Silvia Maioli
About me
I am research group leader and Docent (Associate Professor).
With a PhD from the University of Bologna and a postdoc at KI, I have been immersed in the field of neuroscience, particularly Alzheimer’s Disease (AD), since 2011. My research focuses on investigating the mechanisms for risk factors for Alzheimer's Disease, with a specific emphasis on ApoE, cholesterol metabolism, and oxysterols.
I am currently the main supervisor for 2 PhD students in my lab and a co-supervisor for 3 PhD students. I have directed two PhD theses as the main supervisor.
I have extensive knowledge of mouse behavior and mouse models of neurodegenerative disease, and I am Facility Coordinator for the Animal Behavior Core Facility (ABCF) at KI. In addition, I work with different molecular biology techniques.
Research
- My research is focused on understanding the biological mechanisms behind risk factors for neurodegenerative diseases like Alzheimer's Disease (AD), with a focus on sex-differences.
Changes in brain cholesterol metabolism occurs in early stages of the disease and are considered important drivers of the neurodegenerative cascades in AD. AD risk factors such as hypercholesterolemia, hypertension, lifestyle, affect brain cholesterol metabolism. I study the role of cholesterol metabolites and transporters in the brain during neurodegenerative processes by using in vitro and in vivo models, as well as human samples. In addition, I am interested in the connection between cholesterol metabolism and sex hormones. Sex hormones, including estrogen and testosterone, originate from cholesterol and promote neuroprotective functions in the brain. Both cholesterol and sex hormones are shaped by genes and the environment (for example medications, diet), serving as potential preventive and therapeutic targets for AD.
Another topic in the lab is multi-medication therapies and related sex-differences. We study the effects of different combinations of drugs commonly used in AD comorbidities using mouse models and human data from different clinical cohorts
Teaching
- I am course director for the PhD Course 5239 Behavioral Analysis in Rodents: Classic and Novel Approaches, Neuroscience Programme, Karolinska Institutet.
I teach in courses/study programmes at Karolinska Institutet:
- Clinical Research School in Molecular Medicine.
- PhD course 5539: Alzheimer’s Disease – Clinical features and pathogenic mechanisms.
- Advanced course in Alzheimer’s Disease and other dementias.
- Frontiers in Biomedicine (4Bi107) Master’s Programme in Biomedicine.
Until now I have been supervisor for 15 master students .
Selected publications
- Article: SCIENCE ADVANCES. 2024;10(4):eadj1354Latorre-Leal M; Rodriguez-Rodriguez P; Franchini L; Nikolidakis O; Daniilidou M; Delac L; Varshney MK; Arroyo-Garcia LE; Eroli F; Winblad B; Blennow K; Zetterberg H; Kivipelto M; Pacciarini M; Wang Y; Griffiths WJ; Bjoerkhem I; Matton A; Nalvarte I; Merino-Serrais P; Cedazo-Minguez A; Maioli S
Articles
- Article: NEUROBIOLOGY OF DISEASE. 2025;214:107029Giannelli S; Eroli F; Loera-Valencia R; Leoni V; Latorre-Leal M; Testa G; Staurenghi E; Sottero B; Gamba P; Maioli S; Leonarduzzi G
- Article: ACS CHEMICAL NEUROSCIENCE. 2025;16(11):2035-2047Srivastava I; Goikolea J; Kaya TA; Latorre-Leal M; Eroli F; Iglesias MP; Alvarez-Jimenez L; Arroyo-Garcia LE; Shimozawa M; Nilsson P; Fisahn A; Lindskog M; Maioli S; Loera-Valencia R
- Article: BIOLOGY OF SEX DIFFERENCES. 2025;16(1):29Demetriou A; Lindqvist B; Ali HG; Shamekh MM; Varshney M; Inzunza J; Maioli S; Nilsson P; Nalvarte I
- Article: ALZHEIMERS RESEARCH & THERAPY. 2025;17(1):79Inguanzo A; Poulakis K; Oltra J; Maioli S; Marseglia A; Ferreira D; Mohanty R; Westman E
