic S; Eraslan G; Salmen F; Klughammer J; Stenbeck L; Schapiro D; Aijo T; Bonneau R; Bergenstrahle L; Navarro JF; Gould J; Griffin GK; Borg A; Ronaghi M; Frisen J; Lundeberg J; Regev A; Stahl PL
Article: PLOS BIOLOGY. 2019;17(10):e3000383
Cell generation dynamics underlying naive T-cell homeostasis in adult humans
Mold JE; Reu P; Olin A; Bernard S; Michaelsson J; Rane S; Yates A; Khosravi A; Salehpour M; Possnert G; Brodin P; Frisen J
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2019;39(7):1432-1447
Disruption of the Extracellular Matrix Progressively Impairs Central Nervous System Vascular Maturation Downstream of β-Catenin Signaling
Jensen LD; Hot B; Ramskold D; Germano RFV; Yokota C; Giatrellis S; Lauschke VM; Hubmacher D; Li MX; Hupe M; Arnold TD; Sandberg R; Frisen J; Trusohamn M; Martowicz A; Wisniewska-Kruk J; Nyqvist D; Adams RH; Apte SS; Vanhollebeke B; Stenman JM; Kele J
Article: GENOME BIOLOGY. 2019;20(1):68
Conbase: a software for unsupervised discovery of clonal somatic mutations in single cells through read phasing
Hard J; Al Hakim E; Kindblom M; Bjorklund AK; Sennblad B; Demirci I; Paterlini M; Reu P; Borgstrom E; Stahl PL; Michaelsson J; Mold JE; Frisen J
Article: NATURE BIOTECHNOLOGY. 2019;37(3):232-237
Regenerating the field of cardiovascular cell therapy
Chien KR; Frisen J; Fritsche-Danielson R; Melton DA; Murry CE; Weissman IL
Article: NATURE. 2019;566(7745):538-542
Dynamics of oligodendrocyte generation in multiple sclerosis
Yeung MSY; Djelloul M; Steiner E; Bernard S; Salehpour M; Possnert G; Brundin L; Frisen J
Article: NATURE PROTOCOLS. 2018;13(11):2501-2534
Barcoded solid-phase RNA capture for Spatial Transcriptomics profiling in mammalian tissue sections
Salmen F; Stahl PL; Mollbrink A; Navarro JF; Vickovic S; Frisen J; Lundeberg J
Article: LANCET NEUROLOGY. 2018;17(10):918-926
The hippocampus in multiple sclerosis
Rocca MA; Barkhof F; De Luca J; Frisen J; Geurts JJG; Hulst HE; Sastre-Garriga J; Filippi M
Article: CELL. 2018;173(1):153-165.e22
Reducing Pericyte-Derived Scarring Promotes Recovery after Spinal Cord Injury
Dias DO; Kim H; Holl D; Solnestam BW; Lundeberg J; Carlen M; Goritz C; Frisen J
Article: EBIOMEDICINE. 2018;27:176-181
Meningioma growth dynamics assessed by radiocarbon retrospective birth dating
Huttner HB; Bergmann O; Salehpour M; El Cheikh R; Nakamura M; Tortora A; Heinke P; Coras R; Englund E; Eyuepoglu IY; Kuramatsu JB; Roeder SS; Kloska SP; Muehlen I; Doerfler A; Schwab S; Possnert G; Bernard S; Frisen J
Article: CIRCULATION. 2017;136(7):680-686
Cardiomyocyte Regeneration A Consensus Statement
Eschenhagen T; Bolli R; Braun T; Field LJ; Fleischmann BK; Frisen J; Giacca M; Hare JM; Houser S; Lee RT; Marbn E; Martin JF; Molkentin JD; Murry CE; Riley PR; Ruiz-Lozano P; Sadek HA; Sussman MA; Hill JA
Article: CELL REPORTS. 2017;20(4):779-784
The Lifespan and Turnover of Microglia in the Human Brain
Reu P; Khosravi A; Bernard S; Mold JE; Salehpour M; Alkass K; Perl S; Tisdale J; Possnert G; Druid H; Frisen J
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2017;214(2):309-317
Antibody-secreting plasma cells persist for decades in human intestine
Landsverk OJB; Snir O; Casado RB; Richter L; Mold JE; Reu P; Horneland R; Paulsen V; Yaqub S; Aandahl EM; Oyen OM; Thorarensen HS; Salehpour M; Possnert G; Frisen J; Sollid LM; Baekkevold ES; Jahnsen FL
Article: PLOS ONE. 2017;12(2):e0171566
Comparison of whole genome amplification techniques for human single cell exome sequencing
Borgstrom E; Paterlini M; Mold JE; Frisen J; Lundeberg J
Article: NATURE GENETICS. 2016;48(11):1430-1435
Analysis of allelic expression patterns in clonal somatic cells by single-cell RNA-seq
Reinius B; Mold JE; Ramskold D; Deng Q; Johnsson P; Michaelsson J; Frisen J; Sandberg R
Article: EXPERIMENTAL CELL RESEARCH. 2016;348(1):10-22
Eph receptor interclass cooperation is required for the regulation of cell proliferation
Jurek A; Genander M; Kundu P; Catchpole T; He X; Straat K; Sabelstrom H; Xu N-J; Pettersson S; Henkemeyer M; Frisen J
Article: NATURE COMMUNICATIONS. 2016;7:13182
Massive and parallel expression profiling using microarrayed single-cell sequencing
Vickovic S; Stahl PL; Salmen F; Giatrellis S; Westholm JO; Mollbrink A; Navarro JF; Custodio J; Bienko M; Sutton L-A; Rosenquist R; Frisen J; Lundeberg J
