Several of the projects are based on data from the Swedish birth cohort, BAMSE that allows for unique investigation of health and disease in a large number of subjects up to 24 years. In addition, detailed information about perinatal events, environmental exposures such as air pollution and tobacco smoke exposure from birth and onwards has been collected. In our ongoing genetics projects, genome-wide approaches are primarily used (GWAS, global methylation analyses and RNA sequencing / microarray approaches) together with detailed clinical and epidemiological data. As such, we are conducting translational research, from bench to bedside, using clinical and epidemiological data sets. For example our projects focus on the long-term consequence of preterm birth on lung function in young adulthood, identification of subgroups of the population that are particularly vulnerable to air pollution exposures and elucidation of new genetic mechanisms for disease development.
BAMSE: Barn, Allergi, Miljö, Stockholm, Epidemiologi – a birth cohort study including 4089 participants followed from birth to young adulthood with the aim to study lifestyle, environmental and genetic factors and health. PIs Erik Melén, Anna Bergström and Inger Kull. Web page BAMSE Project.
PERMEABLE: PERsonalized MEdicine Approach for asthma and allergy Biologicals SeLEction – a European collaborative project on allergy / asthma mechanisms, disease biomarkers and biological treatment. Swedish PI: Erik Melén.
EXPANSE: EXposome Powered tools for healthy living in urbAN Settings – a European collaborative project on healthy living, urban exposures and non-communicable diseases. Swedish PI: Erik Melén.
Extensive national and international collaborations in the respiratory and allergy fields are established, and our research group is also involved in international Precision Medicine and Exposome projects.
- European Research Council
- Swedish Research Council
- Swedish Heart-Lung Foundation
- ERA-PERMED (Horizon 2020)
- National Institute of Health, USA
- ALF, medicine
- Karolinska Institutet, SFO Epidemiology