Stephen Malin

Stephen Malin

Principal Researcher | Docent
Visiting address: BioClinicum, plan 8, Karolinska Universitetssjukhuset Solna, 17176 Solna
Postal address: K2 Medicin, Solna, K2 Kardiov m Malin S, 171 77 Stockholm

About me

  • Lipoproteins and the Immune System


  • Lipoproteins transport cholesterol and triglycerides to 

  • and from cells in the body. An excess of 
  • APOB-lipoproteins can result in the 
  • accumulation of these lipids in inappropriate tissues. This provokes the immune system and results in tissue damage, notable examples being atherosclerosis and fatty-liver disease. 

  • Atherosclerosis is a major cause of heart attacks and stroke, which are leading causes of death worldwide. Our approach is aimed at understanding how these diseases are initiated, where in the body this initiation occurs, and the nature of protective and pathogenic responses by the immune system. We create novel models that allow for on-demand APOB-lipoprotein accumulation and combine this with a range of the most modern and classical experimental techniques. This provides us with the opportunity to investigate basic immunology in the context of understanding mechanisms of a global health problem.


All other publications



  • Principal Researcher, Department of Medicine, Karolinska Institutet, 2022-

Degrees and Education

  • Docent, Karolinska Institutet, 2020
  • Doctor Of Philosophy, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 2004

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