Article: SCIENCE. 2016;353(6294):78-82
Visualization and analysis of gene expression in tissue sections by spatial transcriptomics
Stahl PL; Salmen F; Vickovic S; Lundmark A; Navarro JF; Magnusson J; Giacomello S; Asp M; Westholm JO; Huss M; Mollbrink A; Linnarsson S; Codeluppi S; Borg A; Ponten F; Costea PI; Sahlen P; Mulder J; Bergmann O; Lundeberg J; Frisen J
Article: CELL METABOLISM. 2015;22(3):408-417
Transplanted Bone Marrow-Derived Cells Contribute to Human Adipogenesis
Ryden M; Uzunel M; Hard JL; Borgstrom E; Mold JE; Arner E; Mejhert N; Andersson DP; Widlund Y; Hassan M; Jones CV; Spalding KL; Svahn B-M; Ahmadian A; Frisen J; Bernard S; Mattsson J; Arner P
Article: STEM CELL REPORTS. 2015;5(2):174-184
Alpha-Synuclein Expression in the Oligodendrocyte Lineage: an In Vitro and In Vivo Study Using Rodent and Human Models
Djelloul M; Holmqvist S; Boza-Serrano A; Azevedo C; Yeung MS; Goldwurm S; Frisen J; Deierborg T; Roybon L
Article: COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY. 2015;7(7):a018994
Adult Neurogenesis in Humans
Bergmann O; Spalding KL; Frisen J
Article: CELL. 2015;161(7):1566-1575
Dynamics of Cell Generation and Turnover in the Human Heart
Bergmann O; Zdunek S; Felker A; Salehpour M; Alkass K; Bernard S; Sjostrom SL; Szewczykowska M; Jackowska T; dos Remedios C; Malm T; Andrae M; Jashari R; Nyengaard JR; Possnert G; Jovinge S; Druid H; Frisen J
Article: SCIENCE TRANSLATIONAL MEDICINE. 2015;7(281):281ra44
An EphB-Abl signaling pathway is associated with intestinal tumor initiation and growth
Kundu P; Genander M; Straat K; Classon J; Ridgway RA; Tan EH; Bjork J; Martling A; van Es J; Sansom OJ; Clevers H; Pettersson S; Frisen J
Article: JOURNAL OF CLINICAL INVESTIGATION. 2015;125(3):1339-1346
Safety and tolerability of intracerebroventricular PDGF-BB in Parkinson's disease patients
Paul G; Zachrisson O; Varrone A; Almqvist P; Jerling M; Lind G; Rehncrona S; Linderoth B; Bjartmarz H; Shafer LL; Coffey R; Svensson M; Mercer KJ; Forsberg A; Halldin C; Svenningsson P; Widner H; Frisen J; Palhagen S; Haegerstrand A
Article: JAMA NEUROLOGY. 2015;72(2):235-237
Role of Endogenous Neural Stem Cells in Spinal Cord Injury and Repair
Stenudd M; Sabelstroem H; Frisen J
Article: PLOS BIOLOGY. 2015;13(1):e1002045
Adult Neurogenesis in Humans-Common and Unique Traits in Mammals
Ernst A; Frisen J
Article: CELL. 2014;159(4):766-774
Dynamics of Oligodendrocyte Generation and Myelination in the Human Brain
Yeung MSY; Zdunek S; Bergmann O; Bernard S; Salehpour M; Alkass K; Perl S; Tisdale J; Possnert G; Brundin L; Druid H; Frisen J
Article: SCIENCE. 2014;346(6206):237-241
A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse
Magnusson JP; Goritz C; Tatarishvili J; Dias DO; Smith EMK; Lindvall O; Kokaia Z; Frisen J
Article: NEURON. 2014;83(5):1085-1097
A Transcriptional Mechanism Integrating Inputs from Extracellular Signals to Activate Hippocampal Stem Cells
Andersen J; Urban N; Achimastou A; Ito A; Simic M; Ullom K; Martynoga B; Lebel M; Goritz C; Frisen J; Nakafuku M; Guillemot F
Article: NATURE NEUROSCIENCE. 2014;17(6):801-803
The age and genomic integrity of neurons after cortical stroke in humans
Huttner HB; Bergmann O; Salehpour M; Racz A; Tatarishvili J; Lindgren E; Csonka T; Csiba L; Hortobagyi T; Mehes G; Englund E; Solnestam BW; Zdunek S; Scharenberg C; Strom L; Stahl P; Sigurgeirsson B; Dahl A; Schwab S; Possnert G; Bernard S; Kokaia Z; Lindvall O; Lundeberg J; Frisen J
Article: CELL. 2014;156(5):1072-1083
Neurogenesis in the Striatum of the Adult Human Brain
Ernst A; Alkass K; Bernard S; Salehpour M; Perl S; Tisdale J; Possnert G; Druid H; Frisen J
Article: SCIENCE. 2013;342(6158):637-640
Resident Neural Stem Cells Restrict Tissue Damage and Neuronal Loss After Spinal Cord Injury in Mice
Sabelstrom H; Stenudd M; Reu P; Dias DO; Elfineh M; Zdunek S; Damberg P; Goritz C; Frisen J
Article: CELL. 2013;153(6):1219-1227
Dynamics of Hippocampal Neurogenesis in Adult Humans
Spalding KL; Bergmann O; Alkass K; Bernard S; Salehpour M; Huttner HB; Bostrom E; Westerlund I; Vial C; Buchholz BA; Possnert G; Mash DC; Druid H; Frisen J
Article: LAKARTIDNINGEN. 2012;109(41):1814
[2012 Nobel Prize in Physiology or Medicine. Nobel Prize for a life return ticket].
