Jeff Mold

Publications
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Articles

Article: NATURE COMMUNICATIONS. 2023;14(1):982
Reconstructing clonal tree for phylo-phenotypic characterization of cancer using single-cell transcriptomics
Jun S-H; Toosi H; Mold J; Engblom C; Chen X; O'Flanagan C; Hagemann-Jensen M; Sandberg R; Aparicio S; Hartman J; Roth A; Lagergren J
Article: MOLECULAR ONCOLOGY. 2022;16(19):3452-3464
Prostate cancer disease recurrence after radical prostatectomy is associated with HLA type and local cytomegalovirus immunity
Classon J; Zamboni M; Engblom C; Alkass K; Mantovani G; Pou C; Nkulikiyimfura D; Brodin P; Druid H; Mold J; Frisen J
Article: SCIENCE TRANSLATIONAL MEDICINE. 2021;13(599):eabb3107
A biliary immune landscape map of primary sclerosing cholangitis reveals a dominant network of neutrophils and tissue-resident T cells
Zimmer CL; von Seth E; Buggert M; Strauss O; Hertwig L; Nguyen S; Wong AYW; Zotter C; Berglin L; Michaelsson J; Hansson MR; Arnelo U; Sparrelid E; Ellis ECS; Soderholm JD; Keita AV; Holm K; Ozenci V; Hov JR; Mold JE; Cornillet M; Ponzetta A; Bergquist A; Bjorkstrom NK
Article: CELL REPORTS. 2021;35(8):109174
Divergent clonal differentiation trajectories establish CD8⁺ memory T cell heterogeneity during acute viral infections in humans
Mold JE; Modolo L; Hard J; Zamboni M; Larsson AJM; Stenudd M; Eriksson C-J; Durif G; Stahl PL; Borgstrom E; Picelli S; Reinius B; Sandberg R; Reu P; Talavera-Lopez C; Andersson B; Blom K; Sandberg JK; Picard F; Michaelsson J; Frisen J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(11):e2016580118
Expansions of adaptive-like NK cells with a tissue-resident phenotype in human lung and blood
Brownlie D; Scharenberg M; Mold JE; Hard J; Kekalainen E; Buggert M; Nguyen S; Wilson JN; Al-Ameri M; Ljunggren H-G; Marquardt N; Michaelsson J
Article: SCIENCE TRANSLATIONAL MEDICINE. 2021;13(582):eabb0036
A heterozygous germline CD100 mutation in a family with primary sclerosing cholangitis
Jiang X; Bergquist A; Loscher B-S; Venkatesh G; Mold JE; Holm K; Laerdahl JK; Skanland SS; Maleki KT; Cornillet M; Tasken K; Franke A; Karlsen TH; Bjorkstrom NK; Melum E
Article: ELIFE. 2020;9:e59733
Activation of a neural stem cell transcriptional program in parenchymal astrocytes
Magnusson JP; Zamboni M; Santopolo G; Mold JE; Barrientos-Somarribas M; Talavera-Lopez C; Andersson B; Frisen J
Article: BIOINFORMATICS. 2019;35(20):4011-4019
Probabilistic count matrix factorization for single cell expression data analysis
Durif G; Modolo L; Mold JE; Lambert-Lacroix S; Picard F
Article: PLOS BIOLOGY. 2019;17(10):e3000383
Cell generation dynamics underlying naive T-cell homeostasis in adult humans
Mold JE; Reu P; Olin A; Bernard S; Michaelsson J; Rane S; Yates A; Khosravi A; Salehpour M; Possnert G; Brodin P; Frisen J
Article: NATURE COMMUNICATIONS. 2019;10(1):3841
Unique transcriptional and protein-expression signature in human lung tissue-resident NK cells
Marquardt N; Kekalainen E; Chen P; Lourda M; Wilson JN; Scharenberg M; Bergman P; Al-Ameri M; Hard J; Mold JE; Ljunggren H-G; Michaelsson J
