Publications from the Neuro-infections & Neuro-inflammation - Federico Iovino Group

List of selected publications from the Neuro-infections & Neuro-inflammation - Federico Iovino Group.

Selected  publications

Dysfunctional Glymphatic System with Disrupted Aquaporin 4 Expression Pattern on Astrocytes Causes Bacterial Product Accumulation in the CSF during Pneumococcal Meningitis.
Generoso JS, Thorsdottir S, Collodel A, Dominguini D, Santo RRE, Petronilho F, Barichello T, Iovino F
mBio 2022 08;():e0188622

Editorial: Host-Pathogen Interaction in the Central Nervous System.
Barichello T, Iovino F
Front Cell Infect Microbiol 2021 ;11():790761

Neuronal damage and Neuroinflammation, a bridge between bacterial meningitis and neurodegenerative diseases.
Farmen Kristine*, Tofiño-Vian Miguel, Iovino Federico. * Equal contribution
Frontiers in Cellular Neuroscience, 03 June 2021,

Neuronal death in pneumococcal meningitis is triggered by pneumolysin and RrgA interactions with β-actin.
Tabusi M, Thorsdottir S, Lysandrou M, Narciso AR, Minoia M, Srambickal CV, Widengren J, Henriques-Normark B, Iovino F
PLoS Pathog 2021 Mar;17(3):e1009432

Mannose receptor-derived peptides neutralize pore-forming toxins and reduce inflammation and development of pneumococcal disease.
Subramanian K, Iovino F, Tsikourkitoudi V, Merkl P, Ahmed S, Berry SB, Aschtgen MS, Svensson M, Bergman P, Sotiriou GA, Henriques-Normark B
EMBO Mol Med 2020 11;12(11):e12695

The impact of the ancillary pilus-1 protein RrgA of Streptococcus pneumoniae on colonization and disease.
Iovino F, Nannapaneni P, Henriques-Normark B, Normark S
Mol Microbiol 2020 03;113(3):650-658

The Role of Microglia in Bacterial Meningitis: Inflammatory Response, Experimental Models and New Neuroprotective Therapeutic Strategies.
Thorsdottir S, Henriques-Normark B, Iovino F
Front Microbiol 2019 ;10():576

Receptor Blockade: A Novel Approach to Protect the Brain From Pneumococcal Invasion.
Iovino F, Thorsdottir S, Henriques-Normark B
J Infect Dis 2018 07;218(3):476-484

pIgR and PECAM-1 bind to pneumococcal adhesins RrgA and PspC mediating bacterial brain invasion.
Iovino F, Engelen-Lee JY, Brouwer M, van de Beek D, van der Ende A, Valls Seron M, Mellroth P, Muschiol S, Bergstrand J, Widengren J, Henriques-Normark B
J Exp Med 2017 06;214(6):1619-1630

Pneumococcal meningitis is promoted by single cocci expressing pilus adhesin RrgA.
Iovino F, Hammarlöf DL, Garriss G, Brovall S, Nannapaneni P, Henriques-Normark B
J Clin Invest 2016 08;126(8):2821-6

How Does Streptococcus pneumoniae Invade the Brain?
Iovino F, Seinen J, Henriques-Normark B, van Dijl JM
Trends Microbiol 2016 Apr;24(4):307-315

The proteasome-ubiquitin system is required for efficient killing of intracellular Streptococcus pneumoniae by brain endothelial cells.
Iovino F, Gradstedt H, Bijlsma JJ
mBio 2014 Jul;5(4):e00984-14

Platelet endothelial cell adhesion molecule-1, a putative receptor for the adhesion of Streptococcus pneumoniae to the vascular endothelium of the blood-brain barrier.
Iovino F, Molema G, Bijlsma JJ
Infect Immun 2014 Sep;82(9):3555-66

Streptococcus pneumoniae Interacts with pIgR expressed by the brain microvascular endothelium but does not co-localize with PAF receptor.
Iovino F, Molema G, Bijlsma JJ
PLoS One 2014 ;9(5):e97914


  • Federico Iovino, PhD. Medical Microbiology, University of Groningen (Netherlands) 2013-11-11
  • Miguel Tofiño Vian, PhD. Biomedicine and Pharmacy, University of Valencia (Spain) 2018-10-30
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