Chronic myeloid malignancies – Johanna Ungerstedt group

Ungerstedt lab is a translational hematology lab focusing on epigenetics and genetics in the pathobiology of myeloid hematological malignancies, especially chronic myelomonocytic leukemia and systemic mastocytosis, in search for prognostic tools and novel therapeutic targets.

Johanna Ungerstedt's research group. Photo: Private

About our research

The group is part of the Center for Hematology and Regenerative Medicine (HERM).

Mission of the research group

Chronic myeloid malignancies are a diverse group of hematopoietic stem cell diseases with a varying prognosis, with the common feature of having a propensity to progression/transformation to acute myeloid leukemia. Our mission is to a) understand the role of chronic inflammation and microenvironment in disease onset, b) understand how genetic, epigenetic, environment and other factors contribute to disease onset from a pre-disease state and to disease progression and prognosis, c) identify targetable factors responsible for the transition to overt disease, with the ultimate goal to d) keep these malignancies in a pre-malignant chronic state and avoid overt disease outbreak. For systemic mastocytosis, we also study the cell of origin and how this impacts the disease course of indolent (with a normal life expectancy) or advanced (with a life expectancy of 2-4 years).

Keywords

Epigenetics, chromatin, systemic mastocytosis, chronic myelomonocytic leukemia

Overview of objectives a-d for chronic myeloid malignancies, especially focusing on chronic myelomonocytic leukemia (CMML) and systemic mastocytosis (SM).
Overview of objectives a-d for chronic myeloid malignancies, especially focusing on chronic myelomonocytic leukemia (CMML) and systemic mastocytosis (SM). Made by Johanna Ungerstedt

Publications

Selected publications

Funding

  • The Swedish Cancer Society (Cancerfonden) Junior Clinical Research Position, 6 years 2018-23 for J Ungerstedt
  • The Swedish Cancer Society (Cancerfonden)
  • Stockholm Cancer Association (Radiumhemmets Forskningsfonder)
  • KI Clinical Scientist Training Program (CSTP), salary funding for PhD of Matilda Kjellander 2017-2022
  • Svenska Läkaresällskapet, post doc project funding for Stina Söderlund

Staff and contact

Group leader

All members of the group

Alumni