Article: IMMUNITY. 2019;51(1):169-184.e5
Single-Cell RNA Sequencing of the T Helper Cell Response to House Dust Mites Defines a Distinct Gene Expression Signature in Airway Th2 Cells
Tibbitt CA; Stark JM; Martens L; Ma J; Mold JE; Deswarte K; Oliynyk G; Feng X; Lambrecht BN; De Bleser P; Nylen S; Hammad H; Henriksson MA; Saeys Y; Coquet JM
Article: GENOME BIOLOGY. 2019;20(1):68
Conbase: a software for unsupervised discovery of clonal somatic mutations in single cells through read phasing
Hard J; Al Hakim E; Kindblom M; Bjorklund AK; Sennblad B; Demirci I; Paterlini M; Reu P; Borgstrom E; Stahl PL; Michaelsson J; Mold JE; Frisen J
Article: BIOINFORMATICS. 2018;34(3):485-493
High dimensional classification with combined adaptive sparse PLS and logistic regression
Durif G; Modolo L; Michaelsson J; Mold JE; Lambert-Lacroix S; Picard F
Article: CELL REPORTS. 2017;20(4):779-784
The Lifespan and Turnover of Microglia in the Human Brain
Reu P; Khosravi A; Bernard S; Mold JE; Salehpour M; Alkass K; Perl S; Tisdale J; Possnert G; Druid H; Frisen J
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2017;214(2):309-317
Antibody-secreting plasma cells persist for decades in human intestine
Landsverk OJB; Snir O; Casado RB; Richter L; Mold JE; Reu P; Horneland R; Paulsen V; Yaqub S; Aandahl EM; Oyen OM; Thorarensen HS; Salehpour M; Possnert G; Frisen J; Sollid LM; Baekkevold ES; Jahnsen FL
Article: PLOS ONE. 2017;12(2):e0171566
Comparison of whole genome amplification techniques for human single cell exome sequencing
Borgstrom E; Paterlini M; Mold JE; Frisen J; Lundeberg J
Article: PLOS COMPUTATIONAL BIOLOGY. 2017;13(1):e1005313
Identifying T Cell Receptors from High-Throughput Sequencing: Dealing with Promiscuity in TCRα and TCRβ Pairing
Lee ES; Thomas PG; Mold JE; Yates AJ
Article: NATURE GENETICS. 2016;48(11):1430-1435
Analysis of allelic expression patterns in clonal somatic cells by single-cell RNA-seq
Reinius B; Mold JE; Ramskold D; Deng Q; Johnsson P; Michaelsson J; Frisen J; Sandberg R
Article: JOURNAL OF IMMUNOLOGY. 2015;195(9):4096-4105
Continuous Antigenic Stimulation of DO11.10 TCR Transgenic Mice in the Presence or Absence of IL-1β: Possible Implications for Mechanisms of T Cell Depletion in HIV Disease.
Ladell K; Hazenberg MD; Fitch M; Emson C; McEvoy-Hein Asgarian BK; Mold JE; Miller C; Busch R; Price DA; Hellerstein MK; McCune JM
Article: CELL METABOLISM. 2015;22(3):408-417
Transplanted Bone Marrow-Derived Cells Contribute to Human Adipogenesis
Ryden M; Uzunel M; Hard JL; Borgstrom E; Mold JE; Arner E; Mejhert N; Andersson DP; Widlund Y; Hassan M; Jones CV; Spalding KL; Svahn B-M; Ahmadian A; Frisen J; Bernard S; Mattsson J; Arner P
Article: PLOS ONE. 2014;9(2):e87877
Identification of cinnabarinic acid as a novel endogenous aryl hydrocarbon receptor ligand that drives IL-22 production.
Lowe MM; Mold JE; Kanwar B; Huang Y; Louie A; Pollastri MP; Wang C; Patel G; Franks DG; Schlezinger J; Sherr DH; Silverstone AE; Hahn ME; McCune JM
Article: CHIMERISM. 2013;4(3):62-70
A discussion of immune tolerance and the layered immune system hypothesis.