- Article: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2025;80(5):glaf031Li Y; Wang J; Miao Y; Dunk MM; Maioli S; Fang Z; Zhang Q; Xu W
- Article: ALZHEIMERS & DEMENTIA. 2025;21(3):e70081Eroli F; Johnell K; Acararicin Z; Tsagkogianni C; Zerial S; Lancia S; Latorre-Leal M; Alanko V; Hilmer SN; Matton A; Wastesson JW; Cedazo-Minguez A; Maioli S
- Article: BMC MEDICINE. 2025;23(1):82Mo M; Abzhandadze T; Hoang MT; Sacuiu S; Jurado PG; Pereira JB; Naia L; Kele J; Maioli S; Xu H; Eriksdotter M; Garcia-Ptacek S
- Article: JOURNAL OF ALZHEIMERS DISEASE. 2025;103(3):931-940Medications and cognitive decline in Alzheimer's disease: Cohort cluster analysis of 15,428 patientsGrau-Jurado P; Mostafaei S; Xu H; Mo M; Petek B; Kalar I; Naia L; Kele J; Maioli S; Pereira JB; Eriksdotter M; Chatterjee S; Garcia-Ptacek S
- Article: BRAIN BEHAVIOR AND IMMUNITY. 2024;119:286-300Pizzirusso G; Preka E; Goikolea J; Aguilar-Ruiz C; Rodriguez-Rodriguez P; Vazquez-Cabrera G; Laterza S; Latorre-Leal M; Eroli F; Blomgren K; Maioli S; Nilsson P; Fragkopoulou A; Fisahn A; Arroyo-Garcia LE
- Article: FRONTIERS IN CELLULAR NEUROSCIENCE. 2024;18:1347535Spanos F; Gerenu G; Goikolea J; Latorre-Leal M; Balleza-Tapia H; Gomez K; Alvarez-Jimenez L; Piras A; Gomez-Galan M; Fisahn A; Cedazo-Minguez A; Maioli S; Loera-Valencia R
- Article: ALZHEIMERS RESEARCH & THERAPY. 2023;15(1):220Petek B; Habel H; Xu H; Villa-Lopez M; Kalar I; Hoang MT; Maioli S; Pereira JB; Mostafaei S; Winblad B; Gregoric Kramberger M; Eriksdotter M; Garcia-Ptacek S
- Article: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2023;234:106387Goikolea J; Latorre-Leal M; Tsagkogianni C; Pikkupeura S; Gulyas B; Cedazo-Minguez A; Loera-Valencia R; Bjorkhem I; Rodriguez PR; Maioli S
- Article: JOURNAL OF NEUROIMMUNE PHARMACOLOGY. 2023;18(3):529-550Sola-Sevilla N; Mesa-Lombardo A; Aleixo M; Exposito S; Diaz-Perdigon T; Azqueta A; Zamani F; Suzuki T; Maioli S; Eroli F; Matton A; Ramirez MJ; Solas M; Tordera RM; Martin ED; Puerta E
- Article: BRAIN COMMUNICATIONS. 2023;5(5):fcad228Daniilidou M; Eroli F; Alanko V; Goikolea J; Latorre-Leal M; Rodriguez-Rodriguez P; Griffiths WJ; Wang Y; Pacciarini M; Brinkmalm A; Zetterberg H; Blennow K; Rosenberg A; Bogdanovic N; Winblad B; Kivipelto M; Ibghi D; Cedazo-Minguez A; Maioli S; Matton A
- Article: ALZHEIMERS RESEARCH & THERAPY. 2023;15(1):141Ghorbani M; Ferreira D; Maioli S
- Article: GLIA. 2023;71(6):1414-1428Alanko V; Gaminde-Blasco A; Quintela-Lopez T; Loera-Valencia R; Solomon A; Bjorkhem I; Cedazo-Minguez A; Maioli S; Tabacaru G; Latorre-Leal M; Matute C; Kivipelto M; Alberdi E; Sandebring-Matton A
- Article: COMMUNICATIONS BIOLOGY. 2022;5(1):245Emre C; Arroyo-Garcia LE; Do KV; Jun B; Ohshima M; Alcalde SG; Cothern ML; Maioli S; Nilsson P; Hjorth E; Fisahn A; Bazan NG; Schultzberg M
- Article: ALZHEIMERS RESEARCH & THERAPY. 2022;14(1):37Goikolea J; Gerenu G; Daniilidou M; Mangialasche F; Mecocci P; Ngandu T; Rinne J; Solomon A; Kivipelto M; Cedazo-Minguez A; Sandebring-Matton A; Maioli S
- Article: MOLECULAR NEUROBIOLOGY. 2021;58(12):6063-6076Loera-Valencia R; Ismail M-A; Goikolea J; Lodeiro M; Mateos L; Bjorkhem I; Puerta E; Romao MA; Gomes CM; Merino-Serrais P; Maioli S; Cedazo-Minguez A
- Article: AGING-US. 2021;13(11):14729-14744Eroli F; Johnell K; Latorre-Leal M; Hilmer S; Wastesson J; Cedazo-Minguez A; Maioli S
- Article: AGING-US. 2020;12(11):10147-10161Chronic polypharmacy impairs explorative behavior and reduces synaptic functions in young adult miceEroli F; Johnell K; Leal ML; Adamo C; Hilmer S; Wastesson JW; Cedazo-Minguez A; Maioli S
- Article: SCIENTIFIC REPORTS. 2019;9(1):3965Caberlotto L; Nguyen T-P; Lauria M; Priami C; Rimondini R; Maioli S; Cedazo-Minguez A; Sita G; Morroni F; Corsi M; Carboni L
