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BAMSE Project

The BAMSE cohort is an acknowledged world-leading birth cohort with major contributions nationally and internationally in the field so far based on data from more than 200 scientific publications.

The BAMSE (Swedish abbreviation for Children, Allergy, Milieu, Stockholm, Epidemiology) study is an ongoing longitudinal, population-based prospective birth cohort including 4,089 children born between 1994 and 1996 in Stockholm, Sweden. The cohort was initially designed to study risk factors for asthma, allergic diseases and lung function in childhood, and to study factors of importance for prognosis at already established disease.

Questionnaires on respiratory symptoms and medication were answered at age of 1, 2, 4, 8 and 16 years. Response rates ranged from 96-82% at each occasion with very minor selection bias over the years. Exposure to air pollutants and other environmental factors has been mapped since birth.

At the 8 and 16 year follow-up, spirometry and FeNO measurements were performed and at the latter, impulse oscillometry was measured. Blood samples (including plasma) from around 2,500 children were taken at 4, 8 and 16 years and have been analyzed for different IgE-ab and biomarkers. Genome-wide genetic, global methylation and transcriptomic data exist on a subset of the children.

Ongoing follow upp at 24 years

The next follow-up started in 2017 and is ongoing. The participants are now 22-24 years of age, and the follow-up includes questionnaire data, lung function measurements and blood sampling for different –omics analyses. In addition, complimentary data will be sought from national registers on medical diagnoses, drug prescription and health care utilization.

In November 2018 we reached a 70% response rate for the questionnaire and our clinic has examined more than 2000 participants!

With the next follow-up, we aim to lay the foundation for research on chronic allergic and respiratory diseases for decades to come using state-the-art biobank and experimental platforms, and detailed individual information on health and exposure. This project will provide knowledge about potential strategies to prevent childhood allergy, asthma from becoming chronic severe diseases in adulthood. In addition, our results may allow for identification of new candidates for drug development.

Publications

List of publications

List of theses

Documents

Awards

HRH Prins Daniels award for promissing young scientists

2015 the Prins Daniels award for promissing young scientists from The Swedish Heart-Lung Foundation went to Erik Melén, Associate professor, Institute of Environmental Medicine and PI for the BAMSE-project

The BAMSE scientific workshop in the Stockholm archipelago

Around 60 international and national experts, BAMSE researchers and project staff met on the idyllic island Finnhamn in the Stockholm archipelago for a 2 days workshop in late August 2018.

Contact

BAMSE sekretariatet

Telefon: +46 8 - 123 372 50
E-post: bamse-projekt@imm.ki.se
Adress: Centrum för arbets- och miljömedicin CAMM
BAMSE-sekretariat
Solnavägen 4, 10tr
S-113 65 Stockholm

PI (leading group)

Docent

Erik Melén

Telefon: 08-524 875 08
Enhet: Miljömedicinsk epidemiologi
E-post: Erik.Melen@ki.se

Lektor/sjuksköterska

Inger Kull

Enhet: Institutionen för klinisk forskning och utbildning, Södersjukhuset (KI SÖS), S1
E-post: Inger.Kull@ki.se

Forskare

Anna Bergström

Telefon: 08-524 874 56
Enhet: Miljömedicinsk epidemiologi
E-post: Anna.Bergstrom@ki.se

Senior researchers in the group

Professor emeritus

Magnus Wickman

Enhet: Miljömedicinsk epidemiologi
E-post: magnus.wickman@ki.se

Professor/överläkare

Göran Pershagen

Telefon: 08-524 874 60
Enhet: Miljömedicinsk epidemiologi
E-post: Goran.Pershagen@ki.se