Frisén J
Article: NEURON. 2012;74(4):634-639
The Age of Olfactory Bulb Neurons in Humans
Bergmann O; Liebl J; Bernard S; Alkass K; Yeung MSY; Steier P; Kutschera W; Johnson L; Landen M; Druid H; Spalding KL; Frisen J
Article: SCIENCE. 2011;333(6039):238-242
A Pericyte Origin of Spinal Cord Scar Tissue
Goritz C; Dias DO; Tomilin N; Barbacid M; Shupliakov O; Frisen J
Article: CELL STEM CELL. 2011;8(4):426-433
Dopamine Controls Neurogenesis in the Adult Salamander Midbrain in Homeostasis and during Regeneration of Dopamine Neurons
Berg DA; Kirkham M; Wang H; Frisen J; Simon A
Article: EXPERIMENTAL CELL RESEARCH. 2011;317(2):188-194
Identification of cardiomyocyte nuclei and assessment of ploidy for the analysis of cell turnover
Bergmann O; Zdunek S; Alkass K; Druid H; Bernard S; Frisen J
Article: CELL STEM CELL. 2010;7(6):730-743
EphB Signaling Controls Lineage Plasticity of Adult Neural Stem Cell Niche Cells
Nomura T; Goritz C; Catchpole T; Henkemeyer M; Frisen J
Article: JOURNAL OF NEUROSCIENCE. 2010;30(41):13794-13807
RBPJκ-Dependent Signaling Is Essential for Long-Term Maintenance of Neural Stem Cells in the Adult Hippocampus
Ehm O; Goritz C; Covic M; Schaeffner I; Schwarz TJ; Karaca E; Kempkes B; Kremmer E; Pfrieger FW; Espinosa L; Bigas A; Giachino C; Taylor V; Frisen J; Lie DC
Article: CELL STEM CELL. 2010;7(4):470-482
Origin of New Glial Cells in Intact and Injured Adult Spinal Cord
Barnabe-Heider F; Goritz C; Sabelstrom H; Takebayashi H; Pfrieger FW; Meletis K; Frisen J
Article: CURRENT OPINION IN CELL BIOLOGY. 2010;22(5):611-616
Ephrins and Eph receptors in stem cells and cancer
Genander M; Frisen J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(33):14657-14661
Efficient reprogramming of adult neural stem cells to monocytes by ectopic expression of a single gene
Forsberg M; Carlen M; Meletis K; Yeung MSY; Barnabe-Heider F; Persson MAA; Aarum J; Frisen J
Article: STEM CELLS. 2010;28(7):1196-1205
Ephrins Negatively Regulate Cell Proliferation in the Epidermis and Hair Follicle
Genander M; Holmberg J; Frisen J
Article: STEM CELLS. 2010;28(5):974-983
Impaired Hippocampal Neurogenesis and Vascular Formation in Ephrin-A5-Deficient Mice
Hara Y; Nomura T; Yoshizaki K; Frisen J; Osumi N
Article: BRAIN. 2010;133(Pt 4):983-995
A hypoxic niche regulates glioblastoma stem cells through hypoxia inducible factor 2α
Seidel S; Garvalov BK; Wirta V; von Stechow L; Schaenzer A; Meletis K; Wolter M; Sommerlad D; Henze A-T; Nister M; Reifenberger G; Lundeberg J; Frisen J; Acker T
Article: DIABETES. 2010;59(1):105-109
Adipocyte Turnover: Relevance to Human Adipose Tissue Morphology
Arner E; Westermark PO; Spalding KL; Britton T; Ryden M; Frisen J; Bernard S; Arner P
Article: CELL. 2009;139(4):679-692
Dissociation of EphB2 Signaling Pathways Mediating Progenitor Cell Proliferation and Tumor Suppression
Genander M; Halford MM; Xu N-J; Eriksson M; Yu Z; Qiu Z; Martling A; Greicius G; Thakar S; Catchpole T; Chumley MJ; Zdunek S; Wang C; Holm T; Goff SP; Pettersson S; Pestell RG; Henkemeyer M; Frisen J
Article: PLOS ONE. 2009;4(9):e6997
High-density microwell chip for culture and analysis of stem cells.
