Arne Östman's Group

The research aims at a better understanding of the paracrine interplay in the tumor microenvironment between malignant cells, fibroblasts, vascular cells and immune cells. Particular attention is given to the roles of the PDGF system in this context. During the last years we have also identified other proteins, involved in this interplay, that affect tumor growth and metastasis.

Tumor microenvironment

The research aims at a better understanding of the paracrine interplay in the tumormicroenvironment between malignant cells, fibroblasts, vascular cells and immune cells. Particular attention is given to the roles of the PDGF system in this context. During the last years we have also identified other proteins, involved in this interplay, that affect tumor growth and metastasis.

Projects commonly integrate analyses using cell- and animal-models of cancer together with correlative profiling of clinical samples. Studies have been performed across a broad range of tumor types, including breast, prostate, ovarian, colorectal and kidney cancer. Since some years a distinct program on the tumor microenvironment of sarcoma is being headed by Monika Ehnman.

The group actively promotes studies taking advantage of the complementary expertise of biologists, pathologists and oncologists. A number of projects have been performed in collaboration with pharma companies.

Group members

Arne Östman, Professor, Group Leader
Monika Ehnman, PhD, Assistant Professor, team Leader
Mercedes Herrera Torres, PhD, Postdoc
Lina Leiss, PhD, Postdoc
Pablo Moreno Ruiz, PhD, (affiliated)
Sara Corvigno, MD, PhD (affiliated)
Wiem Chaabane, PhD, Postdoc
Alfonso Martin Barnabe, PhD, Postdoc
Magnus Frödin, MD, PhD (affiliated)
Alessandro Mega, PhD (affiliated)
Artur Mezheyeuski, MD, PhD (affiliated)
Huang Linglong, MD, PhD student
Yanhong Su, MD, PhD student
Maya Nisancioglu, MD, PhD (affiliated)
Carina Strell, PhD (affiliated)
Hanna Dahlstrand, MD, PhD (affiliated)

10 Selected publications since 2010

Forkhead box F1 regulates tumor-promoting properties of cancer-associated fibroblasts in lung cancer.  Saito RA, Micke P, Paulsson J, Augsten M, Peña C, Jönsson P, Botling J, Edlund K, Johansson L, Carlsson P, Jirström K, Miyazono K, Ostman A.
Cancer Res. 2010 Apr 1;70(7):2644-54.

The tumor microenvironment controls drug sensitivity.
Ostman A.
Nat Med. 2012 Sep;18(9):1332-4.

STC1 expression by cancer-associated fibroblasts drives metastasis of colorectal cancer.
Peña C, Céspedes MV, Lindh MB, Kiflemariam S, Mezheyeuski A, Edqvist PH, Hägglöf C, Birgisson H, Bojmar L, Jirström K, Sandström P, Olsson E, Veerla S, Gallardo A, Sjöblom T, Chang AC, Reddel RR, Mangues R, Augsten M, Ostman A.
Cancer Res. 2013 Feb 15;73(4):1287-97.

Distinct effects of ligand-induced PDGFRα and PDGFRβ signaling in the human rhabdomyosarcoma tumor cell and stroma cell compartments.
Ehnman M, Missiaglia E, Folestad E, Selfe J, Strell C, Thway K, Brodin B, Pietras K, Shipley J, Östman A, Eriksson U.
Cancer Res. 2013 Apr 1;73(7):2139-49

Selective activation of oxidized PTP1B by the thioredoxin system modulates PDGF-β receptor tyrosine kinase signaling.
Dagnell M, Frijhoff J, Pader I, Augsten M, Boivin B, Xu J, Mandal PK, Tonks NK, Hellberg C, Conrad M, Arnér ES, Östman A.
Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13398-403.

Cancer-associated fibroblasts expressing CXCL14 rely upon NOS1-derived nitric oxide signaling for their tumor-supporting properties.
Augsten M, Sjöberg E, Frings O, Vorrink SU, Frijhoff J, Olsson E, Borg Å, Östman A.
Cancer Res. 2014 Jun 1;74(11):2999-3010.

Local and systemic protumorigenic effects of cancer-associated fibroblast-derived GDF15.
Bruzzese F, Hägglöf C, Leone A, Sjöberg E, Roca MS, Kiflemariam S, Sjöblom T, Hammarsten P, Egevad L, Bergh A, Ostman A, Budillon A, Augsten M.
Cancer Res. 2014 Jul 1;74(13):3408-17.

A Novel ACKR2-Dependent Role of Fibroblast-Derived CXCL14 in Epithelial-to-Mesenchymal Transition and Metastasis of Breast Cancer.
Sjöberg E, Meyrath M, Milde L, Herrera M, Lövrot J, Hägerstrand D, Frings O, Bartish M, Rolny C, Sonnhammer E, Chevigné A, Augsten M, Östman A.
Clin Cancer Res. 2019 Jun 15;25(12):3702-3717.

Impact of Epithelial-Stromal Interactions on Peritumoral Fibroblasts in Ductal Carcinoma in Situ.
Strell C, Paulsson J, Jin SB, Tobin NP, Mezheyeuski A, Roswall P, Mutgan C, Mitsios N, Johansson H, Wickberg SM, Svedlund J, Nilsson M, Hall P, Mulder J, Radisky DC, Pietras K, Bergh J, Lendahl U, Wärnberg F, Östman A.
J Natl Cancer Inst. 2019 Sep 1;111(9):983-995.

High stromal PDGFRb expression predicts lack of benefit from post-operative radiotherapy in ductal breast carcinoma in situ within the SwedDCIS randomized trialStrell, C., Folkvaljon, D., Holmberg, E., Karlsson, P., Bergh, J., Bremer, T., Akslen, L.A., Wärnberg, F.* and Östman, A.*  *equal contribution Clin. Can. Res. 2021 DOI:10.1158/1078-0432.CCR-20-4300 

Full list of publications