Regeneration mechanisms – Andras Simon's Group

We try to understand regeneration mechanisms in newts, which are semiaquatic salamanders, and have the widest repertoire of regenerative abilities among vertebrates.

Image of a newt on a white table

We sequenced a gigantic newt genome, established stable transgenesis, and created means for in vivo genome-editing. To harness these technological developments, we are now combining cell tracking studies, massive parallel sequencing and molecular manipulations in various lesion/regeneration paradigms.

We also carry out cross-species comparisons by which we aim to gain insights into regulatory programs whose appropriate targeting could impose regenerative traits to mammals. We hope that our results will lead to novel regenerative strategies as well as provide explanatory models for the evolutionarily uneven distribution of regenerative capacities.


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