Arne Östman
Professor
E-mail: arne.ostman@ki.se
Visiting address: J6:20 BioClinicum, Akademiska stråket 1, 17164 Solna
Postal address: K7 Onkologi-Patologi, K7 Forskning Östman, 171 77 Stockholm
About me
Professor, Dept of Oncology-Pathology, Karolinska Institutet, 2006-
Professor II, CCBIO, Bergen University, 2016-
Education
Associate Professor, Uppsala University, 1995
Post-doc, Cold Spring Harbor Laboratory, 1992-93
Ph.D., Uppsala University,
Selected qualifications:
Author of more than 170 original research articles and 45+ reviews (Nat Rev Can (2), Cancer Cell, Trends in Cell Biology and Trends in Cancer)- h-factor 69 (Web of Science).
Completed supervision of 14 PhD students and 22 post-doctoral fellows of which the majority continues academic research. Six of these are full professors and 9 have been promoted to PI or junior PI positions.
Coordinator STARGET – a Linnaeus center for translational studies on the tumor microenvironment with funding from VR 2006-16.
Co-director StratCan – the strategic research program in cancer at Karolinska Institutet, 2010-18.
Member of the Nobel assembly (2020-) and the Nobel committee (2023 and 2024).
Ad-hoc reviewer for the Nobel Assembly and the Royal Academy of Science (Sjöberg Prize).
ERC Advanced Grant LS7 panel member (2023).
Member of the Editorial Board Cancer Research (2015-).
Member of the board of “Svenska Sällskapet för Medicinsk Forskning” (2020-).
Supported by research grants from Swedish Cancer Society, Swedish Research Council, “Kreftforeningen”, Stockholm City Council (ALF), “Radiumhemmets forskningsfonder” and "HelseVest".
External grant reviewer for Cancerfonden, Barncancerfonden, SSMF, ERC and national European agencies including CRUK and Wellcome Trust. Reviewer for e.g. Nature, Nature Medicine, Nat Comm., Nat Rev Cancer, Nat Rev Clin Onc, Cancer Cell, EMBO J.
Main- or co-organizer of UICC Advanced Course of Cell Signaling and Cancer, 1999 - Nobel Conference on Breast Cancer, 2012 and Swedish Cancer Research Meeting 2014.
Ad hoc member of international scientific advisory boards for e.g. ImClone, Eli-Lilly and Novartis.
Co-founder of TECKNET AB
Research
- The Östman research group performs translation studies on autocrine and paracrine growth factor signaling in the tumor microenvironment, with particular emphasis on regulation of cancer-associated fibroblasts.
Selected publications
- Article: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2023;115(1):71-82
- Article: CLINICAL CANCER RESEARCH. 2021;27(12):3469-3477
- Article: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2019;111(9):983-995
- Article: CLINICAL CANCER RESEARCH. 2019;25(12):3702-3717
- Article: CANCER RESEARCH. 2014;74(13):3408-3417
- Article: CANCER RESEARCH. 2014;74(11):2999-3010
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(33):13398-13403
- Article: CANCER RESEARCH. 2013;73(7):2139-2149
- Article: CANCER RESEARCH. 2013;73(4):1287-1297
- Editorial comment: NATURE MEDICINE. 2012;18(9):1332-1334
Articles
- Journal article: CANCER AND METASTASIS REVIEWS. 2024;:1-17
- Article: MABS. 2023;15(1):2223750
- Article: CELL REPORTS. 2023;42(12):113507
- Article: NATURE COMMUNICATIONS. 2023;14(1):5024
- Article: BLOOD. 2023;142(1):73-89
- Article: BREAST CANCER RESEARCH AND TREATMENT. 2023;200(2):293-304
- Article: BIOL IMAGING. 2023;3:e6
- Article: CYTOMETRY PART B-CLINICAL CYTOMETRY. 2021;99(12):1176-1186