Lindström S; Eriksson M; Vazin T; Sandberg J; Lundeberg J; Frisén J; Andersson-Svahn H
Article: SCIENCE. 2009;324(5923):98-102
Evidence for Cardiomyocyte Renewal in Humans
Bergmann O; Bhardwaj RD; Bernard S; Zdunek S; Barnabe-Heider F; Walsh S; Zupicich J; Alkass K; Buchholz BA; Druid H; Jovinge S; Frisen J
Article: NATURE NEUROSCIENCE. 2009;12(3):259-267
Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke
Carlen M; Meletis K; Goritz C; Darsalia V; Evergren E; Tanigaki K; Amendola M; Barnabe-Heider F; Yeung MSY; Naldini L; Honjo T; Kokaia Z; Shupliakov O; Cassidy RM; Lindvall O; Frisen J
Article: EXPERIMENTAL CELL RESEARCH. 2008;314(17):3255-3263
Induced pluripotency with endogenous and inducible genes
Duinsbegen D; Eriksson M; 't Hoen PAC; Frisen J; Mikkers H
Article: PLOS ONE. 2008;3(10):e3322
Meltrin beta/ADAM19 interacting with EphA4 in developing neural cells participates in formation of the neuromuscular junction.
Yumoto N; Wakatsuki S; Kurisaki T; Hara Y; Osumi N; Frisén J; Sehara-Fujisawa A
Article: DEVELOPMENT. 2008;135(19):3281-3290
Temporal regulation of ephrin/Eph signalling is required for the spatial patterning of the mammalian striatum
Passante L; Gaspard N; Degraeve M; Frisen J; Kullander K; De Maertelaer V; Vanderhaeghen P
Article: PLOS BIOLOGY. 2008;6(7):1494-1507
Spinal cord injury reveals multilineage differentiation of ependymal cells
Meletis K; Barnabe-Heider F; Carlen M; Evergren E; Tomilin N; Shupliakov O; Frisen J
Article: CELL STEM CELL. 2008;3(1):16-24
Stem cells for spinal cord repair
Barnabe-Heider F; Frisen J
Article: NATURE. 2008;453(7196):783-787
Dynamics of fat cell turnover in humans
Spalding KL; Arner E; Westermark PO; Bernard S; Buchholz BA; Bergmann O; Blomqvist L; Hoffstedt J; Naslund E; Britton T; Concha H; Hassan M; Ryden M; Frisen J; Arner P
Article: NATURE METHODS. 2008;5(2):189-196
Genetic manipulation of adult mouse neurogenic niches by in vivo electroporation
Barnabe-Heider F; Meletis K; Eriksson M; Bergmann O; Sabelstrom H; Harvey MA; Mikkers H; Frisen J
Article: GLIA. 2007;55(15):1565-1576
Transgenic mice for conditional gene manipulation in astroglial cells
Slezak M; Goritz C; Niemiec A; Frisen J; Chambon P; Metzger D; Pfrieger FW
Article: STEM CELLS. 2007;25(6):1539-1545
High-throughput identification of genes promoting neuron formation and lineage choice in mouse embryonic stem cells
Falk A; Karlsson TE; Kurdija S; Frisen J; Zupicich J
Article: SCIENCE. 2007;315(5816):1243-1249
Human neuroblasts migrate to the olfactory bulb via a lateral ventricular extension
Curtis MA; Kam M; Nannmark U; Anderson MF; Axell MZ; Wikkelso C; Holtas S; van Roon-Mom WMC; Bjork-Eriksson T; Nordborg C; Frisen J; Dragunow M; Faull RLM; Eriksson PS
Article: EXPERIMENTAL CELL RESEARCH. 2006;312(15):2851-2859
Genetic visualization of neurogenesis
Carlen M; Meletis K; Barnabe-Heider F; Frisen J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2006;103(33):12564-12568
Neocortical neurogenesis in humans is restricted to development
Bhardwaj RD; Curtis MA; Spalding KL; Buchholz BA; Fink D; Bjork-Eriksson T; Nordborg C; Gage FH; Druid H; Eriksson PS; Frisen J
Article: NEUROSCIENCE. 2006;141(1):109-121
Ephrin-A5 modulates the topographic mapping and connectivity of commissural axons in murine hippocampus
Otal R; Burgaya F; Frisen J; Soriano E; Martinez A
Article: CELL. 2006;125(6):1151-1163
EphB receptors coordinate migrationand proliferation in the intestinal stem cell niche
Holmberg J; Genander M; Halford MM; Anneren C; Sondell M; Chumley MJ; Silvany RE; Henkemeyer M; Frisen J