- Article: CEREBRAL CORTEX. 2019;29(1):429-446Merino-Serrais P; Loera-Valencia R; Rodriguez-Rodriguez P; Parrado-Fernandez C; Ismail MA; Maioli S; Matute E; Jimenez-Mateos EM; Bjorkhem I; DeFelipe J; Cedazo-Minguez A
- Article: PLOS ONE. 2018;13(3):e0194892Wastesson JW; Minguez AC; Fastbom J; Maioli S; Johnell K
- Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2017;214(3):699-717Ismail M-A; Mateos L; Maioli S; Merino-Serrais P; Ali Z; Lodeiro M; Westman E; Leitersdorf E; Gulyas B; Olof-Wahlund L; Winblad B; Savitcheva I; Bjorkhem I; Cedazo-Minguez A
- Article: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2017;72(3):319-328Lodeiro M; Puerta E; Ismail M-A; Rodriguez-Rodriguez P; Ronnback A; Codita A; Parrado-Fernandez C; Maioli S; Gil-Bea F; Merino-Serrais P; Cedazo-Minguez A
- Article: JOURNAL OF ALZHEIMERS DISEASE. 2017;56(2):601-617Persson T; Lattanzio F; Calvo-Garrido J; Rimondini R; Rubio-Rodrigo M; Sundstrom E; Maioli S; Sandebring-Matton A; Cedazo-Minguez A
- Article: JOURNAL OF ALZHEIMERS DISEASE. 2016;53(1):349-361Tajeddinn W; Persson T; Calvo-Garrido J; Ahmed MS; Maioli S; Vijayaraghavan S; Kazokoglu MS; Parrado-Fernandez C; Yoshitake T; Kehr J; Francis P; Winblad B; Hoglund K; Cedazo-Minguez A; Aarsland D
- Article: NEUROSCIENCE LETTERS. 2015;594:137-143Tajeddinn W; Persson T; Maioli S; Calvo-Garrido J; Parrado-Fernandez C; Yoshitake T; Kehr J; Francis P; Winblad B; Hoglund K; Cedazo-Minguez A; Aarsland D
- Article: BEHAVIOURAL BRAIN RESEARCH. 2015;278:356-359Heverin M; Maioli S; Pham T; Mateos L; Camporesi E; Ali Z; Winblad B; Cedazo-Minguez A; Bjorkhem I
- Article: AGING CELL. 2015;14(1):122-129Maioli S; Lodeiro M; Merino-Serrais P; Falahati F; Khan W; Puerta E; Codita A; Rimondini R; Ramirez MJ; Simmons A; Gil-Bea F; Westman E; Cedazo-Minguez A
- Article: FEBS OPEN BIO. 2014;4:393-406Wanngren J; Lara P; Ojemalm K; Maioli S; Moradi N; Chen L; Tjernberg LO; Lundkvist J; Nilsson I; Karlstrom H
- Article: PLOS ONE. 2013;8(7):e68534Maioli S; Bavner A; Ali Z; Heverin M; Ismail M-A; Puerta E; Olin M; Saeed A; Shafaati M; Parini P; Cedazo-Minguez A; Bjorkhem I
- Article: JOURNAL OF ALZHEIMERS DISEASE. 2012;32(2):341-355Maioli S; Puerta E; Merino-Serrais P; Fusari L; Gil-Bea F; Rimondini R; Cedazo-Minguez A
- Article: BEHAVIOURAL BRAIN RESEARCH. 2012;230(2):349-354Maioli S; Gangarossa G; Locchi F; Andrioli A; Bertini G; Rimondini R
- Show more
All other publications
- Preprint: BIORXIV. 2024;BIORXIVDemetriou A; Lindqvist B; Ali HG; Shamekh MM; Maioli S; Inzunza J; Varshney M; Nilsson P; Nalvarte I
- Preprint: BIORXIV. 2024Pizzirusso G; Preka E; Goikolea J; Aguilar-Ruiz C; Rodriguez PR; Cabrera GV; Laterza S; Leal ML; Eroli F; Blomgren K; Maioli S; Nilsson P; Fragkopoulou A; Fisahn A; Arroyo-García LE
- Preprint: BIORXIV. 2022Goikolea J; Roussarie J-P; Gerenu G; Loera-Valencia R; Latorre-Leal M; Cedazo-Minguez A; Rodriguez-Rodriguez P; Maioli S
- Review: ESSAYS IN BIOCHEMISTRY. 2021;65(6):913-925Maioli S; Leander K; Nilsson P; Nalvarte I
- Review: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(18):10139Loera-Valencia R; Eroli F; Garcia-Ptacek S; Maioli S
- Preprint: BIORXIV. 2021Latorre-Leal M; Rodriguez-Rodriguez P; Franchini L; Daniilidou M; Eroli F; Winblad B; Blennow K; Zetterberg H; Kivipelto M; Pacciarini M; Wang Y; Griffiths W; Björkhem I; Sandebring Matton A; Merino-Serrais P; Cedazo-Minguez A; Maioli S
- Review: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2019;190:104-114Loera-Valencia R; Goikolea J; Parrado-Fernandez C; Merino-Serraisa P; Maioli S
Grants