- Article: JOURNAL OF PATHOLOGY CLINICAL RESEARCH. 2021;7(5):482-494
- Article: CANCERS. 2021;13(13):3151
- Article: LUNG CANCER. 2021;155:10-19
- Article: BREAST CANCER RESEARCH AND TREATMENT. 2021;187(1):45-55
- Article: CANCERS. 2021;13(5):1175
- Article: GYNECOLOGIC ONCOLOGY. 2020;159(3):860-868
- Article: CANCERS. 2020;12(11):E3238-3238
- Article: ELIFE. 2020;9:e59996
- Article: GLIA. 2020;68(2):316-327
- Article: SCIENTIFIC REPORTS. 2020;10(1):281
- Article: CELL DEATH DISCOVERY. 2020;6(1):42
- Article: SCIENCE ADVANCES. 2019;5(9):eaax2770
- Article: PROSTATE. 2019;79(13):1505-1513
- Article: BRITISH JOURNAL OF CANCER. 2019;121(4):303-311
- Article: SCIENTIFIC REPORTS. 2019;9(1):10163
- Article: FASEB JOURNAL. 2019;33(5):6609-6621
- Article: BRITISH JOURNAL OF CANCER. 2018;119(7):840-846
- Article: VIRCHOWS ARCHIV. 2018;472(3):395-405
- Article: SCIENCE TRANSLATIONAL MEDICINE. 2018;10(428):eaaf7444
- Article: PLOS ONE. 2018;13(2):e0192157
- Article: NATURE BIOMEDICAL ENGINEERING. 2017;1(10):796-806
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2017;292(35):14371-14380
- Article: JOURNAL OF PATHOLOGY CLINICAL RESEARCH. 2017;3(3):214-224
- Article: BRITISH JOURNAL OF CANCER. 2017;117(1):65-77
- Article: CELL DEATH & DISEASE. 2017;8(6):e2848
- Article: BRITISH JOURNAL OF CANCER. 2017;116(2):195-201
- Article: JOURNAL OF PATHOLOGY CLINICAL RESEARCH. 2017;3(1):38-43
- Article: SCIENTIFIC REPORTS. 2016;6:36149
- Article: NATURE IMMUNOLOGY. 2016;17(11):1282-1290
- Article: ONCOTARGET. 2016;7(27):41948-41958
- Article: BREAST CANCER RESEARCH AND TREATMENT. 2016;158(2):253-261
- Article: CANCER RESEARCH. 2016;76(11):3166-3178
- Article: CLINICAL CANCER RESEARCH. 2016;22(10):2417-2426
- Article: BRITISH JOURNAL OF CANCER. 2016;114(10):1117-1124
- Article: ONCOTARGET. 2016;7(14):18573-18584
- Article: ONCOTARGET. 2016;7(13):16396-16408
- Article: FEBS OPEN BIO. 2016;6(3):179-189
- Article: HISTOLOGY AND HISTOPATHOLOGY. 2015;30(10):1203-1211
- Article: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2015;107(10):djv209
- Article: NEURO-ONCOLOGY. 2015;17(7):953-964
- Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2015;757:59-67
- Article: ANTIOXIDANTS & REDOX SIGNALING. 2015;22(11):938-950
- Article: MOLECULAR METABOLISM. 2015;4(4):325-336
- Article: BRITISH JOURNAL OF CANCER. 2014;111(11):2091-2102
- Article: JOURNAL OF MOLECULAR MEDICINE-JMM. 2014;92(9):983-994
- Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2014;450(4):1600-1605
- Article: FREE RADICAL BIOLOGY AND MEDICINE. 2014;68:268-277
- Article: CELL COMMUNICATION AND SIGNALING. 2013;11:49
- Article: AMERICAN JOURNAL OF PATHOLOGY. 2013;182(6):2037-2047
- Article: PLOS ONE. 2013;8(7):e67579
- Article: HISTOCHEMISTRY AND CELL BIOLOGY. 2012;138(6):847-860
- Article: INTERNATIONAL JOURNAL OF CANCER. 2012;131(10):2264-2273
- Article: MOLECULAR CANCER THERAPEUTICS. 2012;11(11):2419-2428
- Article: MOLECULAR CANCER RESEARCH. 2012;10(9):1158-1168
- Article: BLOOD. 2012;119(19):4499-4511
- Article: NEOPLASMA. 2012;59(6):719-727
- Article: NEURO-ONCOLOGY. 2011;13(11):1178-1191
- Article: CELL. 2011;146(5):826-840
- Article: CELLULAR SIGNALLING. 2011;23(5):820-826
- Article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2011;183(8):1092-1102
- Article: INTERNATIONAL JOURNAL OF CANCER. 2011;128(8):1981-1988