Article: EXPERIMENTAL CELL RESEARCH. 2006;312(10):1798-1812
Catalog of gene expression in adult neural stem cells and their in vivo microenvironment
Williams C; Wirta V; Meletis K; Wikstrom L; Carlsson L; Frisen J; Lundeberg J
Article: NANOTECHNOLOGY. 2006;17(8):1911-1915
Magnetic resonance tracking of nanoparticle labelled neural stem cells in a rat's spinal cord
Wang FH; Lee IH; Holmstrom N; Yoshitake T; Kim DK; Muhammed M; Frisen J; Olson L; Spenger C; Kehr J
Article: DEVELOPMENT. 2006;133(7):1335-1345
Pax6-dependent boundary defines alignment of migrating olfactory cortex neurons via the repulsive activity of ephrin A5
Nomura T; Holmberg J; Frisen J; Osumi N
Article: DEVELOPMENT. 2006;133(2):363-369
P53 suppresses the self-renewal of adult neural stem cells
Meletis K; Wirta V; Hede SM; Nistér M; Lundeberg J; Frisén J
Article: BMC NEUROSCIENCE. 2005;6:55
Epidermal growth factor (EGF) withdrawal masks gene expression differences in the study of pituitary adenylate cyclase-activating polypeptide (PACAP) activation of primary neural stem cell proliferation -: art. no. 55
Sievertzon M; Wirta V; Mercer A; Frisén J; Lundeberg J
Article: EMBO JOURNAL. 2005;24(15):2715-2719
Deconstructing stemness
Mikkers H; Frisén J
Article: CELL. 2005;122(1):133-143
Retrospective birth dating of cells in humans
Spalding KL; Bhardwaj RD; Buchholz BA; Druid H; Frisén J
Article: BMC NEUROSCIENCE. 2005;6:28
Transcriptome analysis in primary neural stem cells using a tag cDNA amplification method -: art. no. 28
Sievertzon M; Wirta V; Mercer A; Meletis K; Erlandsson R; Wikström L; Frisén J; Lundeberg J
Article: NATURE NEUROSCIENCE. 2005;8(3):346-353
Allodynia limits the usefulness of intraspinal neural stem cell grafts;: directed differentiation improves outcome
Hofstetter CP; Holmström NAV; Lilja JA; Schweinhardt P; Hao JX; Spenger C; Wiesenfeld-Hallin Z; Kurpad SN; Frisén J; Olson L
Article: GENES & DEVELOPMENT. 2005;19(4):462-471
Ephrin-A2 reverse signaling negatively regulates neural progenitor proliferation and neurogenesis
Holmberg J; Armulik A; Senti KA; Edoff K; Spalding K; Momma S; Cassidy R; Flanagan JG; Frisén J
Article: EXPERIMENTAL CELL RESEARCH. 2005;302(1):40-47
Survival and neural differentiation of adult neural stem cells transplanted into the mature inner ear
Hu ZQ; Wei DG; Johansson CB; Holmström N; Duan ML; Frisén J; Ulfendahl M
Article: CELL. 2003;114(3):311-322
Axonal ephrin-as and odorant receptors:: Coordinate determination of the olfactory sensory map
Cutforth T; Moring L; Mendelsohn M; Nemes A; Shah NM; Kim MM; Frisén J; Axel R
Article: NEURON. 2003;39(3):453-465
Area specificity and topography of thalamocortical projections are controlled by ephrin/Eph genes
Dufour A; Seibt J; Passante L; Depaepe V; Ciossek T; Frisén J; Kullander K; Flanagan JG; Polleux F; Vanderhaeghen P
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2003;100(13):7925-7930
Evidence for neurogenesis in the adult mammalian substantia nigra
Zhao M; Momma S; Delfani K; Carlén M; Cassidy RM; Johansson CB; Brismar H; Shupliakov O; Frisén J; Janson AM
Article: JOURNAL OF NEUROSCIENCE RESEARCH. 2002;69(6):757-762
Amphiregulin is a mitogen for adult neural stem cells
Falk A; Frisén J
Article: EXPERIMENTAL CELL RESEARCH. 2002;279(1):34-39
Gene delivery to adult neural stem cells
Falk A; Holmström N; Carlén M; Cassidy R; Lundberg C; Frisén J
Article: CURRENT BIOLOGY. 2002;12(7):606-608
Functional integration of adult-born neurons
Carlén M; Cassidy RM; Brismar H; Smith GA; Enquist LW; Frisén J
Article: BIOESSAYS. 2001;23(1):3-7
Oh no, Notch again!