Mold JE; Anderson CC
Article: ARTHRITIS & RHEUMATOLOGY. 2012;64(8):2451-2459
A functional variant in FCRL3 is associated with higher Fc receptor-like 3 expression on T cell subsets and rheumatoid arthritis disease activity.
Bajpai UD; Swainson LA; Mold JE; Graf JD; Imboden JB; McCune JM
Article: CHIMERISM. 2011;2(2):35-41
At the crossroads between tolerance and aggression: Revisiting the "layered immune system" hypothesis.
Mold JE; McCune JM
Article: SCIENCE. 2010;330(6011):1695-1699
Fetal and Adult Hematopoietic Stem Cells Give Rise to Distinct T Cell Lineages in Humans
Mold JE; Venkatasubrahmanyam S; Burt TD; Michaelsson J; Rivera JM; Galkina SA; Weinberg K; Stoddart CA; McCune JM
Article: JOURNAL OF IMMUNOLOGY. 2010;185(9):5279-5288
Naive human T cells are activated and proliferate in response to the heme oxygenase-1 inhibitor tin mesoporphyrin.
Burt TD; Seu L; Mold JE; Kappas A; McCune JM
Article: SCIENCE TRANSLATIONAL MEDICINE. 2010;2(32):32ra36
Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease.
Favre D; Mold J; Hunt PW; Kanwar B; Loke P; Seu L; Barbour JD; Lowe MM; Jayawardene A; Aweeka F; Huang Y; Douek DC; Brenchley JM; Martin JN; Hecht FM; Deeks SG; McCune JM
Article: JOURNAL OF IMMUNOLOGY. 2010;184(7):3639-3647
Expression of the autoimmune susceptibility gene FcRL3 on human regulatory T cells is associated with dysfunction and high levels of programmed cell death-1.
Swainson LA; Mold JE; Bajpai UD; McCune JM
Article: PLOS PATHOGENS. 2009;5(2):e1000295
Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infection.
Favre D; Lederer S; Kanwar B; Ma Z-M; Proll S; Kasakow Z; Mold J; Swainson L; Barbour JD; Baskin CR; Palermo R; Pandrea I; Miller CJ; Katze MG; McCune JM
Article: SCIENCE. 2008;322(5907):1562-1565
Maternal Alloantigens Promote the Development of Tolerogenic Fetal Regulatory T Cells in Utero
Mold JE; Michaelsson J; Burt TD; Muench MO; Beckerman KP; Busch MP; Lee T-H; Nixon DF; McCune JM
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(25):8718-8723
Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE epsilon4/epsilon4 genotype accelerates HIV disease progression.
Burt TD; Agan BK; Marconi VC; He W; Kulkarni H; Mold JE; Cavrois M; Huang Y; Mahley RW; Dolan MJ; McCune JM; Ahuja SK
Article: JOURNAL OF IMMUNOLOGY. 2006;176(10):5741-5748
Regulation of T cell responses in the developing human fetus.
Michaëlsson J; Mold JE; McCune JM; Nixon DF
Article: JOURNAL OF IMMUNOLOGY. 2004;172(11):6626-6633
Requirement for donor and recipient CD40 expression in cardiac allograft rejection: induction of Th1 responses and influence of donor-derived dendritic cells.
Nathan MJ; Mold JE; Wood SC; Csencsits K; Lu G; Eichwald EJ; Bishop DK
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Review: ADVANCES IN IMMUNOLOGY. 2012;115:73-111
Immunological Tolerance During Fetal Development: From Mouse to Man
Mold JE; McCune JM
Meeting abstract: JOURNAL OF REPRODUCTIVE IMMUNOLOGY. 2010;86(1):21
How the immune system 'Grows up': evidence supporting the existence of a layered immune system
Mold JE; Venkatasubrahmanyam S; Burt TD; Rivera J; Galkina SA; Weinberg K; Butte A; Stoddart CA; McCune JM
Meeting abstract: RETROVIROLOGY. 2005;2:s107
CD4+CD25high regulatory T cells in the developing human immune system:: Implications for pediatric HIV infection
Michaelsson J; Mold JE; McCune JM; Nixon DF

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