- Article: SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY. 2011;45(1):39-45
- Article: SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY. 2011;45(1):60-67
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(36):15774-15779
- Article: ANTI-CANCER DRUGS. 2010;21(8):759-765
- Article: NEURO-ONCOLOGY. 2010;12(9):967-975
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2010;285(34):26417-26430
- Article: PLOS ONE. 2010;5(5):e10747
- Article: CANCER RESEARCH. 2010;70(7):2644-2654
- Article: CANCER MICROENVIRONMENT. 2010;3(1):167-176
- Article: AMERICAN JOURNAL OF PATHOLOGY. 2009;175(4):1631-1637
- Article: AMERICAN JOURNAL OF PATHOLOGY. 2009;175(1):334-341
- Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2009;382(4):678-684
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(9):3414-3419
- Article: INTERNATIONAL JOURNAL OF CANCER. 2009;124(5):1227-1234
- Article: ARCHIVES OF DERMATOLOGICAL RESEARCH. 2008;300(9):505-516
- Article: NUCLEIC ACIDS RESEARCH. 2008;36(13):4443-4453
- Article: CIRCULATION RESEARCH. 2008;103(2):149-158
- Article: INTERNATIONAL JOURNAL OF CANCER. 2008;122(7):1548-1556
- Article: BRITISH JOURNAL OF DERMATOLOGY. 2008;158(3):527-538
- Article: MODERN PATHOLOGY. 2008;21(3):265-270
- Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2008;19(2):281-289
- Article: NEURO-ONCOLOGY. 2008;10(1):2-9
- Article: JOURNAL OF ENDODONTICS. 2008;34(1):14-21
- Article: INTERNATIONAL JOURNAL OF CANCER. 2007;121(12):2606-2614
- Article: MOLECULAR & CELLULAR PROTEOMICS. 2007;6(9):1500-1509
- Article: FREE RADICAL BIOLOGY AND MEDICINE. 2007;43(1):100-110
- Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2007;127(6):1516-1523
- Article: FASEB JOURNAL. 2007;21(2):523-534
- Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2006;26(12):2644-2651
- Article: JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES. 2006;43(4):383-392
- Article: MOLECULAR BIOLOGY OF THE CELL. 2006;17(11):4846-4855
- Article: ONCOGENE. 2006;25(47):6319-6324
- Article: ONCOGENE. 2006;25(35):4913-4922
- Article: LABORATORY INVESTIGATION. 2006;86(2):202-211
- Article: CANCER RESEARCH. 2005;65(17):7824-7831
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2005;280(11):10298-10304
- Article: METHODS. 2005;35(1):37-43
- Article: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2004;45(7):2075-2082
- Article: CANCER RESEARCH. 2004;64(8):2725-2733
- Article: MOLECULAR AND CELLULAR BIOLOGY. 2004;24(5):2190-2201
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2004;101(7):1886-1891
- Article: EUROPEAN JOURNAL OF CANCER. 2004;40(2):267-274
- Article: JOURNAL OF PATHOLOGY. 2004;202(1):130-138
- Article: AMBIO. 2003;32(8):495-501
- Article: CLINICAL CANCER RESEARCH. 2003;9(10 Pt 1):3779-3787
- Article: GENES & DEVELOPMENT. 2003;17(15):1835-1840
- Article: AMERICAN JOURNAL OF PATHOLOGY. 2003;163(2):673-682
- Article: ONCOGENE. 2003;22(27):4175-4185
- Article: BIOORGANIC & MEDICINAL CHEMISTRY. 2003;11(9):2007-2018
- Article: CANCER CELL. 2003;3(5):439-443
- Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2003;120(5):742-749
- Article: CANCER RESEARCH. 2002;62(19):5476-5484
- Article: FASEB JOURNAL. 2002;16(12):1575-1583
- Article: NATURE BIOTECHNOLOGY. 2002;20(5):473-477
- Article: FEBS LETTERS. 2002;517(1-3):27-31
- Article: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 2002;398(2):284-290
- Article: ONCOGENE. 2001;20(37):5219-5224
