Our research aims at understanding the mechanisms of action of novel biological pharmaceuticals on tumor cells.
We are focusing on extra- and intracellularly functional antibodies, and fragments to tailor the antibody-target interaction, as well as to widen the druggable proteome for antibody therapeutics.
We also aim at developing new drug delivery technologies to target tumors that for one reason or another are difficult to reach by drugs because of, for example, low exposure levels, metabolism, or adverse toxicity.
A third research interest concerns a novel proteomics methodology for characterization of membrane proteins aimed at epitope discovery for antibody therapeutics targeting ion channels, and GPCRs.
- Oblique Therapeutics AB
Rational antibody design for undruggable targets using kinetically controlled biomolecular probes.
Carolina L. Trkulja1,Oscar Jungholm, Kent Jardemark, Monica M. Marcus, Owe Orwar et al.
Science Advances 16 April 2021
Spatial characterization of a multifunctional pipette for drug delivery in hippocampal brain slices.
Ahemaiti A, Wigström H, Ainla A, Jeffries GD, Orwar O, Jesorka A, et al
J. Neurosci. Methods 2015 Feb;241():132-6
Probing structure and function of ion channels using limited proteolysis and microfluidics.
Trkulja CL, Jansson ET, Jardemark K, Orwar O
J. Am. Chem. Soc. 2014 Oct;136(42):14875-82
Probing enzymatic activity inside single cells.
Olofsson J, Xu S, Jeffries GD, Jesorka A, Bridle H, Isaksson I, et al
Anal. Chem. 2013 Nov;85(21):10126-33
A multifunctional pipette for localized drug administration to brain slices.
Ahemaiti A, Ainla A, Jeffries GD, Wigström H, Orwar O, Jesorka A, et al
J. Neurosci. Methods 2013 Oct;219(2):292-6
Effect of cholesterol depletion on the pore dilation of TRPV1.
Jansson ET, Trkulja CL, Ahemaiti A, Millingen M, Jeffries GD, Jardemark K, et al
Mol Pain 2013 Jan;9():1
Microfluidic flow cell for sequential digestion of immobilized proteoliposomes.
Jansson ET, Trkulja CL, Olofsson J, Millingen M, Wikström J, Jesorka A, et al
Anal. Chem. 2012 Jul;84(13):5582-8