Research Group Ning Xu Landén
Regulatory RNAs, skin wound healing, psoriasis
Both chronic non-healing wounds and psoriasis are major and rising health and economic burdens worldwide and lack of effective treatment. Investigation of the role of regulatory RNAs, for example microRNA and long non-coding RNAs, represents an emerging concept, and constitutes a promising area for pharmaceutical intervention. The goal of our laboratory is to unravel the role(s) of regulatory RNAs in skin wound healing and in psoriasis. Moreover, we aim to translate basic scientific findings into therapeutic interventions for patients.
Major research focus
Project 1. The role of non-coding RNAs in human skin wound healing
The goal of our research is to develop novel RNA-based treatments to improve healing of human skin wounds. The immense economic and social impact of deficient wound healing e.g. chronic ulcers post-surgical wounds care and skin scarring, calls for attention and allocation of resources to understand biological mechanisms underlying wound complications. Due to the complex nature of wounds, efficient targeted approach to enhance healing are essentially lacking today.
The recent discovery of non-coding RNAs (ncRNAs) as powerful gene regulators provides hope to develop novel RNA-based treatments for a wide variety of diseases. However, the role of ncRNAs in human skin wound healing remains largely unexplored.
The objective of our study is to reveal the role(s) of ncRNAs in skin wound healing and to explore the potential of RNA-based therapy for chronic wounds. We primarily focus on small ncRNAs, i.e. microRNAs (miRNAs) and long-non-coding RNAs (lncRNAs) and study:
(i) The expression profiles of miRNA/lncRNA in injured human skin;
(ii) The biological function of differentially expressed miRNAs/lncRNAs in wounds;
(iii) The molecular mechanisms mediating the biological functions of wound related miRNAs/lncRNAs;
(iv) The therapeutic potentials of targeting wound related miRNAs.
Our research network is composed of both clinicians and scientists, which allows us to perform ‘Bench-to-Bedside’ research. At present, we are investigating the novel roles of miRNAs and lncRNAs in skin wounds using our unique collection of human wound tissues. In the next step, we aim to translate our basic scientific findings into therapeutic interventions for wound patients.
Project 2. Investigation of the mechanistic links between psoriasis and co-morbidities
Psoriasis is an immune-mediated inflammatory disease of the skin. It is a lifelong disease with spontaneous remissions and exacerbations, affecting the patients’ life quality substantially, and there is no cure for it today. Epidemiological studies show that psoriasis patients have increased risks of developing systemic co-morbidities, e.g. obesity, overt diabetes and cardiovascular disease; however, the molecular mechanisms behind these co-morbidities remain unexplored. We have previously demonstrated that miRNAs play important roles in skin inflammation of psoriasis. Here, we study whether miRNA could also be a key mechanistic link between psoriasis and its co-morbidities, using materials from a large biobank of psoriasis patients in Stockholm. This study will further increase our understanding about pathogenesis of psoriasis. It is essential for the effective management of psoriasis and prevention of its related co-morbidities.
Ning Xu Landén, Associate Professor, Group leader
Dongqing Li, PhD, Postdoc fellow
Eva Herter, PhD, Postdoc fellow
Jianmin Wu, PhD, Visiting researcher
Xi Li, MD, PhD student
Maria-Alexandra Toma, PhD Student
Recent Key Publications
MicroRNA-132 promotes fibroblast migration via regulating RAS p21 protein activator 1 in skin wound healing.
Li X, Li D, Wikstrom JD, Pivarcsi A, Sonkoly E, Ståhle M, et al
Sci Rep 2017 08;7(1):7797
MicroRNA-132 with Therapeutic Potential in Chronic Wounds.
Li X, Li D, Wang A, Chu T, Lohcharoenkal W, Zheng X, et al
J. Invest. Dermatol. 2017 12;137(12):2630-2638
MicroRNAs in skin wound healing.
Li D, Landén NX
Eur J Dermatol 2017 Jun;27(S1):12-14
Non-Coding RNAs: New Players in Skin Wound Healing.
Herter EK, Xu Landén N
Adv Wound Care (New Rochelle) 2017 Mar;6(3):93-107
Psoriasis Skin Inflammation-Induced microRNA-26b Targets NCEH1 in Underlying Subcutaneous Adipose Tissue.
Cheung L, Fisher RM, Kuzmina N, Li D, Li X, Werngren O, et al
J. Invest. Dermatol. 2016 Mar;136(3):640-648
Transition from inflammation to proliferation: a critical step during wound healing.
Landén NX, Li D, Ståhle M
Cell. Mol. Life Sci. 2016 10;73(20):3861-85
MicroRNA-132 enhances transition from inflammation to proliferation during wound healing.
Li D, Wang A, Liu X, Meisgen F, Grünler J, Botusan IR, et al
J. Clin. Invest. 2015 Aug;125(8):3008-26
MicroRNA-31 is overexpressed in psoriasis and modulates inflammatory cytokine and chemokine production in keratinocytes via targeting serine/threonine kinase 40.
Xu N, Meisgen F, Butler LM, Han G, Wang XJ, Söderberg-Nauclér C, et al
J. Immunol. 2013 Jan;190(2):678-88
MiR-125b, a microRNA downregulated in psoriasis, modulates keratinocyte proliferation by targeting FGFR2.
Xu N, Brodin P, Wei T, Meisgen F, Eidsmo L, Nagy N, et al
J. Invest. Dermatol. 2011 Jul;131(7):1521-9