- Article: CANCER RESEARCH. 2001;61(15):5778-5783
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2001;276(30):27749-27752
- Article: NATURE CELL BIOLOGY. 2001;3(5):512-516
- Article: CANCER RESEARCH. 2001;61(7):2929-2934
- Article: CANCER RESEARCH. 2000;60(23):6723-6729
- Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2000;20(11):E89-E95
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2000;275(21):16219-16226
- Article: NATURE CELL BIOLOGY. 2000;2(5):302-309
- Article: BIOCHEMISTRY. 2000;39(9):2370-2375
- Article: INTERNATIONAL JOURNAL OF CANCER. 2000;85(3):398-406
- Article: ONCOGENE. 1999;18(50):7055-7062
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1998;273(39):25495-25502
- Article: CANCER RESEARCH. 1997;57(24):5598-5604
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(37):23317-23322
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(19):12676-12682
- Article: INTERNATIONAL JOURNAL OF CANCER. 1996;68(6):802-809
- Article: BIOCHEMISTRY. 1996;35(45):14413-14424
- Article: FEBS LETTERS. 1996;385(3):181-184
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1996;271(18):10963-10966
- Article: GROWTH FACTORS. 1995;12(2):159-164
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All other publications
- Editorial comment: FRONTIERS IN IMMUNOLOGY. 2023;14:1283186
- Review: GASTRO HEP ADVANCES. 2022;1(4):678-681
- Review: MECHANISMS AND THERAPY OF LIVER CANCER. 2020;145:99-138
- Review: TRENDS IN CANCER. 2018;4(12):838-848
- Corrigendum: NATURE BIOMEDICAL ENGINEERING. 2018;2(1):48
- Review: ADVANCED DRUG DELIVERY REVIEWS. 2017;121:117-123
- Review: ANTIOXIDANTS & REDOX SIGNALING. 2014;20(13):1994-2010
- Editorial comment: SEMINARS IN CANCER BIOLOGY. 2014;25:1-2
- Review: EXPERT OPINION ON INVESTIGATIONAL DRUGS. 2014;23(2):211-226
- Review: FUTURE ONCOLOGY. 2014;10(9):1695-1708
- Editorial comment: JOURNAL OF INTERNAL MEDICINE. 2013;274(2):102-104
- Editorial comment: EXPERIMENTAL CELL RESEARCH. 2013;319(11):1595
- Review: FEBS JOURNAL. 2013;280(2):413-431
- Review: UPSALA JOURNAL OF MEDICAL SCIENCES. 2012;117(2):187-195
- Review: JOURNAL OF BIOCHEMISTRY. 2011;150(4):345-356
- Review: EXPERIMENTAL CELL RESEARCH. 2010;316(8):1324-1331
- Review: LAKARTIDNINGEN. 2010;107(16):1066-1070
- Review: RECENT RESULTS IN CANCER RESEARCH. 2010;180:103-114
- Letter: NATURE MEDICINE. 2009;15(3):237-238
- Review: CURRENT OPINION IN GENETICS & DEVELOPMENT. 2009;19(1):67-73
- Review: FEBS JOURNAL. 2008;275(5):831-847
- Review: MECHANISMS AND THERAPY OF LIVER CANCER. 2007;97:247-274
- Review: NATURE REVIEWS CANCER. 2006;6(4):307-320
- Review: EXPERT OPINION ON THERAPEUTIC TARGETS. 2005;9(6):1217-1233
- Review: CARDIOVASCULAR RESEARCH. 2005;65(3):587-598
- Review: METHODS IN MOLECULAR BIOLOGY. 2005;293:151-166
- Review: NATURE REVIEWS CANCER. 2004;4(10):806-813
- Published conference paper: LUNG CANCER. 2004;45 Suppl 2:S163-S175
- Review: CYTOKINE & GROWTH FACTOR REVIEWS. 2004;15(4):275-286
- Review: TRENDS IN CELL BIOLOGY. 2001;11(6):258-266
- Review: MECHANISMS AND THERAPY OF LIVER CANCER. 2001;80:1-38
- Review: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 1998;1378(1):F79-F113
- Review: CYTOKINE & GROWTH FACTOR REVIEWS. 1996;7(1):3-10
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Employments
- Professor, Department of Oncology-Pathology, Karolinska Institutet, 2006-
Supervisor
- Huang Linglong, 2021