Publications from the Iovino Laboratory

List of selected publications from the Iovino Laboratory.

Selected  publications

Neuronal damage and Neuroinflammation, a bridge between bacterial meningitis and neurodegenerative diseases.
Farmen Kristine*, Tofiño-Vian Miguel, Iovino Federico. * Equal contribution
Frontiers in Cellular Neuroscience, 03 June 2021,

Neuronal death in pneumococcal meningitis is triggered by pneumolysin and RrgA interactions with β-actin.
Tabusi M, Thorsdottir S, Lysandrou M, Narciso AR, Minoia M, Srambickal CV, Widengren J, Henriques-Normark B, Iovino F
PLoS Pathog 2021 Mar;17(3):e1009432

Experimental Model for Studies of Pneumococcal Colonization in Older Adults.
Iovino F, Henriques-Normark B (2020).
American Journal of Respiratory and Critical Care Medicine. doi: 10.1164/rccm.202009-3681ED

Silica-coated phosphorescent nanoprobes for selective cell targeting and dynamic bioimaging of pathogen-host cell interactions.
Iovino F, Merkl P, Spyrogianni A, Henriques-Normark B, Sotiriou GA
Chem Commun (Camb) 2020 Jun;56(51):6989-6992

The impact of the ancillary pilus-1 protein RrgA of Streptococcus pneumoniae on colonization and disease.
Iovino F, Nannapaneni P, Henriques-Normark B, Normark S
Mol Microbiol 2020 03;113(3):650-658

The Role of Microglia in Bacterial Meningitis: Inflammatory Response, Experimental Models and New Neuroprotective Therapeutic Strategies.
Thorsdottir S, Henriques-Normark B, Iovino F
Frontiers in Microbiology, 10:576

Receptor Blockade: A Novel Approach to Protect the Brain From Pneumococcal Invasion.
Iovino F, Thorsdottir S, Henriques-Normark B
The Journal of Infectious Diseases, 218: 476-484

pIgR and PECAM-1 bind to pneumococcal adhesins RrgA and PspC mediating bacterial brain invasion.
Iovino F, Engelen-Lee JY, Brouwer M, van de Beek D, van der Ende A, Valls Seron M, et al
The Journal of Experimental Medicine. 214, 1619-1630

Pneumococcal meningitis is promoted by single cocci expressing pilus adhesin RrgA.
Iovino F, Hammarlöf DL, Garriss G, Brovall S, Nannapaneni P, Henriques-Normark B
The Journal of Clinical Investigation. 126, 2821-6

How Does Streptococcus pneumoniae Invade the Brain?
Iovino F, Seinen J, Henriques-Normark B, van Dijl JM
Trends in Microbiology. 24, 307-15. * First and corresponding author

The proteasome-ubiquitin system is required for efficient killing of intracellular Streptococcus pneumoniae by brain endothelial cells.
Iovino F, Gradstedt H, Bijlsma JJ
MBio. 5, e00984-14

Platelet endothelial cell adhesion molecule-1, a putative receptor for the adhesion of Streptococcus pneumoniae to the vascular endothelium of the blood-brain barrier.
Iovino F, Molema G, Bijlsma JJ
Infection and Immunity. 82, 3555-66

Streptococcus pneumoniae Interacts with pIgR expressed by the brain microvascular endothelium but does not co-localize with PAF receptor.
Iovino F, Molema G, Bijlsma JJ
PLoS One 9, e97914

Interactions between blood-borne Streptococcus pneumoniae and the blood-brain barrier preceding meningitis.
Iovino F, Orihuela CJ, Moorlag HE, Molema G, Bijlsma JJ
PLoS One 8, e68408


Federico Iovino, PhD. Medical Microbiology, University of Groningen (Netherlands) 2013-11-11

Miguel Tofiño Vian, PhD. Biomedicine and Pharmacy, University of Valencia (Spain) 2018-10-30