Research group Stephen Malin

Focus

Our research focuses on how atherogenic dyslipidemia provokes the immune system, particularly B lymphocytes, and how can this lead to tissue damage.

Collaborations

Cardiovascular disease: Christoph Binder, Vienna; Esther Lutgens, Amsterdam; Carolina Hagberg, Göran Hansson & Peder Olofsson, Stockholm.

Immune system and Inflammation: Meinrad Busslinger, Vienna; Mikael Karlsson, Jonathan Coquet & Rikard Holmdahl, Stockholm

Funding

International Funding: Leducq Foundation, EU FP7, EU-COST, Novo Nordisk

National Funding: Vetenskapsrådet Starting and Project grants, Hjärt-Lungfonden, Åke Wibergs Stiftelse

KI Funding: KID, Dr Åke Olssons stiftelse, VR Linne Center CERIC.

Group members

Stephen Malin PhD, Associate Professor, Group Leader

Giada Di Nunzio PhD, Post doctoral Fellow

Xueming Zhang PhD student

Yuyang Zhang PhD Student, Associated

Key publications

Pax5 regulates B cell immunity by promoting PI3K signaling via PTEN down-regulation.
Calderón L, Schindler K, Malin SG, Schebesta A, Sun Q, Schwickert T, Alberti C, Fischer M, Jaritz M, Tagoh H, Ebert A, Minnich M, Liston A, Cochella L, Busslinger M
Sci Immunol 2021 Jul;6(61):eabg5003.

Repression of the B cell identity factor Pax5 is not required for plasma cell development.
Liu GJ, Jaritz M, Wöhner M, Agerer B, Bergthaler A, Malin SG, Busslinger M
J Exp Med 2020 11;217(11):e20200147.

Combined proinflammatory cytokine and cognate activation of invariant natural killer T cells enhances anti-DNA antibody responses.
Sedimbi SK, Hägglöf T, Garimella MG, Wang S, Duhlin A, Coelho A, Ingelshed K, Mondoc E, Malin SG, Holmdahl R, Lane DP, Leadbetter EA, Karlsson MCI
Proc Natl Acad Sci U S A 2020 04;117(16):9054-9063.

Functions of acetylcholine-producing lymphocytes in immunobiology.
Malin SG, Shavva VS, Tarnawski L, Olofsson PS
Curr Opin Neurobiol 2020 06;62:115-121.

Germinal Center-Derived Antibodies Promote Atherosclerosis Plaque Size and Stability.
Centa M, Jin H, Hofste L, Hellberg S, Busch A, Baumgartner R, Verzaal NJ, Lind Enoksson S, Perisic Matic L, Boddul SV, Atzler D, Li DY, Sun C, Hansson GK, Ketelhuth DFJ, Hedin U, Wermeling F, Lutgens E, Binder CJ, Maegdesfessel L, Malin SG
Circulation 2019 05;139(21):2466-2482.

Acute Loss of Apolipoprotein E Triggers an Autoimmune Response That Accelerates Atherosclerosis.
Centa M, Prokopec KE, Garimella MG, Habir K, Hofste L, Stark JM, Dahdah A, Tibbitt CA, Polyzos KA, Gisterå A, Johansson DK, Maeda NN, Hansson GK, Ketelhuth DFJ, Coquet JM, Binder CJ, Karlsson MCI, Malin S
Arterioscler Thromb Vasc Biol 2018 08;38(8):e145-e158.

A Role for the Transcription Factor Arid3a in Mouse B2 Lymphocyte Expansion and Peritoneal B1a Generation.
Habir K, Aeinehband S, Wermeling F, Malin S
Front Immunol 2017 ;8:1387.

Germinal Center B Cells Are Essential for Collagen-Induced Arthritis.
Dahdah A, Habir K, Nandakumar KS, Saxena A, Xu B, Holmdahl R, Malin S
Arthritis Rheumatol 2018 02;70(2):193-203.

Atherosclerosis Susceptibility in Mice Is Independent of the V1 Immunoglobulin Heavy Chain Gene.
Centa M, Gruber S, Nilsson D, Polyzos KA, Johansson DK, Hansson GK, Ketelhuth DF, Binder CJ, Malin S
Arterioscler Thromb Vasc Biol 2016 Jan;36(1):25-36.

STAT5 in B cell development and leukemia.
Malin S, McManus S, Busslinger M
Curr Opin Immunol 2010 Apr;22(2):168-76.

Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development.
Malin S, McManus S, Cobaleda C, Novatchkova M, Delogu A, Bouillet P, Strasser A, Busslinger M
Nat Immunol 2010 Feb;11(2):171-9.

A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse.
Schotta G, Sengupta R, Kubicek S, Malin S, Kauer M, Callén E, Celeste A, Pagani M, Opravil S, De La Rosa-Velazquez IA, Espejo A, Bedford MT, Nussenzweig A, Busslinger M, Jenuwein T
Genes Dev 2008 Aug;22(15):2048-61.

Instructive role of the transcription factor E2A in early B lymphopoiesis and germinal center B cell development.
Kwon K, Hutter C, Sun Q, Bilic I, Cobaleda C, Malin S, Busslinger M
Immunity 2008 Jun;28(6):751-62.