Frisén J; Lendahl U
Article: NATURE. 2000;408(6809):203-206
Regulation of repulsion versus adhesion by different splice forms of an Eph receptor
Holmberg J; Clarke DL; Frisén J
Article: JOURNAL OF NEUROSCIENCE. 2000;20(15):5841-5847
Malformation of the functional organization of somatosensory cortex in adult ephrin-A5 knock-out mice revealed by in vivo functional imaging
Prakash N; Vanderhaeghen P; Cohen-Cory S; Frisén J; Flanagan JG; Frostig RD
Article: SCIENCE. 2000;288(5471):1660-1663
Generalized potential of adult neural stem cells
Clarke DL; Johansson CB; Wilbertz J; Veress B; Nilsson E; Karlström H; Lendahl U; Frisén J
Article: NATURE NEUROSCIENCE. 2000;3(4):358-365
A mapping label required for normal scale of body representation in the cortex
Vanderhaeghen P; Lu Q; Prakash N; Frisén J; Walsh CA; Frostig RD; Flanagan JG
Article: NEURON. 2000;25(3):563-574
Genetic analysis of ephrin-A2 and ephrin-A5 shows their requirement in multiple aspects of retinocollicular mapping.
Feldheim DA; Kim YI; Bergemann AD; Frisén J; Barbacid M; Flanagan JG
Article: EXPERIMENTAL CELL RESEARCH. 2000;255(1):47-55
Expression of the adenovirus receptor and its interaction with the fiber knob
Tomko RP; Johansson CB; Totrov M; Abagyan R; Frisén J; Philipson L
Article: NEURON. 2000;25(2):295-306
Roles for ephrins in positionally selective synaptogenesis between motor neurons and muscle fibers
Feng GP; Laskowski MB; Feldheim DA; Wang HM; Lewis R; Frisen J; Flanagan JG; Sanes JR
Article: EXPERIMENTAL CELL RESEARCH. 1999;253(2):733-736
Neural stem cells in the adult human brain
Johansson CB; Svensson M; Wallstedt L; Janson AM; Frisén J
Article: JOURNAL OF CELL BIOLOGY. 1999;145(3):503-514
Abnormal reaction to central nervous system injury in mice lacking glial fibrillary acidic protein and vimentin
Pekny M; Johansson CB; Eliasson C; Stakeberg J; Wallén Å; Perlmann T; Lendahl U; Betsholtz C; Berthold CH; Frisén J
Article: CELL. 1999;96(1):25-34
Identification of a neural stem cell in the adult mammalian central nervous system
Johansson CB; Momma S; Clarke DL; Risling M; Lendahl U; Frisén J
Article: NEURON. 1998;21(6):1303-1313
Topographic guidance labels in a sensory projection to the forebrain
Feldheim DA; Vanderhaeghen P; Hansen MJ; Frisén J; Lu Q; Barbacid M; Flanagan JG
Article: NATURE. 1998;395(6700):398-402
Retinoid-X receptor signalling in the developing spinal cord
Solomin L; Johansson CB; Zetterström RH; Bissonnette RP; Heyman RA; Olson L; Lendahl U; Frisén J; Perlmann T
Article: JOURNAL OF NEUROSCIENCE. 1998;18(15):5714-5722
Nerve growth factor induces process formation in meningeal cells:: Implications for scar formation in the injured CNS
Frisén J; Risling M; Korhonen L; Zirrgiebel U; Johansson CB; Cullheim S; Lindholm D
Article: NEURON. 1998;20(2):235-243
Ephrin-A5 (AL-1/RAGS) is essential for proper retinal axon guidance and topographic mapping in the mammalian visual system.
Frisén J; Yates PA; McLaughlin T; Friedman GC; O'Leary DD; Barbacid M
Article: CELL AND TISSUE RESEARCH. 1997;290(2):209-215
Genetic analysis of the role of Eph receptors in the development of the mammalian nervous system.
Frisén J; Barbacid M
Article: EMBO JOURNAL. 1997;16(11):3106-3114
Aberrant axonal projections in mice lacking EphA8 (Eek) tyrosine protein kinase receptors.
Park S; Frisén J; Barbacid M
Article: JOURNAL OF NEUROSCIENCE. 1997;17(10):3623-3633
TrkB signaling is required for postnatal survival of CNS neurons and protects hippocampal and motor neurons from axotomy-induced cell death.
Alcántara S; Frisén J; del Río JA; Soriano E; Barbacid M; Silos-Santiago I
Article: GENES & DEVELOPMENT. 1997;11(8):973-983
Ablation of the CDK inhibitor p57Kip2 results in increased apoptosis and delayed differentiation during mouse development.
Yan Y; Frisén J; Lee MH; Massagué J; Barbacid M
Article: EXPERIMENTAL NEUROLOGY. 1997;143(1):132-140
Apoptotic death of olfactory sensory neurons in the adult rat
Deckner ML; Risling M; Frisen J
Article: NATURE. 1996;382(6586):70-73
Renal agenesis and the absence of enteric neurons in mice lacking GDNF.