- Swedish Research Council1 January 2025 - 31 December 2028Women account for two-thirds of individuals suffering from Alzheimer’s Disease (AD). Women with early menopause and those carrying the APOE4 gene are at higher risk for AD. Menopause-related estrogen loss and dysregulated brain cholesterol metabolism may contribute to AD and represent therapeutic targets, particularly for women. Our data show that activation of the brain enzyme CYP46A1 (responsible for converting excess cholesterol into the oxysterol 24SOH) enhances memory and estrogen signaling in female mice during aging and in menopausal-like conditions.We propose todetermine whether CYP46A1 is a druggable axis for women at higher risk for AD. We will induce menopausal-like conditions and activate CYP46A1 (through genetic and pharmacological approaches) in AD mouse models (App knock-in and APOE4/E3) and study disease mechanisms in depth in vitro. establish whether 24SOH levels can serve as an early blood biomarker to predict higher vulnerability to AD in women, possibly offering a time window for prevention. We will analyze data from the Women Health Initiative Study including levels of oxysterols, sex hormones, APOE genotype, CYP46A1 polymorphisms, reproductive history in women, and AD outcomes. The findings from this project could be revolutionary and lead to novel interventions to increase brain-specific estrogen activity in women at risk. This could be an alternative to hormone therapies, which have led to controversial results until now, including side effects.
- Swedish Research Council1 January 2024 - 31 December 2026APOE variant 4 is the most common genetic risk factor for late-onset Alzheimer’s disease (AD), and it is well known that women carrying APOE4 run a 4-fold higher risk of AD than male carriers. Nevertheless, the cause of this sex difference is still enigmatic. In this project, we address the hypothesis that the drop of female sex hormone estrogen and metabolic changes at menopause impact on APOE4 regulation and downstream factors, and that this contributes to sex differences in AD. Our preliminary results support this hypothesis by suggesting that the estrogen receptor beta (ERβ) to be an important link between menopause and APOE levels. Selective ERβ activation protects against AD pathology in an AD mouse model and can regulate APOE levels in a sex-specific manner. Making use of a multidisciplinary collaboration between experts in neuroendocrinology, AD, epidemiology, biostatistics, and genetics, we will:address the relationship between age at menopause, hormone replacement therapy, APOE4 and other genetic variants, and AD diagnosis in human cohorts,validate such relationships in an AD mouse model where menopause is simulated, andin a data-driven approach identify causative molecular networks underlying these relationships using human APOE4 brain organoid models.The outcome of this project will provide new mechanistic insights into the sex differences in AD and how such knowledge can be used for preventive clinical measures, especially for APOE4-positive women.
- Finansieringsförslag för en kryostat inom inom Avdelningen för NeurogeriatrikOlle Engkvists Stiftelse1 January 2024
- Cholesterol metabolism and sex hormones in Alzheimer’s Disease: from basic mechanisms to precision medicine.The private initiative “Innovative ways to fight Alzheimer’s disease - Leif Lundblad Family and others”1 November 2023 - 31 October 2026
- King Gustaf V:s and Queen Victorias Foundation1 January 2023 - 31 December 2024
- Sex specific effects of CYP46A1 up regulation in brain: roles and implication for cholesterol turnover in neurodegenerative diseases.KID funding1 January 2022 - 31 December 2025
- Understanding the role of menopause and estrogen receptor activation for Alzheimer's disease risk.National Institutes of Health30 September 2020 - 31 May 2024
Employments
- Principal Researcher, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 2025-
- Senior Research Specialist, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 2022-2025
Degrees and Education
- Docent, Karolinska Institutet, 2023