Research group Stephen Malin

Lipoproteins and the Immune System

Lipoproteins transport cholesterol and triglycerides to cells in the body. An excess of lipoproteins can result in the storage of these lipids in inappropriate tissues. This provokes the immune system and results in tissue damage, notable examples being atherosclerosis and fatty-liver disease.  We want to understand how these diseases are initiated.


International funding:
Leducq Foundation, EU FP7, EU-COST, Novo Nordisk

National funding:
Vetenskapsrådet Starting and Project grants
Åke Wibergs Stiftelse

KI funding:
Dr Åke Olssons stiftelse
VR Linne Center CERIC

Group members

Stephen Malin

Principal researcher/Research group leader

Key publications

Kupffer cells dictate hepatic responses to the atherogenic dyslipidemic insult.
Hellberg S, Ahmed O, Zhang Y, Di Nunzio G, Björck HM, Francis R, Fagerberg L, Gisterå A, Zhang X, Metso J, Manfé V, Soto Y, Franco-Cereceda A, Eriksson P, Jauhiainen M, Olofsson PS, Malin SG
bioRxiv 2022.10.13.512086. 

Animal Models of Atherosclerosis-Supportive Notes and Tricks of the Trade.
Gisterå A, Ketelhuth DFJ, Malin SG, Hansson GK
Circ Res 2022 Jun;130(12):1869-1887

Pax5 regulates B cell immunity by promoting PI3K signaling via PTEN down-regulation.
Calderón L, Schindler K, Malin SG, Schebesta A, Sun Q, Schwickert T, Alberti C, Fischer M, Jaritz M, Tagoh H, Ebert A, Minnich M, Liston A, Cochella L, Busslinger M
Sci Immunol 2021 Jul;6(61):eabg5003.

Repression of the B cell identity factor Pax5 is not required for plasma cell development.
Liu GJ, Jaritz M, Wöhner M, Agerer B, Bergthaler A, Malin SG, Busslinger M
J Exp Med 2020 11;217(11):e20200147.

Germinal Center-Derived Antibodies Promote Atherosclerosis Plaque Size and Stability.
Centa M, Jin H, Hofste L, Hellberg S, Busch A, Baumgartner R, Verzaal NJ, Lind Enoksson S, Perisic Matic L, Boddul SV, Atzler D, Li DY, Sun C, Hansson GK, Ketelhuth DFJ, Hedin U, Wermeling F, Lutgens E, Binder CJ, Maegdesfessel L, Malin SG
Circulation 2019 05;139(21):2466-2482.

Acute Loss of Apolipoprotein E Triggers an Autoimmune Response That Accelerates Atherosclerosis.
Centa M, Prokopec KE, Garimella MG, Habir K, Hofste L, Stark JM, Dahdah A, Tibbitt CA, Polyzos KA, Gisterå A, Johansson DK, Maeda NN, Hansson GK, Ketelhuth DFJ, Coquet JM, Binder CJ, Karlsson MCI, Malin S
Arterioscler Thromb Vasc Biol 2018 08;38(8):e145-e158.

Germinal Center B Cells Are Essential for Collagen-Induced Arthritis.
Dahdah A, Habir K, Nandakumar KS, Saxena A, Xu B, Holmdahl R, Malin S
Arthritis Rheumatol 2018 02;70(2):193-203.

Atherosclerosis Susceptibility in Mice Is Independent of the V1 Immunoglobulin Heavy Chain Gene.
Centa M, Gruber S, Nilsson D, Polyzos KA, Johansson DK, Hansson GK, Ketelhuth DF, Binder CJ, Malin S
Arterioscler Thromb Vasc Biol 2016 Jan;36(1):25-36.

Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development.
Malin S, McManus S, Cobaleda C, Novatchkova M, Delogu A, Bouillet P, Strasser A, Busslinger M
Nat Immunol 2010 Feb;11(2):171-9.

Instructive role of the transcription factor E2A in early B lymphopoiesis and germinal center B cell development.
Kwon K, Hutter C, Sun Q, Bilic I, Cobaleda C, Malin S, Busslinger M
Immunity 2008 Jun;28(6):751-62.

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