Sánchez MP; Silos-Santiago I; Frisén J; He B; Lira SA; Barbacid M
Article: JOURNAL OF CELL BIOLOGY. 1995;131(2):453-464
RAPID, WIDESPREAD, AND LONG-LASTING INDUCTION OF NESTIN CONTRIBUTES TO THE GENERATION OF GLIAL SCAR TISSUE AFTER CNS INJURY
FRISEN J; JOHANSSON CB; TOROK C; RISLING M; LENDAHL U
Article: NEUROSCIENCE. 1995;65(1):293-304
SPINAL AXONS IN CENTRAL-NERVOUS-SYSTEM SCAR TISSUE ARE CLOSELY-RELATED TO LAMININ-IMMUNOREACTIVE ASTROCYTES
FRISEN J; HAEGERSTRAND A; RISLING M; FRIED K; JOHANSSON CB; HAMMARBERG H; ELDE R; HOKFELT T; CULLHEIM S
Show more

All other publications

Editorial comment: EUROPEAN UROLOGY ONCOLOGY. 2024;7(5):1144-1146
The Role of Cytomegalovirus in Prostate Cancer Incidence and Mortality
Classon J; Britten A; Alkass K; Druid H; Brenner N; Waterboer T; Wareham NJ; Gkrania-Klotsas E; Frisen J
Review: SEMINARS IN CELL AND DEVELOPMENTAL BIOLOGY. 2021;116:3-9
Revisiting remyelination: Towards a consensus on the regeneration of CNS myelin
Franklina RJM; Frisen J; Lyons DA
Editorial comment: NATURE METHODS. 2021;18(1):15-18
Spatially resolved transcriptomics adds a new dimension to genomics
Larsson L; Frisen J; Lundeberg J
Letter: MOLECULAR PSYCHIATRY. 2020;25(10):2207-2209
Limits to human neurogenesis-really?
Lucassen PJ; Toni N; Kempermann G; Frisen J; Gage FH; Swaab DF
Letter: THE LANCET. 2020;396(10248):E15
COVID-19-a very visible pandemic
King C; Einhorn L; Brusselaers N; Carlsson M; Einhorn S; Elgh F; Frisen J; Gustafsson A; Hanson S; Hanson C; Hedner T; Isaksson O; Jansson A; Lundkvist A; Lotvall J; Lundback B; Olsen B; Soederberg-Naucler C; Wahlin A; Steineck G; Vahlne A
Editorial comment: NATURE MEDICINE. 2019;25(4):542-543
A fresh look at adult neurogenesis
Steiner E; Tata M; Frisen J
Editorial comment: CELL STEM CELL. 2019;24(3):357-359
Voices: The Importance of Fetal Tissue Research
Weissman I; Rawlins E; Jensen K; Barker R; Beltrao-Braga P; Dekel B; Frisen J; Surani A; Fehlings M
Corrigendum: NATURE. 2019;566(7744):E9
Dynamics of oligodendrocyte generation in multiple sclerosis (vol 566, pg 1, 2019)
Yeung MSY; Djelloul M; Steiner E; Bernard S; Salehpour M; Possnert G; Brundin L; Frisen J
Review: CELL STEM CELL. 2018;23(1):25-30
Human Adult Neurogenesis: Evidence and Remaining Questions
Kempermann G; Gage FH; Aigner L; Song H; Curtis MA; Thuret S; Kuhn HG; Jessberger S; Frankland PW; Cameron HA; Gould E; Hen R; Abrous DN; Toni N; Schinder AF; Zhao X; Lucassen PJ; Frisen J
Review: ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY. 2016;32:127-141
Neurogenesis and Gliogenesis in Nervous System Plasticity and Repair
Frisen J
Review: DEVELOPMENT. 2016;143(7):1075-1086
Stars from the darkest night: unlocking the neurogenic potential of astrocytes in different brain regions
Magnusson JP; Frisen J
Review: EXPERIMENTAL NEUROLOGY. 2014;260:44-49
Neural stem cells in the adult spinal cord
Sabelstrom H; Stenudd M; Frisen J
Editorial comment: SCIENCE. 2013;340(6133):695-696
Why Adults Need New Brain Cells
Bergmann O; Frisen J
Editorial comment: NEW ENGLAND JOURNAL OF MEDICINE. 2013;368(14):1358-1360
New Cells in Old Hearts
Bostrom P; Frisen J
Editorial comment: CELL STEM CELL. 2012;11(3):282-284
Noisy Neurons Keep Neural Stem Cells Quiet
Chell JM; Frisen J
Editorial comment: CELL STEM CELL. 2012;10(6):657-659
Neural Stem Cells and Neurogenesis in the Adult
Goritz C; Frisen J
Letter: CIRCULATION RESEARCH. 2012;110(1):e17-e18
Cardiomyocyte Renewal in Humans
Bergmann O; Zdunek S; Frisen J; Bernard S; Druid H; Jovinge S
Editorial comment: CELL CYCLE. 2010;9(10):1865-1866
Eph receptors tangled up in two Independent control of cell positioning and proliferation
Genander M; Frisen J
Published conference paper: NUCLEAR INSTRUMENTS AND METHODS IN PHYSICS RESEARCH, SECTION B: BEAM INTERACTIONS WITH MATERIALS AND ATOMS. 2010;268(7-8):1295-1298
A mathematical model for the interpretation of nuclear bomb test derived ¹⁴C incorporation in biological systems
Bernard S; Frisen J; Spalding KL
Meeting abstract: NEUROSCIENCE RESEARCH. 2009;65:S101
EphB/ephrin-B signaling controls differentiation plasticity of the adult subventricular niche cells
Nomura T; Frisen J
Editorial comment: CELL. 2007;128(5):825-826
From stem cell to progenitor and back again
Simon A; Frisen J
Meeting abstract: NEUROSCIENCE RESEARCH. 2007;58:S209
The function of Ephrin-Eph signaling in postnatal neurogenesis
Hara Y; Frisen J; Osumi N
Editorial comment: NATURE. 2005;437(7057):333-334
Age written in teeth by nuclear tests
Spalding KL; Buchholz BA; Bergman LE; Druid H; Frisén J
Review: ANNALS OF MEDICINE. 2005;37(7):480-486
New neurons in old brains
Falk A; Frisén J
Published conference paper: JOURNAL OF NEUROSCIENCE RESEARCH. 2004;76(2):205-215
PACAP promotes neural stem cell proliferation in adult mouse brain
Mercer A; Rönnholm H; Holmberg J; Lundh H; Heidrich J; Zachrisson O; Ossoinak A; Frisén J; Patrone C
Meeting abstract: SHOCK. 2004;21:136
Grafting of genetically modified adult neural stem cells following an incomplete spinal cord injury
Holmström NAV; Hofstetter CP; Schweinhardt P; Spenger C; Frisén J; Olson L; Kurpad S
Editorial comment: TRENDS IN NEUROSCIENCES. 2003;26(6):292-296
Blood on the tracks:: a simple twist of fate?
Meletis K; Frisén J
Letter: CELL DEATH AND DIFFERENTIATION. 2002;9(12):1377-1378
Cell death in adult neural stem cells
Sleeper E; Tamm C; Frisén J; Zhivotovsky B; Orrenius S; Ceccatelli S
Editorial comment: CURRENT BIOLOGY. 2002;12(20):R705-R706
Embryonic stem cells:: Taming the fountain of youth
Cassidy R; Frisén J
Review: NEURON. 2002;35(3):415-418
Stem cell plasticity?
Frisén J
Review: TRENDS IN NEUROSCIENCES. 2002;25(5):239-243
Ephrins are not only unattractive
Holmberg J; Frisén J
Editorial comment: JOURNAL OF CELL BIOLOGY. 2001;155(5):699-702
Have the bloody cells gone to our heads?
Meletis K; Frisén J
Review: CURRENT OPINION IN GENETICS AND DEVELOPMENT. 2001;11(5):575-580
Differentiation potential of adult stem cells
Clarke D; Frisén J
Editorial comment: NEURON. 2001;31(6):876-877
Eph receptors tingle the spine
Henkemeyer M; Frisén J
Editorial comment: NATURE. 2001;412(6848):690-691
Neurobiology -: Stem cells on the brain
Cassidy R; Frisén J
Published conference paper: ACTA NEUROLOGICA SCANDINAVICA. 2000;102:34
Characterization of neural stem cells in the adult CNS
Johansson CB; Momma S; Clarke DL; Lendahl U; Frisen J
Review: LAKARTIDNINGEN. 2000;97(24):2962-2966
[The up and down world: glia makes nerve cells!].
Frisén J
Review: CURRENT OPINION IN NEUROBIOLOGY. 2000;10(1):45-49
Get to know your stem cells
Momma S; Johansson CB; Frisén J
Conference publication: EUROPEAN JOURNAL OF NEUROSCIENCE. 2000;12:318
Characterization of neural stem cells in the adult CNS
Johansson CB; Momma S; Clarke DL; Lendahl U; Frisen J
Review: EMBO JOURNAL. 1999;18(19):5159-5165
Ephrins and their Eph receptors:: multitalented directors of embryonic development
Frisén J; Holmberg J; Barbacid M
Review: CELLULAR AND MOLECULAR LIFE SCIENCES. 1998;54(9):935-945
Central nervous system stem cells in the embryo and adult
Frisén J; Johansson CB; Lothian C; Lendahl U
Review: HISTOLOGY AND HISTOPATHOLOGY. 1997;12(3):857-868
Determinants of axonal regeneration
Frisen J
Show more

Employments

Professor, Department of Cell and Molecular Biology, Karolinska Institutet, 2001-

Degrees and Education

University Medical Degree, Karolinska Institutet, 1991

About me

Research

Articles

All other publications

Employments

Degrees and Education

News from KI

Events from KI